GEMCITABIN, VINORELBINE AND PREDNISOLONE (GVP)
(Abstract release date: 05/19/16)
EHA Library. Paydas S. 06/09/16; 134755; PB1855
Prof. Dr. Semra Paydas
Contributions
Contributions
Abstract
Abstract: PB1855
Type: Publication Only
Background
Lymphomas are heterogenous group of disorders and relapse is not infrequent after standard chemotherapy regimens. Salvage regimens are used to determine the chemosensitivity before stem cell transplantation. GVP combination is one of the salvage regimens used as in cases with relapsed /refractory Hodgkin Lymphoma (HL) or non- Hodgkin Lymphoma (NHL).
Aims
The aim of this study is to evaluate the results of Gemcitabin, vinorelbine and prednisolone GVP plus minus Rituximab regimen in cases with lymphoma treated by GVP.
Methods
Thirty seven cases with lymphoma were included in this analysis. Age range was between 18-77, male female ratio was 20/17. Twenty one of the cases had HL and 16 had NHL. Among NHL, 8 had diffuse large B cell lymphoma (DLBCL), 3 had peripheral T cell lymphoma (PTCL), 3 had indolent NHL (iNHL), 2 had transformed NHL and one had anaplastic large cell lymphoma. All the cases had been treated by standard first line chemotherapy regimens. Results were analyzed retrospectively.
Results
The most commonly used 1st line salvage regimen was DHAP±Rituximab. GVP±Rituximab was used as 1st line, 2nd line and after than 4th line setting in 7, 28 and 2 cases, respectively.Response to 1st line GVP±Rituximab: complete response (CR) was detected in 1 case, partial response (PR) in four cases, minimal response (MR) in one case and progressive disease (PD) in one case.Response to 2nd line GVP±Rituximab: CR, PR and PD were detected in 5, 9 and 14 cases, respectively.Responses according to lymphoma subtypes: 1st line GVP setting CR, PR and PD were detected in 1, 1, 1 cases with HL and PR and MR in 3 and 1 cases with NHL. In 2nd line GVP setting CR, PR and PD were detected in 5, 6 and 7 cases with HL and 1, 2 and 8 cases with NHL, respectively.
Conclusion
GVP as salvage regimen in second line setting, although the number of the cases treated in 1st line setting is limited, is a reasonable choice with 50% overall response rate in cases with HL but not in NHL.
Session topic: E-poster
Keyword(s): Chemosensitivity, Chemotherapy, Hodgkin's lymphoma, Stem cell transplant
Type: Publication Only
Background
Lymphomas are heterogenous group of disorders and relapse is not infrequent after standard chemotherapy regimens. Salvage regimens are used to determine the chemosensitivity before stem cell transplantation. GVP combination is one of the salvage regimens used as in cases with relapsed /refractory Hodgkin Lymphoma (HL) or non- Hodgkin Lymphoma (NHL).
Aims
The aim of this study is to evaluate the results of Gemcitabin, vinorelbine and prednisolone GVP plus minus Rituximab regimen in cases with lymphoma treated by GVP.
Methods
Thirty seven cases with lymphoma were included in this analysis. Age range was between 18-77, male female ratio was 20/17. Twenty one of the cases had HL and 16 had NHL. Among NHL, 8 had diffuse large B cell lymphoma (DLBCL), 3 had peripheral T cell lymphoma (PTCL), 3 had indolent NHL (iNHL), 2 had transformed NHL and one had anaplastic large cell lymphoma. All the cases had been treated by standard first line chemotherapy regimens. Results were analyzed retrospectively.
Results
The most commonly used 1st line salvage regimen was DHAP±Rituximab. GVP±Rituximab was used as 1st line, 2nd line and after than 4th line setting in 7, 28 and 2 cases, respectively.Response to 1st line GVP±Rituximab: complete response (CR) was detected in 1 case, partial response (PR) in four cases, minimal response (MR) in one case and progressive disease (PD) in one case.Response to 2nd line GVP±Rituximab: CR, PR and PD were detected in 5, 9 and 14 cases, respectively.Responses according to lymphoma subtypes: 1st line GVP setting CR, PR and PD were detected in 1, 1, 1 cases with HL and PR and MR in 3 and 1 cases with NHL. In 2nd line GVP setting CR, PR and PD were detected in 5, 6 and 7 cases with HL and 1, 2 and 8 cases with NHL, respectively.
Conclusion
GVP as salvage regimen in second line setting, although the number of the cases treated in 1st line setting is limited, is a reasonable choice with 50% overall response rate in cases with HL but not in NHL.
Session topic: E-poster
Keyword(s): Chemosensitivity, Chemotherapy, Hodgkin's lymphoma, Stem cell transplant
Abstract: PB1855
Type: Publication Only
Background
Lymphomas are heterogenous group of disorders and relapse is not infrequent after standard chemotherapy regimens. Salvage regimens are used to determine the chemosensitivity before stem cell transplantation. GVP combination is one of the salvage regimens used as in cases with relapsed /refractory Hodgkin Lymphoma (HL) or non- Hodgkin Lymphoma (NHL).
Aims
The aim of this study is to evaluate the results of Gemcitabin, vinorelbine and prednisolone GVP plus minus Rituximab regimen in cases with lymphoma treated by GVP.
Methods
Thirty seven cases with lymphoma were included in this analysis. Age range was between 18-77, male female ratio was 20/17. Twenty one of the cases had HL and 16 had NHL. Among NHL, 8 had diffuse large B cell lymphoma (DLBCL), 3 had peripheral T cell lymphoma (PTCL), 3 had indolent NHL (iNHL), 2 had transformed NHL and one had anaplastic large cell lymphoma. All the cases had been treated by standard first line chemotherapy regimens. Results were analyzed retrospectively.
Results
The most commonly used 1st line salvage regimen was DHAP±Rituximab. GVP±Rituximab was used as 1st line, 2nd line and after than 4th line setting in 7, 28 and 2 cases, respectively.Response to 1st line GVP±Rituximab: complete response (CR) was detected in 1 case, partial response (PR) in four cases, minimal response (MR) in one case and progressive disease (PD) in one case.Response to 2nd line GVP±Rituximab: CR, PR and PD were detected in 5, 9 and 14 cases, respectively.Responses according to lymphoma subtypes: 1st line GVP setting CR, PR and PD were detected in 1, 1, 1 cases with HL and PR and MR in 3 and 1 cases with NHL. In 2nd line GVP setting CR, PR and PD were detected in 5, 6 and 7 cases with HL and 1, 2 and 8 cases with NHL, respectively.
Conclusion
GVP as salvage regimen in second line setting, although the number of the cases treated in 1st line setting is limited, is a reasonable choice with 50% overall response rate in cases with HL but not in NHL.
Session topic: E-poster
Keyword(s): Chemosensitivity, Chemotherapy, Hodgkin's lymphoma, Stem cell transplant
Type: Publication Only
Background
Lymphomas are heterogenous group of disorders and relapse is not infrequent after standard chemotherapy regimens. Salvage regimens are used to determine the chemosensitivity before stem cell transplantation. GVP combination is one of the salvage regimens used as in cases with relapsed /refractory Hodgkin Lymphoma (HL) or non- Hodgkin Lymphoma (NHL).
Aims
The aim of this study is to evaluate the results of Gemcitabin, vinorelbine and prednisolone GVP plus minus Rituximab regimen in cases with lymphoma treated by GVP.
Methods
Thirty seven cases with lymphoma were included in this analysis. Age range was between 18-77, male female ratio was 20/17. Twenty one of the cases had HL and 16 had NHL. Among NHL, 8 had diffuse large B cell lymphoma (DLBCL), 3 had peripheral T cell lymphoma (PTCL), 3 had indolent NHL (iNHL), 2 had transformed NHL and one had anaplastic large cell lymphoma. All the cases had been treated by standard first line chemotherapy regimens. Results were analyzed retrospectively.
Results
The most commonly used 1st line salvage regimen was DHAP±Rituximab. GVP±Rituximab was used as 1st line, 2nd line and after than 4th line setting in 7, 28 and 2 cases, respectively.Response to 1st line GVP±Rituximab: complete response (CR) was detected in 1 case, partial response (PR) in four cases, minimal response (MR) in one case and progressive disease (PD) in one case.Response to 2nd line GVP±Rituximab: CR, PR and PD were detected in 5, 9 and 14 cases, respectively.Responses according to lymphoma subtypes: 1st line GVP setting CR, PR and PD were detected in 1, 1, 1 cases with HL and PR and MR in 3 and 1 cases with NHL. In 2nd line GVP setting CR, PR and PD were detected in 5, 6 and 7 cases with HL and 1, 2 and 8 cases with NHL, respectively.
Conclusion
GVP as salvage regimen in second line setting, although the number of the cases treated in 1st line setting is limited, is a reasonable choice with 50% overall response rate in cases with HL but not in NHL.
Session topic: E-poster
Keyword(s): Chemosensitivity, Chemotherapy, Hodgkin's lymphoma, Stem cell transplant
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