INITIAL TREATMENT RESPONSE PREDICTS THE OUTCOME OF ELDERLY FOLLICULAR LYMPHOMA PATIENTS TREATED WITH IMMUNOCHEMOTHERAPY
(Abstract release date: 05/19/16)
EHA Library. Andjelic B. 06/09/16; 134775; PB1875
Dr. Bosko Andjelic
Contributions
Contributions
Abstract
Abstract: PB1875
Type: Publication Only
Background
Advanced age is considered as an unfavorable prognostic factor for follicular lymphoma (FL). The optimal treatment approach for elderly FL patients is still not clearly defined.
Aims
The aim of this study was to compare the outcome of FL patients between by age (50-60 years and more than 60 years) two adjacent patients groups treated with immunochemotherapy. The second aim was to identify high risk patients for poor outcome.
Methods
A retrospective study was performed on 101 FL patients older than 50 years who had to be treated, including the patients who were previously on watch and wait. Forty-eight patients were older than 60 years. All the patients were treated with immunochemotherapy R-CHOP or R-CVP in the period 2002-2014. Totally 10 patients received R-CVP, of whom 5 were older than 60 years. The examined parameters in statistical analysis were gender, FLIPI score, the presence of B symptoms, bulky disease, bone marrow involvement, ECOG PS, FL grade and response (complete remission or not) on initial treatment.
Results
The median age of the patients was 58 (range 51-82). Complete remission (CR) was achieved in 65 (65.3%) patients. None of the examined parameters was more often present on diagnosis in elderly patients compared to patients 50-60 years old. Patients older than 60 yrs had significantly shorter overall survival (OS) compared to patients 50-60 years old (log rank=4.855, p<0.05), while there was no difference in event free survival (log rank=0.015, p>0.05). Elderly patients with ECOG PS >1, as well as the patients who didn’t achieve CR had significantly worse OS (log rank=4.892, p<0.05; log rank=33.980, p<0.01; respectively), while none of the examined parameters had an influence on EFS. In patients 50-60 years old, the patients who didn’t achieve CR had significantly worse EFS (log rank 13.977, p<0.01), while none of the examined parameters had an influence on OS. The multivariate Cox regression analysis identified treatment response as an independent prognostic factor for OS in elderly patients and for EFS in patients 50-60 years old.
Conclusion
The patients older than 60 years with FL had worse outcome when compared to 50-60 years old patients. According to our results, achieving CR on initial treatment should be one of the goals in treating elderly FL patients.
Session topic: E-poster
Keyword(s): Elderly, Follicular lymphoma, Treatment
Type: Publication Only
Background
Advanced age is considered as an unfavorable prognostic factor for follicular lymphoma (FL). The optimal treatment approach for elderly FL patients is still not clearly defined.
Aims
The aim of this study was to compare the outcome of FL patients between by age (50-60 years and more than 60 years) two adjacent patients groups treated with immunochemotherapy. The second aim was to identify high risk patients for poor outcome.
Methods
A retrospective study was performed on 101 FL patients older than 50 years who had to be treated, including the patients who were previously on watch and wait. Forty-eight patients were older than 60 years. All the patients were treated with immunochemotherapy R-CHOP or R-CVP in the period 2002-2014. Totally 10 patients received R-CVP, of whom 5 were older than 60 years. The examined parameters in statistical analysis were gender, FLIPI score, the presence of B symptoms, bulky disease, bone marrow involvement, ECOG PS, FL grade and response (complete remission or not) on initial treatment.
Results
The median age of the patients was 58 (range 51-82). Complete remission (CR) was achieved in 65 (65.3%) patients. None of the examined parameters was more often present on diagnosis in elderly patients compared to patients 50-60 years old. Patients older than 60 yrs had significantly shorter overall survival (OS) compared to patients 50-60 years old (log rank=4.855, p<0.05), while there was no difference in event free survival (log rank=0.015, p>0.05). Elderly patients with ECOG PS >1, as well as the patients who didn’t achieve CR had significantly worse OS (log rank=4.892, p<0.05; log rank=33.980, p<0.01; respectively), while none of the examined parameters had an influence on EFS. In patients 50-60 years old, the patients who didn’t achieve CR had significantly worse EFS (log rank 13.977, p<0.01), while none of the examined parameters had an influence on OS. The multivariate Cox regression analysis identified treatment response as an independent prognostic factor for OS in elderly patients and for EFS in patients 50-60 years old.
Conclusion
The patients older than 60 years with FL had worse outcome when compared to 50-60 years old patients. According to our results, achieving CR on initial treatment should be one of the goals in treating elderly FL patients.
Session topic: E-poster
Keyword(s): Elderly, Follicular lymphoma, Treatment
Abstract: PB1875
Type: Publication Only
Background
Advanced age is considered as an unfavorable prognostic factor for follicular lymphoma (FL). The optimal treatment approach for elderly FL patients is still not clearly defined.
Aims
The aim of this study was to compare the outcome of FL patients between by age (50-60 years and more than 60 years) two adjacent patients groups treated with immunochemotherapy. The second aim was to identify high risk patients for poor outcome.
Methods
A retrospective study was performed on 101 FL patients older than 50 years who had to be treated, including the patients who were previously on watch and wait. Forty-eight patients were older than 60 years. All the patients were treated with immunochemotherapy R-CHOP or R-CVP in the period 2002-2014. Totally 10 patients received R-CVP, of whom 5 were older than 60 years. The examined parameters in statistical analysis were gender, FLIPI score, the presence of B symptoms, bulky disease, bone marrow involvement, ECOG PS, FL grade and response (complete remission or not) on initial treatment.
Results
The median age of the patients was 58 (range 51-82). Complete remission (CR) was achieved in 65 (65.3%) patients. None of the examined parameters was more often present on diagnosis in elderly patients compared to patients 50-60 years old. Patients older than 60 yrs had significantly shorter overall survival (OS) compared to patients 50-60 years old (log rank=4.855, p<0.05), while there was no difference in event free survival (log rank=0.015, p>0.05). Elderly patients with ECOG PS >1, as well as the patients who didn’t achieve CR had significantly worse OS (log rank=4.892, p<0.05; log rank=33.980, p<0.01; respectively), while none of the examined parameters had an influence on EFS. In patients 50-60 years old, the patients who didn’t achieve CR had significantly worse EFS (log rank 13.977, p<0.01), while none of the examined parameters had an influence on OS. The multivariate Cox regression analysis identified treatment response as an independent prognostic factor for OS in elderly patients and for EFS in patients 50-60 years old.
Conclusion
The patients older than 60 years with FL had worse outcome when compared to 50-60 years old patients. According to our results, achieving CR on initial treatment should be one of the goals in treating elderly FL patients.
Session topic: E-poster
Keyword(s): Elderly, Follicular lymphoma, Treatment
Type: Publication Only
Background
Advanced age is considered as an unfavorable prognostic factor for follicular lymphoma (FL). The optimal treatment approach for elderly FL patients is still not clearly defined.
Aims
The aim of this study was to compare the outcome of FL patients between by age (50-60 years and more than 60 years) two adjacent patients groups treated with immunochemotherapy. The second aim was to identify high risk patients for poor outcome.
Methods
A retrospective study was performed on 101 FL patients older than 50 years who had to be treated, including the patients who were previously on watch and wait. Forty-eight patients were older than 60 years. All the patients were treated with immunochemotherapy R-CHOP or R-CVP in the period 2002-2014. Totally 10 patients received R-CVP, of whom 5 were older than 60 years. The examined parameters in statistical analysis were gender, FLIPI score, the presence of B symptoms, bulky disease, bone marrow involvement, ECOG PS, FL grade and response (complete remission or not) on initial treatment.
Results
The median age of the patients was 58 (range 51-82). Complete remission (CR) was achieved in 65 (65.3%) patients. None of the examined parameters was more often present on diagnosis in elderly patients compared to patients 50-60 years old. Patients older than 60 yrs had significantly shorter overall survival (OS) compared to patients 50-60 years old (log rank=4.855, p<0.05), while there was no difference in event free survival (log rank=0.015, p>0.05). Elderly patients with ECOG PS >1, as well as the patients who didn’t achieve CR had significantly worse OS (log rank=4.892, p<0.05; log rank=33.980, p<0.01; respectively), while none of the examined parameters had an influence on EFS. In patients 50-60 years old, the patients who didn’t achieve CR had significantly worse EFS (log rank 13.977, p<0.01), while none of the examined parameters had an influence on OS. The multivariate Cox regression analysis identified treatment response as an independent prognostic factor for OS in elderly patients and for EFS in patients 50-60 years old.
Conclusion
The patients older than 60 years with FL had worse outcome when compared to 50-60 years old patients. According to our results, achieving CR on initial treatment should be one of the goals in treating elderly FL patients.
Session topic: E-poster
Keyword(s): Elderly, Follicular lymphoma, Treatment
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