PSYCHOMETRIC PROPERTIES OF THE GREEK TRANQOL QUESTIONNAIRE FOR MEASURING QUALITY OF LIFE IN GREEK ADULT PATIENTS WITH THALASSEMIA MAJOR
(Abstract release date: 05/19/16)
EHA Library. Klonizakis P. 06/09/16; 133003; E1454
Dr. Philippos Klonizakis
Contributions
Contributions
Abstract
Abstract: E1454
Type: Eposter Presentation
Background
Greece is a country with a large population of thalassemia patients. To date, there only a few studies measuring quality of life in Greek thalassemia major patients, with the available data mainly derived from generic QoL questionnaires. TranQoL is a novel disease-specific QoL instrument that has been specifically developed to assess QoL in thalassemia major patients.
Aims
This study aimed to evaluate the construct validity, reliability and responsiveness of the Greek translated version of the TranQoL questionnaire.
Methods
The novel Greek TranQoL and the valid generic Greek SF-36v2 questionnaires were administered in 94 consecutive thalassemia major patients that were followed up at the Adult Thalassemia Unit of “Hippokration” general hospital of Thessaloniki, Greece, one of the largest thalassemia centres in Greece. Both questionnaires were completed anonymously during two subsequent transfusion visits, 2 – 3 weeks apart. A week after the transfusion visit the participants were asked to complete the TranQol at home, a third time, and describe any change in their quality of life using a 7-point Likert-type scale. Construct validity was assessed using Pearson’s correlation between the TranQoL scores and the SF-36v2 scores at the first visit. In addition, the t-test or analyses of variance were used to compare TranQoL scores between patient groups that have known differences in quality of life. Assessment of reliability involved the determination of internal consistency by calculating the Cronbach's α-coefficient. Accordingly, the intra - class correlation coefficient (ICC) between the TranQol scores of the baseline visit and the subsequent visit was calculated in order to assess test-retest reliability. In order evaluate responsiveness, we used the paired t – test method to compare TranQoL scores between the transfusion visit and the home visit, in the group of patients who reported to be at least 'a little better' after their last blood transfusion.
Results
There was a moderately strong correlation between the TranQoL summary and both the SF-36 Physical and Mental Component Summaries (r = 0.43, p < 0.001 and r = 0.520, p < 0.001 respectively). There was also a moderately strong correlation between the Physical Health scale of TranQoL and the relevant SF 36 scales, including Physical Functioning (r = 0.4, p < 0.001), role - physical (r = 0.6, p < 0.001) and bodily pain (r = 0.5, p < 0.001). In terms of reliability, TranQoL exhibited good internal consistency, with a Cronbach alpha coefficient reported of 0.89. Test-retest reliability was excellent (intra-class correlation coefficient, 0.9). Regarding know groups validity, patients with hypothyroidism had significantly lower TranQoL summary scores compared to patients without hypothyroidism (65%, range: 57 – 83 vs 75%, range: 42 – 98, p < 0.05). There was also a significant difference in the score of the domain “school and career functioning” for oral (81 ± 17 %) vs subcutaneous iron chelation (70 ± 29 %). In terms of responsiveness, in the patients subgroup that rated their QoL as better in the Likert-type scale, there was a 4.2 point (SD 5.0) improvement in TranQol scores, from their transfusion visit (73.9%) to one week later at the home visit (78.1%), (p < 0.005).
Conclusion
In conclusion, the psychometric properties of the Greek version of TranQoL confirmed that it is valid, reliable and responsive to change. The TranQoL can be incorporated into future studies of thalassemia major in Greek patients.
Session topic: E-poster
Keyword(s): Quality of life, Thalassemia
Type: Eposter Presentation
Background
Greece is a country with a large population of thalassemia patients. To date, there only a few studies measuring quality of life in Greek thalassemia major patients, with the available data mainly derived from generic QoL questionnaires. TranQoL is a novel disease-specific QoL instrument that has been specifically developed to assess QoL in thalassemia major patients.
Aims
This study aimed to evaluate the construct validity, reliability and responsiveness of the Greek translated version of the TranQoL questionnaire.
Methods
The novel Greek TranQoL and the valid generic Greek SF-36v2 questionnaires were administered in 94 consecutive thalassemia major patients that were followed up at the Adult Thalassemia Unit of “Hippokration” general hospital of Thessaloniki, Greece, one of the largest thalassemia centres in Greece. Both questionnaires were completed anonymously during two subsequent transfusion visits, 2 – 3 weeks apart. A week after the transfusion visit the participants were asked to complete the TranQol at home, a third time, and describe any change in their quality of life using a 7-point Likert-type scale. Construct validity was assessed using Pearson’s correlation between the TranQoL scores and the SF-36v2 scores at the first visit. In addition, the t-test or analyses of variance were used to compare TranQoL scores between patient groups that have known differences in quality of life. Assessment of reliability involved the determination of internal consistency by calculating the Cronbach's α-coefficient. Accordingly, the intra - class correlation coefficient (ICC) between the TranQol scores of the baseline visit and the subsequent visit was calculated in order to assess test-retest reliability. In order evaluate responsiveness, we used the paired t – test method to compare TranQoL scores between the transfusion visit and the home visit, in the group of patients who reported to be at least 'a little better' after their last blood transfusion.
Results
There was a moderately strong correlation between the TranQoL summary and both the SF-36 Physical and Mental Component Summaries (r = 0.43, p < 0.001 and r = 0.520, p < 0.001 respectively). There was also a moderately strong correlation between the Physical Health scale of TranQoL and the relevant SF 36 scales, including Physical Functioning (r = 0.4, p < 0.001), role - physical (r = 0.6, p < 0.001) and bodily pain (r = 0.5, p < 0.001). In terms of reliability, TranQoL exhibited good internal consistency, with a Cronbach alpha coefficient reported of 0.89. Test-retest reliability was excellent (intra-class correlation coefficient, 0.9). Regarding know groups validity, patients with hypothyroidism had significantly lower TranQoL summary scores compared to patients without hypothyroidism (65%, range: 57 – 83 vs 75%, range: 42 – 98, p < 0.05). There was also a significant difference in the score of the domain “school and career functioning” for oral (81 ± 17 %) vs subcutaneous iron chelation (70 ± 29 %). In terms of responsiveness, in the patients subgroup that rated their QoL as better in the Likert-type scale, there was a 4.2 point (SD 5.0) improvement in TranQol scores, from their transfusion visit (73.9%) to one week later at the home visit (78.1%), (p < 0.005).
Conclusion
In conclusion, the psychometric properties of the Greek version of TranQoL confirmed that it is valid, reliable and responsive to change. The TranQoL can be incorporated into future studies of thalassemia major in Greek patients.
Session topic: E-poster
Keyword(s): Quality of life, Thalassemia
Abstract: E1454
Type: Eposter Presentation
Background
Greece is a country with a large population of thalassemia patients. To date, there only a few studies measuring quality of life in Greek thalassemia major patients, with the available data mainly derived from generic QoL questionnaires. TranQoL is a novel disease-specific QoL instrument that has been specifically developed to assess QoL in thalassemia major patients.
Aims
This study aimed to evaluate the construct validity, reliability and responsiveness of the Greek translated version of the TranQoL questionnaire.
Methods
The novel Greek TranQoL and the valid generic Greek SF-36v2 questionnaires were administered in 94 consecutive thalassemia major patients that were followed up at the Adult Thalassemia Unit of “Hippokration” general hospital of Thessaloniki, Greece, one of the largest thalassemia centres in Greece. Both questionnaires were completed anonymously during two subsequent transfusion visits, 2 – 3 weeks apart. A week after the transfusion visit the participants were asked to complete the TranQol at home, a third time, and describe any change in their quality of life using a 7-point Likert-type scale. Construct validity was assessed using Pearson’s correlation between the TranQoL scores and the SF-36v2 scores at the first visit. In addition, the t-test or analyses of variance were used to compare TranQoL scores between patient groups that have known differences in quality of life. Assessment of reliability involved the determination of internal consistency by calculating the Cronbach's α-coefficient. Accordingly, the intra - class correlation coefficient (ICC) between the TranQol scores of the baseline visit and the subsequent visit was calculated in order to assess test-retest reliability. In order evaluate responsiveness, we used the paired t – test method to compare TranQoL scores between the transfusion visit and the home visit, in the group of patients who reported to be at least 'a little better' after their last blood transfusion.
Results
There was a moderately strong correlation between the TranQoL summary and both the SF-36 Physical and Mental Component Summaries (r = 0.43, p < 0.001 and r = 0.520, p < 0.001 respectively). There was also a moderately strong correlation between the Physical Health scale of TranQoL and the relevant SF 36 scales, including Physical Functioning (r = 0.4, p < 0.001), role - physical (r = 0.6, p < 0.001) and bodily pain (r = 0.5, p < 0.001). In terms of reliability, TranQoL exhibited good internal consistency, with a Cronbach alpha coefficient reported of 0.89. Test-retest reliability was excellent (intra-class correlation coefficient, 0.9). Regarding know groups validity, patients with hypothyroidism had significantly lower TranQoL summary scores compared to patients without hypothyroidism (65%, range: 57 – 83 vs 75%, range: 42 – 98, p < 0.05). There was also a significant difference in the score of the domain “school and career functioning” for oral (81 ± 17 %) vs subcutaneous iron chelation (70 ± 29 %). In terms of responsiveness, in the patients subgroup that rated their QoL as better in the Likert-type scale, there was a 4.2 point (SD 5.0) improvement in TranQol scores, from their transfusion visit (73.9%) to one week later at the home visit (78.1%), (p < 0.005).
Conclusion
In conclusion, the psychometric properties of the Greek version of TranQoL confirmed that it is valid, reliable and responsive to change. The TranQoL can be incorporated into future studies of thalassemia major in Greek patients.
Session topic: E-poster
Keyword(s): Quality of life, Thalassemia
Type: Eposter Presentation
Background
Greece is a country with a large population of thalassemia patients. To date, there only a few studies measuring quality of life in Greek thalassemia major patients, with the available data mainly derived from generic QoL questionnaires. TranQoL is a novel disease-specific QoL instrument that has been specifically developed to assess QoL in thalassemia major patients.
Aims
This study aimed to evaluate the construct validity, reliability and responsiveness of the Greek translated version of the TranQoL questionnaire.
Methods
The novel Greek TranQoL and the valid generic Greek SF-36v2 questionnaires were administered in 94 consecutive thalassemia major patients that were followed up at the Adult Thalassemia Unit of “Hippokration” general hospital of Thessaloniki, Greece, one of the largest thalassemia centres in Greece. Both questionnaires were completed anonymously during two subsequent transfusion visits, 2 – 3 weeks apart. A week after the transfusion visit the participants were asked to complete the TranQol at home, a third time, and describe any change in their quality of life using a 7-point Likert-type scale. Construct validity was assessed using Pearson’s correlation between the TranQoL scores and the SF-36v2 scores at the first visit. In addition, the t-test or analyses of variance were used to compare TranQoL scores between patient groups that have known differences in quality of life. Assessment of reliability involved the determination of internal consistency by calculating the Cronbach's α-coefficient. Accordingly, the intra - class correlation coefficient (ICC) between the TranQol scores of the baseline visit and the subsequent visit was calculated in order to assess test-retest reliability. In order evaluate responsiveness, we used the paired t – test method to compare TranQoL scores between the transfusion visit and the home visit, in the group of patients who reported to be at least 'a little better' after their last blood transfusion.
Results
There was a moderately strong correlation between the TranQoL summary and both the SF-36 Physical and Mental Component Summaries (r = 0.43, p < 0.001 and r = 0.520, p < 0.001 respectively). There was also a moderately strong correlation between the Physical Health scale of TranQoL and the relevant SF 36 scales, including Physical Functioning (r = 0.4, p < 0.001), role - physical (r = 0.6, p < 0.001) and bodily pain (r = 0.5, p < 0.001). In terms of reliability, TranQoL exhibited good internal consistency, with a Cronbach alpha coefficient reported of 0.89. Test-retest reliability was excellent (intra-class correlation coefficient, 0.9). Regarding know groups validity, patients with hypothyroidism had significantly lower TranQoL summary scores compared to patients without hypothyroidism (65%, range: 57 – 83 vs 75%, range: 42 – 98, p < 0.05). There was also a significant difference in the score of the domain “school and career functioning” for oral (81 ± 17 %) vs subcutaneous iron chelation (70 ± 29 %). In terms of responsiveness, in the patients subgroup that rated their QoL as better in the Likert-type scale, there was a 4.2 point (SD 5.0) improvement in TranQol scores, from their transfusion visit (73.9%) to one week later at the home visit (78.1%), (p < 0.005).
Conclusion
In conclusion, the psychometric properties of the Greek version of TranQoL confirmed that it is valid, reliable and responsive to change. The TranQoL can be incorporated into future studies of thalassemia major in Greek patients.
Session topic: E-poster
Keyword(s): Quality of life, Thalassemia
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