SERUM LEVELS OF E-SELECTIN AND VCAM-1 IN ACTIVE MYELOMA
(Abstract release date: 05/19/16)
EHA Library. Tsirakis G. 06/09/16; 134850; PB1950
Dr. Georgios Tsirakis
Contributions
Contributions
Abstract
Abstract: PB1950
Type: Publication Only
Background
Adhesion of myeloma plasma cells in bone marrow is an important hallmark for their homing. Various adhesion molecules participate in this process, such as E-selectin and VCAM-1. These molecules seem to participate in both cancer and inflammation.
Aims
The study, for the first time, of serum levels of E-selectin and VCAM-1 in active myeloma patients and correlation with bone marrow mast cell’s density (MCD), serum levels of soluble endoglin (sCD105) (marker of endothelial activation) and disease progression.
Methods
We studied 54 newly diagnosed active myeloma patients and 20 healthy controls. We estimated bone marrow MCD using the immunohistochemical expression of tryptase and measured serum levels of E-selectin, VCAM-1 and sCD105 with ELISA.
Results
All parameters were higher in active myeloma patients compared to controls (p<0.001 for all cases) and were also increasing in parallel with ISS stages (p<0.001 for all cases). Significant positive correlations between MCD and levels of E-selectin (r=0.448), VCAM-1 (r=0.597) and sCD105 (r=0.667) (p<0.001 for all cases) were noted.
Conclusion
We found increased serum levels of the adhesion molecules, correlating with MCD, sCD105 and mainly with disease progression. These increased levels may represent increased bone marrow expression, which in turn may be the result of both enhanced angiogenesis and inflammation. By these means, E-selectin and VCAM-1 may be regarded as markers of disease activity.
Session topic: E-poster
Keyword(s): Adhesion, Mast cell, Myeloma
Type: Publication Only
Background
Adhesion of myeloma plasma cells in bone marrow is an important hallmark for their homing. Various adhesion molecules participate in this process, such as E-selectin and VCAM-1. These molecules seem to participate in both cancer and inflammation.
Aims
The study, for the first time, of serum levels of E-selectin and VCAM-1 in active myeloma patients and correlation with bone marrow mast cell’s density (MCD), serum levels of soluble endoglin (sCD105) (marker of endothelial activation) and disease progression.
Methods
We studied 54 newly diagnosed active myeloma patients and 20 healthy controls. We estimated bone marrow MCD using the immunohistochemical expression of tryptase and measured serum levels of E-selectin, VCAM-1 and sCD105 with ELISA.
Results
All parameters were higher in active myeloma patients compared to controls (p<0.001 for all cases) and were also increasing in parallel with ISS stages (p<0.001 for all cases). Significant positive correlations between MCD and levels of E-selectin (r=0.448), VCAM-1 (r=0.597) and sCD105 (r=0.667) (p<0.001 for all cases) were noted.
Conclusion
We found increased serum levels of the adhesion molecules, correlating with MCD, sCD105 and mainly with disease progression. These increased levels may represent increased bone marrow expression, which in turn may be the result of both enhanced angiogenesis and inflammation. By these means, E-selectin and VCAM-1 may be regarded as markers of disease activity.
Session topic: E-poster
Keyword(s): Adhesion, Mast cell, Myeloma
Abstract: PB1950
Type: Publication Only
Background
Adhesion of myeloma plasma cells in bone marrow is an important hallmark for their homing. Various adhesion molecules participate in this process, such as E-selectin and VCAM-1. These molecules seem to participate in both cancer and inflammation.
Aims
The study, for the first time, of serum levels of E-selectin and VCAM-1 in active myeloma patients and correlation with bone marrow mast cell’s density (MCD), serum levels of soluble endoglin (sCD105) (marker of endothelial activation) and disease progression.
Methods
We studied 54 newly diagnosed active myeloma patients and 20 healthy controls. We estimated bone marrow MCD using the immunohistochemical expression of tryptase and measured serum levels of E-selectin, VCAM-1 and sCD105 with ELISA.
Results
All parameters were higher in active myeloma patients compared to controls (p<0.001 for all cases) and were also increasing in parallel with ISS stages (p<0.001 for all cases). Significant positive correlations between MCD and levels of E-selectin (r=0.448), VCAM-1 (r=0.597) and sCD105 (r=0.667) (p<0.001 for all cases) were noted.
Conclusion
We found increased serum levels of the adhesion molecules, correlating with MCD, sCD105 and mainly with disease progression. These increased levels may represent increased bone marrow expression, which in turn may be the result of both enhanced angiogenesis and inflammation. By these means, E-selectin and VCAM-1 may be regarded as markers of disease activity.
Session topic: E-poster
Keyword(s): Adhesion, Mast cell, Myeloma
Type: Publication Only
Background
Adhesion of myeloma plasma cells in bone marrow is an important hallmark for their homing. Various adhesion molecules participate in this process, such as E-selectin and VCAM-1. These molecules seem to participate in both cancer and inflammation.
Aims
The study, for the first time, of serum levels of E-selectin and VCAM-1 in active myeloma patients and correlation with bone marrow mast cell’s density (MCD), serum levels of soluble endoglin (sCD105) (marker of endothelial activation) and disease progression.
Methods
We studied 54 newly diagnosed active myeloma patients and 20 healthy controls. We estimated bone marrow MCD using the immunohistochemical expression of tryptase and measured serum levels of E-selectin, VCAM-1 and sCD105 with ELISA.
Results
All parameters were higher in active myeloma patients compared to controls (p<0.001 for all cases) and were also increasing in parallel with ISS stages (p<0.001 for all cases). Significant positive correlations between MCD and levels of E-selectin (r=0.448), VCAM-1 (r=0.597) and sCD105 (r=0.667) (p<0.001 for all cases) were noted.
Conclusion
We found increased serum levels of the adhesion molecules, correlating with MCD, sCD105 and mainly with disease progression. These increased levels may represent increased bone marrow expression, which in turn may be the result of both enhanced angiogenesis and inflammation. By these means, E-selectin and VCAM-1 may be regarded as markers of disease activity.
Session topic: E-poster
Keyword(s): Adhesion, Mast cell, Myeloma
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