CLINICAL CHARACTERISTICS, OUTCOME AND PROGNOSTIC FACTORS OF SURVIVAL OF MULTIPLE MYELOMA PATIENTS ACHIEVING AT LEAST VERY GOOD PARTIAL RESPONSE AFTER FIRST LINE TREATMENT IN THE ERA OF NOVEL AGENTS
(Abstract release date: 05/19/16)
EHA Library. Giannopoulou E. 06/09/16; 134833; PB1933
Dr. Evlambia Giannopoulou
Contributions
Contributions
Abstract
Abstract: PB1933
Type: Publication Only
Background
Depth of response defined by conventional methods i.e. the achievement of at least very good partial response (≥vgPR) or complete response is correlated with OS in both eligible and non eligible for transplantation Multiple Myeloma (MM) patients. However, there are limited data regarding the prognostic factors for OS in patients who manage to achieve ≥vgPR.
Aims
Our aim was to study the clinical characteristics and outcome of MM patients who achieve ≥vgPR after first line treatment and seek for prognostic factors for OS.
Methods
We reviewed the records of 464 consecutive symptomatic MM patients diagnosed and treated in a single center between 2000-2015 (median age: 68 years, range: 29-90 years; M/F: 247/217; IgG: 261, IgA: 118, light chain: 65, non-secretory: 15, IgD: 4, IgM:1; ISS1: 142, ISS2: 146, ISS3: 176).
Results
Two hundred and sixty-eight patients (58%) achieved ≥vgPR after first line treatment (group A) and 196 (42%) had
Conclusion
Despite the established prognostic significance of the achievement of ≥vgPR, OS within this group is not uniform. High-risk molecular cytogenetics independently predict for PFS and OS suggesting that high-risk patients display gene instability, which compromises sustained response and eventually patients' survival. Despite depth of response, close monitoring, including minimal residual disease is warranted in patients with high-risk molecular cytogenetics in order to optimize treatment strategy, after first line therapy.
Session topic: E-poster
Keyword(s): Multiple myeloma, Prognosis
Type: Publication Only
Background
Depth of response defined by conventional methods i.e. the achievement of at least very good partial response (≥vgPR) or complete response is correlated with OS in both eligible and non eligible for transplantation Multiple Myeloma (MM) patients. However, there are limited data regarding the prognostic factors for OS in patients who manage to achieve ≥vgPR.
Aims
Our aim was to study the clinical characteristics and outcome of MM patients who achieve ≥vgPR after first line treatment and seek for prognostic factors for OS.
Methods
We reviewed the records of 464 consecutive symptomatic MM patients diagnosed and treated in a single center between 2000-2015 (median age: 68 years, range: 29-90 years; M/F: 247/217; IgG: 261, IgA: 118, light chain: 65, non-secretory: 15, IgD: 4, IgM:1; ISS1: 142, ISS2: 146, ISS3: 176).
Results
Two hundred and sixty-eight patients (58%) achieved ≥vgPR after first line treatment (group A) and 196 (42%) had
Conclusion
Despite the established prognostic significance of the achievement of ≥vgPR, OS within this group is not uniform. High-risk molecular cytogenetics independently predict for PFS and OS suggesting that high-risk patients display gene instability, which compromises sustained response and eventually patients' survival. Despite depth of response, close monitoring, including minimal residual disease is warranted in patients with high-risk molecular cytogenetics in order to optimize treatment strategy, after first line therapy.
Session topic: E-poster
Keyword(s): Multiple myeloma, Prognosis
Abstract: PB1933
Type: Publication Only
Background
Depth of response defined by conventional methods i.e. the achievement of at least very good partial response (≥vgPR) or complete response is correlated with OS in both eligible and non eligible for transplantation Multiple Myeloma (MM) patients. However, there are limited data regarding the prognostic factors for OS in patients who manage to achieve ≥vgPR.
Aims
Our aim was to study the clinical characteristics and outcome of MM patients who achieve ≥vgPR after first line treatment and seek for prognostic factors for OS.
Methods
We reviewed the records of 464 consecutive symptomatic MM patients diagnosed and treated in a single center between 2000-2015 (median age: 68 years, range: 29-90 years; M/F: 247/217; IgG: 261, IgA: 118, light chain: 65, non-secretory: 15, IgD: 4, IgM:1; ISS1: 142, ISS2: 146, ISS3: 176).
Results
Two hundred and sixty-eight patients (58%) achieved ≥vgPR after first line treatment (group A) and 196 (42%) had
Conclusion
Despite the established prognostic significance of the achievement of ≥vgPR, OS within this group is not uniform. High-risk molecular cytogenetics independently predict for PFS and OS suggesting that high-risk patients display gene instability, which compromises sustained response and eventually patients' survival. Despite depth of response, close monitoring, including minimal residual disease is warranted in patients with high-risk molecular cytogenetics in order to optimize treatment strategy, after first line therapy.
Session topic: E-poster
Keyword(s): Multiple myeloma, Prognosis
Type: Publication Only
Background
Depth of response defined by conventional methods i.e. the achievement of at least very good partial response (≥vgPR) or complete response is correlated with OS in both eligible and non eligible for transplantation Multiple Myeloma (MM) patients. However, there are limited data regarding the prognostic factors for OS in patients who manage to achieve ≥vgPR.
Aims
Our aim was to study the clinical characteristics and outcome of MM patients who achieve ≥vgPR after first line treatment and seek for prognostic factors for OS.
Methods
We reviewed the records of 464 consecutive symptomatic MM patients diagnosed and treated in a single center between 2000-2015 (median age: 68 years, range: 29-90 years; M/F: 247/217; IgG: 261, IgA: 118, light chain: 65, non-secretory: 15, IgD: 4, IgM:1; ISS1: 142, ISS2: 146, ISS3: 176).
Results
Two hundred and sixty-eight patients (58%) achieved ≥vgPR after first line treatment (group A) and 196 (42%) had
Conclusion
Despite the established prognostic significance of the achievement of ≥vgPR, OS within this group is not uniform. High-risk molecular cytogenetics independently predict for PFS and OS suggesting that high-risk patients display gene instability, which compromises sustained response and eventually patients' survival. Despite depth of response, close monitoring, including minimal residual disease is warranted in patients with high-risk molecular cytogenetics in order to optimize treatment strategy, after first line therapy.
Session topic: E-poster
Keyword(s): Multiple myeloma, Prognosis
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