EFFECT OF EXERCISE AND COUNSELING INTEGRATED IN THE CLINICAL MANAGEMENT OF ACUTE LEUKEMIA ON PHYSICAL FUNCTION AND QUALITY OF LIFE DURING CONSOLIDATION CHEMOTHERAPY: A MULTICENTER RANDOMIZED TRIAL
(Abstract release date: 05/19/16)
EHA Library. Jarden M. 06/09/16; 132985; E1436
Dr. Mary Jarden
Contributions
Contributions
Abstract
Abstract: E1436
Type: Eposter Presentation
Background
Exercise and counseling interventions, widely used as rehabilitation strategies in cancer patients to remedy disease and treatment-related sequelae is novel in patients with acute leukemia due to the life threatening nature of the disease, the intensive treatment and safety monitoring requirements.
Aims
We assessed whether an exercise and counseling intervention could prevent and modulate physical and functional debilitation and improve health-related quality of life (HRQoL) in a two-center, randomized controlled trial of patients with acute leukemia during outpatient consolidation chemotherapy.
Methods
Patients were randomized to usual care or a twelve-week supervised exercise and counseling intervention. The primary outcome was 6 minute walk distance (6MWD), and secondary outcomes included submaximal VO2 max, sit-to-stand test, biceps arm curl, and patient-reported HRQoL questionnaires. 70 patients were randomly assigned to the intervention (n=32) or control group (n=34), and 62 completed study requirements (88.6%).
Results
Changes in the primary outcome 6MWD differed significantly across randomization groups (85.5 m [51.2-119.8], p<0.0001) and physical capacity and functional outcomes were substantial (effect sizes 1 or above). Self-rated leisure-time physical activity levels, health-related quality of life (FACT-An) and levels of depression and anxiety differed significantly between groups, in favor of the intervention group. Eight patients experienced non-serious adverse events.
Conclusion
Exercise and counseling in patients with acute leukemia undergoing outpatient consolidation chemotherapy improved physical and functional capacity, physical activity levels, HRQoL and psychological wellbeing. The role of exercise and counseling integrated in the clinical setting has the potential of optimizing the management of acute leukemia and may facilitate resumption of everyday activities.
Session topic: E-poster
Keyword(s): Acute leukemia, Quality of life, Randomized
Type: Eposter Presentation
Background
Exercise and counseling interventions, widely used as rehabilitation strategies in cancer patients to remedy disease and treatment-related sequelae is novel in patients with acute leukemia due to the life threatening nature of the disease, the intensive treatment and safety monitoring requirements.
Aims
We assessed whether an exercise and counseling intervention could prevent and modulate physical and functional debilitation and improve health-related quality of life (HRQoL) in a two-center, randomized controlled trial of patients with acute leukemia during outpatient consolidation chemotherapy.
Methods
Patients were randomized to usual care or a twelve-week supervised exercise and counseling intervention. The primary outcome was 6 minute walk distance (6MWD), and secondary outcomes included submaximal VO2 max, sit-to-stand test, biceps arm curl, and patient-reported HRQoL questionnaires. 70 patients were randomly assigned to the intervention (n=32) or control group (n=34), and 62 completed study requirements (88.6%).
Results
Changes in the primary outcome 6MWD differed significantly across randomization groups (85.5 m [51.2-119.8], p<0.0001) and physical capacity and functional outcomes were substantial (effect sizes 1 or above). Self-rated leisure-time physical activity levels, health-related quality of life (FACT-An) and levels of depression and anxiety differed significantly between groups, in favor of the intervention group. Eight patients experienced non-serious adverse events.
Conclusion
Exercise and counseling in patients with acute leukemia undergoing outpatient consolidation chemotherapy improved physical and functional capacity, physical activity levels, HRQoL and psychological wellbeing. The role of exercise and counseling integrated in the clinical setting has the potential of optimizing the management of acute leukemia and may facilitate resumption of everyday activities.
Session topic: E-poster
Keyword(s): Acute leukemia, Quality of life, Randomized
Abstract: E1436
Type: Eposter Presentation
Background
Exercise and counseling interventions, widely used as rehabilitation strategies in cancer patients to remedy disease and treatment-related sequelae is novel in patients with acute leukemia due to the life threatening nature of the disease, the intensive treatment and safety monitoring requirements.
Aims
We assessed whether an exercise and counseling intervention could prevent and modulate physical and functional debilitation and improve health-related quality of life (HRQoL) in a two-center, randomized controlled trial of patients with acute leukemia during outpatient consolidation chemotherapy.
Methods
Patients were randomized to usual care or a twelve-week supervised exercise and counseling intervention. The primary outcome was 6 minute walk distance (6MWD), and secondary outcomes included submaximal VO2 max, sit-to-stand test, biceps arm curl, and patient-reported HRQoL questionnaires. 70 patients were randomly assigned to the intervention (n=32) or control group (n=34), and 62 completed study requirements (88.6%).
Results
Changes in the primary outcome 6MWD differed significantly across randomization groups (85.5 m [51.2-119.8], p<0.0001) and physical capacity and functional outcomes were substantial (effect sizes 1 or above). Self-rated leisure-time physical activity levels, health-related quality of life (FACT-An) and levels of depression and anxiety differed significantly between groups, in favor of the intervention group. Eight patients experienced non-serious adverse events.
Conclusion
Exercise and counseling in patients with acute leukemia undergoing outpatient consolidation chemotherapy improved physical and functional capacity, physical activity levels, HRQoL and psychological wellbeing. The role of exercise and counseling integrated in the clinical setting has the potential of optimizing the management of acute leukemia and may facilitate resumption of everyday activities.
Session topic: E-poster
Keyword(s): Acute leukemia, Quality of life, Randomized
Type: Eposter Presentation
Background
Exercise and counseling interventions, widely used as rehabilitation strategies in cancer patients to remedy disease and treatment-related sequelae is novel in patients with acute leukemia due to the life threatening nature of the disease, the intensive treatment and safety monitoring requirements.
Aims
We assessed whether an exercise and counseling intervention could prevent and modulate physical and functional debilitation and improve health-related quality of life (HRQoL) in a two-center, randomized controlled trial of patients with acute leukemia during outpatient consolidation chemotherapy.
Methods
Patients were randomized to usual care or a twelve-week supervised exercise and counseling intervention. The primary outcome was 6 minute walk distance (6MWD), and secondary outcomes included submaximal VO2 max, sit-to-stand test, biceps arm curl, and patient-reported HRQoL questionnaires. 70 patients were randomly assigned to the intervention (n=32) or control group (n=34), and 62 completed study requirements (88.6%).
Results
Changes in the primary outcome 6MWD differed significantly across randomization groups (85.5 m [51.2-119.8], p<0.0001) and physical capacity and functional outcomes were substantial (effect sizes 1 or above). Self-rated leisure-time physical activity levels, health-related quality of life (FACT-An) and levels of depression and anxiety differed significantly between groups, in favor of the intervention group. Eight patients experienced non-serious adverse events.
Conclusion
Exercise and counseling in patients with acute leukemia undergoing outpatient consolidation chemotherapy improved physical and functional capacity, physical activity levels, HRQoL and psychological wellbeing. The role of exercise and counseling integrated in the clinical setting has the potential of optimizing the management of acute leukemia and may facilitate resumption of everyday activities.
Session topic: E-poster
Keyword(s): Acute leukemia, Quality of life, Randomized
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