THE PROGNOSTIC NUTRITIONAL INDEX AS A PREDICTOR OF PROGNOSIS IN PATIENTS WITH DIFFUSE LARGE B CELL LYMPHOMA
(Abstract release date: 05/19/16)
EHA Library. Periša V. 06/09/16; 134597; PB1697
Dr. Vlatka Periša
Contributions
Contributions
Abstract
Abstract: PB1697
Type: Publication Only
Background
The prognostic nutritional index (PNI), an indicator of nutritional status and systemic inflammation, is associated with short- and long-term outcomes of various malignancies. The prognostic value of the PNI in diffuse large B cell lymphoma (DLBCL) remains unknown.
Aims
The aim of present study is to determine the prognostic value of baseline PNI in DLBCL patients.
Methods
We retrospectively analyzed data from 76 DLBCL patients treated with R-CHOP or R-CHOP-like regimens. We evaluated the significance of PNI as a predictor of response to treatment, overall survival (OS) and event-free survival (EFS).
Results
Lower PNI levels were found in patients with advanced Ann Arbor clinical stage (47.56±6.97 vs 53.28±5.43, P<0.001) and in those with poor response to therapy (41.63±6.1 vs 51.08±6.11, P<0.001). Patients with PNI≤44.55 (cut-off was calculated by receiver operating chararacteristics) had significantly worse 5-year OS (35% vs 88.8%, P<0.001, log rank test) and 5-year EFS (28% vs 81.3 %, P<0.001, log rank test). Cox regression analysis showed that PNI≤44.55 was an independent prognostic factor for OS (HR 4.729, 95% CI 1.327-16.854) and EFS (HR 3.024, 95% CI 1.037-18.819).
Conclusion
PNI is an important prognostic factor in DLBCL, in addition to and independent of the International Prognostic Index. PNI may emerge as a simple, fast, easy to use and inexpensive new prognostic marker for DLBCL patients in routine clinical practice.
Session topic: E-poster
Keyword(s): Diffuse large B cell lymphoma, Prognostic factor
Type: Publication Only
Background
The prognostic nutritional index (PNI), an indicator of nutritional status and systemic inflammation, is associated with short- and long-term outcomes of various malignancies. The prognostic value of the PNI in diffuse large B cell lymphoma (DLBCL) remains unknown.
Aims
The aim of present study is to determine the prognostic value of baseline PNI in DLBCL patients.
Methods
We retrospectively analyzed data from 76 DLBCL patients treated with R-CHOP or R-CHOP-like regimens. We evaluated the significance of PNI as a predictor of response to treatment, overall survival (OS) and event-free survival (EFS).
Results
Lower PNI levels were found in patients with advanced Ann Arbor clinical stage (47.56±6.97 vs 53.28±5.43, P<0.001) and in those with poor response to therapy (41.63±6.1 vs 51.08±6.11, P<0.001). Patients with PNI≤44.55 (cut-off was calculated by receiver operating chararacteristics) had significantly worse 5-year OS (35% vs 88.8%, P<0.001, log rank test) and 5-year EFS (28% vs 81.3 %, P<0.001, log rank test). Cox regression analysis showed that PNI≤44.55 was an independent prognostic factor for OS (HR 4.729, 95% CI 1.327-16.854) and EFS (HR 3.024, 95% CI 1.037-18.819).
Conclusion
PNI is an important prognostic factor in DLBCL, in addition to and independent of the International Prognostic Index. PNI may emerge as a simple, fast, easy to use and inexpensive new prognostic marker for DLBCL patients in routine clinical practice.
Session topic: E-poster
Keyword(s): Diffuse large B cell lymphoma, Prognostic factor
Abstract: PB1697
Type: Publication Only
Background
The prognostic nutritional index (PNI), an indicator of nutritional status and systemic inflammation, is associated with short- and long-term outcomes of various malignancies. The prognostic value of the PNI in diffuse large B cell lymphoma (DLBCL) remains unknown.
Aims
The aim of present study is to determine the prognostic value of baseline PNI in DLBCL patients.
Methods
We retrospectively analyzed data from 76 DLBCL patients treated with R-CHOP or R-CHOP-like regimens. We evaluated the significance of PNI as a predictor of response to treatment, overall survival (OS) and event-free survival (EFS).
Results
Lower PNI levels were found in patients with advanced Ann Arbor clinical stage (47.56±6.97 vs 53.28±5.43, P<0.001) and in those with poor response to therapy (41.63±6.1 vs 51.08±6.11, P<0.001). Patients with PNI≤44.55 (cut-off was calculated by receiver operating chararacteristics) had significantly worse 5-year OS (35% vs 88.8%, P<0.001, log rank test) and 5-year EFS (28% vs 81.3 %, P<0.001, log rank test). Cox regression analysis showed that PNI≤44.55 was an independent prognostic factor for OS (HR 4.729, 95% CI 1.327-16.854) and EFS (HR 3.024, 95% CI 1.037-18.819).
Conclusion
PNI is an important prognostic factor in DLBCL, in addition to and independent of the International Prognostic Index. PNI may emerge as a simple, fast, easy to use and inexpensive new prognostic marker for DLBCL patients in routine clinical practice.
Session topic: E-poster
Keyword(s): Diffuse large B cell lymphoma, Prognostic factor
Type: Publication Only
Background
The prognostic nutritional index (PNI), an indicator of nutritional status and systemic inflammation, is associated with short- and long-term outcomes of various malignancies. The prognostic value of the PNI in diffuse large B cell lymphoma (DLBCL) remains unknown.
Aims
The aim of present study is to determine the prognostic value of baseline PNI in DLBCL patients.
Methods
We retrospectively analyzed data from 76 DLBCL patients treated with R-CHOP or R-CHOP-like regimens. We evaluated the significance of PNI as a predictor of response to treatment, overall survival (OS) and event-free survival (EFS).
Results
Lower PNI levels were found in patients with advanced Ann Arbor clinical stage (47.56±6.97 vs 53.28±5.43, P<0.001) and in those with poor response to therapy (41.63±6.1 vs 51.08±6.11, P<0.001). Patients with PNI≤44.55 (cut-off was calculated by receiver operating chararacteristics) had significantly worse 5-year OS (35% vs 88.8%, P<0.001, log rank test) and 5-year EFS (28% vs 81.3 %, P<0.001, log rank test). Cox regression analysis showed that PNI≤44.55 was an independent prognostic factor for OS (HR 4.729, 95% CI 1.327-16.854) and EFS (HR 3.024, 95% CI 1.037-18.819).
Conclusion
PNI is an important prognostic factor in DLBCL, in addition to and independent of the International Prognostic Index. PNI may emerge as a simple, fast, easy to use and inexpensive new prognostic marker for DLBCL patients in routine clinical practice.
Session topic: E-poster
Keyword(s): Diffuse large B cell lymphoma, Prognostic factor
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