PROGNOSIS OF CHILDREN WITH ACUTE HYPERLEUKOCYTIC LYMPHOBLASTIC LEUKEMIA TREATED WITH MODIFIED ST JUDE TOTAL XV PROTOCOL
(Abstract release date: 05/19/16)
EHA Library. Cetin M. 06/09/16; 134513; PB1613
Prof. Dr. Mualla Cetin
Contributions
Contributions
Abstract
Abstract: PB1613
Type: Publication Only
Background
Acute leukemias with high white blood count (greater than or equal to 100,000/mm3) have a poor prognosis with an increased risk of early morbidity and mortality.
Aims
In this study we aim to analyse outcome of all complications due to hyperleucocytosis including tumor lysis syndrome, hyperuricemia, renal failure, disseminated intravascular coagulation and treatment modalities of these complications during remission induction beside long term outcome.
Methods
Between January 2008 to December 2015, 206 children with ALL were diagnosed at Hacettepe University Faculty of Medicine, Ihsan Dogramaci Children's Hospital. However 33 were excluded from the study ( infant leukemia(n=11),relapse ALL referred to our center and/or initialy treatment was given by another center (n=6), secondary ALL(n=1) , mature B cell ALL(n=7), early death (n=7), lost to follow up(n=1)). 173 remained in the study and 20 out of 173 were diagnosed as hyperleukocytic high risk acute ALL.
Results
There were 8 female,12 male with a median age of 5 years old(between 1 to16,7 years).Mean initial WBC conunt is 206x103/µl( 119-462x10-3/µl).9 were T cell immunophenotype however 8 were Calla+B cell and 3 were Calla-B cell phenotype. Initial CNS involvement was 33% among these hyperleukocytic ALL patients. Translocation (9;22) was found to be positive in 2 and they received allogeneic hematopoeitic stem cell transplantation. MRD status by flowcytometer was done on the 15th day of remission induction and all except one was found to be under <0.1%.Relapse was observed 3 out of 20 (15%)in this group(combined relapse BM+CNS(n=1), isolated CNS(n=1), isolated bone marrow(n=1)). However all patients including 3 HSCT patients and relapse patients were in complete remission and alive.
Conclusion
In our study hyperleukocytic high risk All patients did show slightly improved survival when compared with the literature.
Session topic: E-poster
Keyword(s): Children, Hyperleukocytosis, Leukemia, Prognosis
Type: Publication Only
Background
Acute leukemias with high white blood count (greater than or equal to 100,000/mm3) have a poor prognosis with an increased risk of early morbidity and mortality.
Aims
In this study we aim to analyse outcome of all complications due to hyperleucocytosis including tumor lysis syndrome, hyperuricemia, renal failure, disseminated intravascular coagulation and treatment modalities of these complications during remission induction beside long term outcome.
Methods
Between January 2008 to December 2015, 206 children with ALL were diagnosed at Hacettepe University Faculty of Medicine, Ihsan Dogramaci Children's Hospital. However 33 were excluded from the study ( infant leukemia(n=11),relapse ALL referred to our center and/or initialy treatment was given by another center (n=6), secondary ALL(n=1) , mature B cell ALL(n=7), early death (n=7), lost to follow up(n=1)). 173 remained in the study and 20 out of 173 were diagnosed as hyperleukocytic high risk acute ALL.
Results
There were 8 female,12 male with a median age of 5 years old(between 1 to16,7 years).Mean initial WBC conunt is 206x103/µl( 119-462x10-3/µl).9 were T cell immunophenotype however 8 were Calla+B cell and 3 were Calla-B cell phenotype. Initial CNS involvement was 33% among these hyperleukocytic ALL patients. Translocation (9;22) was found to be positive in 2 and they received allogeneic hematopoeitic stem cell transplantation. MRD status by flowcytometer was done on the 15th day of remission induction and all except one was found to be under <0.1%.Relapse was observed 3 out of 20 (15%)in this group(combined relapse BM+CNS(n=1), isolated CNS(n=1), isolated bone marrow(n=1)). However all patients including 3 HSCT patients and relapse patients were in complete remission and alive.
Conclusion
In our study hyperleukocytic high risk All patients did show slightly improved survival when compared with the literature.
Session topic: E-poster
Keyword(s): Children, Hyperleukocytosis, Leukemia, Prognosis
Abstract: PB1613
Type: Publication Only
Background
Acute leukemias with high white blood count (greater than or equal to 100,000/mm3) have a poor prognosis with an increased risk of early morbidity and mortality.
Aims
In this study we aim to analyse outcome of all complications due to hyperleucocytosis including tumor lysis syndrome, hyperuricemia, renal failure, disseminated intravascular coagulation and treatment modalities of these complications during remission induction beside long term outcome.
Methods
Between January 2008 to December 2015, 206 children with ALL were diagnosed at Hacettepe University Faculty of Medicine, Ihsan Dogramaci Children's Hospital. However 33 were excluded from the study ( infant leukemia(n=11),relapse ALL referred to our center and/or initialy treatment was given by another center (n=6), secondary ALL(n=1) , mature B cell ALL(n=7), early death (n=7), lost to follow up(n=1)). 173 remained in the study and 20 out of 173 were diagnosed as hyperleukocytic high risk acute ALL.
Results
There were 8 female,12 male with a median age of 5 years old(between 1 to16,7 years).Mean initial WBC conunt is 206x103/µl( 119-462x10-3/µl).9 were T cell immunophenotype however 8 were Calla+B cell and 3 were Calla-B cell phenotype. Initial CNS involvement was 33% among these hyperleukocytic ALL patients. Translocation (9;22) was found to be positive in 2 and they received allogeneic hematopoeitic stem cell transplantation. MRD status by flowcytometer was done on the 15th day of remission induction and all except one was found to be under <0.1%.Relapse was observed 3 out of 20 (15%)in this group(combined relapse BM+CNS(n=1), isolated CNS(n=1), isolated bone marrow(n=1)). However all patients including 3 HSCT patients and relapse patients were in complete remission and alive.
Conclusion
In our study hyperleukocytic high risk All patients did show slightly improved survival when compared with the literature.
Session topic: E-poster
Keyword(s): Children, Hyperleukocytosis, Leukemia, Prognosis
Type: Publication Only
Background
Acute leukemias with high white blood count (greater than or equal to 100,000/mm3) have a poor prognosis with an increased risk of early morbidity and mortality.
Aims
In this study we aim to analyse outcome of all complications due to hyperleucocytosis including tumor lysis syndrome, hyperuricemia, renal failure, disseminated intravascular coagulation and treatment modalities of these complications during remission induction beside long term outcome.
Methods
Between January 2008 to December 2015, 206 children with ALL were diagnosed at Hacettepe University Faculty of Medicine, Ihsan Dogramaci Children's Hospital. However 33 were excluded from the study ( infant leukemia(n=11),relapse ALL referred to our center and/or initialy treatment was given by another center (n=6), secondary ALL(n=1) , mature B cell ALL(n=7), early death (n=7), lost to follow up(n=1)). 173 remained in the study and 20 out of 173 were diagnosed as hyperleukocytic high risk acute ALL.
Results
There were 8 female,12 male with a median age of 5 years old(between 1 to16,7 years).Mean initial WBC conunt is 206x103/µl( 119-462x10-3/µl).9 were T cell immunophenotype however 8 were Calla+B cell and 3 were Calla-B cell phenotype. Initial CNS involvement was 33% among these hyperleukocytic ALL patients. Translocation (9;22) was found to be positive in 2 and they received allogeneic hematopoeitic stem cell transplantation. MRD status by flowcytometer was done on the 15th day of remission induction and all except one was found to be under <0.1%.Relapse was observed 3 out of 20 (15%)in this group(combined relapse BM+CNS(n=1), isolated CNS(n=1), isolated bone marrow(n=1)). However all patients including 3 HSCT patients and relapse patients were in complete remission and alive.
Conclusion
In our study hyperleukocytic high risk All patients did show slightly improved survival when compared with the literature.
Session topic: E-poster
Keyword(s): Children, Hyperleukocytosis, Leukemia, Prognosis
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