MASSIVE TRANSFUSION IN SON ESPASES UNIVERSITY HOSPITAL FROM 2010 TO 2015: A SINGLE CENTRE EXPERIENCE
(Abstract release date: 05/19/16)
EHA Library. Ruiz De Gracia S. 06/09/16; 133134; E1585
Mrs. Silvia Ruiz De Gracia
Contributions
Contributions
Abstract
Abstract: E1585
Type: Eposter Presentation
Background
The definition of massive transfusion (MT) is the need of at least 10 packed red blood cells units (PRBCs) in 24 hours in response to a situation of uncontrolled bleeding. However there is still no consensus for the clinical management of these situations.
Aims
The aim of this study was to analyze the events of MT in our center and variables associated to mortality within 24 hours and 30 days after MT.
Methods
The records of the Transfusion Service of the Son Espases University Hospital were retrospectively reviewed for cases of patients who required at least 10 PRBCs units within 24 hours during the period of 2010-2015. Their demographic and clinical-biological data were collected.
Results
A total of 93 episodes of MT were identified between 2010 and 2015. The median age of patients was 56 years (15-88) with 69 (74%) males and 24 (26%) females.Descriptive consumption data were: total units transfused in our MT cases were 1444 PRBCs, 537 plasma units and 233 pooled platelets. Median transfusion counts were 13 (10-36) PRBCs, 6 (0-14) plasma units and 2 (0-9) pooled platelets. Median ratio PRBCs/plasma and ratio PRBCs/platelets were 2.7 (1.1-14) and 6 (1.3-23), respectively.We analyze the influence of various variables related to survival at 24 hours and 30 days of the MT. Mortality at 24 hours and 30 days of MT were respectively 28% and 38%, with no differences according to sex (p=NS) or age (p=NS). However these mortalities were significantly higher in politrauma patiens (46% and 43%) compared to aortic pathology (30% and 37%) and other causes (23% and 20%) (p=0.046 and p=0.007), for mortality at 24 hours and 30 days respectively.Variables significantly influencing mortality at 24 hours and 30 days were the number of PRBCs (p=0.008 and p=0.015) and the ratio of PRBCs/plasma transfused (p=0.003 and p=0.049), respectively. Median number of transfused PRBCs was respectively 13 (10-30) and 16 (10-36) for patients surviving and non-surviving after 24 hours and 30 days. Median PRBCs/plasma ratio was respectively 2.5 (1.1-14) and 3.9 (1.5-9) for patients surviving and non-surviving after 24 hours and respectively 2.55 (1.2-14) and 3.3 (1.1-13) for patients surviving and non-surviving after 30 days.
Conclusion
The MT is accompanied by high mortality rates and involves a high consumption of blood components. In our series, we found an increased mortality in the first 24 hours and in the first 30 days, in patients receiving higher number of PRBCs and with higher PRBCs/plasma ratios. It would be necessary to establish protocols for massive transfusion in each center to unify treatment criteria and optimize the ratio PRBCs/plasma.
Session topic: E-poster
Keyword(s): Survival, Transfusion
Type: Eposter Presentation
Background
The definition of massive transfusion (MT) is the need of at least 10 packed red blood cells units (PRBCs) in 24 hours in response to a situation of uncontrolled bleeding. However there is still no consensus for the clinical management of these situations.
Aims
The aim of this study was to analyze the events of MT in our center and variables associated to mortality within 24 hours and 30 days after MT.
Methods
The records of the Transfusion Service of the Son Espases University Hospital were retrospectively reviewed for cases of patients who required at least 10 PRBCs units within 24 hours during the period of 2010-2015. Their demographic and clinical-biological data were collected.
Results
A total of 93 episodes of MT were identified between 2010 and 2015. The median age of patients was 56 years (15-88) with 69 (74%) males and 24 (26%) females.Descriptive consumption data were: total units transfused in our MT cases were 1444 PRBCs, 537 plasma units and 233 pooled platelets. Median transfusion counts were 13 (10-36) PRBCs, 6 (0-14) plasma units and 2 (0-9) pooled platelets. Median ratio PRBCs/plasma and ratio PRBCs/platelets were 2.7 (1.1-14) and 6 (1.3-23), respectively.We analyze the influence of various variables related to survival at 24 hours and 30 days of the MT. Mortality at 24 hours and 30 days of MT were respectively 28% and 38%, with no differences according to sex (p=NS) or age (p=NS). However these mortalities were significantly higher in politrauma patiens (46% and 43%) compared to aortic pathology (30% and 37%) and other causes (23% and 20%) (p=0.046 and p=0.007), for mortality at 24 hours and 30 days respectively.Variables significantly influencing mortality at 24 hours and 30 days were the number of PRBCs (p=0.008 and p=0.015) and the ratio of PRBCs/plasma transfused (p=0.003 and p=0.049), respectively. Median number of transfused PRBCs was respectively 13 (10-30) and 16 (10-36) for patients surviving and non-surviving after 24 hours and 30 days. Median PRBCs/plasma ratio was respectively 2.5 (1.1-14) and 3.9 (1.5-9) for patients surviving and non-surviving after 24 hours and respectively 2.55 (1.2-14) and 3.3 (1.1-13) for patients surviving and non-surviving after 30 days.
Conclusion
The MT is accompanied by high mortality rates and involves a high consumption of blood components. In our series, we found an increased mortality in the first 24 hours and in the first 30 days, in patients receiving higher number of PRBCs and with higher PRBCs/plasma ratios. It would be necessary to establish protocols for massive transfusion in each center to unify treatment criteria and optimize the ratio PRBCs/plasma.
Session topic: E-poster
Keyword(s): Survival, Transfusion
Abstract: E1585
Type: Eposter Presentation
Background
The definition of massive transfusion (MT) is the need of at least 10 packed red blood cells units (PRBCs) in 24 hours in response to a situation of uncontrolled bleeding. However there is still no consensus for the clinical management of these situations.
Aims
The aim of this study was to analyze the events of MT in our center and variables associated to mortality within 24 hours and 30 days after MT.
Methods
The records of the Transfusion Service of the Son Espases University Hospital were retrospectively reviewed for cases of patients who required at least 10 PRBCs units within 24 hours during the period of 2010-2015. Their demographic and clinical-biological data were collected.
Results
A total of 93 episodes of MT were identified between 2010 and 2015. The median age of patients was 56 years (15-88) with 69 (74%) males and 24 (26%) females.Descriptive consumption data were: total units transfused in our MT cases were 1444 PRBCs, 537 plasma units and 233 pooled platelets. Median transfusion counts were 13 (10-36) PRBCs, 6 (0-14) plasma units and 2 (0-9) pooled platelets. Median ratio PRBCs/plasma and ratio PRBCs/platelets were 2.7 (1.1-14) and 6 (1.3-23), respectively.We analyze the influence of various variables related to survival at 24 hours and 30 days of the MT. Mortality at 24 hours and 30 days of MT were respectively 28% and 38%, with no differences according to sex (p=NS) or age (p=NS). However these mortalities were significantly higher in politrauma patiens (46% and 43%) compared to aortic pathology (30% and 37%) and other causes (23% and 20%) (p=0.046 and p=0.007), for mortality at 24 hours and 30 days respectively.Variables significantly influencing mortality at 24 hours and 30 days were the number of PRBCs (p=0.008 and p=0.015) and the ratio of PRBCs/plasma transfused (p=0.003 and p=0.049), respectively. Median number of transfused PRBCs was respectively 13 (10-30) and 16 (10-36) for patients surviving and non-surviving after 24 hours and 30 days. Median PRBCs/plasma ratio was respectively 2.5 (1.1-14) and 3.9 (1.5-9) for patients surviving and non-surviving after 24 hours and respectively 2.55 (1.2-14) and 3.3 (1.1-13) for patients surviving and non-surviving after 30 days.
Conclusion
The MT is accompanied by high mortality rates and involves a high consumption of blood components. In our series, we found an increased mortality in the first 24 hours and in the first 30 days, in patients receiving higher number of PRBCs and with higher PRBCs/plasma ratios. It would be necessary to establish protocols for massive transfusion in each center to unify treatment criteria and optimize the ratio PRBCs/plasma.
Session topic: E-poster
Keyword(s): Survival, Transfusion
Type: Eposter Presentation
Background
The definition of massive transfusion (MT) is the need of at least 10 packed red blood cells units (PRBCs) in 24 hours in response to a situation of uncontrolled bleeding. However there is still no consensus for the clinical management of these situations.
Aims
The aim of this study was to analyze the events of MT in our center and variables associated to mortality within 24 hours and 30 days after MT.
Methods
The records of the Transfusion Service of the Son Espases University Hospital were retrospectively reviewed for cases of patients who required at least 10 PRBCs units within 24 hours during the period of 2010-2015. Their demographic and clinical-biological data were collected.
Results
A total of 93 episodes of MT were identified between 2010 and 2015. The median age of patients was 56 years (15-88) with 69 (74%) males and 24 (26%) females.Descriptive consumption data were: total units transfused in our MT cases were 1444 PRBCs, 537 plasma units and 233 pooled platelets. Median transfusion counts were 13 (10-36) PRBCs, 6 (0-14) plasma units and 2 (0-9) pooled platelets. Median ratio PRBCs/plasma and ratio PRBCs/platelets were 2.7 (1.1-14) and 6 (1.3-23), respectively.We analyze the influence of various variables related to survival at 24 hours and 30 days of the MT. Mortality at 24 hours and 30 days of MT were respectively 28% and 38%, with no differences according to sex (p=NS) or age (p=NS). However these mortalities were significantly higher in politrauma patiens (46% and 43%) compared to aortic pathology (30% and 37%) and other causes (23% and 20%) (p=0.046 and p=0.007), for mortality at 24 hours and 30 days respectively.Variables significantly influencing mortality at 24 hours and 30 days were the number of PRBCs (p=0.008 and p=0.015) and the ratio of PRBCs/plasma transfused (p=0.003 and p=0.049), respectively. Median number of transfused PRBCs was respectively 13 (10-30) and 16 (10-36) for patients surviving and non-surviving after 24 hours and 30 days. Median PRBCs/plasma ratio was respectively 2.5 (1.1-14) and 3.9 (1.5-9) for patients surviving and non-surviving after 24 hours and respectively 2.55 (1.2-14) and 3.3 (1.1-13) for patients surviving and non-surviving after 30 days.
Conclusion
The MT is accompanied by high mortality rates and involves a high consumption of blood components. In our series, we found an increased mortality in the first 24 hours and in the first 30 days, in patients receiving higher number of PRBCs and with higher PRBCs/plasma ratios. It would be necessary to establish protocols for massive transfusion in each center to unify treatment criteria and optimize the ratio PRBCs/plasma.
Session topic: E-poster
Keyword(s): Survival, Transfusion
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