REVIEW OF PATIENTS WITH CEREBRAL SINUS THROMBOSIS OVER A 7 YEAR PERIOD: SINGLE CENTRE EXPERIENCE FROM A UNIVERSITY HOSPITAL IN THE UNITED KINGDOM
(Abstract release date: 05/19/16)
EHA Library. Kaddam I. 06/09/16; 133114; E1565
Dr. Israa Kaddam
Contributions
Contributions
Abstract
Abstract: E1565
Type: Eposter Presentation
Background
Cerebral sinus venous thrombosis (CVST) is a rare form of venous thromboembolism, usually affecting younger individuals. It has a wide range of clinical presentation and sometimes difficult to diagnose.
Aims
We present a retrospective review of 83 patients who were diagnosed and treated for CVST over a 7 year period at a University hospital in the United Kingdom
Methods
Electronic clinical records of all patients who were diagnosed and treated for CVST between 1st January 2008 and 31st December 2014 were reviewed.
Results
Eighty three patients (45 females, 38 males) with median age 35 years (range between 2 months - 80 years) were diagnosed and treated for CVST during this period. Headache was the most common presentation reported by 70% patients, followed by seizures (19%), motor deficit & aphasia (18%), altered sensorium (13%), confusion (7%), photophobia(6%), and cranial nerve palsy( 5%). Twenty five (30%) of patients had intracranial bleed at the time of presentation. Diagnosis of CVST was confirmed by contrast head CT (14%), CT venogram (54%), contrast brain MR (16%) and MR venogram (20%). Twenty patients (24%) developed CVST during pregnancy, puerpurium or due to oral contraceptive use. Cancer (glioblastoma 1, meningioma 4, acute leukaemia 3, other cancers 8), neurosurgery (n=11), head injury (n=6) and ENT infections (n=9) were provoking factors in (50%) of the patients. No provocation could be identified in 16 patients (19%). The commonest affected site involved was the transverse sinus (62%) followed by sigmoid sinus (51%) and superior saggital sinus (44%). In over half of the patients (n=47) more than one sinus was involved with thrombosis.Patients were treated with anticoagulation (83%), hemi-craniotomy (4%), endovascular surgery (3%). No anticoagulation was given in 14 (16%) patients. After a follow-up of 24-84months, 54% of patients had a complete recovery. Residual neurologic impairment was seen in 25 patients (intracranial HT, persistent headaches, secondary epilepsy). Thirteen patients died (median age =57, range14-71 years). Cause of death was unrelated to CVST in 10 patients (progressive cancer 9; cerebral abscess 1).Adequate follow up clinical information was not available for 5 patients
Conclusion
CVST is a rare site thrombosis usually affects younger individuals and has a varied clinical presentation. Clinician should have a low index of suspicion to ensure prompt diagnosis and effective treatment. With modern management majority of patients can expect a complete recovery with no residual sequelae.
Session topic: E-poster
Keyword(s): Thrombosis
Type: Eposter Presentation
Background
Cerebral sinus venous thrombosis (CVST) is a rare form of venous thromboembolism, usually affecting younger individuals. It has a wide range of clinical presentation and sometimes difficult to diagnose.
Aims
We present a retrospective review of 83 patients who were diagnosed and treated for CVST over a 7 year period at a University hospital in the United Kingdom
Methods
Electronic clinical records of all patients who were diagnosed and treated for CVST between 1st January 2008 and 31st December 2014 were reviewed.
Results
Eighty three patients (45 females, 38 males) with median age 35 years (range between 2 months - 80 years) were diagnosed and treated for CVST during this period. Headache was the most common presentation reported by 70% patients, followed by seizures (19%), motor deficit & aphasia (18%), altered sensorium (13%), confusion (7%), photophobia(6%), and cranial nerve palsy( 5%). Twenty five (30%) of patients had intracranial bleed at the time of presentation. Diagnosis of CVST was confirmed by contrast head CT (14%), CT venogram (54%), contrast brain MR (16%) and MR venogram (20%). Twenty patients (24%) developed CVST during pregnancy, puerpurium or due to oral contraceptive use. Cancer (glioblastoma 1, meningioma 4, acute leukaemia 3, other cancers 8), neurosurgery (n=11), head injury (n=6) and ENT infections (n=9) were provoking factors in (50%) of the patients. No provocation could be identified in 16 patients (19%). The commonest affected site involved was the transverse sinus (62%) followed by sigmoid sinus (51%) and superior saggital sinus (44%). In over half of the patients (n=47) more than one sinus was involved with thrombosis.Patients were treated with anticoagulation (83%), hemi-craniotomy (4%), endovascular surgery (3%). No anticoagulation was given in 14 (16%) patients. After a follow-up of 24-84months, 54% of patients had a complete recovery. Residual neurologic impairment was seen in 25 patients (intracranial HT, persistent headaches, secondary epilepsy). Thirteen patients died (median age =57, range14-71 years). Cause of death was unrelated to CVST in 10 patients (progressive cancer 9; cerebral abscess 1).Adequate follow up clinical information was not available for 5 patients
Conclusion
CVST is a rare site thrombosis usually affects younger individuals and has a varied clinical presentation. Clinician should have a low index of suspicion to ensure prompt diagnosis and effective treatment. With modern management majority of patients can expect a complete recovery with no residual sequelae.
Session topic: E-poster
Keyword(s): Thrombosis
Abstract: E1565
Type: Eposter Presentation
Background
Cerebral sinus venous thrombosis (CVST) is a rare form of venous thromboembolism, usually affecting younger individuals. It has a wide range of clinical presentation and sometimes difficult to diagnose.
Aims
We present a retrospective review of 83 patients who were diagnosed and treated for CVST over a 7 year period at a University hospital in the United Kingdom
Methods
Electronic clinical records of all patients who were diagnosed and treated for CVST between 1st January 2008 and 31st December 2014 were reviewed.
Results
Eighty three patients (45 females, 38 males) with median age 35 years (range between 2 months - 80 years) were diagnosed and treated for CVST during this period. Headache was the most common presentation reported by 70% patients, followed by seizures (19%), motor deficit & aphasia (18%), altered sensorium (13%), confusion (7%), photophobia(6%), and cranial nerve palsy( 5%). Twenty five (30%) of patients had intracranial bleed at the time of presentation. Diagnosis of CVST was confirmed by contrast head CT (14%), CT venogram (54%), contrast brain MR (16%) and MR venogram (20%). Twenty patients (24%) developed CVST during pregnancy, puerpurium or due to oral contraceptive use. Cancer (glioblastoma 1, meningioma 4, acute leukaemia 3, other cancers 8), neurosurgery (n=11), head injury (n=6) and ENT infections (n=9) were provoking factors in (50%) of the patients. No provocation could be identified in 16 patients (19%). The commonest affected site involved was the transverse sinus (62%) followed by sigmoid sinus (51%) and superior saggital sinus (44%). In over half of the patients (n=47) more than one sinus was involved with thrombosis.Patients were treated with anticoagulation (83%), hemi-craniotomy (4%), endovascular surgery (3%). No anticoagulation was given in 14 (16%) patients. After a follow-up of 24-84months, 54% of patients had a complete recovery. Residual neurologic impairment was seen in 25 patients (intracranial HT, persistent headaches, secondary epilepsy). Thirteen patients died (median age =57, range14-71 years). Cause of death was unrelated to CVST in 10 patients (progressive cancer 9; cerebral abscess 1).Adequate follow up clinical information was not available for 5 patients
Conclusion
CVST is a rare site thrombosis usually affects younger individuals and has a varied clinical presentation. Clinician should have a low index of suspicion to ensure prompt diagnosis and effective treatment. With modern management majority of patients can expect a complete recovery with no residual sequelae.
Session topic: E-poster
Keyword(s): Thrombosis
Type: Eposter Presentation
Background
Cerebral sinus venous thrombosis (CVST) is a rare form of venous thromboembolism, usually affecting younger individuals. It has a wide range of clinical presentation and sometimes difficult to diagnose.
Aims
We present a retrospective review of 83 patients who were diagnosed and treated for CVST over a 7 year period at a University hospital in the United Kingdom
Methods
Electronic clinical records of all patients who were diagnosed and treated for CVST between 1st January 2008 and 31st December 2014 were reviewed.
Results
Eighty three patients (45 females, 38 males) with median age 35 years (range between 2 months - 80 years) were diagnosed and treated for CVST during this period. Headache was the most common presentation reported by 70% patients, followed by seizures (19%), motor deficit & aphasia (18%), altered sensorium (13%), confusion (7%), photophobia(6%), and cranial nerve palsy( 5%). Twenty five (30%) of patients had intracranial bleed at the time of presentation. Diagnosis of CVST was confirmed by contrast head CT (14%), CT venogram (54%), contrast brain MR (16%) and MR venogram (20%). Twenty patients (24%) developed CVST during pregnancy, puerpurium or due to oral contraceptive use. Cancer (glioblastoma 1, meningioma 4, acute leukaemia 3, other cancers 8), neurosurgery (n=11), head injury (n=6) and ENT infections (n=9) were provoking factors in (50%) of the patients. No provocation could be identified in 16 patients (19%). The commonest affected site involved was the transverse sinus (62%) followed by sigmoid sinus (51%) and superior saggital sinus (44%). In over half of the patients (n=47) more than one sinus was involved with thrombosis.Patients were treated with anticoagulation (83%), hemi-craniotomy (4%), endovascular surgery (3%). No anticoagulation was given in 14 (16%) patients. After a follow-up of 24-84months, 54% of patients had a complete recovery. Residual neurologic impairment was seen in 25 patients (intracranial HT, persistent headaches, secondary epilepsy). Thirteen patients died (median age =57, range14-71 years). Cause of death was unrelated to CVST in 10 patients (progressive cancer 9; cerebral abscess 1).Adequate follow up clinical information was not available for 5 patients
Conclusion
CVST is a rare site thrombosis usually affects younger individuals and has a varied clinical presentation. Clinician should have a low index of suspicion to ensure prompt diagnosis and effective treatment. With modern management majority of patients can expect a complete recovery with no residual sequelae.
Session topic: E-poster
Keyword(s): Thrombosis
{{ help_message }}
{{filter}}