THE INFLUENCE OF CARDIOVASCULAR COMORBIDITIES ON THE THERAPEUTIC RESPONSE AND PROGNOSIS OF PATIENTS DIAGNOSED WITH AGGRESSIVE NON HODGKIN LYMPHOMA
(Abstract release date: 05/19/16)
EHA Library. Monica P. 06/09/16; 134637; PB1737
Mrs. Pescaru Monica
Contributions
Contributions
Abstract
Abstract: PB1737
Type: Publication Only
Background
The NHLs are a heterogeneous group of lymphoproliferative malignancies with different patterns of behavior and responses to treatment. The aggressive type of NHL has a shorter natural history, but a significant number of these patients can be cured with intensive chemotherapy regimens.
Aims
The aim of this study was to determine to what extent cardiovascular comorbidities influence choice of therapy, treatment response and survival of patients diagnosed with NHL.
Methods
We have retrospectively analyzed clinical data of 47 aggresive NHL patients who were consecutively diagnosed at the Hematology Department of the Municipality Hospital of Timisoara,between 2009 and 2015. Disease stage and treatment were established after collecting clinical,laboratory, and pathological data. Survival analysis was estimated by means of the Kaplan-Meier curves and comparison of survival between subgroups was performed using the log-rank test. IBM SPSS Statistics 23 was the software that was used.
Results
There were 20 patients males and 27 females, averaging the age of 53.82 years, a median age at diagnosis of 56 years and a standard deviation of 15.49.The estimated overall survival at 5 years for the whole group of patients is 45% while the free survival disease at 5 years is 38%. In the case of patients diagnosed with high blood pressure (HBP), the overall survival is 45% at 5 years compared to the 43% for the patients who did not show HBP while the free survival disease for the patients diagnosed with HBP at 5 years is 45% compared to those who did not indicate the presence of HBP (37%). As for the coronary artery disease (CID), there were found differences both for the overall survival at 5 years (59% versus 41 %) and for the free survival disease at 5 years (58% versus 32%). Also, for the patients diagnosed with heart failure the overall survival at 30 months proved to be 0% compared to the overall survival for those who did not show this pathology (65%), and this is the same for the free survival disease found at these patients (p=0.025).
Conclusion
All the patients were subjected to polychemotherapy of R-CHOP or R-CNOP type. Referring to the associated cardiovascular commomorbidty neither the high blood pressure nor the coronary artery disease prove to be factors of negative prognosis, neither did they influence the survival and nor required the diminution of the chemotherapy dosages. Only the heart failure influenced the survival.
Session topic: E-poster
Keyword(s): Non-Hodgkin's lymphoma, Prognosis
Type: Publication Only
Background
The NHLs are a heterogeneous group of lymphoproliferative malignancies with different patterns of behavior and responses to treatment. The aggressive type of NHL has a shorter natural history, but a significant number of these patients can be cured with intensive chemotherapy regimens.
Aims
The aim of this study was to determine to what extent cardiovascular comorbidities influence choice of therapy, treatment response and survival of patients diagnosed with NHL.
Methods
We have retrospectively analyzed clinical data of 47 aggresive NHL patients who were consecutively diagnosed at the Hematology Department of the Municipality Hospital of Timisoara,between 2009 and 2015. Disease stage and treatment were established after collecting clinical,laboratory, and pathological data. Survival analysis was estimated by means of the Kaplan-Meier curves and comparison of survival between subgroups was performed using the log-rank test. IBM SPSS Statistics 23 was the software that was used.
Results
There were 20 patients males and 27 females, averaging the age of 53.82 years, a median age at diagnosis of 56 years and a standard deviation of 15.49.The estimated overall survival at 5 years for the whole group of patients is 45% while the free survival disease at 5 years is 38%. In the case of patients diagnosed with high blood pressure (HBP), the overall survival is 45% at 5 years compared to the 43% for the patients who did not show HBP while the free survival disease for the patients diagnosed with HBP at 5 years is 45% compared to those who did not indicate the presence of HBP (37%). As for the coronary artery disease (CID), there were found differences both for the overall survival at 5 years (59% versus 41 %) and for the free survival disease at 5 years (58% versus 32%). Also, for the patients diagnosed with heart failure the overall survival at 30 months proved to be 0% compared to the overall survival for those who did not show this pathology (65%), and this is the same for the free survival disease found at these patients (p=0.025).
Conclusion
All the patients were subjected to polychemotherapy of R-CHOP or R-CNOP type. Referring to the associated cardiovascular commomorbidty neither the high blood pressure nor the coronary artery disease prove to be factors of negative prognosis, neither did they influence the survival and nor required the diminution of the chemotherapy dosages. Only the heart failure influenced the survival.
Session topic: E-poster
Keyword(s): Non-Hodgkin's lymphoma, Prognosis
Abstract: PB1737
Type: Publication Only
Background
The NHLs are a heterogeneous group of lymphoproliferative malignancies with different patterns of behavior and responses to treatment. The aggressive type of NHL has a shorter natural history, but a significant number of these patients can be cured with intensive chemotherapy regimens.
Aims
The aim of this study was to determine to what extent cardiovascular comorbidities influence choice of therapy, treatment response and survival of patients diagnosed with NHL.
Methods
We have retrospectively analyzed clinical data of 47 aggresive NHL patients who were consecutively diagnosed at the Hematology Department of the Municipality Hospital of Timisoara,between 2009 and 2015. Disease stage and treatment were established after collecting clinical,laboratory, and pathological data. Survival analysis was estimated by means of the Kaplan-Meier curves and comparison of survival between subgroups was performed using the log-rank test. IBM SPSS Statistics 23 was the software that was used.
Results
There were 20 patients males and 27 females, averaging the age of 53.82 years, a median age at diagnosis of 56 years and a standard deviation of 15.49.The estimated overall survival at 5 years for the whole group of patients is 45% while the free survival disease at 5 years is 38%. In the case of patients diagnosed with high blood pressure (HBP), the overall survival is 45% at 5 years compared to the 43% for the patients who did not show HBP while the free survival disease for the patients diagnosed with HBP at 5 years is 45% compared to those who did not indicate the presence of HBP (37%). As for the coronary artery disease (CID), there were found differences both for the overall survival at 5 years (59% versus 41 %) and for the free survival disease at 5 years (58% versus 32%). Also, for the patients diagnosed with heart failure the overall survival at 30 months proved to be 0% compared to the overall survival for those who did not show this pathology (65%), and this is the same for the free survival disease found at these patients (p=0.025).
Conclusion
All the patients were subjected to polychemotherapy of R-CHOP or R-CNOP type. Referring to the associated cardiovascular commomorbidty neither the high blood pressure nor the coronary artery disease prove to be factors of negative prognosis, neither did they influence the survival and nor required the diminution of the chemotherapy dosages. Only the heart failure influenced the survival.
Session topic: E-poster
Keyword(s): Non-Hodgkin's lymphoma, Prognosis
Type: Publication Only
Background
The NHLs are a heterogeneous group of lymphoproliferative malignancies with different patterns of behavior and responses to treatment. The aggressive type of NHL has a shorter natural history, but a significant number of these patients can be cured with intensive chemotherapy regimens.
Aims
The aim of this study was to determine to what extent cardiovascular comorbidities influence choice of therapy, treatment response and survival of patients diagnosed with NHL.
Methods
We have retrospectively analyzed clinical data of 47 aggresive NHL patients who were consecutively diagnosed at the Hematology Department of the Municipality Hospital of Timisoara,between 2009 and 2015. Disease stage and treatment were established after collecting clinical,laboratory, and pathological data. Survival analysis was estimated by means of the Kaplan-Meier curves and comparison of survival between subgroups was performed using the log-rank test. IBM SPSS Statistics 23 was the software that was used.
Results
There were 20 patients males and 27 females, averaging the age of 53.82 years, a median age at diagnosis of 56 years and a standard deviation of 15.49.The estimated overall survival at 5 years for the whole group of patients is 45% while the free survival disease at 5 years is 38%. In the case of patients diagnosed with high blood pressure (HBP), the overall survival is 45% at 5 years compared to the 43% for the patients who did not show HBP while the free survival disease for the patients diagnosed with HBP at 5 years is 45% compared to those who did not indicate the presence of HBP (37%). As for the coronary artery disease (CID), there were found differences both for the overall survival at 5 years (59% versus 41 %) and for the free survival disease at 5 years (58% versus 32%). Also, for the patients diagnosed with heart failure the overall survival at 30 months proved to be 0% compared to the overall survival for those who did not show this pathology (65%), and this is the same for the free survival disease found at these patients (p=0.025).
Conclusion
All the patients were subjected to polychemotherapy of R-CHOP or R-CNOP type. Referring to the associated cardiovascular commomorbidty neither the high blood pressure nor the coronary artery disease prove to be factors of negative prognosis, neither did they influence the survival and nor required the diminution of the chemotherapy dosages. Only the heart failure influenced the survival.
Session topic: E-poster
Keyword(s): Non-Hodgkin's lymphoma, Prognosis
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