18FDG-PET ROLE OF IN THE EVALUATION OF BONE MARROW INFILTRATION IN PATIENTS WITH NHL
(Abstract release date: 05/19/16)
EHA Library. Trastulli F. 06/09/16; 134771; PB1871
Dr. Fabio Trastulli
Contributions
Contributions
Abstract
Abstract: PB1871
Type: Publication Only
Background
18FDG PET/CT is now the standard procedure to evaluate indolent and non indolent non-Hodgkin lymphoma (NHL). It plays an important role in staging, restaging, prognosis and planning treatment. On the other hand bone marrow infiltration affects stage, prognosis and therapeutic approach
Aims
To compare three basal 18FDG PET/CT parameters to detect bone marrow infiltration in patients with newly diagnosed non Hodgkin lymphoma (NHL).
Methods
25 patients with newly diagnosed NHL from February 2012 to February 2016 were retrospectively analyzed. All patients received diagnosis both 18FDG PET/CT contrast enhanced scan and bone marrow biopsy in the posterior iliac crest. There were three evaluation parameters of 18FDG PET/CT to detect bone marrow infiltration: visual analysis, maximal standardized uptake values (SUVmax) in bone marrow of iliac crest (>2.5) and ratio of maximal standardized uptake values of iliac crest bone marrow to liver intensity (Deauville score positive when ratio >1). All results were compared with the bone marrow biopsy.Twelve patients (48%) had an aggressive NHL (9 DLBCL, 1 Burkitt Lymphoma, 1 T cell lymphoma, 1 mantle cell lymphoma,); 13 (52%) had indolent NHL (7 follicular lymphoma, 2 marginal zone lymphoma, 4 small lymphocytic lymphoma)
Results
We divided patients in two different groups: indolent and aggressive NHL. For each group we analyzed the accuracy, sensitivity and specificity of the three parameters (visual analysis, SUVmax and Deauville score).Aggressive NHL :Accuracy, sensitivity and specificity accord to visual analysis were 60%, 75% and 25%, respectively.Accuracy, sensitivity and specificity accord to SUVmax were 50%, 71% and 20%, respectivelyAccuracy, sensitivity and specificity according to Deauville score were75 %, 89% and 33%, respectivelyIndolent NHL:Accuracy, sensitivity and specificity accord to visual analysis were 53%, 14% and 100%, respectivelyAccuracy, sensitivity and specificity accord to SUV max were 46%, 43% and 50%, respectivelyAccuracy, sensitivity and specificity according to Deauville score were77%, 57% and 100%, respectively.Taking into consideration the aggressive NHL group the three parameters compared to standard bone marrow biopsy point to high sensitivity and low specificity. In indolent group the three parameters point to low sensitivity and high specificity.In particular, in this later group, the presence of 4 CLL patients (31%) commonly not FDG avid could have reduced the sensitivity of the imaging procedure compared to bone marrowAccording to preliminary observation Deauville score seems to be more accurate in evaluation of bone marrow infiltration both in indolent and in aggressive NHL patients.
Conclusion
Although obtained in a small group of patients, our results show a significant correlation between bone marrow infiltration verified by biopsy procedures and peculiar aspects of bone marrow FDG uptake, in particular when they are analyzed by the Deauville score.
Session topic: E-poster
Keyword(s): Bone marrow biopsy, FDG-PET, Indolent non-Hodgkin's lymphoma
Type: Publication Only
Background
18FDG PET/CT is now the standard procedure to evaluate indolent and non indolent non-Hodgkin lymphoma (NHL). It plays an important role in staging, restaging, prognosis and planning treatment. On the other hand bone marrow infiltration affects stage, prognosis and therapeutic approach
Aims
To compare three basal 18FDG PET/CT parameters to detect bone marrow infiltration in patients with newly diagnosed non Hodgkin lymphoma (NHL).
Methods
25 patients with newly diagnosed NHL from February 2012 to February 2016 were retrospectively analyzed. All patients received diagnosis both 18FDG PET/CT contrast enhanced scan and bone marrow biopsy in the posterior iliac crest. There were three evaluation parameters of 18FDG PET/CT to detect bone marrow infiltration: visual analysis, maximal standardized uptake values (SUVmax) in bone marrow of iliac crest (>2.5) and ratio of maximal standardized uptake values of iliac crest bone marrow to liver intensity (Deauville score positive when ratio >1). All results were compared with the bone marrow biopsy.Twelve patients (48%) had an aggressive NHL (9 DLBCL, 1 Burkitt Lymphoma, 1 T cell lymphoma, 1 mantle cell lymphoma,); 13 (52%) had indolent NHL (7 follicular lymphoma, 2 marginal zone lymphoma, 4 small lymphocytic lymphoma)
Results
We divided patients in two different groups: indolent and aggressive NHL. For each group we analyzed the accuracy, sensitivity and specificity of the three parameters (visual analysis, SUVmax and Deauville score).Aggressive NHL :Accuracy, sensitivity and specificity accord to visual analysis were 60%, 75% and 25%, respectively.Accuracy, sensitivity and specificity accord to SUVmax were 50%, 71% and 20%, respectivelyAccuracy, sensitivity and specificity according to Deauville score were75 %, 89% and 33%, respectivelyIndolent NHL:Accuracy, sensitivity and specificity accord to visual analysis were 53%, 14% and 100%, respectivelyAccuracy, sensitivity and specificity accord to SUV max were 46%, 43% and 50%, respectivelyAccuracy, sensitivity and specificity according to Deauville score were77%, 57% and 100%, respectively.Taking into consideration the aggressive NHL group the three parameters compared to standard bone marrow biopsy point to high sensitivity and low specificity. In indolent group the three parameters point to low sensitivity and high specificity.In particular, in this later group, the presence of 4 CLL patients (31%) commonly not FDG avid could have reduced the sensitivity of the imaging procedure compared to bone marrowAccording to preliminary observation Deauville score seems to be more accurate in evaluation of bone marrow infiltration both in indolent and in aggressive NHL patients.
Conclusion
Although obtained in a small group of patients, our results show a significant correlation between bone marrow infiltration verified by biopsy procedures and peculiar aspects of bone marrow FDG uptake, in particular when they are analyzed by the Deauville score.
Session topic: E-poster
Keyword(s): Bone marrow biopsy, FDG-PET, Indolent non-Hodgkin's lymphoma
Abstract: PB1871
Type: Publication Only
Background
18FDG PET/CT is now the standard procedure to evaluate indolent and non indolent non-Hodgkin lymphoma (NHL). It plays an important role in staging, restaging, prognosis and planning treatment. On the other hand bone marrow infiltration affects stage, prognosis and therapeutic approach
Aims
To compare three basal 18FDG PET/CT parameters to detect bone marrow infiltration in patients with newly diagnosed non Hodgkin lymphoma (NHL).
Methods
25 patients with newly diagnosed NHL from February 2012 to February 2016 were retrospectively analyzed. All patients received diagnosis both 18FDG PET/CT contrast enhanced scan and bone marrow biopsy in the posterior iliac crest. There were three evaluation parameters of 18FDG PET/CT to detect bone marrow infiltration: visual analysis, maximal standardized uptake values (SUVmax) in bone marrow of iliac crest (>2.5) and ratio of maximal standardized uptake values of iliac crest bone marrow to liver intensity (Deauville score positive when ratio >1). All results were compared with the bone marrow biopsy.Twelve patients (48%) had an aggressive NHL (9 DLBCL, 1 Burkitt Lymphoma, 1 T cell lymphoma, 1 mantle cell lymphoma,); 13 (52%) had indolent NHL (7 follicular lymphoma, 2 marginal zone lymphoma, 4 small lymphocytic lymphoma)
Results
We divided patients in two different groups: indolent and aggressive NHL. For each group we analyzed the accuracy, sensitivity and specificity of the three parameters (visual analysis, SUVmax and Deauville score).Aggressive NHL :Accuracy, sensitivity and specificity accord to visual analysis were 60%, 75% and 25%, respectively.Accuracy, sensitivity and specificity accord to SUVmax were 50%, 71% and 20%, respectivelyAccuracy, sensitivity and specificity according to Deauville score were75 %, 89% and 33%, respectivelyIndolent NHL:Accuracy, sensitivity and specificity accord to visual analysis were 53%, 14% and 100%, respectivelyAccuracy, sensitivity and specificity accord to SUV max were 46%, 43% and 50%, respectivelyAccuracy, sensitivity and specificity according to Deauville score were77%, 57% and 100%, respectively.Taking into consideration the aggressive NHL group the three parameters compared to standard bone marrow biopsy point to high sensitivity and low specificity. In indolent group the three parameters point to low sensitivity and high specificity.In particular, in this later group, the presence of 4 CLL patients (31%) commonly not FDG avid could have reduced the sensitivity of the imaging procedure compared to bone marrowAccording to preliminary observation Deauville score seems to be more accurate in evaluation of bone marrow infiltration both in indolent and in aggressive NHL patients.
Conclusion
Although obtained in a small group of patients, our results show a significant correlation between bone marrow infiltration verified by biopsy procedures and peculiar aspects of bone marrow FDG uptake, in particular when they are analyzed by the Deauville score.
Session topic: E-poster
Keyword(s): Bone marrow biopsy, FDG-PET, Indolent non-Hodgkin's lymphoma
Type: Publication Only
Background
18FDG PET/CT is now the standard procedure to evaluate indolent and non indolent non-Hodgkin lymphoma (NHL). It plays an important role in staging, restaging, prognosis and planning treatment. On the other hand bone marrow infiltration affects stage, prognosis and therapeutic approach
Aims
To compare three basal 18FDG PET/CT parameters to detect bone marrow infiltration in patients with newly diagnosed non Hodgkin lymphoma (NHL).
Methods
25 patients with newly diagnosed NHL from February 2012 to February 2016 were retrospectively analyzed. All patients received diagnosis both 18FDG PET/CT contrast enhanced scan and bone marrow biopsy in the posterior iliac crest. There were three evaluation parameters of 18FDG PET/CT to detect bone marrow infiltration: visual analysis, maximal standardized uptake values (SUVmax) in bone marrow of iliac crest (>2.5) and ratio of maximal standardized uptake values of iliac crest bone marrow to liver intensity (Deauville score positive when ratio >1). All results were compared with the bone marrow biopsy.Twelve patients (48%) had an aggressive NHL (9 DLBCL, 1 Burkitt Lymphoma, 1 T cell lymphoma, 1 mantle cell lymphoma,); 13 (52%) had indolent NHL (7 follicular lymphoma, 2 marginal zone lymphoma, 4 small lymphocytic lymphoma)
Results
We divided patients in two different groups: indolent and aggressive NHL. For each group we analyzed the accuracy, sensitivity and specificity of the three parameters (visual analysis, SUVmax and Deauville score).Aggressive NHL :Accuracy, sensitivity and specificity accord to visual analysis were 60%, 75% and 25%, respectively.Accuracy, sensitivity and specificity accord to SUVmax were 50%, 71% and 20%, respectivelyAccuracy, sensitivity and specificity according to Deauville score were75 %, 89% and 33%, respectivelyIndolent NHL:Accuracy, sensitivity and specificity accord to visual analysis were 53%, 14% and 100%, respectivelyAccuracy, sensitivity and specificity accord to SUV max were 46%, 43% and 50%, respectivelyAccuracy, sensitivity and specificity according to Deauville score were77%, 57% and 100%, respectively.Taking into consideration the aggressive NHL group the three parameters compared to standard bone marrow biopsy point to high sensitivity and low specificity. In indolent group the three parameters point to low sensitivity and high specificity.In particular, in this later group, the presence of 4 CLL patients (31%) commonly not FDG avid could have reduced the sensitivity of the imaging procedure compared to bone marrowAccording to preliminary observation Deauville score seems to be more accurate in evaluation of bone marrow infiltration both in indolent and in aggressive NHL patients.
Conclusion
Although obtained in a small group of patients, our results show a significant correlation between bone marrow infiltration verified by biopsy procedures and peculiar aspects of bone marrow FDG uptake, in particular when they are analyzed by the Deauville score.
Session topic: E-poster
Keyword(s): Bone marrow biopsy, FDG-PET, Indolent non-Hodgkin's lymphoma
{{ help_message }}
{{filter}}