INVASIVE FUNGAL INFECTIONS IN CHILDREN WITH ACUTE LYMPHOBLASTIC LEUKEMIA: SINGLE CENTER EXPERIENCE IN TURKEY
(Abstract release date: 05/19/16)
EHA Library. Patıroglu T. 06/09/16; 134800; PB1900
Prof. Dr. Turkan Patıroglu
Contributions
Contributions
Abstract
Abstract: PB1900
Type: Publication Only
Background
Invasive fungal infections (IFI) are a major cause of morbidity and mortality in patients with hematological malignancies. The risk of IFI increase in prolonged febrile neutropenia and stem cell transplantation.
Aims
We aim to present the data of patients with acute lymphoblastic leukemia (ALL), who developed IFI between the years of 2010 and 2015 at the pediatric hematology department of Erciyes University’s Medical Faculty.
Methods
We assessed 166 patients with ALL, aged between 2 and 18 years (mean age of 5 years) in this retrospective study. There were 73 female and 93 male patients. They were grouped as IFI and oral candidiasis. Serum galactomannan, computerized tomography scanning and cultures of tissue, blood or fluids were used to make a definitive diagnosis of IFI.
Results
Among 166 patients with ALL, 21 (12.6 %) developed IFI. Furthermore, 110 patients (66.2 %) had oral candidiasis. Ten patients (47.6%) with IFI had relapsed/ refractory ALL and three of them underwent haploidentical stem cell transplantation. Five patients ( 23.8 %) also had high-risk ALL. We found Candida spp in 7 patients (33.3 %) with IFI, 10 Aspergillus spp (47.6 %), 1 Zygomycetes (4.76 %), 1 G. capitatum (4.76 %), 1 A. strictum (4.76 %) respectively. One patient (4.76 %) had candidiasis and aspergillosis. All patients received fluconazole as proflactic antifungal therapy during chemotherapy. Effective antifungal drugs were started after diagnosis of IFI. Nine patients received granulocyte suspensions in addition to antifungal therapy. Eleven patients (52.8 %) died because of IFI despite all the therapy efforts.
Conclusion
Since invasive fungal infections (IFI) are a major cause of morbidity and mortality in patients with ALL, further studies are needed to investigate new diagnostic and therapeutic strategies to identify and prevent IFI.
Session topic: E-poster
Keyword(s): Acute lymphoblastic leukemia, Children, Fungal infection, Treatment
Type: Publication Only
Background
Invasive fungal infections (IFI) are a major cause of morbidity and mortality in patients with hematological malignancies. The risk of IFI increase in prolonged febrile neutropenia and stem cell transplantation.
Aims
We aim to present the data of patients with acute lymphoblastic leukemia (ALL), who developed IFI between the years of 2010 and 2015 at the pediatric hematology department of Erciyes University’s Medical Faculty.
Methods
We assessed 166 patients with ALL, aged between 2 and 18 years (mean age of 5 years) in this retrospective study. There were 73 female and 93 male patients. They were grouped as IFI and oral candidiasis. Serum galactomannan, computerized tomography scanning and cultures of tissue, blood or fluids were used to make a definitive diagnosis of IFI.
Results
Among 166 patients with ALL, 21 (12.6 %) developed IFI. Furthermore, 110 patients (66.2 %) had oral candidiasis. Ten patients (47.6%) with IFI had relapsed/ refractory ALL and three of them underwent haploidentical stem cell transplantation. Five patients ( 23.8 %) also had high-risk ALL. We found Candida spp in 7 patients (33.3 %) with IFI, 10 Aspergillus spp (47.6 %), 1 Zygomycetes (4.76 %), 1 G. capitatum (4.76 %), 1 A. strictum (4.76 %) respectively. One patient (4.76 %) had candidiasis and aspergillosis. All patients received fluconazole as proflactic antifungal therapy during chemotherapy. Effective antifungal drugs were started after diagnosis of IFI. Nine patients received granulocyte suspensions in addition to antifungal therapy. Eleven patients (52.8 %) died because of IFI despite all the therapy efforts.
Conclusion
Since invasive fungal infections (IFI) are a major cause of morbidity and mortality in patients with ALL, further studies are needed to investigate new diagnostic and therapeutic strategies to identify and prevent IFI.
Session topic: E-poster
Keyword(s): Acute lymphoblastic leukemia, Children, Fungal infection, Treatment
Abstract: PB1900
Type: Publication Only
Background
Invasive fungal infections (IFI) are a major cause of morbidity and mortality in patients with hematological malignancies. The risk of IFI increase in prolonged febrile neutropenia and stem cell transplantation.
Aims
We aim to present the data of patients with acute lymphoblastic leukemia (ALL), who developed IFI between the years of 2010 and 2015 at the pediatric hematology department of Erciyes University’s Medical Faculty.
Methods
We assessed 166 patients with ALL, aged between 2 and 18 years (mean age of 5 years) in this retrospective study. There were 73 female and 93 male patients. They were grouped as IFI and oral candidiasis. Serum galactomannan, computerized tomography scanning and cultures of tissue, blood or fluids were used to make a definitive diagnosis of IFI.
Results
Among 166 patients with ALL, 21 (12.6 %) developed IFI. Furthermore, 110 patients (66.2 %) had oral candidiasis. Ten patients (47.6%) with IFI had relapsed/ refractory ALL and three of them underwent haploidentical stem cell transplantation. Five patients ( 23.8 %) also had high-risk ALL. We found Candida spp in 7 patients (33.3 %) with IFI, 10 Aspergillus spp (47.6 %), 1 Zygomycetes (4.76 %), 1 G. capitatum (4.76 %), 1 A. strictum (4.76 %) respectively. One patient (4.76 %) had candidiasis and aspergillosis. All patients received fluconazole as proflactic antifungal therapy during chemotherapy. Effective antifungal drugs were started after diagnosis of IFI. Nine patients received granulocyte suspensions in addition to antifungal therapy. Eleven patients (52.8 %) died because of IFI despite all the therapy efforts.
Conclusion
Since invasive fungal infections (IFI) are a major cause of morbidity and mortality in patients with ALL, further studies are needed to investigate new diagnostic and therapeutic strategies to identify and prevent IFI.
Session topic: E-poster
Keyword(s): Acute lymphoblastic leukemia, Children, Fungal infection, Treatment
Type: Publication Only
Background
Invasive fungal infections (IFI) are a major cause of morbidity and mortality in patients with hematological malignancies. The risk of IFI increase in prolonged febrile neutropenia and stem cell transplantation.
Aims
We aim to present the data of patients with acute lymphoblastic leukemia (ALL), who developed IFI between the years of 2010 and 2015 at the pediatric hematology department of Erciyes University’s Medical Faculty.
Methods
We assessed 166 patients with ALL, aged between 2 and 18 years (mean age of 5 years) in this retrospective study. There were 73 female and 93 male patients. They were grouped as IFI and oral candidiasis. Serum galactomannan, computerized tomography scanning and cultures of tissue, blood or fluids were used to make a definitive diagnosis of IFI.
Results
Among 166 patients with ALL, 21 (12.6 %) developed IFI. Furthermore, 110 patients (66.2 %) had oral candidiasis. Ten patients (47.6%) with IFI had relapsed/ refractory ALL and three of them underwent haploidentical stem cell transplantation. Five patients ( 23.8 %) also had high-risk ALL. We found Candida spp in 7 patients (33.3 %) with IFI, 10 Aspergillus spp (47.6 %), 1 Zygomycetes (4.76 %), 1 G. capitatum (4.76 %), 1 A. strictum (4.76 %) respectively. One patient (4.76 %) had candidiasis and aspergillosis. All patients received fluconazole as proflactic antifungal therapy during chemotherapy. Effective antifungal drugs were started after diagnosis of IFI. Nine patients received granulocyte suspensions in addition to antifungal therapy. Eleven patients (52.8 %) died because of IFI despite all the therapy efforts.
Conclusion
Since invasive fungal infections (IFI) are a major cause of morbidity and mortality in patients with ALL, further studies are needed to investigate new diagnostic and therapeutic strategies to identify and prevent IFI.
Session topic: E-poster
Keyword(s): Acute lymphoblastic leukemia, Children, Fungal infection, Treatment
{{ help_message }}
{{filter}}