THE PROGNOSTIC IMPACT OF SERUM ALBUMIN IN DOUBLE HIT/DOUBLE EXPRESSING AGGRESSIVE B CELL LYMPHOMAS: A PILOT STUDY EVALUATING SAAB SCORING SYSTEM
(Abstract release date: 05/19/16)
EHA Library. Talati C. 06/09/16; 134588; PB1688
Dr. Chetasi Talati
Contributions
Contributions
Abstract
Abstract: PB1688
Type: Publication Only
Background
Double hit lymphomas (DHL) [rearrangements of MYC and BCL2/BCL6, and double expressing lymphomas (DEL) [expression of MYC and BCL6/BCL2 by immunohistochemistry] represent a subset of diffuse large B-cell lymphoma (DLBCL) with poor overall survival (OS). Several prognostic scores have been tested to clinically stratify these patients with the double hit score (DHS) being the most recently developed model (Petrich 2014).
Aims
We explored the use of serum albumin (SA) as prognostic factor in DHL as previously shown in DLBCL (Dalia 2013).
Methods
We included 100 patients from Moffitt Cancer Center database from January 2008 to December 2015 with DHL and performed a retrospective chart review. Recorded clinical data included SA, hemoglobin, age, International Prognostic Index (IPI), DHS, and lymphopenia. Pairwise Cox Comparison was used to develop a weighted scoring system. Kaplan-Meier method with Cox proportional hazard model was used to determine OS.
Results
The median age was 63 (18-87), stage III/IV in 73.1%, bulky disease (>10cm) in 47.4%, B symptoms in 41.67%, CNS involvement in 14.1%, extranodal (EN) involvement in 34.7% of the patients. Patients with DHL and DEL were 60.2% and 39.8%, respectively. The median OS for the cohort was 15 months. Multivariate analysis identified Age > 60 (1 point), SA <3.7 (4 points), bulky disease (2 points) and Stage III/IV (1 point) as prognostically significant. LDH and EN dropped from the model. SAAB scoring consisted of 3 groups: Very good (0-2), Good (3-5), Poor (6-8). The 3-years OS was compared among scoring systems (Table 1).
*Highest survival was 18 months.
Conclusion
Compared to the R-IPI and DHS, the new SAAB score better discriminated prognostic groups in DHL/DEL. Confirmation in a larger and multicenter study is needed to validate these findings. SA might represent a surrogate of comorbid status and worse biology in patients with DHL/DEL.
Session topic: E-poster
Keyword(s): DLBCL
Type: Publication Only
Background
Double hit lymphomas (DHL) [rearrangements of MYC and BCL2/BCL6, and double expressing lymphomas (DEL) [expression of MYC and BCL6/BCL2 by immunohistochemistry] represent a subset of diffuse large B-cell lymphoma (DLBCL) with poor overall survival (OS). Several prognostic scores have been tested to clinically stratify these patients with the double hit score (DHS) being the most recently developed model (Petrich 2014).
Aims
We explored the use of serum albumin (SA) as prognostic factor in DHL as previously shown in DLBCL (Dalia 2013).
Methods
We included 100 patients from Moffitt Cancer Center database from January 2008 to December 2015 with DHL and performed a retrospective chart review. Recorded clinical data included SA, hemoglobin, age, International Prognostic Index (IPI), DHS, and lymphopenia. Pairwise Cox Comparison was used to develop a weighted scoring system. Kaplan-Meier method with Cox proportional hazard model was used to determine OS.
Results
The median age was 63 (18-87), stage III/IV in 73.1%, bulky disease (>10cm) in 47.4%, B symptoms in 41.67%, CNS involvement in 14.1%, extranodal (EN) involvement in 34.7% of the patients. Patients with DHL and DEL were 60.2% and 39.8%, respectively. The median OS for the cohort was 15 months. Multivariate analysis identified Age > 60 (1 point), SA <3.7 (4 points), bulky disease (2 points) and Stage III/IV (1 point) as prognostically significant. LDH and EN dropped from the model. SAAB scoring consisted of 3 groups: Very good (0-2), Good (3-5), Poor (6-8). The 3-years OS was compared among scoring systems (Table 1).
| Score (N=100) | 3 Year-OS | P-value |
| SAAB | 0.005 | |
| Very good (SAAB = 0-2) | 45% | |
| Good (SAAB 3-5) | 30% | |
| Poor (SAAB = 6-8) | NA* | |
| R-IPI | 0.437 | |
| Very Good (R-IPI = 0) | 100% | |
| Good (R-IPI = 1-2) | 30% | |
| Poor (R-IPI = 3-5) | 32% | |
| Double Hit Score (DHS) | 0.281 | |
| Low (DHS = 0) | 26% | |
| Intermediate (DHS = 1) | 29% | |
| High (DHS = 2 or more) | 27% |
Conclusion
Compared to the R-IPI and DHS, the new SAAB score better discriminated prognostic groups in DHL/DEL. Confirmation in a larger and multicenter study is needed to validate these findings. SA might represent a surrogate of comorbid status and worse biology in patients with DHL/DEL.
Session topic: E-poster
Keyword(s): DLBCL
Abstract: PB1688
Type: Publication Only
Background
Double hit lymphomas (DHL) [rearrangements of MYC and BCL2/BCL6, and double expressing lymphomas (DEL) [expression of MYC and BCL6/BCL2 by immunohistochemistry] represent a subset of diffuse large B-cell lymphoma (DLBCL) with poor overall survival (OS). Several prognostic scores have been tested to clinically stratify these patients with the double hit score (DHS) being the most recently developed model (Petrich 2014).
Aims
We explored the use of serum albumin (SA) as prognostic factor in DHL as previously shown in DLBCL (Dalia 2013).
Methods
We included 100 patients from Moffitt Cancer Center database from January 2008 to December 2015 with DHL and performed a retrospective chart review. Recorded clinical data included SA, hemoglobin, age, International Prognostic Index (IPI), DHS, and lymphopenia. Pairwise Cox Comparison was used to develop a weighted scoring system. Kaplan-Meier method with Cox proportional hazard model was used to determine OS.
Results
The median age was 63 (18-87), stage III/IV in 73.1%, bulky disease (>10cm) in 47.4%, B symptoms in 41.67%, CNS involvement in 14.1%, extranodal (EN) involvement in 34.7% of the patients. Patients with DHL and DEL were 60.2% and 39.8%, respectively. The median OS for the cohort was 15 months. Multivariate analysis identified Age > 60 (1 point), SA <3.7 (4 points), bulky disease (2 points) and Stage III/IV (1 point) as prognostically significant. LDH and EN dropped from the model. SAAB scoring consisted of 3 groups: Very good (0-2), Good (3-5), Poor (6-8). The 3-years OS was compared among scoring systems (Table 1).
*Highest survival was 18 months.
Conclusion
Compared to the R-IPI and DHS, the new SAAB score better discriminated prognostic groups in DHL/DEL. Confirmation in a larger and multicenter study is needed to validate these findings. SA might represent a surrogate of comorbid status and worse biology in patients with DHL/DEL.
Session topic: E-poster
Keyword(s): DLBCL
Type: Publication Only
Background
Double hit lymphomas (DHL) [rearrangements of MYC and BCL2/BCL6, and double expressing lymphomas (DEL) [expression of MYC and BCL6/BCL2 by immunohistochemistry] represent a subset of diffuse large B-cell lymphoma (DLBCL) with poor overall survival (OS). Several prognostic scores have been tested to clinically stratify these patients with the double hit score (DHS) being the most recently developed model (Petrich 2014).
Aims
We explored the use of serum albumin (SA) as prognostic factor in DHL as previously shown in DLBCL (Dalia 2013).
Methods
We included 100 patients from Moffitt Cancer Center database from January 2008 to December 2015 with DHL and performed a retrospective chart review. Recorded clinical data included SA, hemoglobin, age, International Prognostic Index (IPI), DHS, and lymphopenia. Pairwise Cox Comparison was used to develop a weighted scoring system. Kaplan-Meier method with Cox proportional hazard model was used to determine OS.
Results
The median age was 63 (18-87), stage III/IV in 73.1%, bulky disease (>10cm) in 47.4%, B symptoms in 41.67%, CNS involvement in 14.1%, extranodal (EN) involvement in 34.7% of the patients. Patients with DHL and DEL were 60.2% and 39.8%, respectively. The median OS for the cohort was 15 months. Multivariate analysis identified Age > 60 (1 point), SA <3.7 (4 points), bulky disease (2 points) and Stage III/IV (1 point) as prognostically significant. LDH and EN dropped from the model. SAAB scoring consisted of 3 groups: Very good (0-2), Good (3-5), Poor (6-8). The 3-years OS was compared among scoring systems (Table 1).
| Score (N=100) | 3 Year-OS | P-value |
| SAAB | 0.005 | |
| Very good (SAAB = 0-2) | 45% | |
| Good (SAAB 3-5) | 30% | |
| Poor (SAAB = 6-8) | NA* | |
| R-IPI | 0.437 | |
| Very Good (R-IPI = 0) | 100% | |
| Good (R-IPI = 1-2) | 30% | |
| Poor (R-IPI = 3-5) | 32% | |
| Double Hit Score (DHS) | 0.281 | |
| Low (DHS = 0) | 26% | |
| Intermediate (DHS = 1) | 29% | |
| High (DHS = 2 or more) | 27% |
Conclusion
Compared to the R-IPI and DHS, the new SAAB score better discriminated prognostic groups in DHL/DEL. Confirmation in a larger and multicenter study is needed to validate these findings. SA might represent a surrogate of comorbid status and worse biology in patients with DHL/DEL.
Session topic: E-poster
Keyword(s): DLBCL
{{ help_message }}
{{filter}}