THE ABSOLUTE MONOCYTE AND PLATELET COUNTS IN PRIMARY GASTRIC DIFFUSE LARGE B-CELL LYMPHOMA PATIENTS TREATED WITH RITUXIMAB AND CHOP
(Abstract release date: 05/19/16)
EHA Library. Spassov B. 06/09/16; 134605; PB1705
Dr. Branimir Spassov
Contributions
Contributions
Abstract
Abstract: PB1705
Type: Publication Only
Background
Primary gastric lymphoma (PGL) accounts for 3% of gastric malignancies and 10% of lymphomas. The most common histological subtype of PGL is the primary gastric diffuse large B cell lymphoma (PGDLBCL). The standard of care of PGDLBCL patients (pts) is the combination rituximab-CHOP immunochemotherapy (R-CHOP). Recently serum albumin (SA), β2-microglobulin (B2M), hemoglobin level (Hb), absolute neutrophil (ANC), lymphocyte (ALC), monocyte (AMC) and platelet counts (PC) etc have been introduced into the clinical practice for better pts’ stratification. However the data regarding the prognostic significance of these markers are limited.
Aims
Therefore, we decided to access the possible prognostic impact of SA, B2M, Hb, ANC, ALC, AMC and PC in R-CHOP treated PGDLBCL pts.
Methods
We retrospectively reviewed the clinical outcome of 42 R-CHOP treated PGDLBCL pts with median age 56.7 years and 54.76 % male. The laboratory levels of SA, Hb, ANC, ALC, AMC and PC were recorded. Serum B2M levels were measured radioimmunologically. The best cut off values of SA, B2M, ANC, ALC, AMC and PC to predict overall survival (OS) by Kaplan-Meier method were calculated by a receiver operating characteristic (ROC) curve analysis. Univariate and multivariate analyses were performed by the log rank and Cox proportional-hazards methods, respectively.
Results
The estimated 5-year OS of the whole group was 80.9%. The median values of SA, B2M, Hb, ANC, ALC, AMC and PC were 39.1 g/L, 2.95 mg/L, 121 g/L, 4.69 G/L, 1.79 G/L, 0.51 G/L and 324 G/L, respectively. By applying the best cut off values of SA, B2M, Hb, ANC, ALC, AMC and PC that were 33.9 g/L, 2.6 mg/L, 105 g/L, 6.12 G/L, 1.77 G/L, 0.518 G/L and 335 G/L, respectively, it was observed that only Hb, ANC, AMC and PC correlated with OS. The independent prognostic significance, however, was confirmed in multivariate analysis only for AMC and PC (hazard ratios 15.482 and 13.525; p=0.012 and p=0.017, respectively). The dichotomized AMC and PC generated the AMC/PC prognostic index (PI) and stratified patients into 3 risk groups: very good (AMC <0.518 G/L and PC <335 G/L), good (AMC <0.518 G/L or PC <335 G/L) and poor-risk (AMC ≥0.518 G/L and PC ≥335 G/L) populations. For both the very good and good-risk groups median OS has not been reached with estimated 5-year OS of 100% and 86.4%, respectively whereas the median OS for poor-risk pts was 4 months with an estimated 5-year OS of 28.6% (p<0.001).
Conclusion
AMC and PC are independent prognostic markers to predict survival in PGDLBCL patients. AMC/PC PI could provide additional prognostic information for better stratification of these pts.
Session topic: E-poster
Type: Publication Only
Background
Primary gastric lymphoma (PGL) accounts for 3% of gastric malignancies and 10% of lymphomas. The most common histological subtype of PGL is the primary gastric diffuse large B cell lymphoma (PGDLBCL). The standard of care of PGDLBCL patients (pts) is the combination rituximab-CHOP immunochemotherapy (R-CHOP). Recently serum albumin (SA), β2-microglobulin (B2M), hemoglobin level (Hb), absolute neutrophil (ANC), lymphocyte (ALC), monocyte (AMC) and platelet counts (PC) etc have been introduced into the clinical practice for better pts’ stratification. However the data regarding the prognostic significance of these markers are limited.
Aims
Therefore, we decided to access the possible prognostic impact of SA, B2M, Hb, ANC, ALC, AMC and PC in R-CHOP treated PGDLBCL pts.
Methods
We retrospectively reviewed the clinical outcome of 42 R-CHOP treated PGDLBCL pts with median age 56.7 years and 54.76 % male. The laboratory levels of SA, Hb, ANC, ALC, AMC and PC were recorded. Serum B2M levels were measured radioimmunologically. The best cut off values of SA, B2M, ANC, ALC, AMC and PC to predict overall survival (OS) by Kaplan-Meier method were calculated by a receiver operating characteristic (ROC) curve analysis. Univariate and multivariate analyses were performed by the log rank and Cox proportional-hazards methods, respectively.
Results
The estimated 5-year OS of the whole group was 80.9%. The median values of SA, B2M, Hb, ANC, ALC, AMC and PC were 39.1 g/L, 2.95 mg/L, 121 g/L, 4.69 G/L, 1.79 G/L, 0.51 G/L and 324 G/L, respectively. By applying the best cut off values of SA, B2M, Hb, ANC, ALC, AMC and PC that were 33.9 g/L, 2.6 mg/L, 105 g/L, 6.12 G/L, 1.77 G/L, 0.518 G/L and 335 G/L, respectively, it was observed that only Hb, ANC, AMC and PC correlated with OS. The independent prognostic significance, however, was confirmed in multivariate analysis only for AMC and PC (hazard ratios 15.482 and 13.525; p=0.012 and p=0.017, respectively). The dichotomized AMC and PC generated the AMC/PC prognostic index (PI) and stratified patients into 3 risk groups: very good (AMC <0.518 G/L and PC <335 G/L), good (AMC <0.518 G/L or PC <335 G/L) and poor-risk (AMC ≥0.518 G/L and PC ≥335 G/L) populations. For both the very good and good-risk groups median OS has not been reached with estimated 5-year OS of 100% and 86.4%, respectively whereas the median OS for poor-risk pts was 4 months with an estimated 5-year OS of 28.6% (p<0.001).
Conclusion
AMC and PC are independent prognostic markers to predict survival in PGDLBCL patients. AMC/PC PI could provide additional prognostic information for better stratification of these pts.
Session topic: E-poster
Abstract: PB1705
Type: Publication Only
Background
Primary gastric lymphoma (PGL) accounts for 3% of gastric malignancies and 10% of lymphomas. The most common histological subtype of PGL is the primary gastric diffuse large B cell lymphoma (PGDLBCL). The standard of care of PGDLBCL patients (pts) is the combination rituximab-CHOP immunochemotherapy (R-CHOP). Recently serum albumin (SA), β2-microglobulin (B2M), hemoglobin level (Hb), absolute neutrophil (ANC), lymphocyte (ALC), monocyte (AMC) and platelet counts (PC) etc have been introduced into the clinical practice for better pts’ stratification. However the data regarding the prognostic significance of these markers are limited.
Aims
Therefore, we decided to access the possible prognostic impact of SA, B2M, Hb, ANC, ALC, AMC and PC in R-CHOP treated PGDLBCL pts.
Methods
We retrospectively reviewed the clinical outcome of 42 R-CHOP treated PGDLBCL pts with median age 56.7 years and 54.76 % male. The laboratory levels of SA, Hb, ANC, ALC, AMC and PC were recorded. Serum B2M levels were measured radioimmunologically. The best cut off values of SA, B2M, ANC, ALC, AMC and PC to predict overall survival (OS) by Kaplan-Meier method were calculated by a receiver operating characteristic (ROC) curve analysis. Univariate and multivariate analyses were performed by the log rank and Cox proportional-hazards methods, respectively.
Results
The estimated 5-year OS of the whole group was 80.9%. The median values of SA, B2M, Hb, ANC, ALC, AMC and PC were 39.1 g/L, 2.95 mg/L, 121 g/L, 4.69 G/L, 1.79 G/L, 0.51 G/L and 324 G/L, respectively. By applying the best cut off values of SA, B2M, Hb, ANC, ALC, AMC and PC that were 33.9 g/L, 2.6 mg/L, 105 g/L, 6.12 G/L, 1.77 G/L, 0.518 G/L and 335 G/L, respectively, it was observed that only Hb, ANC, AMC and PC correlated with OS. The independent prognostic significance, however, was confirmed in multivariate analysis only for AMC and PC (hazard ratios 15.482 and 13.525; p=0.012 and p=0.017, respectively). The dichotomized AMC and PC generated the AMC/PC prognostic index (PI) and stratified patients into 3 risk groups: very good (AMC <0.518 G/L and PC <335 G/L), good (AMC <0.518 G/L or PC <335 G/L) and poor-risk (AMC ≥0.518 G/L and PC ≥335 G/L) populations. For both the very good and good-risk groups median OS has not been reached with estimated 5-year OS of 100% and 86.4%, respectively whereas the median OS for poor-risk pts was 4 months with an estimated 5-year OS of 28.6% (p<0.001).
Conclusion
AMC and PC are independent prognostic markers to predict survival in PGDLBCL patients. AMC/PC PI could provide additional prognostic information for better stratification of these pts.
Session topic: E-poster
Type: Publication Only
Background
Primary gastric lymphoma (PGL) accounts for 3% of gastric malignancies and 10% of lymphomas. The most common histological subtype of PGL is the primary gastric diffuse large B cell lymphoma (PGDLBCL). The standard of care of PGDLBCL patients (pts) is the combination rituximab-CHOP immunochemotherapy (R-CHOP). Recently serum albumin (SA), β2-microglobulin (B2M), hemoglobin level (Hb), absolute neutrophil (ANC), lymphocyte (ALC), monocyte (AMC) and platelet counts (PC) etc have been introduced into the clinical practice for better pts’ stratification. However the data regarding the prognostic significance of these markers are limited.
Aims
Therefore, we decided to access the possible prognostic impact of SA, B2M, Hb, ANC, ALC, AMC and PC in R-CHOP treated PGDLBCL pts.
Methods
We retrospectively reviewed the clinical outcome of 42 R-CHOP treated PGDLBCL pts with median age 56.7 years and 54.76 % male. The laboratory levels of SA, Hb, ANC, ALC, AMC and PC were recorded. Serum B2M levels were measured radioimmunologically. The best cut off values of SA, B2M, ANC, ALC, AMC and PC to predict overall survival (OS) by Kaplan-Meier method were calculated by a receiver operating characteristic (ROC) curve analysis. Univariate and multivariate analyses were performed by the log rank and Cox proportional-hazards methods, respectively.
Results
The estimated 5-year OS of the whole group was 80.9%. The median values of SA, B2M, Hb, ANC, ALC, AMC and PC were 39.1 g/L, 2.95 mg/L, 121 g/L, 4.69 G/L, 1.79 G/L, 0.51 G/L and 324 G/L, respectively. By applying the best cut off values of SA, B2M, Hb, ANC, ALC, AMC and PC that were 33.9 g/L, 2.6 mg/L, 105 g/L, 6.12 G/L, 1.77 G/L, 0.518 G/L and 335 G/L, respectively, it was observed that only Hb, ANC, AMC and PC correlated with OS. The independent prognostic significance, however, was confirmed in multivariate analysis only for AMC and PC (hazard ratios 15.482 and 13.525; p=0.012 and p=0.017, respectively). The dichotomized AMC and PC generated the AMC/PC prognostic index (PI) and stratified patients into 3 risk groups: very good (AMC <0.518 G/L and PC <335 G/L), good (AMC <0.518 G/L or PC <335 G/L) and poor-risk (AMC ≥0.518 G/L and PC ≥335 G/L) populations. For both the very good and good-risk groups median OS has not been reached with estimated 5-year OS of 100% and 86.4%, respectively whereas the median OS for poor-risk pts was 4 months with an estimated 5-year OS of 28.6% (p<0.001).
Conclusion
AMC and PC are independent prognostic markers to predict survival in PGDLBCL patients. AMC/PC PI could provide additional prognostic information for better stratification of these pts.
Session topic: E-poster
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