PREVALENCE AND PATTERNS OF TREATMENT OF APLASTIC ANEMIA IN KOREA
(Abstract release date: 05/19/16)
EHA Library. Kim H. 06/09/16; 134666; PB1766
Prof. Dr. Hawk Kim
Contributions
Contributions
Abstract
Abstract: PB1766
Type: Publication Only
Background
Aplastic anemia (AA) is a relatively rare bone marrow failure syndrome and has the wide variety of cytopenia spectrum from transfusion-independent mild cytopenia to severe pancytopenia that needs for allogeneic hematopoietic cell transplantation (HCT). However, the exact incidence of AA in whole-nation-wide survey and the whole picture of treatment pattern is extremely rare.
Aims
We aimed to figure out the real incidence and treatment pattern of AA in Korea as a nation-wide database analysis. Also we wanted to know whether incidence and treatment had regional variation.
Methods
We collected AA patients from Korea National Health Insurance Service (KNHIS) database. The minimal requirements for the diagnosis of AA were registation to a rare/difficult to treat disease as AA and performance of bone marrow biopsy at the time of registration. Newly diagnosed patients were defined as a new entry to registration as AA. Treatment were collected from the each drug prescription. Region was categorized into 4 areas according to city size; capital city, metropolitan city, samll city and rural area.
Results
Data between year 2008 and 2012 were collected from KNHIS database. The annual prevalance of AA was 8.6, 15.3, 20.5, 22.9 and 23.6 (average 17.5) patients per million (PPM) in years 2008, 2009, 2010, 2011, 2012, respectively. Prevalence of male (average 17.5 PPM) and female (average 18.9 PPM) were similar. Prevalence increased as the age increased: average 12.9 PPM in younger than 10y old; average 25.5 PPM in older than 80y old. Reginal differences were found: average 17.3 PPM in capital city, 17.7 PPM in metropolitan cities, 12.9 PPM in small cities and 24.2 PPM in rural areas. The crude incidence rates (CIRs) were similar in recent 5 years: 6.8 PPM in 2008, 8.9 PPM in 2009, 9.5 PPM in 2010, 9.4 PPM in 2011 and 8.4 PPM in 2012. There were age differences in CIRs. CIR in elderly population was more than 2 times higher when comparing with younger population: average 5.4 PPM in population younger than 10y; average 13.2 PPM in elderly population older than 80y. Average CIRs in reginal categories were 8.6 PPM in capital city, 8.3 PPM in metropolitan cities, 6.1 PPM in small cities and 10.8 PPM in rural areas. Treatments of newly diagnosed AA patients were follows: transfusion in 74.1%, cyclosporin in 34%, thymoglobulin in 26.4%, G-CSF in 44.6% and HCT in 12.5% . Thymoglobulin and HCT were received 34.5% and 21.5% of newly diagnosed AA youger than 40y, but the rates were droped to 16.8% and 4.5%, respectively in older than 40y patients.
Conclusion
Korea has high CIR of AA than wetern countries. CIR increases as age increases. Rural areas has higher CIR than small cities. The treatment pattern was different between younger age group and older age group as expected.
Session topic: E-poster
Keyword(s): Aplastic anemia, Prevalence, Treatment
Type: Publication Only
Background
Aplastic anemia (AA) is a relatively rare bone marrow failure syndrome and has the wide variety of cytopenia spectrum from transfusion-independent mild cytopenia to severe pancytopenia that needs for allogeneic hematopoietic cell transplantation (HCT). However, the exact incidence of AA in whole-nation-wide survey and the whole picture of treatment pattern is extremely rare.
Aims
We aimed to figure out the real incidence and treatment pattern of AA in Korea as a nation-wide database analysis. Also we wanted to know whether incidence and treatment had regional variation.
Methods
We collected AA patients from Korea National Health Insurance Service (KNHIS) database. The minimal requirements for the diagnosis of AA were registation to a rare/difficult to treat disease as AA and performance of bone marrow biopsy at the time of registration. Newly diagnosed patients were defined as a new entry to registration as AA. Treatment were collected from the each drug prescription. Region was categorized into 4 areas according to city size; capital city, metropolitan city, samll city and rural area.
Results
Data between year 2008 and 2012 were collected from KNHIS database. The annual prevalance of AA was 8.6, 15.3, 20.5, 22.9 and 23.6 (average 17.5) patients per million (PPM) in years 2008, 2009, 2010, 2011, 2012, respectively. Prevalence of male (average 17.5 PPM) and female (average 18.9 PPM) were similar. Prevalence increased as the age increased: average 12.9 PPM in younger than 10y old; average 25.5 PPM in older than 80y old. Reginal differences were found: average 17.3 PPM in capital city, 17.7 PPM in metropolitan cities, 12.9 PPM in small cities and 24.2 PPM in rural areas. The crude incidence rates (CIRs) were similar in recent 5 years: 6.8 PPM in 2008, 8.9 PPM in 2009, 9.5 PPM in 2010, 9.4 PPM in 2011 and 8.4 PPM in 2012. There were age differences in CIRs. CIR in elderly population was more than 2 times higher when comparing with younger population: average 5.4 PPM in population younger than 10y; average 13.2 PPM in elderly population older than 80y. Average CIRs in reginal categories were 8.6 PPM in capital city, 8.3 PPM in metropolitan cities, 6.1 PPM in small cities and 10.8 PPM in rural areas. Treatments of newly diagnosed AA patients were follows: transfusion in 74.1%, cyclosporin in 34%, thymoglobulin in 26.4%, G-CSF in 44.6% and HCT in 12.5% . Thymoglobulin and HCT were received 34.5% and 21.5% of newly diagnosed AA youger than 40y, but the rates were droped to 16.8% and 4.5%, respectively in older than 40y patients.
Conclusion
Korea has high CIR of AA than wetern countries. CIR increases as age increases. Rural areas has higher CIR than small cities. The treatment pattern was different between younger age group and older age group as expected.
Session topic: E-poster
Keyword(s): Aplastic anemia, Prevalence, Treatment
Abstract: PB1766
Type: Publication Only
Background
Aplastic anemia (AA) is a relatively rare bone marrow failure syndrome and has the wide variety of cytopenia spectrum from transfusion-independent mild cytopenia to severe pancytopenia that needs for allogeneic hematopoietic cell transplantation (HCT). However, the exact incidence of AA in whole-nation-wide survey and the whole picture of treatment pattern is extremely rare.
Aims
We aimed to figure out the real incidence and treatment pattern of AA in Korea as a nation-wide database analysis. Also we wanted to know whether incidence and treatment had regional variation.
Methods
We collected AA patients from Korea National Health Insurance Service (KNHIS) database. The minimal requirements for the diagnosis of AA were registation to a rare/difficult to treat disease as AA and performance of bone marrow biopsy at the time of registration. Newly diagnosed patients were defined as a new entry to registration as AA. Treatment were collected from the each drug prescription. Region was categorized into 4 areas according to city size; capital city, metropolitan city, samll city and rural area.
Results
Data between year 2008 and 2012 were collected from KNHIS database. The annual prevalance of AA was 8.6, 15.3, 20.5, 22.9 and 23.6 (average 17.5) patients per million (PPM) in years 2008, 2009, 2010, 2011, 2012, respectively. Prevalence of male (average 17.5 PPM) and female (average 18.9 PPM) were similar. Prevalence increased as the age increased: average 12.9 PPM in younger than 10y old; average 25.5 PPM in older than 80y old. Reginal differences were found: average 17.3 PPM in capital city, 17.7 PPM in metropolitan cities, 12.9 PPM in small cities and 24.2 PPM in rural areas. The crude incidence rates (CIRs) were similar in recent 5 years: 6.8 PPM in 2008, 8.9 PPM in 2009, 9.5 PPM in 2010, 9.4 PPM in 2011 and 8.4 PPM in 2012. There were age differences in CIRs. CIR in elderly population was more than 2 times higher when comparing with younger population: average 5.4 PPM in population younger than 10y; average 13.2 PPM in elderly population older than 80y. Average CIRs in reginal categories were 8.6 PPM in capital city, 8.3 PPM in metropolitan cities, 6.1 PPM in small cities and 10.8 PPM in rural areas. Treatments of newly diagnosed AA patients were follows: transfusion in 74.1%, cyclosporin in 34%, thymoglobulin in 26.4%, G-CSF in 44.6% and HCT in 12.5% . Thymoglobulin and HCT were received 34.5% and 21.5% of newly diagnosed AA youger than 40y, but the rates were droped to 16.8% and 4.5%, respectively in older than 40y patients.
Conclusion
Korea has high CIR of AA than wetern countries. CIR increases as age increases. Rural areas has higher CIR than small cities. The treatment pattern was different between younger age group and older age group as expected.
Session topic: E-poster
Keyword(s): Aplastic anemia, Prevalence, Treatment
Type: Publication Only
Background
Aplastic anemia (AA) is a relatively rare bone marrow failure syndrome and has the wide variety of cytopenia spectrum from transfusion-independent mild cytopenia to severe pancytopenia that needs for allogeneic hematopoietic cell transplantation (HCT). However, the exact incidence of AA in whole-nation-wide survey and the whole picture of treatment pattern is extremely rare.
Aims
We aimed to figure out the real incidence and treatment pattern of AA in Korea as a nation-wide database analysis. Also we wanted to know whether incidence and treatment had regional variation.
Methods
We collected AA patients from Korea National Health Insurance Service (KNHIS) database. The minimal requirements for the diagnosis of AA were registation to a rare/difficult to treat disease as AA and performance of bone marrow biopsy at the time of registration. Newly diagnosed patients were defined as a new entry to registration as AA. Treatment were collected from the each drug prescription. Region was categorized into 4 areas according to city size; capital city, metropolitan city, samll city and rural area.
Results
Data between year 2008 and 2012 were collected from KNHIS database. The annual prevalance of AA was 8.6, 15.3, 20.5, 22.9 and 23.6 (average 17.5) patients per million (PPM) in years 2008, 2009, 2010, 2011, 2012, respectively. Prevalence of male (average 17.5 PPM) and female (average 18.9 PPM) were similar. Prevalence increased as the age increased: average 12.9 PPM in younger than 10y old; average 25.5 PPM in older than 80y old. Reginal differences were found: average 17.3 PPM in capital city, 17.7 PPM in metropolitan cities, 12.9 PPM in small cities and 24.2 PPM in rural areas. The crude incidence rates (CIRs) were similar in recent 5 years: 6.8 PPM in 2008, 8.9 PPM in 2009, 9.5 PPM in 2010, 9.4 PPM in 2011 and 8.4 PPM in 2012. There were age differences in CIRs. CIR in elderly population was more than 2 times higher when comparing with younger population: average 5.4 PPM in population younger than 10y; average 13.2 PPM in elderly population older than 80y. Average CIRs in reginal categories were 8.6 PPM in capital city, 8.3 PPM in metropolitan cities, 6.1 PPM in small cities and 10.8 PPM in rural areas. Treatments of newly diagnosed AA patients were follows: transfusion in 74.1%, cyclosporin in 34%, thymoglobulin in 26.4%, G-CSF in 44.6% and HCT in 12.5% . Thymoglobulin and HCT were received 34.5% and 21.5% of newly diagnosed AA youger than 40y, but the rates were droped to 16.8% and 4.5%, respectively in older than 40y patients.
Conclusion
Korea has high CIR of AA than wetern countries. CIR increases as age increases. Rural areas has higher CIR than small cities. The treatment pattern was different between younger age group and older age group as expected.
Session topic: E-poster
Keyword(s): Aplastic anemia, Prevalence, Treatment
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