POSITRON EMISSION TOMOGRAPHY COMPUTED TOMOGRAPHY FEATURES OF TYPE II ENTEROPATHY ASSOCIATED T CELL LYMPHOMA
(Abstract release date: 05/19/16)
EHA Library. Chan T. 06/09/16; 134590; PB1690
Thomas Sau Yan Chan
Contributions
Contributions
Abstract
Abstract: PB1690
Type: Publication Only
Background
Type II enteropathy associated T cell lymphoma (EATL) is a rare malignancy in the West and the only form of EATL in the East. 18F-fluorodeoxyglucose (FDG) positron emission tomography computed tomography (PET/CT) findings have not been described for type II EATL.
Aims
Type II EATL is increasingly recognized as a separate entity from type I EATL, we report herein the PET/CT findings of in a large cohort of patients, so that more can be known for this new disease entity.
Methods
Consecutive patients with type II EATL diagnosed between January 2008 and July 2015 were studied. The diagnosis was based on typical histopathological and immunophenotypical features. Standard clinical and biochemical evaluations for staging and response assessment were undertaken. Treatment protocols evolved over this period and were heterogeneous.
Results
Six men and four women with type II EATL investigated by PET/CT at diagnosis and relapse were retrospectively analysed. On presentation, the primary involved sites were the small bowel (N=8), stomach (N=1) and large bowel (N=1). The uninvolved small bowel did not show undue FDG-avidity to suggest enteropathy. Distant lymph nodes and organs were involved in four cases (40%). The primary lesions were hypermetabolic except in one case, where the colonic lesion was eumetabolic. At relapse, the stomach and large bowel might be involved even if the primary tumours arose from the small bowel, and multiple extra-intestinal metastases occurred. Interestingly, the lung and the brain were frequently involved (40% and 20% respectively).
Conclusion
These findings showed that in contrast to classical EATL, where the small bowel is the exclusive primary site (owing to its origin from coeliac disease associated enteropathy) and distant metastases even during relapse are exceptional, type II EATL could on presentation and during relapse involve any part of the gut, and metastasize to multiple extra-intestinal sites. These observations support the proposition of classifying this lymphoma as a distinct clinicopathological entity (monomorphic epitheliotropic intestinal T-cell lymphoma) to differentiate it from classical EATL.
Session topic: E-poster
Keyword(s): PET, T cell lymphoma
Type: Publication Only
Background
Type II enteropathy associated T cell lymphoma (EATL) is a rare malignancy in the West and the only form of EATL in the East. 18F-fluorodeoxyglucose (FDG) positron emission tomography computed tomography (PET/CT) findings have not been described for type II EATL.
Aims
Type II EATL is increasingly recognized as a separate entity from type I EATL, we report herein the PET/CT findings of in a large cohort of patients, so that more can be known for this new disease entity.
Methods
Consecutive patients with type II EATL diagnosed between January 2008 and July 2015 were studied. The diagnosis was based on typical histopathological and immunophenotypical features. Standard clinical and biochemical evaluations for staging and response assessment were undertaken. Treatment protocols evolved over this period and were heterogeneous.
Results
Six men and four women with type II EATL investigated by PET/CT at diagnosis and relapse were retrospectively analysed. On presentation, the primary involved sites were the small bowel (N=8), stomach (N=1) and large bowel (N=1). The uninvolved small bowel did not show undue FDG-avidity to suggest enteropathy. Distant lymph nodes and organs were involved in four cases (40%). The primary lesions were hypermetabolic except in one case, where the colonic lesion was eumetabolic. At relapse, the stomach and large bowel might be involved even if the primary tumours arose from the small bowel, and multiple extra-intestinal metastases occurred. Interestingly, the lung and the brain were frequently involved (40% and 20% respectively).
Conclusion
These findings showed that in contrast to classical EATL, where the small bowel is the exclusive primary site (owing to its origin from coeliac disease associated enteropathy) and distant metastases even during relapse are exceptional, type II EATL could on presentation and during relapse involve any part of the gut, and metastasize to multiple extra-intestinal sites. These observations support the proposition of classifying this lymphoma as a distinct clinicopathological entity (monomorphic epitheliotropic intestinal T-cell lymphoma) to differentiate it from classical EATL.
Session topic: E-poster
Keyword(s): PET, T cell lymphoma
Abstract: PB1690
Type: Publication Only
Background
Type II enteropathy associated T cell lymphoma (EATL) is a rare malignancy in the West and the only form of EATL in the East. 18F-fluorodeoxyglucose (FDG) positron emission tomography computed tomography (PET/CT) findings have not been described for type II EATL.
Aims
Type II EATL is increasingly recognized as a separate entity from type I EATL, we report herein the PET/CT findings of in a large cohort of patients, so that more can be known for this new disease entity.
Methods
Consecutive patients with type II EATL diagnosed between January 2008 and July 2015 were studied. The diagnosis was based on typical histopathological and immunophenotypical features. Standard clinical and biochemical evaluations for staging and response assessment were undertaken. Treatment protocols evolved over this period and were heterogeneous.
Results
Six men and four women with type II EATL investigated by PET/CT at diagnosis and relapse were retrospectively analysed. On presentation, the primary involved sites were the small bowel (N=8), stomach (N=1) and large bowel (N=1). The uninvolved small bowel did not show undue FDG-avidity to suggest enteropathy. Distant lymph nodes and organs were involved in four cases (40%). The primary lesions were hypermetabolic except in one case, where the colonic lesion was eumetabolic. At relapse, the stomach and large bowel might be involved even if the primary tumours arose from the small bowel, and multiple extra-intestinal metastases occurred. Interestingly, the lung and the brain were frequently involved (40% and 20% respectively).
Conclusion
These findings showed that in contrast to classical EATL, where the small bowel is the exclusive primary site (owing to its origin from coeliac disease associated enteropathy) and distant metastases even during relapse are exceptional, type II EATL could on presentation and during relapse involve any part of the gut, and metastasize to multiple extra-intestinal sites. These observations support the proposition of classifying this lymphoma as a distinct clinicopathological entity (monomorphic epitheliotropic intestinal T-cell lymphoma) to differentiate it from classical EATL.
Session topic: E-poster
Keyword(s): PET, T cell lymphoma
Type: Publication Only
Background
Type II enteropathy associated T cell lymphoma (EATL) is a rare malignancy in the West and the only form of EATL in the East. 18F-fluorodeoxyglucose (FDG) positron emission tomography computed tomography (PET/CT) findings have not been described for type II EATL.
Aims
Type II EATL is increasingly recognized as a separate entity from type I EATL, we report herein the PET/CT findings of in a large cohort of patients, so that more can be known for this new disease entity.
Methods
Consecutive patients with type II EATL diagnosed between January 2008 and July 2015 were studied. The diagnosis was based on typical histopathological and immunophenotypical features. Standard clinical and biochemical evaluations for staging and response assessment were undertaken. Treatment protocols evolved over this period and were heterogeneous.
Results
Six men and four women with type II EATL investigated by PET/CT at diagnosis and relapse were retrospectively analysed. On presentation, the primary involved sites were the small bowel (N=8), stomach (N=1) and large bowel (N=1). The uninvolved small bowel did not show undue FDG-avidity to suggest enteropathy. Distant lymph nodes and organs were involved in four cases (40%). The primary lesions were hypermetabolic except in one case, where the colonic lesion was eumetabolic. At relapse, the stomach and large bowel might be involved even if the primary tumours arose from the small bowel, and multiple extra-intestinal metastases occurred. Interestingly, the lung and the brain were frequently involved (40% and 20% respectively).
Conclusion
These findings showed that in contrast to classical EATL, where the small bowel is the exclusive primary site (owing to its origin from coeliac disease associated enteropathy) and distant metastases even during relapse are exceptional, type II EATL could on presentation and during relapse involve any part of the gut, and metastasize to multiple extra-intestinal sites. These observations support the proposition of classifying this lymphoma as a distinct clinicopathological entity (monomorphic epitheliotropic intestinal T-cell lymphoma) to differentiate it from classical EATL.
Session topic: E-poster
Keyword(s): PET, T cell lymphoma
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