TRABECULAR BONE SCORE (TBS) AND DEVELOPMENT OF FRACTURE IN MULTIPLE MYELOMA
(Abstract release date: 05/19/16)
EHA Library. Lee E. 06/09/16; 134884; PB1984
Ms. Eun Mi Lee
Contributions
Contributions
Abstract
Abstract: PB1984
Type: Publication Only
Background
Osteolytic bone lesions are common complications in patients with multiple myeloma, and have impact on the quality of life because of the risk of fractures. Trabecular bone score (TBS) is a novel texture index derived from dual energy X-ray absorptiometry (DXA) of lumbar spine images, providing information of bone microarchitecture independent of bone mineral density.
Aims
The aim of this study was to test if TBS may be useful to predict bone fractures in patients with multiple myeloma.
Methods
TBS was calculated retrospectively from existing DXA images of the lumbar spine, in 20 patients with newly diagnosed multiple myeloma. We analyzed the development of fractures in these patients.
Results
The median age of the patients was 66 years (range, 49-77), and 15 patients (75%) were female. Fifteen patients had osteopenia (5 patients, 25%) or osteoporosis (10 patients, 50%) by using DXA. Osteolytic bone lesions were observed in 18 patients (90%) at the time of diagnosis. The median duration of follow-up was 31.9 months (95% CI, 20.1-43.7 months), 6 events (long-bone fractures in 5 events, vertebral fracture in 1) of fracture were occurred in 5 patients (25%). The mean TBS of lumbar spine (L1-4) in patients who experienced development of fractures (1.162 ± 0.032 [95% CI, 1.122-1.201]) was lower than patients who did not (1.255 ± 0.154 [95% CI, 1.170-1.3]), however, there was no statistical significance (p=0.061). Among TBS of individual lumbar spines, L2 showed significantly lower score in patient who experienced development of fractures (1.135 ± 0.085 [95% CI, 1.030-1.241] vs. 1.243 ± 0.169 [95% CI, 1.149-1.336], p=0.032).
Conclusion
TBS of lumbar spine in patients with multiple myeloma could be helpful to predict development of fractures, however, further investigations are needed.
Session topic: E-poster
Keyword(s): Multiple myeloma
Type: Publication Only
Background
Osteolytic bone lesions are common complications in patients with multiple myeloma, and have impact on the quality of life because of the risk of fractures. Trabecular bone score (TBS) is a novel texture index derived from dual energy X-ray absorptiometry (DXA) of lumbar spine images, providing information of bone microarchitecture independent of bone mineral density.
Aims
The aim of this study was to test if TBS may be useful to predict bone fractures in patients with multiple myeloma.
Methods
TBS was calculated retrospectively from existing DXA images of the lumbar spine, in 20 patients with newly diagnosed multiple myeloma. We analyzed the development of fractures in these patients.
Results
The median age of the patients was 66 years (range, 49-77), and 15 patients (75%) were female. Fifteen patients had osteopenia (5 patients, 25%) or osteoporosis (10 patients, 50%) by using DXA. Osteolytic bone lesions were observed in 18 patients (90%) at the time of diagnosis. The median duration of follow-up was 31.9 months (95% CI, 20.1-43.7 months), 6 events (long-bone fractures in 5 events, vertebral fracture in 1) of fracture were occurred in 5 patients (25%). The mean TBS of lumbar spine (L1-4) in patients who experienced development of fractures (1.162 ± 0.032 [95% CI, 1.122-1.201]) was lower than patients who did not (1.255 ± 0.154 [95% CI, 1.170-1.3]), however, there was no statistical significance (p=0.061). Among TBS of individual lumbar spines, L2 showed significantly lower score in patient who experienced development of fractures (1.135 ± 0.085 [95% CI, 1.030-1.241] vs. 1.243 ± 0.169 [95% CI, 1.149-1.336], p=0.032).
Conclusion
TBS of lumbar spine in patients with multiple myeloma could be helpful to predict development of fractures, however, further investigations are needed.
Session topic: E-poster
Keyword(s): Multiple myeloma
Abstract: PB1984
Type: Publication Only
Background
Osteolytic bone lesions are common complications in patients with multiple myeloma, and have impact on the quality of life because of the risk of fractures. Trabecular bone score (TBS) is a novel texture index derived from dual energy X-ray absorptiometry (DXA) of lumbar spine images, providing information of bone microarchitecture independent of bone mineral density.
Aims
The aim of this study was to test if TBS may be useful to predict bone fractures in patients with multiple myeloma.
Methods
TBS was calculated retrospectively from existing DXA images of the lumbar spine, in 20 patients with newly diagnosed multiple myeloma. We analyzed the development of fractures in these patients.
Results
The median age of the patients was 66 years (range, 49-77), and 15 patients (75%) were female. Fifteen patients had osteopenia (5 patients, 25%) or osteoporosis (10 patients, 50%) by using DXA. Osteolytic bone lesions were observed in 18 patients (90%) at the time of diagnosis. The median duration of follow-up was 31.9 months (95% CI, 20.1-43.7 months), 6 events (long-bone fractures in 5 events, vertebral fracture in 1) of fracture were occurred in 5 patients (25%). The mean TBS of lumbar spine (L1-4) in patients who experienced development of fractures (1.162 ± 0.032 [95% CI, 1.122-1.201]) was lower than patients who did not (1.255 ± 0.154 [95% CI, 1.170-1.3]), however, there was no statistical significance (p=0.061). Among TBS of individual lumbar spines, L2 showed significantly lower score in patient who experienced development of fractures (1.135 ± 0.085 [95% CI, 1.030-1.241] vs. 1.243 ± 0.169 [95% CI, 1.149-1.336], p=0.032).
Conclusion
TBS of lumbar spine in patients with multiple myeloma could be helpful to predict development of fractures, however, further investigations are needed.
Session topic: E-poster
Keyword(s): Multiple myeloma
Type: Publication Only
Background
Osteolytic bone lesions are common complications in patients with multiple myeloma, and have impact on the quality of life because of the risk of fractures. Trabecular bone score (TBS) is a novel texture index derived from dual energy X-ray absorptiometry (DXA) of lumbar spine images, providing information of bone microarchitecture independent of bone mineral density.
Aims
The aim of this study was to test if TBS may be useful to predict bone fractures in patients with multiple myeloma.
Methods
TBS was calculated retrospectively from existing DXA images of the lumbar spine, in 20 patients with newly diagnosed multiple myeloma. We analyzed the development of fractures in these patients.
Results
The median age of the patients was 66 years (range, 49-77), and 15 patients (75%) were female. Fifteen patients had osteopenia (5 patients, 25%) or osteoporosis (10 patients, 50%) by using DXA. Osteolytic bone lesions were observed in 18 patients (90%) at the time of diagnosis. The median duration of follow-up was 31.9 months (95% CI, 20.1-43.7 months), 6 events (long-bone fractures in 5 events, vertebral fracture in 1) of fracture were occurred in 5 patients (25%). The mean TBS of lumbar spine (L1-4) in patients who experienced development of fractures (1.162 ± 0.032 [95% CI, 1.122-1.201]) was lower than patients who did not (1.255 ± 0.154 [95% CI, 1.170-1.3]), however, there was no statistical significance (p=0.061). Among TBS of individual lumbar spines, L2 showed significantly lower score in patient who experienced development of fractures (1.135 ± 0.085 [95% CI, 1.030-1.241] vs. 1.243 ± 0.169 [95% CI, 1.149-1.336], p=0.032).
Conclusion
TBS of lumbar spine in patients with multiple myeloma could be helpful to predict development of fractures, however, further investigations are needed.
Session topic: E-poster
Keyword(s): Multiple myeloma
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