FREQUENCY OF RED CELL ANTIGENS AND ANTIBODIES IN THE POPULATION OF NORTH-EASTERN REGIONS OF RUSSIAN FEDERATION
(Abstract release date: 05/19/16)
EHA Library. Butina E. 06/09/16; 133136; E1587
Mrs. Elena Butina
Contributions
Contributions
Abstract
Abstract: E1587
Type: Eposter Presentation
Background
Providing immunological compatibility of donor and recipient can prevent the development alloimmunization, the occurrence of hemolytic transfusion reactions and increase the effectiveness of transfusion therapy. The frequency of red blood cell (RBC) antigens and alloantibodies is different in populations from different races and geographic areas.
Aims
To study the frequency of Rhesus phenotypes and RBC alloantibodies in donors and recipients of blood components residing in north-eastern regions of the Russian Federation .
Methods
Data from 8087 donors and 2648 patients with hematological diseases were analysed in 2009-2015. Research blood samples was carried out by erythrocyte-magnetized technology (Diagast, France) and gel agglutination assay (BioRad, USA).
Results
Established following frequency of Rhesus phenotypes: СсDее - 30.35%, ССDee – 19.39%, СсDЕе – 15.88%, ссddee – 15.34%, ccDEe – 13.00%, ccDEE – 3.24%, ccDee – 1.72%, Ccddee - 0.90%, ccddEe – 0.07%, CCddee – 0.05%, CcDEE – 0.05%, CCDEe – 0.02%, CCDEE – 0%, CCddEE – 0%.The incidence of RBC antibodies in blood donors is very low (0.49%) compared with the incidence in patients with hematological diseases, who received transfusion therapy (1.93%) (p<0.01). The most common specificities of antibodies in donors were anti-D (0.22%), in recipients - anti-E (0.3%), anti-K (0.26%), anti-D (0.23%). Differences in the frequency of anti-E and anti-K antibody in donors and recipients are significant (p <0.01) (table).Table. Frequency and specificity of RBC alloantibodies in blood donor and patients with hematological diseases
* - The differences between the groups of donor and patients were significant (p <0.01)
Conclusion
In the population of north-eastern regions of Russian Federation the most frequent phenotypes СсDee, ССDee, ссddee, СсDEe and anti-D, -E, -K alloantibodies. Analysis of immunohematological parameters of donors and recipients allows targeted collection, banking and storage of blood components.
Session topic: E-poster
Keyword(s): Antibody, Phenotype, Red blood cell
Type: Eposter Presentation
Background
Providing immunological compatibility of donor and recipient can prevent the development alloimmunization, the occurrence of hemolytic transfusion reactions and increase the effectiveness of transfusion therapy. The frequency of red blood cell (RBC) antigens and alloantibodies is different in populations from different races and geographic areas.
Aims
To study the frequency of Rhesus phenotypes and RBC alloantibodies in donors and recipients of blood components residing in north-eastern regions of the Russian Federation .
Methods
Data from 8087 donors and 2648 patients with hematological diseases were analysed in 2009-2015. Research blood samples was carried out by erythrocyte-magnetized technology (Diagast, France) and gel agglutination assay (BioRad, USA).
Results
Established following frequency of Rhesus phenotypes: СсDее - 30.35%, ССDee – 19.39%, СсDЕе – 15.88%, ссddee – 15.34%, ccDEe – 13.00%, ccDEE – 3.24%, ccDee – 1.72%, Ccddee - 0.90%, ccddEe – 0.07%, CCddee – 0.05%, CcDEE – 0.05%, CCDEe – 0.02%, CCDEE – 0%, CCddEE – 0%.The incidence of RBC antibodies in blood donors is very low (0.49%) compared with the incidence in patients with hematological diseases, who received transfusion therapy (1.93%) (p<0.01). The most common specificities of antibodies in donors were anti-D (0.22%), in recipients - anti-E (0.3%), anti-K (0.26%), anti-D (0.23%). Differences in the frequency of anti-E and anti-K antibody in donors and recipients are significant (p <0.01) (table).Table. Frequency and specificity of RBC alloantibodies in blood donor and patients with hematological diseases
| Specificity of RBC alloantibodies | Frequency of RBC alloantibodies (%) | |
| donors | patients with hematological diseases | |
| D | 0.21 | 0.23 |
| DC | 0.02 | 0.08 |
| C | 0.01 | 0.08 |
| c | 0 | 0.08 |
| E | 0.05 | 0.30* |
| Сw | 0.02 | 0.04 |
| К | 0.02 | 0.26* |
| М | 0.02 | 0.11 |
| Lea | 0.02 | 0.11 |
| Leb | 0.02 | 0.08 |
| Lua | 0 | 0.08 |
| Fya | 0 | 0.04 |
| Fyb | 0.01 | 0 |
| Jkb | 0.01 | 0 |
Conclusion
In the population of north-eastern regions of Russian Federation the most frequent phenotypes СсDee, ССDee, ссddee, СсDEe and anti-D, -E, -K alloantibodies. Analysis of immunohematological parameters of donors and recipients allows targeted collection, banking and storage of blood components.
Session topic: E-poster
Keyword(s): Antibody, Phenotype, Red blood cell
Abstract: E1587
Type: Eposter Presentation
Background
Providing immunological compatibility of donor and recipient can prevent the development alloimmunization, the occurrence of hemolytic transfusion reactions and increase the effectiveness of transfusion therapy. The frequency of red blood cell (RBC) antigens and alloantibodies is different in populations from different races and geographic areas.
Aims
To study the frequency of Rhesus phenotypes and RBC alloantibodies in donors and recipients of blood components residing in north-eastern regions of the Russian Federation .
Methods
Data from 8087 donors and 2648 patients with hematological diseases were analysed in 2009-2015. Research blood samples was carried out by erythrocyte-magnetized technology (Diagast, France) and gel agglutination assay (BioRad, USA).
Results
Established following frequency of Rhesus phenotypes: СсDее - 30.35%, ССDee – 19.39%, СсDЕе – 15.88%, ссddee – 15.34%, ccDEe – 13.00%, ccDEE – 3.24%, ccDee – 1.72%, Ccddee - 0.90%, ccddEe – 0.07%, CCddee – 0.05%, CcDEE – 0.05%, CCDEe – 0.02%, CCDEE – 0%, CCddEE – 0%.The incidence of RBC antibodies in blood donors is very low (0.49%) compared with the incidence in patients with hematological diseases, who received transfusion therapy (1.93%) (p<0.01). The most common specificities of antibodies in donors were anti-D (0.22%), in recipients - anti-E (0.3%), anti-K (0.26%), anti-D (0.23%). Differences in the frequency of anti-E and anti-K antibody in donors and recipients are significant (p <0.01) (table).Table. Frequency and specificity of RBC alloantibodies in blood donor and patients with hematological diseases
* - The differences between the groups of donor and patients were significant (p <0.01)
Conclusion
In the population of north-eastern regions of Russian Federation the most frequent phenotypes СсDee, ССDee, ссddee, СсDEe and anti-D, -E, -K alloantibodies. Analysis of immunohematological parameters of donors and recipients allows targeted collection, banking and storage of blood components.
Session topic: E-poster
Keyword(s): Antibody, Phenotype, Red blood cell
Type: Eposter Presentation
Background
Providing immunological compatibility of donor and recipient can prevent the development alloimmunization, the occurrence of hemolytic transfusion reactions and increase the effectiveness of transfusion therapy. The frequency of red blood cell (RBC) antigens and alloantibodies is different in populations from different races and geographic areas.
Aims
To study the frequency of Rhesus phenotypes and RBC alloantibodies in donors and recipients of blood components residing in north-eastern regions of the Russian Federation .
Methods
Data from 8087 donors and 2648 patients with hematological diseases were analysed in 2009-2015. Research blood samples was carried out by erythrocyte-magnetized technology (Diagast, France) and gel agglutination assay (BioRad, USA).
Results
Established following frequency of Rhesus phenotypes: СсDее - 30.35%, ССDee – 19.39%, СсDЕе – 15.88%, ссddee – 15.34%, ccDEe – 13.00%, ccDEE – 3.24%, ccDee – 1.72%, Ccddee - 0.90%, ccddEe – 0.07%, CCddee – 0.05%, CcDEE – 0.05%, CCDEe – 0.02%, CCDEE – 0%, CCddEE – 0%.The incidence of RBC antibodies in blood donors is very low (0.49%) compared with the incidence in patients with hematological diseases, who received transfusion therapy (1.93%) (p<0.01). The most common specificities of antibodies in donors were anti-D (0.22%), in recipients - anti-E (0.3%), anti-K (0.26%), anti-D (0.23%). Differences in the frequency of anti-E and anti-K antibody in donors and recipients are significant (p <0.01) (table).Table. Frequency and specificity of RBC alloantibodies in blood donor and patients with hematological diseases
| Specificity of RBC alloantibodies | Frequency of RBC alloantibodies (%) | |
| donors | patients with hematological diseases | |
| D | 0.21 | 0.23 |
| DC | 0.02 | 0.08 |
| C | 0.01 | 0.08 |
| c | 0 | 0.08 |
| E | 0.05 | 0.30* |
| Сw | 0.02 | 0.04 |
| К | 0.02 | 0.26* |
| М | 0.02 | 0.11 |
| Lea | 0.02 | 0.11 |
| Leb | 0.02 | 0.08 |
| Lua | 0 | 0.08 |
| Fya | 0 | 0.04 |
| Fyb | 0.01 | 0 |
| Jkb | 0.01 | 0 |
Conclusion
In the population of north-eastern regions of Russian Federation the most frequent phenotypes СсDee, ССDee, ссddee, СсDEe and anti-D, -E, -K alloantibodies. Analysis of immunohematological parameters of donors and recipients allows targeted collection, banking and storage of blood components.
Session topic: E-poster
Keyword(s): Antibody, Phenotype, Red blood cell
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