THE INCIDENCE OF ACUTE LEUKEMIA IN SOME REGIONS OF THE RUSSIAN FEDERATION.
(Abstract release date: 05/19/16)
EHA Library. Akhmerzaeva Z. 06/09/16; 134518; PB1618
Ms. Zalina Akhmerzaeva
Contributions
Contributions
Abstract
Abstract: PB1618
Type: Publication Only
Background
The incidence of acute leukemia (AL) in US and European countries is about 5 per 100000 according data from cancer registries. Russian Federal Сancer Register (RFCR) reported AL incidence rate across the country as about 3 per 100000.
Aims
To evaluate the age-gender specific incidence, profile and other epidemiologic characteristics AL in Russia regions.
Methods
Russian Hematology Society in 2013 initiated the AL population based registry study in which participated 5 regions of Russia Federation. The primary goal was to pre-registry patients for clinical studies, and secondary - to evaluate the epidemiology of AL. 5 regions were included into analysis of epidemiology statistics. The criteria were the fullness and reliability of AL cases registration. Also, only regions with one big hematological center accumulating all AL cases were chosen. All new cases were recorded on-line into special Web based data capture system.
Results
The registry was started at 1st April of 2013 and is ongoing. 216 new ALL cases from Kirov, Ryazan, Kaluga, Tambov regions and Mordovia republic (4,7 M of population) were included into analysis. The distribution by AL subtypes was following: AML - 131 (60,6%), ALL - 40 (18,5%), APL - 8(3,7%), other - 37 (17,1%). Median age was for AML - 59 (17-85), ALL - 38 (16-80), APL 55 (38-79) years. Gender female/male proportions 121\95. The incidence rate estimates by region are listed in table1. Table.1 Incidence of adult AL in 5 Russian regions.
The frequencies of AL cases in age strata are distributed as following: 5 (2,3%) - in 15-19 age group; 39 (18%) - in 20-39 age group; 78 (36,1%) - in 40-59 age group; 89 (41,2%) - in 60-79 age group; 5 (2,3%) - in 80-99 age group.
Conclusion
AL patients registered in the Russian Federation are younger then AL patients of European registries (AML -58years vs 71years; ALL - 38 years vs 54years, respectively). The significant percentage of unidentified variants AL (17.1 %) is a significant problem. We should emphasize that the recorded incidence of AL in our study is quite low. It's close of morbidity estimations of RFCR, but notably lower than European and American registers. This discrepancy can be explained by significantly reduced registration activity and primary diagnostics of AL in the older age groups.
Session topic: E-poster
Keyword(s): Acute leukemia
Type: Publication Only
Background
The incidence of acute leukemia (AL) in US and European countries is about 5 per 100000 according data from cancer registries. Russian Federal Сancer Register (RFCR) reported AL incidence rate across the country as about 3 per 100000.
Aims
To evaluate the age-gender specific incidence, profile and other epidemiologic characteristics AL in Russia regions.
Methods
Russian Hematology Society in 2013 initiated the AL population based registry study in which participated 5 regions of Russia Federation. The primary goal was to pre-registry patients for clinical studies, and secondary - to evaluate the epidemiology of AL. 5 regions were included into analysis of epidemiology statistics. The criteria were the fullness and reliability of AL cases registration. Also, only regions with one big hematological center accumulating all AL cases were chosen. All new cases were recorded on-line into special Web based data capture system.
Results
The registry was started at 1st April of 2013 and is ongoing. 216 new ALL cases from Kirov, Ryazan, Kaluga, Tambov regions and Mordovia republic (4,7 M of population) were included into analysis. The distribution by AL subtypes was following: AML - 131 (60,6%), ALL - 40 (18,5%), APL - 8(3,7%), other - 37 (17,1%). Median age was for AML - 59 (17-85), ALL - 38 (16-80), APL 55 (38-79) years. Gender female/male proportions 121\95. The incidence rate estimates by region are listed in table1. Table.1 Incidence of adult AL in 5 Russian regions.
| region | Adult population (106) | Registered cases | Duration | Incidence | ||||||
| All | M | F | All | M | F | (y) | All | M | F | |
| Kirov | 1.15 | 0.52 | 0.63 | 47 | 22 | 25 | 2.14 | 1.90 | 1.98 | 1.84 |
| Mordovia | 0.72 | 0.33 | 0.40 | 52 | 29 | 23 | 2.06 | 3.49 | 4.31 | 2.81 |
| Ryazan | 1.01 | 0.45 | 0.56 | 45 | 17 | 28 | 1.90 | 2.34 | 1.98 | 2.63 |
| Kaluga | 0.88 | 0.39 | 0.48 | 33 | 15 | 18 | 2.03 | 1.84 | 1.86 | 1.83 |
| Tambov | 0.95 | 0.43 | 0.52 | 39 | 12 | 27 | 1.98 | 2.06 | 1.41 | 2.60 |
Conclusion
AL patients registered in the Russian Federation are younger then AL patients of European registries (AML -58years vs 71years; ALL - 38 years vs 54years, respectively). The significant percentage of unidentified variants AL (17.1 %) is a significant problem. We should emphasize that the recorded incidence of AL in our study is quite low. It's close of morbidity estimations of RFCR, but notably lower than European and American registers. This discrepancy can be explained by significantly reduced registration activity and primary diagnostics of AL in the older age groups.
Session topic: E-poster
Keyword(s): Acute leukemia
Abstract: PB1618
Type: Publication Only
Background
The incidence of acute leukemia (AL) in US and European countries is about 5 per 100000 according data from cancer registries. Russian Federal Сancer Register (RFCR) reported AL incidence rate across the country as about 3 per 100000.
Aims
To evaluate the age-gender specific incidence, profile and other epidemiologic characteristics AL in Russia regions.
Methods
Russian Hematology Society in 2013 initiated the AL population based registry study in which participated 5 regions of Russia Federation. The primary goal was to pre-registry patients for clinical studies, and secondary - to evaluate the epidemiology of AL. 5 regions were included into analysis of epidemiology statistics. The criteria were the fullness and reliability of AL cases registration. Also, only regions with one big hematological center accumulating all AL cases were chosen. All new cases were recorded on-line into special Web based data capture system.
Results
The registry was started at 1st April of 2013 and is ongoing. 216 new ALL cases from Kirov, Ryazan, Kaluga, Tambov regions and Mordovia republic (4,7 M of population) were included into analysis. The distribution by AL subtypes was following: AML - 131 (60,6%), ALL - 40 (18,5%), APL - 8(3,7%), other - 37 (17,1%). Median age was for AML - 59 (17-85), ALL - 38 (16-80), APL 55 (38-79) years. Gender female/male proportions 121\95. The incidence rate estimates by region are listed in table1. Table.1 Incidence of adult AL in 5 Russian regions.
The frequencies of AL cases in age strata are distributed as following: 5 (2,3%) - in 15-19 age group; 39 (18%) - in 20-39 age group; 78 (36,1%) - in 40-59 age group; 89 (41,2%) - in 60-79 age group; 5 (2,3%) - in 80-99 age group.
Conclusion
AL patients registered in the Russian Federation are younger then AL patients of European registries (AML -58years vs 71years; ALL - 38 years vs 54years, respectively). The significant percentage of unidentified variants AL (17.1 %) is a significant problem. We should emphasize that the recorded incidence of AL in our study is quite low. It's close of morbidity estimations of RFCR, but notably lower than European and American registers. This discrepancy can be explained by significantly reduced registration activity and primary diagnostics of AL in the older age groups.
Session topic: E-poster
Keyword(s): Acute leukemia
Type: Publication Only
Background
The incidence of acute leukemia (AL) in US and European countries is about 5 per 100000 according data from cancer registries. Russian Federal Сancer Register (RFCR) reported AL incidence rate across the country as about 3 per 100000.
Aims
To evaluate the age-gender specific incidence, profile and other epidemiologic characteristics AL in Russia regions.
Methods
Russian Hematology Society in 2013 initiated the AL population based registry study in which participated 5 regions of Russia Federation. The primary goal was to pre-registry patients for clinical studies, and secondary - to evaluate the epidemiology of AL. 5 regions were included into analysis of epidemiology statistics. The criteria were the fullness and reliability of AL cases registration. Also, only regions with one big hematological center accumulating all AL cases were chosen. All new cases were recorded on-line into special Web based data capture system.
Results
The registry was started at 1st April of 2013 and is ongoing. 216 new ALL cases from Kirov, Ryazan, Kaluga, Tambov regions and Mordovia republic (4,7 M of population) were included into analysis. The distribution by AL subtypes was following: AML - 131 (60,6%), ALL - 40 (18,5%), APL - 8(3,7%), other - 37 (17,1%). Median age was for AML - 59 (17-85), ALL - 38 (16-80), APL 55 (38-79) years. Gender female/male proportions 121\95. The incidence rate estimates by region are listed in table1. Table.1 Incidence of adult AL in 5 Russian regions.
| region | Adult population (106) | Registered cases | Duration | Incidence | ||||||
| All | M | F | All | M | F | (y) | All | M | F | |
| Kirov | 1.15 | 0.52 | 0.63 | 47 | 22 | 25 | 2.14 | 1.90 | 1.98 | 1.84 |
| Mordovia | 0.72 | 0.33 | 0.40 | 52 | 29 | 23 | 2.06 | 3.49 | 4.31 | 2.81 |
| Ryazan | 1.01 | 0.45 | 0.56 | 45 | 17 | 28 | 1.90 | 2.34 | 1.98 | 2.63 |
| Kaluga | 0.88 | 0.39 | 0.48 | 33 | 15 | 18 | 2.03 | 1.84 | 1.86 | 1.83 |
| Tambov | 0.95 | 0.43 | 0.52 | 39 | 12 | 27 | 1.98 | 2.06 | 1.41 | 2.60 |
Conclusion
AL patients registered in the Russian Federation are younger then AL patients of European registries (AML -58years vs 71years; ALL - 38 years vs 54years, respectively). The significant percentage of unidentified variants AL (17.1 %) is a significant problem. We should emphasize that the recorded incidence of AL in our study is quite low. It's close of morbidity estimations of RFCR, but notably lower than European and American registers. This discrepancy can be explained by significantly reduced registration activity and primary diagnostics of AL in the older age groups.
Session topic: E-poster
Keyword(s): Acute leukemia
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