WHAT IS THE EFFECT OF VENOUS THROMBOEMBOLISM AND POST-THROMBOTIC SYNDROME ON HEALTH-RELATED QUALITY OF LIFE? A SYSTEMATIC REVIEW AND META-ANALYSIS
(Abstract release date: 05/19/16)
EHA Library. Lubberts B. 06/09/16; 132993; E1444
Dr. Bart Lubberts
Contributions
Contributions
Abstract
Abstract: E1444
Type: Eposter Presentation
Background
There is limited insight for patients, their families, and their providers into the mid and long-term effects of pulmonary embolism (PE), deep vein thrombosis (DVT), and post thrombotic syndrome (PTS) on health related quality of life (HRQOL).
Aims
We conducted a systematic review and meta-analysis of the literature to (1) assess the HRQOL for patients with a minimum follow-up of one year after an episode of PE or DVT, and (2) to assess the HRQOL for patients with DVT who develop PTS.
Methods
PubMed, EMBASE, and the Cochrane Library were search from inception to October 12th, 2015. All studies measuring HRQOL at least one year after an episode of PE or DVT, with or without development of PTS, were selected. Data were extracted by two of the authors and pooled using random-effects meta-analysis. Heterogeneity was assessed with I2 and Tau2 tests. SF-12, SF-36, and VEINES-QOL were evaluated with pooled standardized mean difference (SMD) and 95% confidence intervals (CI).
Results
Fourteen studies were included for meta-analyses. In patients with PE physical health was impaired (SMD:-0.30, 95% CI: -0.46 to -0.15, Tau2: 0.0, I2:0%, 2 studies) and mental health was similar to population norms (SMD: 0.14, 95% CI: -0.01 to 0.30, Tau2: 0.0, I2: 0%, 2 studies). In patients with DVT physical health (SMD:-0.22, 95% CI: -0.53 to 0.10, Tau2: 0.21, I2: 94%, 9 studies), mental health (SMD: 0.03, 95% CI: -0.12 to 0.19, Tau2: 0.03, I2: 73%, 9 studies), and disease specific quality of life (SMD: 0.04, 95% CI: -0.10 to 0.18, I2: 2.5%, Tau2: 0.0, 8 studies) were similar to population norms. Patients who develop PTS reported worse physical health (SMD:-0.89, 95% CI: -1.21 to -0.57, Tau2: 0.14, I2: 82%, 7 studies), mental health (SMD:-0.27, 95% CI: -0.43 to -0.11, Tau2: 0.01, I2: 31%, 7 studies), and disease specific quality of life (SMD:-0.97, 95% CI: -1.35 to -0.59, Tau2: 0.30, I2: 84%, 10 studies) than population norms.
Conclusion
Patients who had a PE event report worse physical health. Quality of life after a DVT event is comparable to population norms, although those who develop a PTS have worse overall quality of life. These data can be used to inform patients in the rehabilitation process.
Session topic: E-poster
Keyword(s): Meta-analysis, Quality of life, Venous thromboembolism
Type: Eposter Presentation
Background
There is limited insight for patients, their families, and their providers into the mid and long-term effects of pulmonary embolism (PE), deep vein thrombosis (DVT), and post thrombotic syndrome (PTS) on health related quality of life (HRQOL).
Aims
We conducted a systematic review and meta-analysis of the literature to (1) assess the HRQOL for patients with a minimum follow-up of one year after an episode of PE or DVT, and (2) to assess the HRQOL for patients with DVT who develop PTS.
Methods
PubMed, EMBASE, and the Cochrane Library were search from inception to October 12th, 2015. All studies measuring HRQOL at least one year after an episode of PE or DVT, with or without development of PTS, were selected. Data were extracted by two of the authors and pooled using random-effects meta-analysis. Heterogeneity was assessed with I2 and Tau2 tests. SF-12, SF-36, and VEINES-QOL were evaluated with pooled standardized mean difference (SMD) and 95% confidence intervals (CI).
Results
Fourteen studies were included for meta-analyses. In patients with PE physical health was impaired (SMD:-0.30, 95% CI: -0.46 to -0.15, Tau2: 0.0, I2:0%, 2 studies) and mental health was similar to population norms (SMD: 0.14, 95% CI: -0.01 to 0.30, Tau2: 0.0, I2: 0%, 2 studies). In patients with DVT physical health (SMD:-0.22, 95% CI: -0.53 to 0.10, Tau2: 0.21, I2: 94%, 9 studies), mental health (SMD: 0.03, 95% CI: -0.12 to 0.19, Tau2: 0.03, I2: 73%, 9 studies), and disease specific quality of life (SMD: 0.04, 95% CI: -0.10 to 0.18, I2: 2.5%, Tau2: 0.0, 8 studies) were similar to population norms. Patients who develop PTS reported worse physical health (SMD:-0.89, 95% CI: -1.21 to -0.57, Tau2: 0.14, I2: 82%, 7 studies), mental health (SMD:-0.27, 95% CI: -0.43 to -0.11, Tau2: 0.01, I2: 31%, 7 studies), and disease specific quality of life (SMD:-0.97, 95% CI: -1.35 to -0.59, Tau2: 0.30, I2: 84%, 10 studies) than population norms.
Conclusion
Patients who had a PE event report worse physical health. Quality of life after a DVT event is comparable to population norms, although those who develop a PTS have worse overall quality of life. These data can be used to inform patients in the rehabilitation process.
Session topic: E-poster
Keyword(s): Meta-analysis, Quality of life, Venous thromboembolism
Abstract: E1444
Type: Eposter Presentation
Background
There is limited insight for patients, their families, and their providers into the mid and long-term effects of pulmonary embolism (PE), deep vein thrombosis (DVT), and post thrombotic syndrome (PTS) on health related quality of life (HRQOL).
Aims
We conducted a systematic review and meta-analysis of the literature to (1) assess the HRQOL for patients with a minimum follow-up of one year after an episode of PE or DVT, and (2) to assess the HRQOL for patients with DVT who develop PTS.
Methods
PubMed, EMBASE, and the Cochrane Library were search from inception to October 12th, 2015. All studies measuring HRQOL at least one year after an episode of PE or DVT, with or without development of PTS, were selected. Data were extracted by two of the authors and pooled using random-effects meta-analysis. Heterogeneity was assessed with I2 and Tau2 tests. SF-12, SF-36, and VEINES-QOL were evaluated with pooled standardized mean difference (SMD) and 95% confidence intervals (CI).
Results
Fourteen studies were included for meta-analyses. In patients with PE physical health was impaired (SMD:-0.30, 95% CI: -0.46 to -0.15, Tau2: 0.0, I2:0%, 2 studies) and mental health was similar to population norms (SMD: 0.14, 95% CI: -0.01 to 0.30, Tau2: 0.0, I2: 0%, 2 studies). In patients with DVT physical health (SMD:-0.22, 95% CI: -0.53 to 0.10, Tau2: 0.21, I2: 94%, 9 studies), mental health (SMD: 0.03, 95% CI: -0.12 to 0.19, Tau2: 0.03, I2: 73%, 9 studies), and disease specific quality of life (SMD: 0.04, 95% CI: -0.10 to 0.18, I2: 2.5%, Tau2: 0.0, 8 studies) were similar to population norms. Patients who develop PTS reported worse physical health (SMD:-0.89, 95% CI: -1.21 to -0.57, Tau2: 0.14, I2: 82%, 7 studies), mental health (SMD:-0.27, 95% CI: -0.43 to -0.11, Tau2: 0.01, I2: 31%, 7 studies), and disease specific quality of life (SMD:-0.97, 95% CI: -1.35 to -0.59, Tau2: 0.30, I2: 84%, 10 studies) than population norms.
Conclusion
Patients who had a PE event report worse physical health. Quality of life after a DVT event is comparable to population norms, although those who develop a PTS have worse overall quality of life. These data can be used to inform patients in the rehabilitation process.
Session topic: E-poster
Keyword(s): Meta-analysis, Quality of life, Venous thromboembolism
Type: Eposter Presentation
Background
There is limited insight for patients, their families, and their providers into the mid and long-term effects of pulmonary embolism (PE), deep vein thrombosis (DVT), and post thrombotic syndrome (PTS) on health related quality of life (HRQOL).
Aims
We conducted a systematic review and meta-analysis of the literature to (1) assess the HRQOL for patients with a minimum follow-up of one year after an episode of PE or DVT, and (2) to assess the HRQOL for patients with DVT who develop PTS.
Methods
PubMed, EMBASE, and the Cochrane Library were search from inception to October 12th, 2015. All studies measuring HRQOL at least one year after an episode of PE or DVT, with or without development of PTS, were selected. Data were extracted by two of the authors and pooled using random-effects meta-analysis. Heterogeneity was assessed with I2 and Tau2 tests. SF-12, SF-36, and VEINES-QOL were evaluated with pooled standardized mean difference (SMD) and 95% confidence intervals (CI).
Results
Fourteen studies were included for meta-analyses. In patients with PE physical health was impaired (SMD:-0.30, 95% CI: -0.46 to -0.15, Tau2: 0.0, I2:0%, 2 studies) and mental health was similar to population norms (SMD: 0.14, 95% CI: -0.01 to 0.30, Tau2: 0.0, I2: 0%, 2 studies). In patients with DVT physical health (SMD:-0.22, 95% CI: -0.53 to 0.10, Tau2: 0.21, I2: 94%, 9 studies), mental health (SMD: 0.03, 95% CI: -0.12 to 0.19, Tau2: 0.03, I2: 73%, 9 studies), and disease specific quality of life (SMD: 0.04, 95% CI: -0.10 to 0.18, I2: 2.5%, Tau2: 0.0, 8 studies) were similar to population norms. Patients who develop PTS reported worse physical health (SMD:-0.89, 95% CI: -1.21 to -0.57, Tau2: 0.14, I2: 82%, 7 studies), mental health (SMD:-0.27, 95% CI: -0.43 to -0.11, Tau2: 0.01, I2: 31%, 7 studies), and disease specific quality of life (SMD:-0.97, 95% CI: -1.35 to -0.59, Tau2: 0.30, I2: 84%, 10 studies) than population norms.
Conclusion
Patients who had a PE event report worse physical health. Quality of life after a DVT event is comparable to population norms, although those who develop a PTS have worse overall quality of life. These data can be used to inform patients in the rehabilitation process.
Session topic: E-poster
Keyword(s): Meta-analysis, Quality of life, Venous thromboembolism
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