ASSESSMENT OF B AND T LYMPHOCYTES FUNCTION IN PATIENTS WITHMYELODYSPLASTIC SYNDROMES
(Abstract release date: 05/19/16)
EHA Library. Moussa M. 06/09/16; 134830; PB1930
Dr. Mohamed Moussa
Contributions
Contributions
Abstract
Abstract: PB1930
Type: Publication Only
Background
An activated immune system has been observed in patients with myelodysplastic syndrome but its exact contribution to disease development and control is not fully clarified. The successful use of immunosuppressive therapies, the potentially curative role of allogeneic stem cell transplant, and the more recent data showing improved peripheral cytopenias and elimination of certain common cytogenetic abnormalities with immunomodulatory agents; highlight the role immune dysregulation in the development of MDS.
Aims
The aim of this study is to assess B and T cell function in patients with MDS and correlate them to the risk status of MDS.
Methods
The study included 30 adult Egyptian patients diagnosed with MDS based on blood picture, bone marrow examination and cytogenetic studies. Patients were classified according to IPSS risk scoring system.Immune system assessment was done by performing: antinuclear antibodies, coombs’ test, serum protein electrophoresis and CD4/CD8 ratio in peripheral blood.
Results
We’ve found an association between inverted CD4/CD8 ratio and higher risk strata, presence of neutropenia and transfusion dependence. Regarding Humoral immune system involvement, positive coombs test was related significantly to younger age, higher bone marrow blasts count. Polyclonal gammopathy-as well-was found to be associated with higher bone marrow blasts count and presence of cytogenetic abnormalities.
Conclusion
Immune dysregulation-in the form of inverted CD4/CD8 ratio, positive ANA, positive coombs’ test and polyclonal gammopathy-is well documented in myelodysplastic syndrome, and it is probably related to younger age, higher IPPS risk, higher bone marrow blasts count and the presence of cytogenetic abnormalities.
Session topic: E-poster
Keyword(s): CD4, CD8 T cells, MDS
Type: Publication Only
Background
An activated immune system has been observed in patients with myelodysplastic syndrome but its exact contribution to disease development and control is not fully clarified. The successful use of immunosuppressive therapies, the potentially curative role of allogeneic stem cell transplant, and the more recent data showing improved peripheral cytopenias and elimination of certain common cytogenetic abnormalities with immunomodulatory agents; highlight the role immune dysregulation in the development of MDS.
Aims
The aim of this study is to assess B and T cell function in patients with MDS and correlate them to the risk status of MDS.
Methods
The study included 30 adult Egyptian patients diagnosed with MDS based on blood picture, bone marrow examination and cytogenetic studies. Patients were classified according to IPSS risk scoring system.Immune system assessment was done by performing: antinuclear antibodies, coombs’ test, serum protein electrophoresis and CD4/CD8 ratio in peripheral blood.
Results
We’ve found an association between inverted CD4/CD8 ratio and higher risk strata, presence of neutropenia and transfusion dependence. Regarding Humoral immune system involvement, positive coombs test was related significantly to younger age, higher bone marrow blasts count. Polyclonal gammopathy-as well-was found to be associated with higher bone marrow blasts count and presence of cytogenetic abnormalities.
Conclusion
Immune dysregulation-in the form of inverted CD4/CD8 ratio, positive ANA, positive coombs’ test and polyclonal gammopathy-is well documented in myelodysplastic syndrome, and it is probably related to younger age, higher IPPS risk, higher bone marrow blasts count and the presence of cytogenetic abnormalities.
Session topic: E-poster
Keyword(s): CD4, CD8 T cells, MDS
Abstract: PB1930
Type: Publication Only
Background
An activated immune system has been observed in patients with myelodysplastic syndrome but its exact contribution to disease development and control is not fully clarified. The successful use of immunosuppressive therapies, the potentially curative role of allogeneic stem cell transplant, and the more recent data showing improved peripheral cytopenias and elimination of certain common cytogenetic abnormalities with immunomodulatory agents; highlight the role immune dysregulation in the development of MDS.
Aims
The aim of this study is to assess B and T cell function in patients with MDS and correlate them to the risk status of MDS.
Methods
The study included 30 adult Egyptian patients diagnosed with MDS based on blood picture, bone marrow examination and cytogenetic studies. Patients were classified according to IPSS risk scoring system.Immune system assessment was done by performing: antinuclear antibodies, coombs’ test, serum protein electrophoresis and CD4/CD8 ratio in peripheral blood.
Results
We’ve found an association between inverted CD4/CD8 ratio and higher risk strata, presence of neutropenia and transfusion dependence. Regarding Humoral immune system involvement, positive coombs test was related significantly to younger age, higher bone marrow blasts count. Polyclonal gammopathy-as well-was found to be associated with higher bone marrow blasts count and presence of cytogenetic abnormalities.
Conclusion
Immune dysregulation-in the form of inverted CD4/CD8 ratio, positive ANA, positive coombs’ test and polyclonal gammopathy-is well documented in myelodysplastic syndrome, and it is probably related to younger age, higher IPPS risk, higher bone marrow blasts count and the presence of cytogenetic abnormalities.
Session topic: E-poster
Keyword(s): CD4, CD8 T cells, MDS
Type: Publication Only
Background
An activated immune system has been observed in patients with myelodysplastic syndrome but its exact contribution to disease development and control is not fully clarified. The successful use of immunosuppressive therapies, the potentially curative role of allogeneic stem cell transplant, and the more recent data showing improved peripheral cytopenias and elimination of certain common cytogenetic abnormalities with immunomodulatory agents; highlight the role immune dysregulation in the development of MDS.
Aims
The aim of this study is to assess B and T cell function in patients with MDS and correlate them to the risk status of MDS.
Methods
The study included 30 adult Egyptian patients diagnosed with MDS based on blood picture, bone marrow examination and cytogenetic studies. Patients were classified according to IPSS risk scoring system.Immune system assessment was done by performing: antinuclear antibodies, coombs’ test, serum protein electrophoresis and CD4/CD8 ratio in peripheral blood.
Results
We’ve found an association between inverted CD4/CD8 ratio and higher risk strata, presence of neutropenia and transfusion dependence. Regarding Humoral immune system involvement, positive coombs test was related significantly to younger age, higher bone marrow blasts count. Polyclonal gammopathy-as well-was found to be associated with higher bone marrow blasts count and presence of cytogenetic abnormalities.
Conclusion
Immune dysregulation-in the form of inverted CD4/CD8 ratio, positive ANA, positive coombs’ test and polyclonal gammopathy-is well documented in myelodysplastic syndrome, and it is probably related to younger age, higher IPPS risk, higher bone marrow blasts count and the presence of cytogenetic abnormalities.
Session topic: E-poster
Keyword(s): CD4, CD8 T cells, MDS
{{ help_message }}
{{filter}}