CELLULAR IMMUNOTHERAPY: A STORY OF HOPE
(Abstract release date: 05/19/16)
EHA Library. VAN DE VELDE A. 06/09/16; 134745; PB1845
Dr. Ann VAN DE VELDE
Contributions
Contributions
Abstract
Abstract: PB1845
Type: Publication Only
Background
Narrative medicine is a medical approach that recognises the value of people's narratives in clinical practice, research and education. Narrative medicine aims not only to validate the experience of the patient, but also to encourage creativity and self-reflection in the health care provider and researcher.
Aims
Rupert Suply, a young adult diagnosed with Ewing Sarcoma, was included in a study with dendritic cell vaccination to prolong his second remission period. This new therapy slowed down the aggressive tumor growth. Because he is convinced that cellular immunotherapy gave him many extra quality years and he believes in its future possibilities he knows that his story of HOPE is his way of contributing to clinical practice and research.
Methods
In a documentary short film, directed by Hedwige Daenens, we use narrative medicine to describe our progress of adoptive cellular therapy in diseases where relapse remains a major problem and has an important impact on survival. Rupert tells us his moving story and guides the audience through the different steps in making a cancer vaccine. We filmed at the Center for Cell Therapy and Regenerative Medicine CCRG of the University Hospital Antwerp. This project was made possible by a collaboration with Biological and Medical Art in Belgium BIOMAB, based at the University of Antwerp, and the country's leading organisation to promote interdisciplinary research between scientists and those with an interest in the synergy between Art, Science and Technology .
Results
Leukapheresis, DC generation, antigen loading of DCs by electroporation of WT1-encoding mRNA, cryopreservation of WT1 mRNA-electroporated DCs, timing of first vaccination, thawing of the DC vaccine, immunisation schedule, route of administration and vaccine dose are described by using documentary methods in a hospital and research setting. Each procedure is explained in detail by a qualified member of staff understandable for a general audience. This movie shows a series of various interactive scenes at different departments, mostly restricted areas, during Rupert’s path creating his personal cancer vaccine.
Conclusion
Narrative medicine is a valuable tool to describe cell collection, processing and therapy. It promotes understanding between researcher, clinician, nurse and patient, encourages additional therapeutic options and generates new hypotheses. The documentary A STORY OF HOPE was presented for the first time at this year’s EBMT meeting.
Session topic: E-poster
Keyword(s): Cancer vaccine, Immunotherapy, Patient, Quality of life
Type: Publication Only
Background
Narrative medicine is a medical approach that recognises the value of people's narratives in clinical practice, research and education. Narrative medicine aims not only to validate the experience of the patient, but also to encourage creativity and self-reflection in the health care provider and researcher.
Aims
Rupert Suply, a young adult diagnosed with Ewing Sarcoma, was included in a study with dendritic cell vaccination to prolong his second remission period. This new therapy slowed down the aggressive tumor growth. Because he is convinced that cellular immunotherapy gave him many extra quality years and he believes in its future possibilities he knows that his story of HOPE is his way of contributing to clinical practice and research.
Methods
In a documentary short film, directed by Hedwige Daenens, we use narrative medicine to describe our progress of adoptive cellular therapy in diseases where relapse remains a major problem and has an important impact on survival. Rupert tells us his moving story and guides the audience through the different steps in making a cancer vaccine. We filmed at the Center for Cell Therapy and Regenerative Medicine CCRG of the University Hospital Antwerp. This project was made possible by a collaboration with Biological and Medical Art in Belgium BIOMAB, based at the University of Antwerp, and the country's leading organisation to promote interdisciplinary research between scientists and those with an interest in the synergy between Art, Science and Technology .
Results
Leukapheresis, DC generation, antigen loading of DCs by electroporation of WT1-encoding mRNA, cryopreservation of WT1 mRNA-electroporated DCs, timing of first vaccination, thawing of the DC vaccine, immunisation schedule, route of administration and vaccine dose are described by using documentary methods in a hospital and research setting. Each procedure is explained in detail by a qualified member of staff understandable for a general audience. This movie shows a series of various interactive scenes at different departments, mostly restricted areas, during Rupert’s path creating his personal cancer vaccine.
Conclusion
Narrative medicine is a valuable tool to describe cell collection, processing and therapy. It promotes understanding between researcher, clinician, nurse and patient, encourages additional therapeutic options and generates new hypotheses. The documentary A STORY OF HOPE was presented for the first time at this year’s EBMT meeting.
Session topic: E-poster
Keyword(s): Cancer vaccine, Immunotherapy, Patient, Quality of life
Abstract: PB1845
Type: Publication Only
Background
Narrative medicine is a medical approach that recognises the value of people's narratives in clinical practice, research and education. Narrative medicine aims not only to validate the experience of the patient, but also to encourage creativity and self-reflection in the health care provider and researcher.
Aims
Rupert Suply, a young adult diagnosed with Ewing Sarcoma, was included in a study with dendritic cell vaccination to prolong his second remission period. This new therapy slowed down the aggressive tumor growth. Because he is convinced that cellular immunotherapy gave him many extra quality years and he believes in its future possibilities he knows that his story of HOPE is his way of contributing to clinical practice and research.
Methods
In a documentary short film, directed by Hedwige Daenens, we use narrative medicine to describe our progress of adoptive cellular therapy in diseases where relapse remains a major problem and has an important impact on survival. Rupert tells us his moving story and guides the audience through the different steps in making a cancer vaccine. We filmed at the Center for Cell Therapy and Regenerative Medicine CCRG of the University Hospital Antwerp. This project was made possible by a collaboration with Biological and Medical Art in Belgium BIOMAB, based at the University of Antwerp, and the country's leading organisation to promote interdisciplinary research between scientists and those with an interest in the synergy between Art, Science and Technology .
Results
Leukapheresis, DC generation, antigen loading of DCs by electroporation of WT1-encoding mRNA, cryopreservation of WT1 mRNA-electroporated DCs, timing of first vaccination, thawing of the DC vaccine, immunisation schedule, route of administration and vaccine dose are described by using documentary methods in a hospital and research setting. Each procedure is explained in detail by a qualified member of staff understandable for a general audience. This movie shows a series of various interactive scenes at different departments, mostly restricted areas, during Rupert’s path creating his personal cancer vaccine.
Conclusion
Narrative medicine is a valuable tool to describe cell collection, processing and therapy. It promotes understanding between researcher, clinician, nurse and patient, encourages additional therapeutic options and generates new hypotheses. The documentary A STORY OF HOPE was presented for the first time at this year’s EBMT meeting.
Session topic: E-poster
Keyword(s): Cancer vaccine, Immunotherapy, Patient, Quality of life
Type: Publication Only
Background
Narrative medicine is a medical approach that recognises the value of people's narratives in clinical practice, research and education. Narrative medicine aims not only to validate the experience of the patient, but also to encourage creativity and self-reflection in the health care provider and researcher.
Aims
Rupert Suply, a young adult diagnosed with Ewing Sarcoma, was included in a study with dendritic cell vaccination to prolong his second remission period. This new therapy slowed down the aggressive tumor growth. Because he is convinced that cellular immunotherapy gave him many extra quality years and he believes in its future possibilities he knows that his story of HOPE is his way of contributing to clinical practice and research.
Methods
In a documentary short film, directed by Hedwige Daenens, we use narrative medicine to describe our progress of adoptive cellular therapy in diseases where relapse remains a major problem and has an important impact on survival. Rupert tells us his moving story and guides the audience through the different steps in making a cancer vaccine. We filmed at the Center for Cell Therapy and Regenerative Medicine CCRG of the University Hospital Antwerp. This project was made possible by a collaboration with Biological and Medical Art in Belgium BIOMAB, based at the University of Antwerp, and the country's leading organisation to promote interdisciplinary research between scientists and those with an interest in the synergy between Art, Science and Technology .
Results
Leukapheresis, DC generation, antigen loading of DCs by electroporation of WT1-encoding mRNA, cryopreservation of WT1 mRNA-electroporated DCs, timing of first vaccination, thawing of the DC vaccine, immunisation schedule, route of administration and vaccine dose are described by using documentary methods in a hospital and research setting. Each procedure is explained in detail by a qualified member of staff understandable for a general audience. This movie shows a series of various interactive scenes at different departments, mostly restricted areas, during Rupert’s path creating his personal cancer vaccine.
Conclusion
Narrative medicine is a valuable tool to describe cell collection, processing and therapy. It promotes understanding between researcher, clinician, nurse and patient, encourages additional therapeutic options and generates new hypotheses. The documentary A STORY OF HOPE was presented for the first time at this year’s EBMT meeting.
Session topic: E-poster
Keyword(s): Cancer vaccine, Immunotherapy, Patient, Quality of life
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