CONTINUOUS INFUSION FOR LIFE THREATENING HEMORRHAGE OF HEMOPHILIA PATIENT
(Abstract release date: 05/19/16)
EHA Library. Lee K. 06/09/16; 134648; PB1748
Prof. Kun Soo Lee
Contributions
Contributions
Abstract
Abstract: PB1748
Type: Publication Only
Background
Continuous infusion (CI) compare to bolus infusion has a merit of factor concentrate saving as much as 30% with same hemostatic effect. All biologic products will drcrease its activity even in vitro.
Aims
According to the instruction of inside package the factor concentrate recommend to administer within 3 hours of reconstitution at room temperature. Universally 24 hours’ volume of CI were reconstituted at one time in almost all hospital. We applied this CI for life-threatening hemorrhage with a different method since 1996.
Methods
Thirty five of life threatening hemorrhage or major surgery from 28 patients were enrolled in this study for 15 years. All patients received FVIII concentrates with initial loading dose of FVIII 50U/kg and then the continuous infusion, 3 U/kg/hr for 3 days, and then gradually decreased the amount for 2 weeks. We empirically prepared the material of CI with every 2-4 hours reconstitution to keep a desired in vivo factor level. To verify of this we checked in vitro factor activity of 3 drugs as time goes on recently.
Results
Thirty five events were intracranial hemorrhage in 17, general surgery in 9 and orthopedic surgery in 9. Age distribution was 0-32 yr (mean; 24.8 yr). Severity was severe (16), moderate (7) and mild (5). We confirmed in vivo factor activity within permissible level in all patients. All recovered from hemorrhage or surgery and are healthy, but one had limping gate and one had mild neurologic sequelae for more than 10 years. The mean in vitro factor activity at 2, 4, 6, 8 and 24hours of reconstitution were gradually decreased to 97.7%, 95.3%, 92.9%, 90.6 and 73.0% respectively in all 3 drugs.
Conclusion
All biologic products decrease their activity as time goes on even in vitro. Empirically, we reconstitute the concentrate every 2-4 hours for CI since 1996. And we confirmed the in vitro activity will decrease as time goes on. In continuous infusion we have to reconstitute the concentrate every 2-4 hours to make a desired in vivo factor level.
Session topic: E-poster
Keyword(s): Hemophilia, Treatment
Type: Publication Only
Background
Continuous infusion (CI) compare to bolus infusion has a merit of factor concentrate saving as much as 30% with same hemostatic effect. All biologic products will drcrease its activity even in vitro.
Aims
According to the instruction of inside package the factor concentrate recommend to administer within 3 hours of reconstitution at room temperature. Universally 24 hours’ volume of CI were reconstituted at one time in almost all hospital. We applied this CI for life-threatening hemorrhage with a different method since 1996.
Methods
Thirty five of life threatening hemorrhage or major surgery from 28 patients were enrolled in this study for 15 years. All patients received FVIII concentrates with initial loading dose of FVIII 50U/kg and then the continuous infusion, 3 U/kg/hr for 3 days, and then gradually decreased the amount for 2 weeks. We empirically prepared the material of CI with every 2-4 hours reconstitution to keep a desired in vivo factor level. To verify of this we checked in vitro factor activity of 3 drugs as time goes on recently.
Results
Thirty five events were intracranial hemorrhage in 17, general surgery in 9 and orthopedic surgery in 9. Age distribution was 0-32 yr (mean; 24.8 yr). Severity was severe (16), moderate (7) and mild (5). We confirmed in vivo factor activity within permissible level in all patients. All recovered from hemorrhage or surgery and are healthy, but one had limping gate and one had mild neurologic sequelae for more than 10 years. The mean in vitro factor activity at 2, 4, 6, 8 and 24hours of reconstitution were gradually decreased to 97.7%, 95.3%, 92.9%, 90.6 and 73.0% respectively in all 3 drugs.
Conclusion
All biologic products decrease their activity as time goes on even in vitro. Empirically, we reconstitute the concentrate every 2-4 hours for CI since 1996. And we confirmed the in vitro activity will decrease as time goes on. In continuous infusion we have to reconstitute the concentrate every 2-4 hours to make a desired in vivo factor level.
Session topic: E-poster
Keyword(s): Hemophilia, Treatment
Abstract: PB1748
Type: Publication Only
Background
Continuous infusion (CI) compare to bolus infusion has a merit of factor concentrate saving as much as 30% with same hemostatic effect. All biologic products will drcrease its activity even in vitro.
Aims
According to the instruction of inside package the factor concentrate recommend to administer within 3 hours of reconstitution at room temperature. Universally 24 hours’ volume of CI were reconstituted at one time in almost all hospital. We applied this CI for life-threatening hemorrhage with a different method since 1996.
Methods
Thirty five of life threatening hemorrhage or major surgery from 28 patients were enrolled in this study for 15 years. All patients received FVIII concentrates with initial loading dose of FVIII 50U/kg and then the continuous infusion, 3 U/kg/hr for 3 days, and then gradually decreased the amount for 2 weeks. We empirically prepared the material of CI with every 2-4 hours reconstitution to keep a desired in vivo factor level. To verify of this we checked in vitro factor activity of 3 drugs as time goes on recently.
Results
Thirty five events were intracranial hemorrhage in 17, general surgery in 9 and orthopedic surgery in 9. Age distribution was 0-32 yr (mean; 24.8 yr). Severity was severe (16), moderate (7) and mild (5). We confirmed in vivo factor activity within permissible level in all patients. All recovered from hemorrhage or surgery and are healthy, but one had limping gate and one had mild neurologic sequelae for more than 10 years. The mean in vitro factor activity at 2, 4, 6, 8 and 24hours of reconstitution were gradually decreased to 97.7%, 95.3%, 92.9%, 90.6 and 73.0% respectively in all 3 drugs.
Conclusion
All biologic products decrease their activity as time goes on even in vitro. Empirically, we reconstitute the concentrate every 2-4 hours for CI since 1996. And we confirmed the in vitro activity will decrease as time goes on. In continuous infusion we have to reconstitute the concentrate every 2-4 hours to make a desired in vivo factor level.
Session topic: E-poster
Keyword(s): Hemophilia, Treatment
Type: Publication Only
Background
Continuous infusion (CI) compare to bolus infusion has a merit of factor concentrate saving as much as 30% with same hemostatic effect. All biologic products will drcrease its activity even in vitro.
Aims
According to the instruction of inside package the factor concentrate recommend to administer within 3 hours of reconstitution at room temperature. Universally 24 hours’ volume of CI were reconstituted at one time in almost all hospital. We applied this CI for life-threatening hemorrhage with a different method since 1996.
Methods
Thirty five of life threatening hemorrhage or major surgery from 28 patients were enrolled in this study for 15 years. All patients received FVIII concentrates with initial loading dose of FVIII 50U/kg and then the continuous infusion, 3 U/kg/hr for 3 days, and then gradually decreased the amount for 2 weeks. We empirically prepared the material of CI with every 2-4 hours reconstitution to keep a desired in vivo factor level. To verify of this we checked in vitro factor activity of 3 drugs as time goes on recently.
Results
Thirty five events were intracranial hemorrhage in 17, general surgery in 9 and orthopedic surgery in 9. Age distribution was 0-32 yr (mean; 24.8 yr). Severity was severe (16), moderate (7) and mild (5). We confirmed in vivo factor activity within permissible level in all patients. All recovered from hemorrhage or surgery and are healthy, but one had limping gate and one had mild neurologic sequelae for more than 10 years. The mean in vitro factor activity at 2, 4, 6, 8 and 24hours of reconstitution were gradually decreased to 97.7%, 95.3%, 92.9%, 90.6 and 73.0% respectively in all 3 drugs.
Conclusion
All biologic products decrease their activity as time goes on even in vitro. Empirically, we reconstitute the concentrate every 2-4 hours for CI since 1996. And we confirmed the in vitro activity will decrease as time goes on. In continuous infusion we have to reconstitute the concentrate every 2-4 hours to make a desired in vivo factor level.
Session topic: E-poster
Keyword(s): Hemophilia, Treatment
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