TWO IMPORTANT FACTORS WHICH AFFECT HEMOSTASIS IN HEMOPHILIA PAITENT WITH SURGERY
(Abstract release date: 05/19/16)
EHA Library. Hyun S. 06/09/16; 134658; PB1758
Prof. Dr. Shinyoung Hyun
Contributions
Contributions
Abstract
Abstract: PB1758
Type: Publication Only
Background
The severity and hemostasis in hemophilia is based on one’s factor level. In surgery of hemophilia patient appropriate hemostasis is very important for prognosis. Individual pharmacokinetic is quite different especially in recovery rate (RR).
Aims
We evaluate the prognosis of surgical cases according to different recovery rate recently. And we infused the concentrate in bolus followed by continuous infusion method during and after surgery. Also we checked in vitro factor activity as time goes on.
Methods
Twenty seven major surgeries were done in 20 patients (severe; 12, moderate; 4 and mild; 4). The mean age was 32 yr. The patient was divided into 3 groups. Group A (A) composed of 12 patients whose RR was above 0.8 with no further correction. Group B (B) composed of 10 patients whose RR are below 0.8 with further correction to make 1.0 before surgery. Group C (C) composed 5 patients whose RR was below 0.8 without further correction because of emergency operation. In continuous infusion we reconstitute the concentrate every 2-4 hours volume because in vitro factor activity will decrease as time goes on.
Results
The hospitalization periods of A, B and C were 14.5+/-12.1, 13.9+/-4.0, and 45.8+/-15.7 respectively (p=0,015 and 0.006 in A & C and B & C). The consumption of factor A concentrate of A, B and C were 481+/-195 U/kg, 1,311+/-283 U/kg and 3,502+/-1,529 respectively (p<0,001 in A & B and p=0.006 in B & C). Complications such as hematoma, sepsis CNS infection and hydrocephalus were observed in C. The mean in vitro factor activity at 2, 4, 6, 8 and 24 hours of reconstitution were gradually decreased to 97.7%, 95.3%, 92.9%, 90.6 and 73.0% respectively in all 3 drugs. Best activity at 24 hours was observed in light shield sample.
Conclusion
Although the recovery rate will be changed in different condition and time preliminary check is important for the emergency. In continuous infusion we recommend to reconstitute the concentrate every 2-4 hours to make a desired in vivo factor level.
Session topic: E-poster
Keyword(s): Hemophilia, Treatment
Type: Publication Only
Background
The severity and hemostasis in hemophilia is based on one’s factor level. In surgery of hemophilia patient appropriate hemostasis is very important for prognosis. Individual pharmacokinetic is quite different especially in recovery rate (RR).
Aims
We evaluate the prognosis of surgical cases according to different recovery rate recently. And we infused the concentrate in bolus followed by continuous infusion method during and after surgery. Also we checked in vitro factor activity as time goes on.
Methods
Twenty seven major surgeries were done in 20 patients (severe; 12, moderate; 4 and mild; 4). The mean age was 32 yr. The patient was divided into 3 groups. Group A (A) composed of 12 patients whose RR was above 0.8 with no further correction. Group B (B) composed of 10 patients whose RR are below 0.8 with further correction to make 1.0 before surgery. Group C (C) composed 5 patients whose RR was below 0.8 without further correction because of emergency operation. In continuous infusion we reconstitute the concentrate every 2-4 hours volume because in vitro factor activity will decrease as time goes on.
Results
The hospitalization periods of A, B and C were 14.5+/-12.1, 13.9+/-4.0, and 45.8+/-15.7 respectively (p=0,015 and 0.006 in A & C and B & C). The consumption of factor A concentrate of A, B and C were 481+/-195 U/kg, 1,311+/-283 U/kg and 3,502+/-1,529 respectively (p<0,001 in A & B and p=0.006 in B & C). Complications such as hematoma, sepsis CNS infection and hydrocephalus were observed in C. The mean in vitro factor activity at 2, 4, 6, 8 and 24 hours of reconstitution were gradually decreased to 97.7%, 95.3%, 92.9%, 90.6 and 73.0% respectively in all 3 drugs. Best activity at 24 hours was observed in light shield sample.
Conclusion
Although the recovery rate will be changed in different condition and time preliminary check is important for the emergency. In continuous infusion we recommend to reconstitute the concentrate every 2-4 hours to make a desired in vivo factor level.
Session topic: E-poster
Keyword(s): Hemophilia, Treatment
Abstract: PB1758
Type: Publication Only
Background
The severity and hemostasis in hemophilia is based on one’s factor level. In surgery of hemophilia patient appropriate hemostasis is very important for prognosis. Individual pharmacokinetic is quite different especially in recovery rate (RR).
Aims
We evaluate the prognosis of surgical cases according to different recovery rate recently. And we infused the concentrate in bolus followed by continuous infusion method during and after surgery. Also we checked in vitro factor activity as time goes on.
Methods
Twenty seven major surgeries were done in 20 patients (severe; 12, moderate; 4 and mild; 4). The mean age was 32 yr. The patient was divided into 3 groups. Group A (A) composed of 12 patients whose RR was above 0.8 with no further correction. Group B (B) composed of 10 patients whose RR are below 0.8 with further correction to make 1.0 before surgery. Group C (C) composed 5 patients whose RR was below 0.8 without further correction because of emergency operation. In continuous infusion we reconstitute the concentrate every 2-4 hours volume because in vitro factor activity will decrease as time goes on.
Results
The hospitalization periods of A, B and C were 14.5+/-12.1, 13.9+/-4.0, and 45.8+/-15.7 respectively (p=0,015 and 0.006 in A & C and B & C). The consumption of factor A concentrate of A, B and C were 481+/-195 U/kg, 1,311+/-283 U/kg and 3,502+/-1,529 respectively (p<0,001 in A & B and p=0.006 in B & C). Complications such as hematoma, sepsis CNS infection and hydrocephalus were observed in C. The mean in vitro factor activity at 2, 4, 6, 8 and 24 hours of reconstitution were gradually decreased to 97.7%, 95.3%, 92.9%, 90.6 and 73.0% respectively in all 3 drugs. Best activity at 24 hours was observed in light shield sample.
Conclusion
Although the recovery rate will be changed in different condition and time preliminary check is important for the emergency. In continuous infusion we recommend to reconstitute the concentrate every 2-4 hours to make a desired in vivo factor level.
Session topic: E-poster
Keyword(s): Hemophilia, Treatment
Type: Publication Only
Background
The severity and hemostasis in hemophilia is based on one’s factor level. In surgery of hemophilia patient appropriate hemostasis is very important for prognosis. Individual pharmacokinetic is quite different especially in recovery rate (RR).
Aims
We evaluate the prognosis of surgical cases according to different recovery rate recently. And we infused the concentrate in bolus followed by continuous infusion method during and after surgery. Also we checked in vitro factor activity as time goes on.
Methods
Twenty seven major surgeries were done in 20 patients (severe; 12, moderate; 4 and mild; 4). The mean age was 32 yr. The patient was divided into 3 groups. Group A (A) composed of 12 patients whose RR was above 0.8 with no further correction. Group B (B) composed of 10 patients whose RR are below 0.8 with further correction to make 1.0 before surgery. Group C (C) composed 5 patients whose RR was below 0.8 without further correction because of emergency operation. In continuous infusion we reconstitute the concentrate every 2-4 hours volume because in vitro factor activity will decrease as time goes on.
Results
The hospitalization periods of A, B and C were 14.5+/-12.1, 13.9+/-4.0, and 45.8+/-15.7 respectively (p=0,015 and 0.006 in A & C and B & C). The consumption of factor A concentrate of A, B and C were 481+/-195 U/kg, 1,311+/-283 U/kg and 3,502+/-1,529 respectively (p<0,001 in A & B and p=0.006 in B & C). Complications such as hematoma, sepsis CNS infection and hydrocephalus were observed in C. The mean in vitro factor activity at 2, 4, 6, 8 and 24 hours of reconstitution were gradually decreased to 97.7%, 95.3%, 92.9%, 90.6 and 73.0% respectively in all 3 drugs. Best activity at 24 hours was observed in light shield sample.
Conclusion
Although the recovery rate will be changed in different condition and time preliminary check is important for the emergency. In continuous infusion we recommend to reconstitute the concentrate every 2-4 hours to make a desired in vivo factor level.
Session topic: E-poster
Keyword(s): Hemophilia, Treatment
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