VENOUS THROMBOSIS IN PUERPERIUM IS ALSO DOMINANTLY LOCALIZED IN LEFT LEG, BUT TENDS TO BE MORE MASSIVE THAN THROMBOSIS DURING GESTATION
(Abstract release date: 05/19/16)
EHA Library. Bodrozic J. 06/09/16; 133109; E1560
Mrs. Jelena Bodrozic
Contributions
Contributions
Abstract
Abstract: E1560
Type: Eposter Presentation
Background
During pregnancy and puerperium different factors play role in pathogenesis of venous thrombosis, and they may influence on localization and extent of thrombosis. Compression of iliac veins by gravid uterus is responsible for dominance of thrombosis in left leg during gestation. On the other hand, after delivery and during puerperium blood hypercoagulability plays a key role in pathogenesis of thrombosis, but little is known about anatomic distribution and extent of venous thrombosis in legs during puerperium.
Aims
To investigate the anatomic distribution and extent of deep vein thrombosis of the lower extremity during pregnancy and puerperium.
Methods
Retrospective analysis of 174 consecutive women with pregnancy related venous thrombosis of lower extremities that were referred to our institution from January 2004 to December 2015 has been performed. The localisation of thrombosis was classified as a thrombosis of left or right leg, proximal, distal or massive (proximal + distal). Thrombosis of superficial veins was excluded. All thrombotic episodes were confirmed with duplex ultrasonography. Descriptive statistics and chi square test were used for statistical analysis.
Results
Out of 174 women with pregnancy related thrombosis, 26 (15,5%) developed thrombosis during the first trimester, 23 (13,3%) during second, 37 (21,2%) during third and 87 (50%) during puerperium. Thrombosis of the left leg developed 127 (73%) women, and of the right leg 40 (23%). Bilateral thrombosis occurred in 7 (4%) of women. Prevalence of left leg thrombosis was 66%, 78%, 83%, 69% during first, second, third trimester and puerperium, respectively. Prevalence of right leg thrombosis was 33%, 13%, 13%, 26%. Left leg thrombosis was more frequent throughout gestation but also during puerperium than thrombosis in right leg (p<0,05). In our group of patients, 68 (39%) developed massive thrombosis, 81 (47%) proximal and 25 (14%) distal thrombosis. Prevalence of massive thrombosis during first, second, third trimester and puerperium was 41%, 30%, 13%, 52% respectively, of isolated proximal veins was 48%, 57%, 84%, 27%, and of distal veins 11%, 13%, 3%, 21%. The difference between different periods of pregnancy and puerperium regarding distribution and extent of thrombosis was statistical significant (p<0,05). Before the delivery most common localization of thrombosis was in proximal veins, while massive thrombosis occurred most frequently in puerperium.
Conclusion
We observed that deep vein thrombosis of the left leg occurred more frequently than thrombosis of the right leg not only during gestation but also during puerperium. This indicates that significant proportion of thromboses in pueperium might have initiated in last period of gestation and become clinically overt only after delivery. More massive thrombosis observed in puerperium points to importance of blood hypercoagulability on extent of thrombosis.
Session topic: E-poster
Keyword(s): Deep venous thrombosis, Pregnancy
Type: Eposter Presentation
Background
During pregnancy and puerperium different factors play role in pathogenesis of venous thrombosis, and they may influence on localization and extent of thrombosis. Compression of iliac veins by gravid uterus is responsible for dominance of thrombosis in left leg during gestation. On the other hand, after delivery and during puerperium blood hypercoagulability plays a key role in pathogenesis of thrombosis, but little is known about anatomic distribution and extent of venous thrombosis in legs during puerperium.
Aims
To investigate the anatomic distribution and extent of deep vein thrombosis of the lower extremity during pregnancy and puerperium.
Methods
Retrospective analysis of 174 consecutive women with pregnancy related venous thrombosis of lower extremities that were referred to our institution from January 2004 to December 2015 has been performed. The localisation of thrombosis was classified as a thrombosis of left or right leg, proximal, distal or massive (proximal + distal). Thrombosis of superficial veins was excluded. All thrombotic episodes were confirmed with duplex ultrasonography. Descriptive statistics and chi square test were used for statistical analysis.
Results
Out of 174 women with pregnancy related thrombosis, 26 (15,5%) developed thrombosis during the first trimester, 23 (13,3%) during second, 37 (21,2%) during third and 87 (50%) during puerperium. Thrombosis of the left leg developed 127 (73%) women, and of the right leg 40 (23%). Bilateral thrombosis occurred in 7 (4%) of women. Prevalence of left leg thrombosis was 66%, 78%, 83%, 69% during first, second, third trimester and puerperium, respectively. Prevalence of right leg thrombosis was 33%, 13%, 13%, 26%. Left leg thrombosis was more frequent throughout gestation but also during puerperium than thrombosis in right leg (p<0,05). In our group of patients, 68 (39%) developed massive thrombosis, 81 (47%) proximal and 25 (14%) distal thrombosis. Prevalence of massive thrombosis during first, second, third trimester and puerperium was 41%, 30%, 13%, 52% respectively, of isolated proximal veins was 48%, 57%, 84%, 27%, and of distal veins 11%, 13%, 3%, 21%. The difference between different periods of pregnancy and puerperium regarding distribution and extent of thrombosis was statistical significant (p<0,05). Before the delivery most common localization of thrombosis was in proximal veins, while massive thrombosis occurred most frequently in puerperium.
Conclusion
We observed that deep vein thrombosis of the left leg occurred more frequently than thrombosis of the right leg not only during gestation but also during puerperium. This indicates that significant proportion of thromboses in pueperium might have initiated in last period of gestation and become clinically overt only after delivery. More massive thrombosis observed in puerperium points to importance of blood hypercoagulability on extent of thrombosis.
Session topic: E-poster
Keyword(s): Deep venous thrombosis, Pregnancy
Abstract: E1560
Type: Eposter Presentation
Background
During pregnancy and puerperium different factors play role in pathogenesis of venous thrombosis, and they may influence on localization and extent of thrombosis. Compression of iliac veins by gravid uterus is responsible for dominance of thrombosis in left leg during gestation. On the other hand, after delivery and during puerperium blood hypercoagulability plays a key role in pathogenesis of thrombosis, but little is known about anatomic distribution and extent of venous thrombosis in legs during puerperium.
Aims
To investigate the anatomic distribution and extent of deep vein thrombosis of the lower extremity during pregnancy and puerperium.
Methods
Retrospective analysis of 174 consecutive women with pregnancy related venous thrombosis of lower extremities that were referred to our institution from January 2004 to December 2015 has been performed. The localisation of thrombosis was classified as a thrombosis of left or right leg, proximal, distal or massive (proximal + distal). Thrombosis of superficial veins was excluded. All thrombotic episodes were confirmed with duplex ultrasonography. Descriptive statistics and chi square test were used for statistical analysis.
Results
Out of 174 women with pregnancy related thrombosis, 26 (15,5%) developed thrombosis during the first trimester, 23 (13,3%) during second, 37 (21,2%) during third and 87 (50%) during puerperium. Thrombosis of the left leg developed 127 (73%) women, and of the right leg 40 (23%). Bilateral thrombosis occurred in 7 (4%) of women. Prevalence of left leg thrombosis was 66%, 78%, 83%, 69% during first, second, third trimester and puerperium, respectively. Prevalence of right leg thrombosis was 33%, 13%, 13%, 26%. Left leg thrombosis was more frequent throughout gestation but also during puerperium than thrombosis in right leg (p<0,05). In our group of patients, 68 (39%) developed massive thrombosis, 81 (47%) proximal and 25 (14%) distal thrombosis. Prevalence of massive thrombosis during first, second, third trimester and puerperium was 41%, 30%, 13%, 52% respectively, of isolated proximal veins was 48%, 57%, 84%, 27%, and of distal veins 11%, 13%, 3%, 21%. The difference between different periods of pregnancy and puerperium regarding distribution and extent of thrombosis was statistical significant (p<0,05). Before the delivery most common localization of thrombosis was in proximal veins, while massive thrombosis occurred most frequently in puerperium.
Conclusion
We observed that deep vein thrombosis of the left leg occurred more frequently than thrombosis of the right leg not only during gestation but also during puerperium. This indicates that significant proportion of thromboses in pueperium might have initiated in last period of gestation and become clinically overt only after delivery. More massive thrombosis observed in puerperium points to importance of blood hypercoagulability on extent of thrombosis.
Session topic: E-poster
Keyword(s): Deep venous thrombosis, Pregnancy
Type: Eposter Presentation
Background
During pregnancy and puerperium different factors play role in pathogenesis of venous thrombosis, and they may influence on localization and extent of thrombosis. Compression of iliac veins by gravid uterus is responsible for dominance of thrombosis in left leg during gestation. On the other hand, after delivery and during puerperium blood hypercoagulability plays a key role in pathogenesis of thrombosis, but little is known about anatomic distribution and extent of venous thrombosis in legs during puerperium.
Aims
To investigate the anatomic distribution and extent of deep vein thrombosis of the lower extremity during pregnancy and puerperium.
Methods
Retrospective analysis of 174 consecutive women with pregnancy related venous thrombosis of lower extremities that were referred to our institution from January 2004 to December 2015 has been performed. The localisation of thrombosis was classified as a thrombosis of left or right leg, proximal, distal or massive (proximal + distal). Thrombosis of superficial veins was excluded. All thrombotic episodes were confirmed with duplex ultrasonography. Descriptive statistics and chi square test were used for statistical analysis.
Results
Out of 174 women with pregnancy related thrombosis, 26 (15,5%) developed thrombosis during the first trimester, 23 (13,3%) during second, 37 (21,2%) during third and 87 (50%) during puerperium. Thrombosis of the left leg developed 127 (73%) women, and of the right leg 40 (23%). Bilateral thrombosis occurred in 7 (4%) of women. Prevalence of left leg thrombosis was 66%, 78%, 83%, 69% during first, second, third trimester and puerperium, respectively. Prevalence of right leg thrombosis was 33%, 13%, 13%, 26%. Left leg thrombosis was more frequent throughout gestation but also during puerperium than thrombosis in right leg (p<0,05). In our group of patients, 68 (39%) developed massive thrombosis, 81 (47%) proximal and 25 (14%) distal thrombosis. Prevalence of massive thrombosis during first, second, third trimester and puerperium was 41%, 30%, 13%, 52% respectively, of isolated proximal veins was 48%, 57%, 84%, 27%, and of distal veins 11%, 13%, 3%, 21%. The difference between different periods of pregnancy and puerperium regarding distribution and extent of thrombosis was statistical significant (p<0,05). Before the delivery most common localization of thrombosis was in proximal veins, while massive thrombosis occurred most frequently in puerperium.
Conclusion
We observed that deep vein thrombosis of the left leg occurred more frequently than thrombosis of the right leg not only during gestation but also during puerperium. This indicates that significant proportion of thromboses in pueperium might have initiated in last period of gestation and become clinically overt only after delivery. More massive thrombosis observed in puerperium points to importance of blood hypercoagulability on extent of thrombosis.
Session topic: E-poster
Keyword(s): Deep venous thrombosis, Pregnancy
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