CURRENT STATUS OF INCIDENTS CAUSED BY HEMOSIDEROSIS IN PATIENTS WITH HEMATOLOGIC DISEASES: RESULTS FROM SPANISH HAEMOVIGILANCE SYSTEM.
(Abstract release date: 05/19/16)
EHA Library. Garcia Ruiz M. 06/09/16; 133126; E1577
Dr. Maria Almudana Garcia Ruiz
Contributions
Contributions
Abstract
Abstract: E1577
Type: Eposter Presentation
Background
The Blood Safety System (Haemovigilance - HV) enables to collect and analyze incidents related to donation, preparation of blood components and transfusion. The purpose is to know the complications and adverse reactions occurred during the transfusion process, to establish effective control measures that can prevent these events. HV should cover the entire transfusion chain. Among transfusion-related complications, the Hemosiderosis is an incident characterized by a very low level of reporting. We have analyzed Hemosiderosis at national state and inside our CCAA (Andalusia). Post-transfusion hemosiderosis is a frequent complication of hematologic diseases, as well as part of their treatment. It is defined as the accumulation of iron in organs and tissues in patients who are receiving regular transfusions of packed red blood cells. Malignant hematological diseases will require regularly transfusions, iron overload, therefore, will be a common side effect in these patients. It is directly related to the number of transfusions received. After transfusing 10 bags, iron is deposited in tissues, after 20, the risk of developing a secondary hemochromatosis increases.
Aims
We intend to investigate the percentage of hemosiderosis reports to the Spanish Haemovigilance system. In the European Union, there are various HV systems, to note: French Haemovigilance system: Is governmental, with a complex structure, notification of all adverse effects and mandatory reporting. English Haemovigilance system (SHOT): notification of serious adverse effects and voluntary reporting. Spanish system (HV): a simpler structure model, voluntary reporting of adverse events and reactions. Notifications are virtually nonexistent except in the French system. Although reporting of post-transfusion hemosiderosis is mandatory in the French haemovigilance network since 1994, existing data is limited.
Methods
We reviewed the transfusion incidents caused by iron overload which have been reported to the Spanish HV system and the Andalusia HV system of, comparing them with the ones notified by our hospital from 2013 to 2015 and their underlying hematologic diseases.Cases in Spanish HV system: 2007: 3. 2008: 15. 2009: 10. 2010: 10. 2011: 16. 2012: 10. 2013: 88. Andalusia: 2007-2012: 0. 2013: 71. (Figure 1).
Results
In 2013 we identified 57 cases, 32 men and 25 women, from 20 to 87 years old, average of 56, who have been transfused with packed red blood cells. The results vary from 10 CH to 73 CH transfused (average of 25 CH per patient). Postransfusional ferritin levels were over 1000 mg/l (average of 2869 mg/l).In 2014 we have notified 76 cases, 50 men and 26 women, from 24 to 83 years old) (average of 56). The number of CH transfused varied from 10 to 130 (average of 31 CH). The number of post-transfusion ferritin ranged between 1,041 and 15,190 mg/l.In 2015, 42 cases have been reported: 18 women and 24 men, between the ages of 17 and 81, with an average of 51 years old. The number of CH transfused ranged from 10 to 107 (average of 33.3 CH). Post-transfusion ferritin ranged between 1.274 and 8.858.4 mg/l.Firstly, the largest number of hyperferritinemia cases was found in patients with acute myeloid leukemia. Secondly, in patients with monoclonal gammopathies found. And thirdly, in patients with non-Hodgkin lymphoma. Other diagnoses were myelodysplastic syndrome, chronic lymphocytic leukemia etc. (Figure 2).
Conclusion
The most frequent cause of hemosiderosis secondary to transfusion in our hospital has been acute leukemia, with a predominance of acute myeloid leukemia over acute lymphoblastic leukemia. It is very important to properly track ferritin levels in patients undergoing multiple transfusions in order to establish chelation therapy when necessary and to prevent the organic damage of secondary hemochromatosis. In the results published by the Andalusian HV system in 2013, we can highlight the increase of notifications of post-transfusion hemosiderosis to the Hemovigilance system, as well as the increasing number of near-miss reported in 2013. This is valued as an improvement in the notification of such events. Communication of Hemosiderosis cases to the Hemovigilance System helps to create protocols for polytransfused patients because of hematologic diseases.Hemovigilance in Spain is, today, a fully integrated tool within the activities carried out by Transfusion Hospital Centers and Services. Among the remaining challenges we highlight: Getting a more uniform level of notification and to Advance in the optimal use of blood and blood components: safe, effective and efficient.
Session topic: E-poster
Keyword(s): Iron chelation, Iron overload, Transfusion
Type: Eposter Presentation
Background
The Blood Safety System (Haemovigilance - HV) enables to collect and analyze incidents related to donation, preparation of blood components and transfusion. The purpose is to know the complications and adverse reactions occurred during the transfusion process, to establish effective control measures that can prevent these events. HV should cover the entire transfusion chain. Among transfusion-related complications, the Hemosiderosis is an incident characterized by a very low level of reporting. We have analyzed Hemosiderosis at national state and inside our CCAA (Andalusia). Post-transfusion hemosiderosis is a frequent complication of hematologic diseases, as well as part of their treatment. It is defined as the accumulation of iron in organs and tissues in patients who are receiving regular transfusions of packed red blood cells. Malignant hematological diseases will require regularly transfusions, iron overload, therefore, will be a common side effect in these patients. It is directly related to the number of transfusions received. After transfusing 10 bags, iron is deposited in tissues, after 20, the risk of developing a secondary hemochromatosis increases.
Aims
We intend to investigate the percentage of hemosiderosis reports to the Spanish Haemovigilance system. In the European Union, there are various HV systems, to note: French Haemovigilance system: Is governmental, with a complex structure, notification of all adverse effects and mandatory reporting. English Haemovigilance system (SHOT): notification of serious adverse effects and voluntary reporting. Spanish system (HV): a simpler structure model, voluntary reporting of adverse events and reactions. Notifications are virtually nonexistent except in the French system. Although reporting of post-transfusion hemosiderosis is mandatory in the French haemovigilance network since 1994, existing data is limited.
Methods
We reviewed the transfusion incidents caused by iron overload which have been reported to the Spanish HV system and the Andalusia HV system of, comparing them with the ones notified by our hospital from 2013 to 2015 and their underlying hematologic diseases.Cases in Spanish HV system: 2007: 3. 2008: 15. 2009: 10. 2010: 10. 2011: 16. 2012: 10. 2013: 88. Andalusia: 2007-2012: 0. 2013: 71. (Figure 1).
Results
In 2013 we identified 57 cases, 32 men and 25 women, from 20 to 87 years old, average of 56, who have been transfused with packed red blood cells. The results vary from 10 CH to 73 CH transfused (average of 25 CH per patient). Postransfusional ferritin levels were over 1000 mg/l (average of 2869 mg/l).In 2014 we have notified 76 cases, 50 men and 26 women, from 24 to 83 years old) (average of 56). The number of CH transfused varied from 10 to 130 (average of 31 CH). The number of post-transfusion ferritin ranged between 1,041 and 15,190 mg/l.In 2015, 42 cases have been reported: 18 women and 24 men, between the ages of 17 and 81, with an average of 51 years old. The number of CH transfused ranged from 10 to 107 (average of 33.3 CH). Post-transfusion ferritin ranged between 1.274 and 8.858.4 mg/l.Firstly, the largest number of hyperferritinemia cases was found in patients with acute myeloid leukemia. Secondly, in patients with monoclonal gammopathies found. And thirdly, in patients with non-Hodgkin lymphoma. Other diagnoses were myelodysplastic syndrome, chronic lymphocytic leukemia etc. (Figure 2).
Conclusion
The most frequent cause of hemosiderosis secondary to transfusion in our hospital has been acute leukemia, with a predominance of acute myeloid leukemia over acute lymphoblastic leukemia. It is very important to properly track ferritin levels in patients undergoing multiple transfusions in order to establish chelation therapy when necessary and to prevent the organic damage of secondary hemochromatosis. In the results published by the Andalusian HV system in 2013, we can highlight the increase of notifications of post-transfusion hemosiderosis to the Hemovigilance system, as well as the increasing number of near-miss reported in 2013. This is valued as an improvement in the notification of such events. Communication of Hemosiderosis cases to the Hemovigilance System helps to create protocols for polytransfused patients because of hematologic diseases.Hemovigilance in Spain is, today, a fully integrated tool within the activities carried out by Transfusion Hospital Centers and Services. Among the remaining challenges we highlight: Getting a more uniform level of notification and to Advance in the optimal use of blood and blood components: safe, effective and efficient.
Session topic: E-poster
Keyword(s): Iron chelation, Iron overload, Transfusion
Abstract: E1577
Type: Eposter Presentation
Background
The Blood Safety System (Haemovigilance - HV) enables to collect and analyze incidents related to donation, preparation of blood components and transfusion. The purpose is to know the complications and adverse reactions occurred during the transfusion process, to establish effective control measures that can prevent these events. HV should cover the entire transfusion chain. Among transfusion-related complications, the Hemosiderosis is an incident characterized by a very low level of reporting. We have analyzed Hemosiderosis at national state and inside our CCAA (Andalusia). Post-transfusion hemosiderosis is a frequent complication of hematologic diseases, as well as part of their treatment. It is defined as the accumulation of iron in organs and tissues in patients who are receiving regular transfusions of packed red blood cells. Malignant hematological diseases will require regularly transfusions, iron overload, therefore, will be a common side effect in these patients. It is directly related to the number of transfusions received. After transfusing 10 bags, iron is deposited in tissues, after 20, the risk of developing a secondary hemochromatosis increases.
Aims
We intend to investigate the percentage of hemosiderosis reports to the Spanish Haemovigilance system. In the European Union, there are various HV systems, to note: French Haemovigilance system: Is governmental, with a complex structure, notification of all adverse effects and mandatory reporting. English Haemovigilance system (SHOT): notification of serious adverse effects and voluntary reporting. Spanish system (HV): a simpler structure model, voluntary reporting of adverse events and reactions. Notifications are virtually nonexistent except in the French system. Although reporting of post-transfusion hemosiderosis is mandatory in the French haemovigilance network since 1994, existing data is limited.
Methods
We reviewed the transfusion incidents caused by iron overload which have been reported to the Spanish HV system and the Andalusia HV system of, comparing them with the ones notified by our hospital from 2013 to 2015 and their underlying hematologic diseases.Cases in Spanish HV system: 2007: 3. 2008: 15. 2009: 10. 2010: 10. 2011: 16. 2012: 10. 2013: 88. Andalusia: 2007-2012: 0. 2013: 71. (Figure 1).
Results
In 2013 we identified 57 cases, 32 men and 25 women, from 20 to 87 years old, average of 56, who have been transfused with packed red blood cells. The results vary from 10 CH to 73 CH transfused (average of 25 CH per patient). Postransfusional ferritin levels were over 1000 mg/l (average of 2869 mg/l).In 2014 we have notified 76 cases, 50 men and 26 women, from 24 to 83 years old) (average of 56). The number of CH transfused varied from 10 to 130 (average of 31 CH). The number of post-transfusion ferritin ranged between 1,041 and 15,190 mg/l.In 2015, 42 cases have been reported: 18 women and 24 men, between the ages of 17 and 81, with an average of 51 years old. The number of CH transfused ranged from 10 to 107 (average of 33.3 CH). Post-transfusion ferritin ranged between 1.274 and 8.858.4 mg/l.Firstly, the largest number of hyperferritinemia cases was found in patients with acute myeloid leukemia. Secondly, in patients with monoclonal gammopathies found. And thirdly, in patients with non-Hodgkin lymphoma. Other diagnoses were myelodysplastic syndrome, chronic lymphocytic leukemia etc. (Figure 2).
Conclusion
The most frequent cause of hemosiderosis secondary to transfusion in our hospital has been acute leukemia, with a predominance of acute myeloid leukemia over acute lymphoblastic leukemia. It is very important to properly track ferritin levels in patients undergoing multiple transfusions in order to establish chelation therapy when necessary and to prevent the organic damage of secondary hemochromatosis. In the results published by the Andalusian HV system in 2013, we can highlight the increase of notifications of post-transfusion hemosiderosis to the Hemovigilance system, as well as the increasing number of near-miss reported in 2013. This is valued as an improvement in the notification of such events. Communication of Hemosiderosis cases to the Hemovigilance System helps to create protocols for polytransfused patients because of hematologic diseases.Hemovigilance in Spain is, today, a fully integrated tool within the activities carried out by Transfusion Hospital Centers and Services. Among the remaining challenges we highlight: Getting a more uniform level of notification and to Advance in the optimal use of blood and blood components: safe, effective and efficient.
Session topic: E-poster
Keyword(s): Iron chelation, Iron overload, Transfusion
Type: Eposter Presentation
Background
The Blood Safety System (Haemovigilance - HV) enables to collect and analyze incidents related to donation, preparation of blood components and transfusion. The purpose is to know the complications and adverse reactions occurred during the transfusion process, to establish effective control measures that can prevent these events. HV should cover the entire transfusion chain. Among transfusion-related complications, the Hemosiderosis is an incident characterized by a very low level of reporting. We have analyzed Hemosiderosis at national state and inside our CCAA (Andalusia). Post-transfusion hemosiderosis is a frequent complication of hematologic diseases, as well as part of their treatment. It is defined as the accumulation of iron in organs and tissues in patients who are receiving regular transfusions of packed red blood cells. Malignant hematological diseases will require regularly transfusions, iron overload, therefore, will be a common side effect in these patients. It is directly related to the number of transfusions received. After transfusing 10 bags, iron is deposited in tissues, after 20, the risk of developing a secondary hemochromatosis increases.
Aims
We intend to investigate the percentage of hemosiderosis reports to the Spanish Haemovigilance system. In the European Union, there are various HV systems, to note: French Haemovigilance system: Is governmental, with a complex structure, notification of all adverse effects and mandatory reporting. English Haemovigilance system (SHOT): notification of serious adverse effects and voluntary reporting. Spanish system (HV): a simpler structure model, voluntary reporting of adverse events and reactions. Notifications are virtually nonexistent except in the French system. Although reporting of post-transfusion hemosiderosis is mandatory in the French haemovigilance network since 1994, existing data is limited.
Methods
We reviewed the transfusion incidents caused by iron overload which have been reported to the Spanish HV system and the Andalusia HV system of, comparing them with the ones notified by our hospital from 2013 to 2015 and their underlying hematologic diseases.Cases in Spanish HV system: 2007: 3. 2008: 15. 2009: 10. 2010: 10. 2011: 16. 2012: 10. 2013: 88. Andalusia: 2007-2012: 0. 2013: 71. (Figure 1).
Results
In 2013 we identified 57 cases, 32 men and 25 women, from 20 to 87 years old, average of 56, who have been transfused with packed red blood cells. The results vary from 10 CH to 73 CH transfused (average of 25 CH per patient). Postransfusional ferritin levels were over 1000 mg/l (average of 2869 mg/l).In 2014 we have notified 76 cases, 50 men and 26 women, from 24 to 83 years old) (average of 56). The number of CH transfused varied from 10 to 130 (average of 31 CH). The number of post-transfusion ferritin ranged between 1,041 and 15,190 mg/l.In 2015, 42 cases have been reported: 18 women and 24 men, between the ages of 17 and 81, with an average of 51 years old. The number of CH transfused ranged from 10 to 107 (average of 33.3 CH). Post-transfusion ferritin ranged between 1.274 and 8.858.4 mg/l.Firstly, the largest number of hyperferritinemia cases was found in patients with acute myeloid leukemia. Secondly, in patients with monoclonal gammopathies found. And thirdly, in patients with non-Hodgkin lymphoma. Other diagnoses were myelodysplastic syndrome, chronic lymphocytic leukemia etc. (Figure 2).
Conclusion
The most frequent cause of hemosiderosis secondary to transfusion in our hospital has been acute leukemia, with a predominance of acute myeloid leukemia over acute lymphoblastic leukemia. It is very important to properly track ferritin levels in patients undergoing multiple transfusions in order to establish chelation therapy when necessary and to prevent the organic damage of secondary hemochromatosis. In the results published by the Andalusian HV system in 2013, we can highlight the increase of notifications of post-transfusion hemosiderosis to the Hemovigilance system, as well as the increasing number of near-miss reported in 2013. This is valued as an improvement in the notification of such events. Communication of Hemosiderosis cases to the Hemovigilance System helps to create protocols for polytransfused patients because of hematologic diseases.Hemovigilance in Spain is, today, a fully integrated tool within the activities carried out by Transfusion Hospital Centers and Services. Among the remaining challenges we highlight: Getting a more uniform level of notification and to Advance in the optimal use of blood and blood components: safe, effective and efficient.
Session topic: E-poster
Keyword(s): Iron chelation, Iron overload, Transfusion
{{ help_message }}
{{filter}}