CHARACTERIZATION OF HEPATITIS C VIRUS ASSOCIATED B-CELL NON-HODGKIN LYMPHOMA IN MANSOURA REGION (EGYPT), ANRS 12263 STUDY
(Abstract release date: 05/19/16)
EHA Library. Emarah Z. 06/09/16; 134634; PB1734
Dr. Ziad Emarah
Contributions
Contributions
Abstract
Abstract: PB1734
Type: Publication Only
Background
The prevalence of Hepatitis C virus in Egypt is 14.7%, which is considered the highest in the world. Genotype 4 represents about 93.1 % of cases which is considered among the highest prevalence areas of genotype 4 all over the world. Non-Hodgkin lymphoma is the 5th most common cancer in both male and female in Egypt. The association of HCV infection and development of B-cell lymphoproliferative especially the causative relationship not yet clear in Egypt.
Aims
the aim of this primary pilot study is to evaluate the incidence and clinical characteristics of HCV associated lymphoma in Egypt.
Methods
Between January 2012 and January 2013, we enrolled 110 adult patients with newly diagnosed B cell NHL. HCV infection was defined by the detection of anti-HCV antibodies by enzyme-linked immunosorbent assays with or without viraemia at initial diagnosis. Patients with Hepatitis B virus co-infection could be included but not those with HIV co-infection. Anti HCV positive samples, underwent HCV-RNA testing at disease diagnosis beside a rheumatoid factor screen.
Results
The incidence of B cell non-Hodgkin lymphoma associated with HCV infection was 60.9% (67/110 patients) which is considered the highest reported value in the literature. The incidence of cases presented with viraemia was 80 % (32/40 patients). As regard histology, the majority of HCV associated lymphoma were DLBCLs (71.6 %), SLL/CLL (13.4%), marginal zone (7.5%) and follicular (7.5%).
Conclusion
B cell lymphomas are highly associated with HCV infection (In Egypt incidence =60.9% vs. 2.5% in France). The difference in genotype distribution may be responsible for different incidence and behavior of HCV associated lymphoma. Further studies is needed to have a molecular signature for this unique environmental and genetic background.
Session topic: E-poster
Keyword(s): Genotype, Hepatitis C virus
Type: Publication Only
Background
The prevalence of Hepatitis C virus in Egypt is 14.7%, which is considered the highest in the world. Genotype 4 represents about 93.1 % of cases which is considered among the highest prevalence areas of genotype 4 all over the world. Non-Hodgkin lymphoma is the 5th most common cancer in both male and female in Egypt. The association of HCV infection and development of B-cell lymphoproliferative especially the causative relationship not yet clear in Egypt.
Aims
the aim of this primary pilot study is to evaluate the incidence and clinical characteristics of HCV associated lymphoma in Egypt.
Methods
Between January 2012 and January 2013, we enrolled 110 adult patients with newly diagnosed B cell NHL. HCV infection was defined by the detection of anti-HCV antibodies by enzyme-linked immunosorbent assays with or without viraemia at initial diagnosis. Patients with Hepatitis B virus co-infection could be included but not those with HIV co-infection. Anti HCV positive samples, underwent HCV-RNA testing at disease diagnosis beside a rheumatoid factor screen.
Results
The incidence of B cell non-Hodgkin lymphoma associated with HCV infection was 60.9% (67/110 patients) which is considered the highest reported value in the literature. The incidence of cases presented with viraemia was 80 % (32/40 patients). As regard histology, the majority of HCV associated lymphoma were DLBCLs (71.6 %), SLL/CLL (13.4%), marginal zone (7.5%) and follicular (7.5%).
Conclusion
B cell lymphomas are highly associated with HCV infection (In Egypt incidence =60.9% vs. 2.5% in France). The difference in genotype distribution may be responsible for different incidence and behavior of HCV associated lymphoma. Further studies is needed to have a molecular signature for this unique environmental and genetic background.
Session topic: E-poster
Keyword(s): Genotype, Hepatitis C virus
Abstract: PB1734
Type: Publication Only
Background
The prevalence of Hepatitis C virus in Egypt is 14.7%, which is considered the highest in the world. Genotype 4 represents about 93.1 % of cases which is considered among the highest prevalence areas of genotype 4 all over the world. Non-Hodgkin lymphoma is the 5th most common cancer in both male and female in Egypt. The association of HCV infection and development of B-cell lymphoproliferative especially the causative relationship not yet clear in Egypt.
Aims
the aim of this primary pilot study is to evaluate the incidence and clinical characteristics of HCV associated lymphoma in Egypt.
Methods
Between January 2012 and January 2013, we enrolled 110 adult patients with newly diagnosed B cell NHL. HCV infection was defined by the detection of anti-HCV antibodies by enzyme-linked immunosorbent assays with or without viraemia at initial diagnosis. Patients with Hepatitis B virus co-infection could be included but not those with HIV co-infection. Anti HCV positive samples, underwent HCV-RNA testing at disease diagnosis beside a rheumatoid factor screen.
Results
The incidence of B cell non-Hodgkin lymphoma associated with HCV infection was 60.9% (67/110 patients) which is considered the highest reported value in the literature. The incidence of cases presented with viraemia was 80 % (32/40 patients). As regard histology, the majority of HCV associated lymphoma were DLBCLs (71.6 %), SLL/CLL (13.4%), marginal zone (7.5%) and follicular (7.5%).
Conclusion
B cell lymphomas are highly associated with HCV infection (In Egypt incidence =60.9% vs. 2.5% in France). The difference in genotype distribution may be responsible for different incidence and behavior of HCV associated lymphoma. Further studies is needed to have a molecular signature for this unique environmental and genetic background.
Session topic: E-poster
Keyword(s): Genotype, Hepatitis C virus
Type: Publication Only
Background
The prevalence of Hepatitis C virus in Egypt is 14.7%, which is considered the highest in the world. Genotype 4 represents about 93.1 % of cases which is considered among the highest prevalence areas of genotype 4 all over the world. Non-Hodgkin lymphoma is the 5th most common cancer in both male and female in Egypt. The association of HCV infection and development of B-cell lymphoproliferative especially the causative relationship not yet clear in Egypt.
Aims
the aim of this primary pilot study is to evaluate the incidence and clinical characteristics of HCV associated lymphoma in Egypt.
Methods
Between January 2012 and January 2013, we enrolled 110 adult patients with newly diagnosed B cell NHL. HCV infection was defined by the detection of anti-HCV antibodies by enzyme-linked immunosorbent assays with or without viraemia at initial diagnosis. Patients with Hepatitis B virus co-infection could be included but not those with HIV co-infection. Anti HCV positive samples, underwent HCV-RNA testing at disease diagnosis beside a rheumatoid factor screen.
Results
The incidence of B cell non-Hodgkin lymphoma associated with HCV infection was 60.9% (67/110 patients) which is considered the highest reported value in the literature. The incidence of cases presented with viraemia was 80 % (32/40 patients). As regard histology, the majority of HCV associated lymphoma were DLBCLs (71.6 %), SLL/CLL (13.4%), marginal zone (7.5%) and follicular (7.5%).
Conclusion
B cell lymphomas are highly associated with HCV infection (In Egypt incidence =60.9% vs. 2.5% in France). The difference in genotype distribution may be responsible for different incidence and behavior of HCV associated lymphoma. Further studies is needed to have a molecular signature for this unique environmental and genetic background.
Session topic: E-poster
Keyword(s): Genotype, Hepatitis C virus
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