FATIGUE, QUALITY OF LIFE AND PHYSICAL FITNESS IN PATIENTS WITH MYELOMA
(Abstract release date: 05/19/16)
EHA Library. McCourt O. 06/09/16; 132999; E1450
Disclosure(s): The study is funded by Cancer Research UK (Programme grant no. C1418/A14133), Cancer Development Fund and Celgene.
Ms. Orla McCourt
Contributions
Contributions
Abstract
Abstract: E1450
Type: Eposter Presentation
Background
Myeloma is a haematological malignancy characterised by periods of active, symptomatic disease that require intensive treatment, followed by periods of stable disease of ‘plateau phase’. Complications include anaemia, hypercalcaemia, infections, renal failure, neuropathy and bone destruction which can lead to significant physical disability and impaired quality of life (QOL). Additionally, cancer-related fatigue is a common, chronic and often-debilitating side-effect of treatment. Combined, these factors could potentially lead to very low levels of physical fitness, further accelerating the decline in QOL of patients with myeloma. There are, however, limited data on objectively measured fitness in patients with myeloma, and it is unclear to what extent fitness is related to fatigue and QOL.
Aims
To evaluate levels of physical fitness, cancer-related fatigue and QOL in a myeloma survivorship population, and examine how these variables are related to one another.
Methods
Patients with myeloma were recruited to a survivorship lifestyle cohort study from hospital outpatient clinics. Participants were included if they had stable disease for at least 6 weeks, off treatment or on maintenance treatment, with ECOG 0-2, and were clinically able to carry out exercise testing. Fatigue was measured using the fatigue sub-scale of the Functional Assessment of Chronic Illness Therapy Fatigue Score (FACIT-F). A high score on the FACIT-F represents less fatigue, ranging from 0-52. QOL was assessed using the emotional well-being and functional well-being sub-scales of the Functional Assessment of Cancer Therapy (FACT-G) score. Higher scores in the FACT-G indicate better QOL, ranging between 0-52. VO2peak was measured during cardiopulmonary exercise testing (CPET) with a cycle ergometer.
Results
51 patients in plateau phase were included in these analyses. Median age was 64 years (range 42-78), and 59% were male. 5 patients were older than 70. Median time from last treatment was 19 months (range3-139). Mean fatigue (FACIT-F) score was 40.94 (median 45, range 8-52), and 20 patients had a score below the mean reference range of 40.1.Mean quality of life (FACT-G) score was 40.58 (median 42, range 19.4-52), and 21 patients had a score below the mean reference value of 38.4. Mean VO2peak was 17.59ml/kg/min (SD ±4.94, range 10-28ml/kg/min). FACIT-F scores and VO2peak were positively correlated r=0.30 p<0.04. FACT-G scores and VO2peak were positive correlated r=0.31 p<0.03. FACIT-F and FACT-G scores were positively correlated r= 0.60 p<0.001.
Conclusion
Patients with higher levels of cardiopulmonary fitness scored higher on FACIT-F fatigue and FACT-G QOL measures. This indicates that patients with higher levels of fitness were less fatigued and had higher levels of emotional and functional well-being. A significant proportion of patients had scores below normative means for both fatigue and QOL. This analysis of baseline data in a post treatment myeloma survivorship group provides support for further investigation into the use of PA interventions delivered during and post cancer treatment to improve physical fitness and reduce fatigue so as to enhance QOL in this population.
Session topic: E-poster
Keyword(s): Fatigue, Myeloma, Quality of life
Type: Eposter Presentation
Background
Myeloma is a haematological malignancy characterised by periods of active, symptomatic disease that require intensive treatment, followed by periods of stable disease of ‘plateau phase’. Complications include anaemia, hypercalcaemia, infections, renal failure, neuropathy and bone destruction which can lead to significant physical disability and impaired quality of life (QOL). Additionally, cancer-related fatigue is a common, chronic and often-debilitating side-effect of treatment. Combined, these factors could potentially lead to very low levels of physical fitness, further accelerating the decline in QOL of patients with myeloma. There are, however, limited data on objectively measured fitness in patients with myeloma, and it is unclear to what extent fitness is related to fatigue and QOL.
Aims
To evaluate levels of physical fitness, cancer-related fatigue and QOL in a myeloma survivorship population, and examine how these variables are related to one another.
Methods
Patients with myeloma were recruited to a survivorship lifestyle cohort study from hospital outpatient clinics. Participants were included if they had stable disease for at least 6 weeks, off treatment or on maintenance treatment, with ECOG 0-2, and were clinically able to carry out exercise testing. Fatigue was measured using the fatigue sub-scale of the Functional Assessment of Chronic Illness Therapy Fatigue Score (FACIT-F). A high score on the FACIT-F represents less fatigue, ranging from 0-52. QOL was assessed using the emotional well-being and functional well-being sub-scales of the Functional Assessment of Cancer Therapy (FACT-G) score. Higher scores in the FACT-G indicate better QOL, ranging between 0-52. VO2peak was measured during cardiopulmonary exercise testing (CPET) with a cycle ergometer.
Results
51 patients in plateau phase were included in these analyses. Median age was 64 years (range 42-78), and 59% were male. 5 patients were older than 70. Median time from last treatment was 19 months (range3-139). Mean fatigue (FACIT-F) score was 40.94 (median 45, range 8-52), and 20 patients had a score below the mean reference range of 40.1.Mean quality of life (FACT-G) score was 40.58 (median 42, range 19.4-52), and 21 patients had a score below the mean reference value of 38.4. Mean VO2peak was 17.59ml/kg/min (SD ±4.94, range 10-28ml/kg/min). FACIT-F scores and VO2peak were positively correlated r=0.30 p<0.04. FACT-G scores and VO2peak were positive correlated r=0.31 p<0.03. FACIT-F and FACT-G scores were positively correlated r= 0.60 p<0.001.
Conclusion
Patients with higher levels of cardiopulmonary fitness scored higher on FACIT-F fatigue and FACT-G QOL measures. This indicates that patients with higher levels of fitness were less fatigued and had higher levels of emotional and functional well-being. A significant proportion of patients had scores below normative means for both fatigue and QOL. This analysis of baseline data in a post treatment myeloma survivorship group provides support for further investigation into the use of PA interventions delivered during and post cancer treatment to improve physical fitness and reduce fatigue so as to enhance QOL in this population.
Session topic: E-poster
Keyword(s): Fatigue, Myeloma, Quality of life
Abstract: E1450
Type: Eposter Presentation
Background
Myeloma is a haematological malignancy characterised by periods of active, symptomatic disease that require intensive treatment, followed by periods of stable disease of ‘plateau phase’. Complications include anaemia, hypercalcaemia, infections, renal failure, neuropathy and bone destruction which can lead to significant physical disability and impaired quality of life (QOL). Additionally, cancer-related fatigue is a common, chronic and often-debilitating side-effect of treatment. Combined, these factors could potentially lead to very low levels of physical fitness, further accelerating the decline in QOL of patients with myeloma. There are, however, limited data on objectively measured fitness in patients with myeloma, and it is unclear to what extent fitness is related to fatigue and QOL.
Aims
To evaluate levels of physical fitness, cancer-related fatigue and QOL in a myeloma survivorship population, and examine how these variables are related to one another.
Methods
Patients with myeloma were recruited to a survivorship lifestyle cohort study from hospital outpatient clinics. Participants were included if they had stable disease for at least 6 weeks, off treatment or on maintenance treatment, with ECOG 0-2, and were clinically able to carry out exercise testing. Fatigue was measured using the fatigue sub-scale of the Functional Assessment of Chronic Illness Therapy Fatigue Score (FACIT-F). A high score on the FACIT-F represents less fatigue, ranging from 0-52. QOL was assessed using the emotional well-being and functional well-being sub-scales of the Functional Assessment of Cancer Therapy (FACT-G) score. Higher scores in the FACT-G indicate better QOL, ranging between 0-52. VO2peak was measured during cardiopulmonary exercise testing (CPET) with a cycle ergometer.
Results
51 patients in plateau phase were included in these analyses. Median age was 64 years (range 42-78), and 59% were male. 5 patients were older than 70. Median time from last treatment was 19 months (range3-139). Mean fatigue (FACIT-F) score was 40.94 (median 45, range 8-52), and 20 patients had a score below the mean reference range of 40.1.Mean quality of life (FACT-G) score was 40.58 (median 42, range 19.4-52), and 21 patients had a score below the mean reference value of 38.4. Mean VO2peak was 17.59ml/kg/min (SD ±4.94, range 10-28ml/kg/min). FACIT-F scores and VO2peak were positively correlated r=0.30 p<0.04. FACT-G scores and VO2peak were positive correlated r=0.31 p<0.03. FACIT-F and FACT-G scores were positively correlated r= 0.60 p<0.001.
Conclusion
Patients with higher levels of cardiopulmonary fitness scored higher on FACIT-F fatigue and FACT-G QOL measures. This indicates that patients with higher levels of fitness were less fatigued and had higher levels of emotional and functional well-being. A significant proportion of patients had scores below normative means for both fatigue and QOL. This analysis of baseline data in a post treatment myeloma survivorship group provides support for further investigation into the use of PA interventions delivered during and post cancer treatment to improve physical fitness and reduce fatigue so as to enhance QOL in this population.
Session topic: E-poster
Keyword(s): Fatigue, Myeloma, Quality of life
Type: Eposter Presentation
Background
Myeloma is a haematological malignancy characterised by periods of active, symptomatic disease that require intensive treatment, followed by periods of stable disease of ‘plateau phase’. Complications include anaemia, hypercalcaemia, infections, renal failure, neuropathy and bone destruction which can lead to significant physical disability and impaired quality of life (QOL). Additionally, cancer-related fatigue is a common, chronic and often-debilitating side-effect of treatment. Combined, these factors could potentially lead to very low levels of physical fitness, further accelerating the decline in QOL of patients with myeloma. There are, however, limited data on objectively measured fitness in patients with myeloma, and it is unclear to what extent fitness is related to fatigue and QOL.
Aims
To evaluate levels of physical fitness, cancer-related fatigue and QOL in a myeloma survivorship population, and examine how these variables are related to one another.
Methods
Patients with myeloma were recruited to a survivorship lifestyle cohort study from hospital outpatient clinics. Participants were included if they had stable disease for at least 6 weeks, off treatment or on maintenance treatment, with ECOG 0-2, and were clinically able to carry out exercise testing. Fatigue was measured using the fatigue sub-scale of the Functional Assessment of Chronic Illness Therapy Fatigue Score (FACIT-F). A high score on the FACIT-F represents less fatigue, ranging from 0-52. QOL was assessed using the emotional well-being and functional well-being sub-scales of the Functional Assessment of Cancer Therapy (FACT-G) score. Higher scores in the FACT-G indicate better QOL, ranging between 0-52. VO2peak was measured during cardiopulmonary exercise testing (CPET) with a cycle ergometer.
Results
51 patients in plateau phase were included in these analyses. Median age was 64 years (range 42-78), and 59% were male. 5 patients were older than 70. Median time from last treatment was 19 months (range3-139). Mean fatigue (FACIT-F) score was 40.94 (median 45, range 8-52), and 20 patients had a score below the mean reference range of 40.1.Mean quality of life (FACT-G) score was 40.58 (median 42, range 19.4-52), and 21 patients had a score below the mean reference value of 38.4. Mean VO2peak was 17.59ml/kg/min (SD ±4.94, range 10-28ml/kg/min). FACIT-F scores and VO2peak were positively correlated r=0.30 p<0.04. FACT-G scores and VO2peak were positive correlated r=0.31 p<0.03. FACIT-F and FACT-G scores were positively correlated r= 0.60 p<0.001.
Conclusion
Patients with higher levels of cardiopulmonary fitness scored higher on FACIT-F fatigue and FACT-G QOL measures. This indicates that patients with higher levels of fitness were less fatigued and had higher levels of emotional and functional well-being. A significant proportion of patients had scores below normative means for both fatigue and QOL. This analysis of baseline data in a post treatment myeloma survivorship group provides support for further investigation into the use of PA interventions delivered during and post cancer treatment to improve physical fitness and reduce fatigue so as to enhance QOL in this population.
Session topic: E-poster
Keyword(s): Fatigue, Myeloma, Quality of life
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