EPIDEMIOLOGY AND CLINICAL CHARACTERISTICS OF BLOODSTREAM INFECTIONS IN HEMATOLOGICAL CANCER PATIENTS
(Abstract release date: 05/19/16)
EHA Library. Chebotkevich V. 06/09/16; 134797; PB1897
Dr. Vitalii Chebotkevich
Contributions
Contributions
Abstract
Abstract: PB1897
Type: Publication Only
Background
Bloodstream infections (BSI) are life-threatening illness for immunocompromised patients with hematological malignancies.
Aims
To compare epidemiology, causative pathogens and outcome of hospital-acquired BSI.
Methods
During the period 2007-2014 239 blood samples obtained from patients (pts) with hematological malignancies wеre studied. All blood cultures were incubated in the continuous monitoring system for 7 days before discard. The real-time PCR was used for indication DNA of human herpesviruses: Herpesvirus 6 (HHV-6), Cytomegalovirus (CMV) and Epstein-Barr virus (EBV). All patients, who showed fever or signs/symptoms of infection underwent at least two sets of blood culture. In this study 65 pts (with 79 episodes of BSI) who fulfilled criteria of systemic inflammatory response syndrome with positive peripheral blood cultures were investigated. All pts received empirical anti-infectious therapy with subsequent correction based on the bacteriological, virological and mycological analyses results.
Results
A total Gram-positive (G+) accounted for 62.7% of BSI, Gram-negative (G-) for 33.3% and mixed (G+ and G-) for 4,0%. Among G+ BSI Coagulase Negative Staphylococci and Staphylococcus aureus were the most frequent pathogens (92.0%), among G- BSI Escherichia coli (42.9%) was predominant. Fungi (Candida spp (5), Rhodotorula spp. (1), Aspergillus fumigatus (3)), including mixed infections, were responsible in 11.4 % of BSI. It is shown that the incidences of BSI were significantly more frequent at the background of detectable CMV and EBV specific DNA in blood (38.1% and 51.1% respectively vs. 4.8 and 24.9% in pts without BSI, p< 0.05) With regard to the outcome 30 days mortality was 15/79 (19.0%) (7/47 (14.9%) in G+ vs. 6/25 (24.0%) in G- BSI).
Conclusion
The empirical anti-infectious therapy showed high efficacy. Further epidemiological surveillance is warranted in order emerging resistant strains and related mortality. Reactivation of CMV and EBV is significantly associated with higher incidence of bacterial BSI.
Session topic: E-poster
Keyword(s): Herpesvirus, Infection, Sepsis
Type: Publication Only
Background
Bloodstream infections (BSI) are life-threatening illness for immunocompromised patients with hematological malignancies.
Aims
To compare epidemiology, causative pathogens and outcome of hospital-acquired BSI.
Methods
During the period 2007-2014 239 blood samples obtained from patients (pts) with hematological malignancies wеre studied. All blood cultures were incubated in the continuous monitoring system for 7 days before discard. The real-time PCR was used for indication DNA of human herpesviruses: Herpesvirus 6 (HHV-6), Cytomegalovirus (CMV) and Epstein-Barr virus (EBV). All patients, who showed fever or signs/symptoms of infection underwent at least two sets of blood culture. In this study 65 pts (with 79 episodes of BSI) who fulfilled criteria of systemic inflammatory response syndrome with positive peripheral blood cultures were investigated. All pts received empirical anti-infectious therapy with subsequent correction based on the bacteriological, virological and mycological analyses results.
Results
A total Gram-positive (G+) accounted for 62.7% of BSI, Gram-negative (G-) for 33.3% and mixed (G+ and G-) for 4,0%. Among G+ BSI Coagulase Negative Staphylococci and Staphylococcus aureus were the most frequent pathogens (92.0%), among G- BSI Escherichia coli (42.9%) was predominant. Fungi (Candida spp (5), Rhodotorula spp. (1), Aspergillus fumigatus (3)), including mixed infections, were responsible in 11.4 % of BSI. It is shown that the incidences of BSI were significantly more frequent at the background of detectable CMV and EBV specific DNA in blood (38.1% and 51.1% respectively vs. 4.8 and 24.9% in pts without BSI, p< 0.05) With regard to the outcome 30 days mortality was 15/79 (19.0%) (7/47 (14.9%) in G+ vs. 6/25 (24.0%) in G- BSI).
Conclusion
The empirical anti-infectious therapy showed high efficacy. Further epidemiological surveillance is warranted in order emerging resistant strains and related mortality. Reactivation of CMV and EBV is significantly associated with higher incidence of bacterial BSI.
Session topic: E-poster
Keyword(s): Herpesvirus, Infection, Sepsis
Abstract: PB1897
Type: Publication Only
Background
Bloodstream infections (BSI) are life-threatening illness for immunocompromised patients with hematological malignancies.
Aims
To compare epidemiology, causative pathogens and outcome of hospital-acquired BSI.
Methods
During the period 2007-2014 239 blood samples obtained from patients (pts) with hematological malignancies wеre studied. All blood cultures were incubated in the continuous monitoring system for 7 days before discard. The real-time PCR was used for indication DNA of human herpesviruses: Herpesvirus 6 (HHV-6), Cytomegalovirus (CMV) and Epstein-Barr virus (EBV). All patients, who showed fever or signs/symptoms of infection underwent at least two sets of blood culture. In this study 65 pts (with 79 episodes of BSI) who fulfilled criteria of systemic inflammatory response syndrome with positive peripheral blood cultures were investigated. All pts received empirical anti-infectious therapy with subsequent correction based on the bacteriological, virological and mycological analyses results.
Results
A total Gram-positive (G+) accounted for 62.7% of BSI, Gram-negative (G-) for 33.3% and mixed (G+ and G-) for 4,0%. Among G+ BSI Coagulase Negative Staphylococci and Staphylococcus aureus were the most frequent pathogens (92.0%), among G- BSI Escherichia coli (42.9%) was predominant. Fungi (Candida spp (5), Rhodotorula spp. (1), Aspergillus fumigatus (3)), including mixed infections, were responsible in 11.4 % of BSI. It is shown that the incidences of BSI were significantly more frequent at the background of detectable CMV and EBV specific DNA in blood (38.1% and 51.1% respectively vs. 4.8 and 24.9% in pts without BSI, p< 0.05) With regard to the outcome 30 days mortality was 15/79 (19.0%) (7/47 (14.9%) in G+ vs. 6/25 (24.0%) in G- BSI).
Conclusion
The empirical anti-infectious therapy showed high efficacy. Further epidemiological surveillance is warranted in order emerging resistant strains and related mortality. Reactivation of CMV and EBV is significantly associated with higher incidence of bacterial BSI.
Session topic: E-poster
Keyword(s): Herpesvirus, Infection, Sepsis
Type: Publication Only
Background
Bloodstream infections (BSI) are life-threatening illness for immunocompromised patients with hematological malignancies.
Aims
To compare epidemiology, causative pathogens and outcome of hospital-acquired BSI.
Methods
During the period 2007-2014 239 blood samples obtained from patients (pts) with hematological malignancies wеre studied. All blood cultures were incubated in the continuous monitoring system for 7 days before discard. The real-time PCR was used for indication DNA of human herpesviruses: Herpesvirus 6 (HHV-6), Cytomegalovirus (CMV) and Epstein-Barr virus (EBV). All patients, who showed fever or signs/symptoms of infection underwent at least two sets of blood culture. In this study 65 pts (with 79 episodes of BSI) who fulfilled criteria of systemic inflammatory response syndrome with positive peripheral blood cultures were investigated. All pts received empirical anti-infectious therapy with subsequent correction based on the bacteriological, virological and mycological analyses results.
Results
A total Gram-positive (G+) accounted for 62.7% of BSI, Gram-negative (G-) for 33.3% and mixed (G+ and G-) for 4,0%. Among G+ BSI Coagulase Negative Staphylococci and Staphylococcus aureus were the most frequent pathogens (92.0%), among G- BSI Escherichia coli (42.9%) was predominant. Fungi (Candida spp (5), Rhodotorula spp. (1), Aspergillus fumigatus (3)), including mixed infections, were responsible in 11.4 % of BSI. It is shown that the incidences of BSI were significantly more frequent at the background of detectable CMV and EBV specific DNA in blood (38.1% and 51.1% respectively vs. 4.8 and 24.9% in pts without BSI, p< 0.05) With regard to the outcome 30 days mortality was 15/79 (19.0%) (7/47 (14.9%) in G+ vs. 6/25 (24.0%) in G- BSI).
Conclusion
The empirical anti-infectious therapy showed high efficacy. Further epidemiological surveillance is warranted in order emerging resistant strains and related mortality. Reactivation of CMV and EBV is significantly associated with higher incidence of bacterial BSI.
Session topic: E-poster
Keyword(s): Herpesvirus, Infection, Sepsis
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