FRONTLINE AUTOLOGOUS STEM CELL TRANSPLANTATION FOR AGGRESSIVE B AND T CELL LYMPHOMA
(Abstract release date: 05/19/16)
EHA Library. Tan T. 06/09/16; 133098; E1549
Dr. Tran-Der Tan
Contributions
Contributions
Abstract
Abstract: E1549
Type: Eposter Presentation
Background
Either autologous or allogeneic haematopoietic stem cell transplantation is the salvage and even curative treatment for relapsed lymphoma. For high risk aggressive B cell or T cell lymphoma, frontline auto-transplantation can also improve survival.
Aims
We investigated the outcome between frontline versus salvage auto-transplantation for aggressive lymphoma including B cell, T cell, and Hodgkin lymphomas.
Methods
For high risk aggressive B cell lymphoma (stage III and IV or IPI score above 3) and aggressive T cell lymphoma except ALK+ ALCL, we retrospectively compared the outcome of frontline autologous transplantation and non-transplant or salvage transplant patients.
Results
Between 2001 and 2015, we have 95 patients undergoing autologous (N=67) and allogeneic (N=28) haematopoietic stem cell transplantation. The 5-year overall survival was 70.4% and 59.1%, respectively. For high risk aggressive B cell lymphoma undergoing frontline autotransplant, the overall survival was 81.8%. During the same period, 5-year overall survival of stage III and IV diffuse large B cell lymphoma patients treated at our institute were 58% and 45%, respectively. For aggressive T cell lymphoma, 66.7% versus 0% of 5-year overall survival for frontline versus salvage autotransplant.
Conclusion
Frontline autotransplant should be considered in selected high risk aggressive B cell lymphoma patients and is very important for aggressive T cell lymphoma patients.
Session topic: E-poster
Keyword(s): Autologous hematopoietic stem cell transplantation, Lymphoma
Type: Eposter Presentation
Background
Either autologous or allogeneic haematopoietic stem cell transplantation is the salvage and even curative treatment for relapsed lymphoma. For high risk aggressive B cell or T cell lymphoma, frontline auto-transplantation can also improve survival.
Aims
We investigated the outcome between frontline versus salvage auto-transplantation for aggressive lymphoma including B cell, T cell, and Hodgkin lymphomas.
Methods
For high risk aggressive B cell lymphoma (stage III and IV or IPI score above 3) and aggressive T cell lymphoma except ALK+ ALCL, we retrospectively compared the outcome of frontline autologous transplantation and non-transplant or salvage transplant patients.
Results
Between 2001 and 2015, we have 95 patients undergoing autologous (N=67) and allogeneic (N=28) haematopoietic stem cell transplantation. The 5-year overall survival was 70.4% and 59.1%, respectively. For high risk aggressive B cell lymphoma undergoing frontline autotransplant, the overall survival was 81.8%. During the same period, 5-year overall survival of stage III and IV diffuse large B cell lymphoma patients treated at our institute were 58% and 45%, respectively. For aggressive T cell lymphoma, 66.7% versus 0% of 5-year overall survival for frontline versus salvage autotransplant.
Conclusion
Frontline autotransplant should be considered in selected high risk aggressive B cell lymphoma patients and is very important for aggressive T cell lymphoma patients.
Session topic: E-poster
Keyword(s): Autologous hematopoietic stem cell transplantation, Lymphoma
Abstract: E1549
Type: Eposter Presentation
Background
Either autologous or allogeneic haematopoietic stem cell transplantation is the salvage and even curative treatment for relapsed lymphoma. For high risk aggressive B cell or T cell lymphoma, frontline auto-transplantation can also improve survival.
Aims
We investigated the outcome between frontline versus salvage auto-transplantation for aggressive lymphoma including B cell, T cell, and Hodgkin lymphomas.
Methods
For high risk aggressive B cell lymphoma (stage III and IV or IPI score above 3) and aggressive T cell lymphoma except ALK+ ALCL, we retrospectively compared the outcome of frontline autologous transplantation and non-transplant or salvage transplant patients.
Results
Between 2001 and 2015, we have 95 patients undergoing autologous (N=67) and allogeneic (N=28) haematopoietic stem cell transplantation. The 5-year overall survival was 70.4% and 59.1%, respectively. For high risk aggressive B cell lymphoma undergoing frontline autotransplant, the overall survival was 81.8%. During the same period, 5-year overall survival of stage III and IV diffuse large B cell lymphoma patients treated at our institute were 58% and 45%, respectively. For aggressive T cell lymphoma, 66.7% versus 0% of 5-year overall survival for frontline versus salvage autotransplant.
Conclusion
Frontline autotransplant should be considered in selected high risk aggressive B cell lymphoma patients and is very important for aggressive T cell lymphoma patients.
Session topic: E-poster
Keyword(s): Autologous hematopoietic stem cell transplantation, Lymphoma
Type: Eposter Presentation
Background
Either autologous or allogeneic haematopoietic stem cell transplantation is the salvage and even curative treatment for relapsed lymphoma. For high risk aggressive B cell or T cell lymphoma, frontline auto-transplantation can also improve survival.
Aims
We investigated the outcome between frontline versus salvage auto-transplantation for aggressive lymphoma including B cell, T cell, and Hodgkin lymphomas.
Methods
For high risk aggressive B cell lymphoma (stage III and IV or IPI score above 3) and aggressive T cell lymphoma except ALK+ ALCL, we retrospectively compared the outcome of frontline autologous transplantation and non-transplant or salvage transplant patients.
Results
Between 2001 and 2015, we have 95 patients undergoing autologous (N=67) and allogeneic (N=28) haematopoietic stem cell transplantation. The 5-year overall survival was 70.4% and 59.1%, respectively. For high risk aggressive B cell lymphoma undergoing frontline autotransplant, the overall survival was 81.8%. During the same period, 5-year overall survival of stage III and IV diffuse large B cell lymphoma patients treated at our institute were 58% and 45%, respectively. For aggressive T cell lymphoma, 66.7% versus 0% of 5-year overall survival for frontline versus salvage autotransplant.
Conclusion
Frontline autotransplant should be considered in selected high risk aggressive B cell lymphoma patients and is very important for aggressive T cell lymphoma patients.
Session topic: E-poster
Keyword(s): Autologous hematopoietic stem cell transplantation, Lymphoma
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