PRIMARY BONE DIFFUSE LARGE B CELL LYMPHOMA: EXPERIENCE AT A SINGLE CENTER IN JORDAN
(Abstract release date: 05/19/16)
EHA Library. Ayesh Ayesh Haj Yousef M. 06/09/16; 134636; PB1736
Mahmoud Ayesh Ayesh Haj Yousef
Contributions
Contributions
Abstract
Abstract: PB1736
Type: Publication Only
Background
Diffuse large B cell lymphoma (DLBCL) is the most common type of non-Hodgkin’s lymphoma, although there may be geographical and ethnic differences with respect to DLBL; these differences are associated with particular clinicopathologic features and outcomes. Primary bone diffuse large B cell lymphoma (PBDLBL) comprises 4–5% of all extranodal non-Hodgkin lymphoma (ENHL) cases and less than 1% of all malignant lymphomas. PBDLBL is so rare that many of its characteristics remain unknown, with no data at all available from Jordan
Aims
To examine the epidemiology and clinical features of PBDLBL in Jordanian patients as a model for other Middle East countries in which such data are scarce
Methods
Between September 2002 and December 2015, 112 patients aged 16 years and above were diagnosed with DLBL and treated at King Abdullah University Hospital.Patients with ENHL were included in the study only if they had a tissue diagnosis of DLBL at the site of involvement. According to the site of ENHL involvement at the time presentation Clinical stage was defined according to the Ann Arbor classification. Disease involving the lymph nodes, spleen, and Waldeyer's ring were defined as “nodal”.
Results
This retrospective study included 114 patients with DLBCL (54 females and 60 males; age range, 16 to 94 years; mean (SD), 51.0 (18.7) years). Of these, 66 (57.9%) presented with heterogeneous extranodal organ involvement. Of all extranodal sites, bone was involved in nine (14%) cases. Of these cases, 33% were female and 67% were male. The mean age of patients with extra nodal involvement was 46.7 (20.6) years. There was no significant difference between those with nodal and those with extranodal lymphomas in terms of gender (p = 0.656) or age (p = 0.158). The spine was the most common site of extranodal involvement with DLBL in six patients, the pelvis in one patient, the clavicle in one patient, and the scapulae in one patient. Back pain was the most common presenting symptom (six (67%) patients). A pathological fracture was noted in one patient (11%), a shoulder mass in one patient, and lower limb paralysis in one patient. No B symptoms were present in any patient. Serum lactic dehydrogenase (LDH) levels were elevated in only one patient
Conclusion
PBDLBL was the second most common extranodal manifestation of DLBL (14%), with the spine being the most frequent site.the most common extranodal site was the gastrointestinal tract (18%). Back pain was the main presenting symptom, with an absence of B symptoms. LDL levels were normal in most patients. The present study highlights geographic and ethnic variations in the primary disease site in patients with DLBL.
Session topic: E-poster
Keyword(s): Diffuse large cell lymphoma, Extranodal lymphoma
Type: Publication Only
Background
Diffuse large B cell lymphoma (DLBCL) is the most common type of non-Hodgkin’s lymphoma, although there may be geographical and ethnic differences with respect to DLBL; these differences are associated with particular clinicopathologic features and outcomes. Primary bone diffuse large B cell lymphoma (PBDLBL) comprises 4–5% of all extranodal non-Hodgkin lymphoma (ENHL) cases and less than 1% of all malignant lymphomas. PBDLBL is so rare that many of its characteristics remain unknown, with no data at all available from Jordan
Aims
To examine the epidemiology and clinical features of PBDLBL in Jordanian patients as a model for other Middle East countries in which such data are scarce
Methods
Between September 2002 and December 2015, 112 patients aged 16 years and above were diagnosed with DLBL and treated at King Abdullah University Hospital.Patients with ENHL were included in the study only if they had a tissue diagnosis of DLBL at the site of involvement. According to the site of ENHL involvement at the time presentation Clinical stage was defined according to the Ann Arbor classification. Disease involving the lymph nodes, spleen, and Waldeyer's ring were defined as “nodal”.
Results
This retrospective study included 114 patients with DLBCL (54 females and 60 males; age range, 16 to 94 years; mean (SD), 51.0 (18.7) years). Of these, 66 (57.9%) presented with heterogeneous extranodal organ involvement. Of all extranodal sites, bone was involved in nine (14%) cases. Of these cases, 33% were female and 67% were male. The mean age of patients with extra nodal involvement was 46.7 (20.6) years. There was no significant difference between those with nodal and those with extranodal lymphomas in terms of gender (p = 0.656) or age (p = 0.158). The spine was the most common site of extranodal involvement with DLBL in six patients, the pelvis in one patient, the clavicle in one patient, and the scapulae in one patient. Back pain was the most common presenting symptom (six (67%) patients). A pathological fracture was noted in one patient (11%), a shoulder mass in one patient, and lower limb paralysis in one patient. No B symptoms were present in any patient. Serum lactic dehydrogenase (LDH) levels were elevated in only one patient
Conclusion
PBDLBL was the second most common extranodal manifestation of DLBL (14%), with the spine being the most frequent site.the most common extranodal site was the gastrointestinal tract (18%). Back pain was the main presenting symptom, with an absence of B symptoms. LDL levels were normal in most patients. The present study highlights geographic and ethnic variations in the primary disease site in patients with DLBL.
Session topic: E-poster
Keyword(s): Diffuse large cell lymphoma, Extranodal lymphoma
Abstract: PB1736
Type: Publication Only
Background
Diffuse large B cell lymphoma (DLBCL) is the most common type of non-Hodgkin’s lymphoma, although there may be geographical and ethnic differences with respect to DLBL; these differences are associated with particular clinicopathologic features and outcomes. Primary bone diffuse large B cell lymphoma (PBDLBL) comprises 4–5% of all extranodal non-Hodgkin lymphoma (ENHL) cases and less than 1% of all malignant lymphomas. PBDLBL is so rare that many of its characteristics remain unknown, with no data at all available from Jordan
Aims
To examine the epidemiology and clinical features of PBDLBL in Jordanian patients as a model for other Middle East countries in which such data are scarce
Methods
Between September 2002 and December 2015, 112 patients aged 16 years and above were diagnosed with DLBL and treated at King Abdullah University Hospital.Patients with ENHL were included in the study only if they had a tissue diagnosis of DLBL at the site of involvement. According to the site of ENHL involvement at the time presentation Clinical stage was defined according to the Ann Arbor classification. Disease involving the lymph nodes, spleen, and Waldeyer's ring were defined as “nodal”.
Results
This retrospective study included 114 patients with DLBCL (54 females and 60 males; age range, 16 to 94 years; mean (SD), 51.0 (18.7) years). Of these, 66 (57.9%) presented with heterogeneous extranodal organ involvement. Of all extranodal sites, bone was involved in nine (14%) cases. Of these cases, 33% were female and 67% were male. The mean age of patients with extra nodal involvement was 46.7 (20.6) years. There was no significant difference between those with nodal and those with extranodal lymphomas in terms of gender (p = 0.656) or age (p = 0.158). The spine was the most common site of extranodal involvement with DLBL in six patients, the pelvis in one patient, the clavicle in one patient, and the scapulae in one patient. Back pain was the most common presenting symptom (six (67%) patients). A pathological fracture was noted in one patient (11%), a shoulder mass in one patient, and lower limb paralysis in one patient. No B symptoms were present in any patient. Serum lactic dehydrogenase (LDH) levels were elevated in only one patient
Conclusion
PBDLBL was the second most common extranodal manifestation of DLBL (14%), with the spine being the most frequent site.the most common extranodal site was the gastrointestinal tract (18%). Back pain was the main presenting symptom, with an absence of B symptoms. LDL levels were normal in most patients. The present study highlights geographic and ethnic variations in the primary disease site in patients with DLBL.
Session topic: E-poster
Keyword(s): Diffuse large cell lymphoma, Extranodal lymphoma
Type: Publication Only
Background
Diffuse large B cell lymphoma (DLBCL) is the most common type of non-Hodgkin’s lymphoma, although there may be geographical and ethnic differences with respect to DLBL; these differences are associated with particular clinicopathologic features and outcomes. Primary bone diffuse large B cell lymphoma (PBDLBL) comprises 4–5% of all extranodal non-Hodgkin lymphoma (ENHL) cases and less than 1% of all malignant lymphomas. PBDLBL is so rare that many of its characteristics remain unknown, with no data at all available from Jordan
Aims
To examine the epidemiology and clinical features of PBDLBL in Jordanian patients as a model for other Middle East countries in which such data are scarce
Methods
Between September 2002 and December 2015, 112 patients aged 16 years and above were diagnosed with DLBL and treated at King Abdullah University Hospital.Patients with ENHL were included in the study only if they had a tissue diagnosis of DLBL at the site of involvement. According to the site of ENHL involvement at the time presentation Clinical stage was defined according to the Ann Arbor classification. Disease involving the lymph nodes, spleen, and Waldeyer's ring were defined as “nodal”.
Results
This retrospective study included 114 patients with DLBCL (54 females and 60 males; age range, 16 to 94 years; mean (SD), 51.0 (18.7) years). Of these, 66 (57.9%) presented with heterogeneous extranodal organ involvement. Of all extranodal sites, bone was involved in nine (14%) cases. Of these cases, 33% were female and 67% were male. The mean age of patients with extra nodal involvement was 46.7 (20.6) years. There was no significant difference between those with nodal and those with extranodal lymphomas in terms of gender (p = 0.656) or age (p = 0.158). The spine was the most common site of extranodal involvement with DLBL in six patients, the pelvis in one patient, the clavicle in one patient, and the scapulae in one patient. Back pain was the most common presenting symptom (six (67%) patients). A pathological fracture was noted in one patient (11%), a shoulder mass in one patient, and lower limb paralysis in one patient. No B symptoms were present in any patient. Serum lactic dehydrogenase (LDH) levels were elevated in only one patient
Conclusion
PBDLBL was the second most common extranodal manifestation of DLBL (14%), with the spine being the most frequent site.the most common extranodal site was the gastrointestinal tract (18%). Back pain was the main presenting symptom, with an absence of B symptoms. LDL levels were normal in most patients. The present study highlights geographic and ethnic variations in the primary disease site in patients with DLBL.
Session topic: E-poster
Keyword(s): Diffuse large cell lymphoma, Extranodal lymphoma
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