THE USAGE OF NEUT-X AND NEUT-Y PARAMETRES IN A ROUTINE HEMATOLOGY LABORATORY AS DIAGNOSTIC MARKERS OF MYELODYSPLASTIC SYNDROMES (MDS )
(Abstract release date: 05/19/16)
EHA Library. Tsiatsiou P. 06/09/16; 134812; PB1912
Mrs. Panagiota Tsiatsiou
Contributions
Contributions
Abstract
Abstract: PB1912
Type: Publication Only
Background
NEUT-X and NEUT-Y are structural parameters provided by a hematological analyzer, SYSMEX XE-5000. Notably, NEUT-X evaluates the neutrophil granularity and NEUT-Y the nuclear maturity, which are the average value side scatter diffraction and fluorence, respectively.
Aims
The aim of this study is to investigate the values of NEUT-X and NEUT-Y as diagnostic markers in a routine hematology laboratory in patients with Myelodysplastic Syndromes (MDS)
Methods
The investigation was conducted in ΑΗEPA University hospital. A total of 134 whole-blood samples were collected in tubes with K3-EDTA and were analysed in approximately 3 h of collection, from outpatients and inpatients from different hospital units. 67 of them were from patients with MDS defined from clinical and laboratory findings. Also, 67 randomly selected samples from patients without MDS were included in this study, as a control group. These patients didn’t have, perforce, normal values for the complete blood count (CBC). Some of them had anemia due to various causes. Patients with MDS revealed in their majority microscopically hypogranulation or agranulation (N=45) and patients in the other group showed in their blood films neutrophils with normal granulation.The two groups were similar in regard to sex (67 males - 67 females) and age (52 - 90 years avg = 78 years). The values of the NEUT-X and NEUT-Y parameters were measured by SYSMEX XE-5000. Mean value comparison independent samples tests was used in order to examine the statistical significance between patients with MDS and control group. The significance level was defined as p < 0.05 All statistical analysis was performed using SPSS 22 and Mc Excel 2010.
Results
The values of NEUT-X and NEUT-Y (mean +/- SD) for the control group were (137,49 +/- 3.17) and (41,02 +/- 2,70) respectively. The MDS group revealed lower mean values for NEUT-X and NEUT-Y (131,44 +/- 9,01) and (38,40 +/-8,21). The values of NEYT-X and NEYT-Y of MDS were statistically significant lower than the NEYT-X and NEYT-Y values of control (p-values were less than 0,05).
Conclusion
There is a proportion between low NEUT-X and NEUT-Y values and neutrophil dysplasia. These structural parameters can contribute as auxiliary indicators to the differential diagnosis MDS from other diseases especially in elderly people with anemia. Also, they can be used as an important part of the daily routine complete blood count.
Session topic: E-poster
Type: Publication Only
Background
NEUT-X and NEUT-Y are structural parameters provided by a hematological analyzer, SYSMEX XE-5000. Notably, NEUT-X evaluates the neutrophil granularity and NEUT-Y the nuclear maturity, which are the average value side scatter diffraction and fluorence, respectively.
Aims
The aim of this study is to investigate the values of NEUT-X and NEUT-Y as diagnostic markers in a routine hematology laboratory in patients with Myelodysplastic Syndromes (MDS)
Methods
The investigation was conducted in ΑΗEPA University hospital. A total of 134 whole-blood samples were collected in tubes with K3-EDTA and were analysed in approximately 3 h of collection, from outpatients and inpatients from different hospital units. 67 of them were from patients with MDS defined from clinical and laboratory findings. Also, 67 randomly selected samples from patients without MDS were included in this study, as a control group. These patients didn’t have, perforce, normal values for the complete blood count (CBC). Some of them had anemia due to various causes. Patients with MDS revealed in their majority microscopically hypogranulation or agranulation (N=45) and patients in the other group showed in their blood films neutrophils with normal granulation.The two groups were similar in regard to sex (67 males - 67 females) and age (52 - 90 years avg = 78 years). The values of the NEUT-X and NEUT-Y parameters were measured by SYSMEX XE-5000. Mean value comparison independent samples tests was used in order to examine the statistical significance between patients with MDS and control group. The significance level was defined as p < 0.05 All statistical analysis was performed using SPSS 22 and Mc Excel 2010.
Results
The values of NEUT-X and NEUT-Y (mean +/- SD) for the control group were (137,49 +/- 3.17) and (41,02 +/- 2,70) respectively. The MDS group revealed lower mean values for NEUT-X and NEUT-Y (131,44 +/- 9,01) and (38,40 +/-8,21). The values of NEYT-X and NEYT-Y of MDS were statistically significant lower than the NEYT-X and NEYT-Y values of control (p-values were less than 0,05).
Conclusion
There is a proportion between low NEUT-X and NEUT-Y values and neutrophil dysplasia. These structural parameters can contribute as auxiliary indicators to the differential diagnosis MDS from other diseases especially in elderly people with anemia. Also, they can be used as an important part of the daily routine complete blood count.
Session topic: E-poster
Abstract: PB1912
Type: Publication Only
Background
NEUT-X and NEUT-Y are structural parameters provided by a hematological analyzer, SYSMEX XE-5000. Notably, NEUT-X evaluates the neutrophil granularity and NEUT-Y the nuclear maturity, which are the average value side scatter diffraction and fluorence, respectively.
Aims
The aim of this study is to investigate the values of NEUT-X and NEUT-Y as diagnostic markers in a routine hematology laboratory in patients with Myelodysplastic Syndromes (MDS)
Methods
The investigation was conducted in ΑΗEPA University hospital. A total of 134 whole-blood samples were collected in tubes with K3-EDTA and were analysed in approximately 3 h of collection, from outpatients and inpatients from different hospital units. 67 of them were from patients with MDS defined from clinical and laboratory findings. Also, 67 randomly selected samples from patients without MDS were included in this study, as a control group. These patients didn’t have, perforce, normal values for the complete blood count (CBC). Some of them had anemia due to various causes. Patients with MDS revealed in their majority microscopically hypogranulation or agranulation (N=45) and patients in the other group showed in their blood films neutrophils with normal granulation.The two groups were similar in regard to sex (67 males - 67 females) and age (52 - 90 years avg = 78 years). The values of the NEUT-X and NEUT-Y parameters were measured by SYSMEX XE-5000. Mean value comparison independent samples tests was used in order to examine the statistical significance between patients with MDS and control group. The significance level was defined as p < 0.05 All statistical analysis was performed using SPSS 22 and Mc Excel 2010.
Results
The values of NEUT-X and NEUT-Y (mean +/- SD) for the control group were (137,49 +/- 3.17) and (41,02 +/- 2,70) respectively. The MDS group revealed lower mean values for NEUT-X and NEUT-Y (131,44 +/- 9,01) and (38,40 +/-8,21). The values of NEYT-X and NEYT-Y of MDS were statistically significant lower than the NEYT-X and NEYT-Y values of control (p-values were less than 0,05).
Conclusion
There is a proportion between low NEUT-X and NEUT-Y values and neutrophil dysplasia. These structural parameters can contribute as auxiliary indicators to the differential diagnosis MDS from other diseases especially in elderly people with anemia. Also, they can be used as an important part of the daily routine complete blood count.
Session topic: E-poster
Type: Publication Only
Background
NEUT-X and NEUT-Y are structural parameters provided by a hematological analyzer, SYSMEX XE-5000. Notably, NEUT-X evaluates the neutrophil granularity and NEUT-Y the nuclear maturity, which are the average value side scatter diffraction and fluorence, respectively.
Aims
The aim of this study is to investigate the values of NEUT-X and NEUT-Y as diagnostic markers in a routine hematology laboratory in patients with Myelodysplastic Syndromes (MDS)
Methods
The investigation was conducted in ΑΗEPA University hospital. A total of 134 whole-blood samples were collected in tubes with K3-EDTA and were analysed in approximately 3 h of collection, from outpatients and inpatients from different hospital units. 67 of them were from patients with MDS defined from clinical and laboratory findings. Also, 67 randomly selected samples from patients without MDS were included in this study, as a control group. These patients didn’t have, perforce, normal values for the complete blood count (CBC). Some of them had anemia due to various causes. Patients with MDS revealed in their majority microscopically hypogranulation or agranulation (N=45) and patients in the other group showed in their blood films neutrophils with normal granulation.The two groups were similar in regard to sex (67 males - 67 females) and age (52 - 90 years avg = 78 years). The values of the NEUT-X and NEUT-Y parameters were measured by SYSMEX XE-5000. Mean value comparison independent samples tests was used in order to examine the statistical significance between patients with MDS and control group. The significance level was defined as p < 0.05 All statistical analysis was performed using SPSS 22 and Mc Excel 2010.
Results
The values of NEUT-X and NEUT-Y (mean +/- SD) for the control group were (137,49 +/- 3.17) and (41,02 +/- 2,70) respectively. The MDS group revealed lower mean values for NEUT-X and NEUT-Y (131,44 +/- 9,01) and (38,40 +/-8,21). The values of NEYT-X and NEYT-Y of MDS were statistically significant lower than the NEYT-X and NEYT-Y values of control (p-values were less than 0,05).
Conclusion
There is a proportion between low NEUT-X and NEUT-Y values and neutrophil dysplasia. These structural parameters can contribute as auxiliary indicators to the differential diagnosis MDS from other diseases especially in elderly people with anemia. Also, they can be used as an important part of the daily routine complete blood count.
Session topic: E-poster
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