PROGNOSTIC FACTORS IN MYELODYSPLASTIC SYNDROMES AND THEIR INFLUENCE ON OVERALL SURVIVAL
(Abstract release date: 05/19/16)
EHA Library. Sotirova T. 06/09/16; 134825; PB1925
Prof. Tatjana Sotirova
Contributions
Contributions
Abstract
Abstract: PB1925
Type: Publication Only
Background
Prognostic factors have been evaluated so far in different combinations in order to detect those that would influence overall survival (OS) in patients with MDS and would be incorporated in future revisions of prognostic scoring systems.
Aims
1.Analysis of chromosomal abnormalities with ‘Multiplex ligation-dependent probe amplification’ (MLPA), 2.Evaluation of the prognostic significance of age, sex, bone marrow (BM) blast percentage, cytopenias, MCV, transfusion dependency, serum ferritin, LDH, serum albumin, comorbidities and chromosomal abnormalities and 3.Their implication on OS and transformation in acute myeloid leukemia (AML).
Methods
215 adult patients with ‘de novo’ and t-MDS were included in the study, diagnosed at the University Clinic of Hematology in Skopje, from January 2011 till April 2015, with follow-up period of 52 months. Patients were divided into two groups: 70 patients as an investigational group (IG) and 145 patients as a control group (CG). Detection of the chromosomal abnormalities was performed with the method MLPA. Informed consent was obtained.
Results
Patients were classified according to the FAB and WHO classifications. Risk stratification was made in accordance with IPSS and R-IPSS. OS and transformation in AML were followed. We evaluated the association among 17 factors and OS in the IG. The univariate analysis revealed only 4 from 17 factors associated with OS: platelet number, blast percentage in the BM, IPSS and R-IPSS. Multivariate analysis revealed that predictors of the event were platelets < 100x109/L, IPSS - low risk and R-IPSS – intermediate risk. We also evaluated the association among 14 factors and OS in the CG. The univariate analysis revealed only 5 from 14 factors associated with OS. The OS was associated only with age, platelet number, blast percentage in the BM, WHO subtypes and comorbidities. Multivariate analysis revealed that predictors of the event were age <50 years and platelets <100x109/L. Transformation in AML was detected in 26 (12.1%) patients.
Conclusion
MLPA proved to be a reliable method for detection of chromosomal abnormalities in MDS. Platelets < 100x109/L, IPSS - low risk and R-IPSS – intermediate risk in the IG and age <50 years and platelets <100x109/L in the CG influenced OS in our cohort. Only age was not incorporated in the IPSS and R-IPSS. Probably, it should be taken in consideration in further refinement of the prognostic scoring systems.
Session topic: E-poster
Keyword(s): Chromosomal abnormality, Prognostic factor, Survival
Type: Publication Only
Background
Prognostic factors have been evaluated so far in different combinations in order to detect those that would influence overall survival (OS) in patients with MDS and would be incorporated in future revisions of prognostic scoring systems.
Aims
1.Analysis of chromosomal abnormalities with ‘Multiplex ligation-dependent probe amplification’ (MLPA), 2.Evaluation of the prognostic significance of age, sex, bone marrow (BM) blast percentage, cytopenias, MCV, transfusion dependency, serum ferritin, LDH, serum albumin, comorbidities and chromosomal abnormalities and 3.Their implication on OS and transformation in acute myeloid leukemia (AML).
Methods
215 adult patients with ‘de novo’ and t-MDS were included in the study, diagnosed at the University Clinic of Hematology in Skopje, from January 2011 till April 2015, with follow-up period of 52 months. Patients were divided into two groups: 70 patients as an investigational group (IG) and 145 patients as a control group (CG). Detection of the chromosomal abnormalities was performed with the method MLPA. Informed consent was obtained.
Results
Patients were classified according to the FAB and WHO classifications. Risk stratification was made in accordance with IPSS and R-IPSS. OS and transformation in AML were followed. We evaluated the association among 17 factors and OS in the IG. The univariate analysis revealed only 4 from 17 factors associated with OS: platelet number, blast percentage in the BM, IPSS and R-IPSS. Multivariate analysis revealed that predictors of the event were platelets < 100x109/L, IPSS - low risk and R-IPSS – intermediate risk. We also evaluated the association among 14 factors and OS in the CG. The univariate analysis revealed only 5 from 14 factors associated with OS. The OS was associated only with age, platelet number, blast percentage in the BM, WHO subtypes and comorbidities. Multivariate analysis revealed that predictors of the event were age <50 years and platelets <100x109/L. Transformation in AML was detected in 26 (12.1%) patients.
Conclusion
MLPA proved to be a reliable method for detection of chromosomal abnormalities in MDS. Platelets < 100x109/L, IPSS - low risk and R-IPSS – intermediate risk in the IG and age <50 years and platelets <100x109/L in the CG influenced OS in our cohort. Only age was not incorporated in the IPSS and R-IPSS. Probably, it should be taken in consideration in further refinement of the prognostic scoring systems.
Session topic: E-poster
Keyword(s): Chromosomal abnormality, Prognostic factor, Survival
Abstract: PB1925
Type: Publication Only
Background
Prognostic factors have been evaluated so far in different combinations in order to detect those that would influence overall survival (OS) in patients with MDS and would be incorporated in future revisions of prognostic scoring systems.
Aims
1.Analysis of chromosomal abnormalities with ‘Multiplex ligation-dependent probe amplification’ (MLPA), 2.Evaluation of the prognostic significance of age, sex, bone marrow (BM) blast percentage, cytopenias, MCV, transfusion dependency, serum ferritin, LDH, serum albumin, comorbidities and chromosomal abnormalities and 3.Their implication on OS and transformation in acute myeloid leukemia (AML).
Methods
215 adult patients with ‘de novo’ and t-MDS were included in the study, diagnosed at the University Clinic of Hematology in Skopje, from January 2011 till April 2015, with follow-up period of 52 months. Patients were divided into two groups: 70 patients as an investigational group (IG) and 145 patients as a control group (CG). Detection of the chromosomal abnormalities was performed with the method MLPA. Informed consent was obtained.
Results
Patients were classified according to the FAB and WHO classifications. Risk stratification was made in accordance with IPSS and R-IPSS. OS and transformation in AML were followed. We evaluated the association among 17 factors and OS in the IG. The univariate analysis revealed only 4 from 17 factors associated with OS: platelet number, blast percentage in the BM, IPSS and R-IPSS. Multivariate analysis revealed that predictors of the event were platelets < 100x109/L, IPSS - low risk and R-IPSS – intermediate risk. We also evaluated the association among 14 factors and OS in the CG. The univariate analysis revealed only 5 from 14 factors associated with OS. The OS was associated only with age, platelet number, blast percentage in the BM, WHO subtypes and comorbidities. Multivariate analysis revealed that predictors of the event were age <50 years and platelets <100x109/L. Transformation in AML was detected in 26 (12.1%) patients.
Conclusion
MLPA proved to be a reliable method for detection of chromosomal abnormalities in MDS. Platelets < 100x109/L, IPSS - low risk and R-IPSS – intermediate risk in the IG and age <50 years and platelets <100x109/L in the CG influenced OS in our cohort. Only age was not incorporated in the IPSS and R-IPSS. Probably, it should be taken in consideration in further refinement of the prognostic scoring systems.
Session topic: E-poster
Keyword(s): Chromosomal abnormality, Prognostic factor, Survival
Type: Publication Only
Background
Prognostic factors have been evaluated so far in different combinations in order to detect those that would influence overall survival (OS) in patients with MDS and would be incorporated in future revisions of prognostic scoring systems.
Aims
1.Analysis of chromosomal abnormalities with ‘Multiplex ligation-dependent probe amplification’ (MLPA), 2.Evaluation of the prognostic significance of age, sex, bone marrow (BM) blast percentage, cytopenias, MCV, transfusion dependency, serum ferritin, LDH, serum albumin, comorbidities and chromosomal abnormalities and 3.Their implication on OS and transformation in acute myeloid leukemia (AML).
Methods
215 adult patients with ‘de novo’ and t-MDS were included in the study, diagnosed at the University Clinic of Hematology in Skopje, from January 2011 till April 2015, with follow-up period of 52 months. Patients were divided into two groups: 70 patients as an investigational group (IG) and 145 patients as a control group (CG). Detection of the chromosomal abnormalities was performed with the method MLPA. Informed consent was obtained.
Results
Patients were classified according to the FAB and WHO classifications. Risk stratification was made in accordance with IPSS and R-IPSS. OS and transformation in AML were followed. We evaluated the association among 17 factors and OS in the IG. The univariate analysis revealed only 4 from 17 factors associated with OS: platelet number, blast percentage in the BM, IPSS and R-IPSS. Multivariate analysis revealed that predictors of the event were platelets < 100x109/L, IPSS - low risk and R-IPSS – intermediate risk. We also evaluated the association among 14 factors and OS in the CG. The univariate analysis revealed only 5 from 14 factors associated with OS. The OS was associated only with age, platelet number, blast percentage in the BM, WHO subtypes and comorbidities. Multivariate analysis revealed that predictors of the event were age <50 years and platelets <100x109/L. Transformation in AML was detected in 26 (12.1%) patients.
Conclusion
MLPA proved to be a reliable method for detection of chromosomal abnormalities in MDS. Platelets < 100x109/L, IPSS - low risk and R-IPSS – intermediate risk in the IG and age <50 years and platelets <100x109/L in the CG influenced OS in our cohort. Only age was not incorporated in the IPSS and R-IPSS. Probably, it should be taken in consideration in further refinement of the prognostic scoring systems.
Session topic: E-poster
Keyword(s): Chromosomal abnormality, Prognostic factor, Survival
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