USE OF COMBINED ORAL ADMINISTRATION OF ANALGESIA AND ANXIOLYSIS FOR PAIN ASSOCIATED WITH BONE MARROW ASPIRATION AND BIOPSY
(Abstract release date: 05/19/16)
EHA Library. Cerchione C. 06/09/16; 133006; E1457
Dr. Claudio Cerchione
Contributions
Contributions
Abstract
Abstract: E1457
Type: Eposter Presentation
Background
Bone marrow aspiration and biopsy (BMB) is central to the diagnosis and management of many haematological disorders and is a safe procedure associated with low morbidity and mortality. For adults, the infiltration of local anesthesia at the biopsy site has been used as the principal form of analgesia for BMBA. Unfortunately pain relief is often incomplete especially during aspiration of the bone marrow. In addition, pain is likely to contribute to the anxiety the patient may already be experiencing.
Aims
In this study we assessed an oral administration of analgesia (fentanil – ACTIQ) and anxiolysis (midazolam). 107 consecutive ambulatory adult patients referred for bone marrow examination were enrolled. Informed consent for the procedure was obtained from all patients.
Methods
All patients received local anaesthesia (LA) with 10 mL of injected 2% lignocaine, but 52 patients received LA alone (group A) and 55 patients LA plus 5 mg midazolam (oral administration) and 200 mcg of Fentanyl trans-mucoso (group B), 30 min before the procedure. The pain level was assessed with the Numeric Rating Scale which distinguishes ten levels of pain, from 0 to 10 in five times of procedure (baseline, start LA T1, aspiration T2a, biopsy T2b, five minutes after the end of the procedure T3). At the end, all were given a questionnaire about efficacy, satisfaction, comfort with three levels (1/low – 2/medium – 3/high).
Results
This medium values were found : at time T1 the medium level of pain was 0.87 for the group A vs 0.88 of group B, at time T2a 3,63 group A vs 3,54 group B, at time T2b 4,63 group A vs 4 group B (p<0,05), time T3 0,41 group A vs 0,16 group B (p<0.05). In addition 21 Patients, who have already undergone the procedure without sedoanalgesia, saw to prefer the new medication.
Conclusion
Our preliminary results seem interesting because underline the different subjective perception of pain in the two groups and especially show a main level of satisfaction and comfortable in our patients undergone medication with sedoanalgesia and a lower level of anxiety in view of a possible repeat of examination.
Session topic: E-poster
Type: Eposter Presentation
Background
Bone marrow aspiration and biopsy (BMB) is central to the diagnosis and management of many haematological disorders and is a safe procedure associated with low morbidity and mortality. For adults, the infiltration of local anesthesia at the biopsy site has been used as the principal form of analgesia for BMBA. Unfortunately pain relief is often incomplete especially during aspiration of the bone marrow. In addition, pain is likely to contribute to the anxiety the patient may already be experiencing.
Aims
In this study we assessed an oral administration of analgesia (fentanil – ACTIQ) and anxiolysis (midazolam). 107 consecutive ambulatory adult patients referred for bone marrow examination were enrolled. Informed consent for the procedure was obtained from all patients.
Methods
All patients received local anaesthesia (LA) with 10 mL of injected 2% lignocaine, but 52 patients received LA alone (group A) and 55 patients LA plus 5 mg midazolam (oral administration) and 200 mcg of Fentanyl trans-mucoso (group B), 30 min before the procedure. The pain level was assessed with the Numeric Rating Scale which distinguishes ten levels of pain, from 0 to 10 in five times of procedure (baseline, start LA T1, aspiration T2a, biopsy T2b, five minutes after the end of the procedure T3). At the end, all were given a questionnaire about efficacy, satisfaction, comfort with three levels (1/low – 2/medium – 3/high).
Results
This medium values were found : at time T1 the medium level of pain was 0.87 for the group A vs 0.88 of group B, at time T2a 3,63 group A vs 3,54 group B, at time T2b 4,63 group A vs 4 group B (p<0,05), time T3 0,41 group A vs 0,16 group B (p<0.05). In addition 21 Patients, who have already undergone the procedure without sedoanalgesia, saw to prefer the new medication.
Conclusion
Our preliminary results seem interesting because underline the different subjective perception of pain in the two groups and especially show a main level of satisfaction and comfortable in our patients undergone medication with sedoanalgesia and a lower level of anxiety in view of a possible repeat of examination.
Session topic: E-poster
Abstract: E1457
Type: Eposter Presentation
Background
Bone marrow aspiration and biopsy (BMB) is central to the diagnosis and management of many haematological disorders and is a safe procedure associated with low morbidity and mortality. For adults, the infiltration of local anesthesia at the biopsy site has been used as the principal form of analgesia for BMBA. Unfortunately pain relief is often incomplete especially during aspiration of the bone marrow. In addition, pain is likely to contribute to the anxiety the patient may already be experiencing.
Aims
In this study we assessed an oral administration of analgesia (fentanil – ACTIQ) and anxiolysis (midazolam). 107 consecutive ambulatory adult patients referred for bone marrow examination were enrolled. Informed consent for the procedure was obtained from all patients.
Methods
All patients received local anaesthesia (LA) with 10 mL of injected 2% lignocaine, but 52 patients received LA alone (group A) and 55 patients LA plus 5 mg midazolam (oral administration) and 200 mcg of Fentanyl trans-mucoso (group B), 30 min before the procedure. The pain level was assessed with the Numeric Rating Scale which distinguishes ten levels of pain, from 0 to 10 in five times of procedure (baseline, start LA T1, aspiration T2a, biopsy T2b, five minutes after the end of the procedure T3). At the end, all were given a questionnaire about efficacy, satisfaction, comfort with three levels (1/low – 2/medium – 3/high).
Results
This medium values were found : at time T1 the medium level of pain was 0.87 for the group A vs 0.88 of group B, at time T2a 3,63 group A vs 3,54 group B, at time T2b 4,63 group A vs 4 group B (p<0,05), time T3 0,41 group A vs 0,16 group B (p<0.05). In addition 21 Patients, who have already undergone the procedure without sedoanalgesia, saw to prefer the new medication.
Conclusion
Our preliminary results seem interesting because underline the different subjective perception of pain in the two groups and especially show a main level of satisfaction and comfortable in our patients undergone medication with sedoanalgesia and a lower level of anxiety in view of a possible repeat of examination.
Session topic: E-poster
Type: Eposter Presentation
Background
Bone marrow aspiration and biopsy (BMB) is central to the diagnosis and management of many haematological disorders and is a safe procedure associated with low morbidity and mortality. For adults, the infiltration of local anesthesia at the biopsy site has been used as the principal form of analgesia for BMBA. Unfortunately pain relief is often incomplete especially during aspiration of the bone marrow. In addition, pain is likely to contribute to the anxiety the patient may already be experiencing.
Aims
In this study we assessed an oral administration of analgesia (fentanil – ACTIQ) and anxiolysis (midazolam). 107 consecutive ambulatory adult patients referred for bone marrow examination were enrolled. Informed consent for the procedure was obtained from all patients.
Methods
All patients received local anaesthesia (LA) with 10 mL of injected 2% lignocaine, but 52 patients received LA alone (group A) and 55 patients LA plus 5 mg midazolam (oral administration) and 200 mcg of Fentanyl trans-mucoso (group B), 30 min before the procedure. The pain level was assessed with the Numeric Rating Scale which distinguishes ten levels of pain, from 0 to 10 in five times of procedure (baseline, start LA T1, aspiration T2a, biopsy T2b, five minutes after the end of the procedure T3). At the end, all were given a questionnaire about efficacy, satisfaction, comfort with three levels (1/low – 2/medium – 3/high).
Results
This medium values were found : at time T1 the medium level of pain was 0.87 for the group A vs 0.88 of group B, at time T2a 3,63 group A vs 3,54 group B, at time T2b 4,63 group A vs 4 group B (p<0,05), time T3 0,41 group A vs 0,16 group B (p<0.05). In addition 21 Patients, who have already undergone the procedure without sedoanalgesia, saw to prefer the new medication.
Conclusion
Our preliminary results seem interesting because underline the different subjective perception of pain in the two groups and especially show a main level of satisfaction and comfortable in our patients undergone medication with sedoanalgesia and a lower level of anxiety in view of a possible repeat of examination.
Session topic: E-poster
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