EVALUATION OF IRON OVERLOAD IN THE HEART AND LIVER TISSUE BY MAGNETIC RESONANCE IMAGING AND ITS RELATION TO SERUM FERRITIN AND HEPCIDIN CONCENTRATIONS IN PATIENTS WITH THALASSEMIA SYNDROMES
(Abstract release date: 05/19/16)
EHA Library. Karakus V. 06/09/16; 132951; E1402
Dr. Volkan Karakus
Contributions
Contributions
Abstract
Abstract: E1402
Type: Eposter Presentation
Background
Thalassemias are inherited disorders characterized by the presence of hypochromic microcytic anemia due to the reduced or absent production of one or more globin chains in hemoglobin. Individuals with thalassemia are classified according to genotype and the severity of anemia as thalassemia major, intermedia, or minor. Life expectancy is dependent on lifelong blood transfusions and iron-binding therapies. Iron overload (IOL) and associated tissue damage are the most important factors that determine mortality and morbidity.
Aims
We aimed to evaluate iron accumulation in the heart and liver by MRI in thalassemia major, thalassemia intermedia, and S-ß thalassemia patients and to examine its association with ferritin and hepcidin levels.
Methods
Serum ferritin and hepcidin levels were recorded. Iron overload (IOL) in the liver and heart parenchyma was determined based on the standardized R2 and T2* values calculated on MRI. The results were evaluated considering the tissue iron overload, serum ferritin and hepcidin levels.
Results
Comparing the 109 patients with the 30 healthy controls showed the mean age: 24.4±11 vs 31.2±5 years, and, median levels of serum ferritin and hepcidin: 1693 vs 40 ng/mL and 1.94 vs 0.355 ng/mL; (p=0.0001), respectively. In order of the disease diagnosis, the median cardiac T2* and hepatic R2 values were: 25.3 msec, 31.4 msec, 28.2 msec, and, 4.49 msec, 8.14 msec, and 10.35 msec on MRI, respectively. Comparing age, serum ferritin and hepcidin levels in the patients with or without iron overload, only ferritin was significantly higher (p=0.004) in the patients with IOL by means of cardiac tissue, and, age and ferritin were significantly higher (p=0.036 and p<0.001) in the patients with IOL by means of liver tissue. Positive correlations between serum ferritin levels and the severity of IOL were found (p=0.002 and p<0.001).
Conclusion
In the present study, enhanced intestinal iron absorption in the intervals between successive transfusions characterized by decreased serum hepcidin levels were considered to result in iron accumulation in our patients.
Session topic: E-poster
Keyword(s): Hepcidin, Magnetic resonance imaging, Thalassemia
Type: Eposter Presentation
Background
Thalassemias are inherited disorders characterized by the presence of hypochromic microcytic anemia due to the reduced or absent production of one or more globin chains in hemoglobin. Individuals with thalassemia are classified according to genotype and the severity of anemia as thalassemia major, intermedia, or minor. Life expectancy is dependent on lifelong blood transfusions and iron-binding therapies. Iron overload (IOL) and associated tissue damage are the most important factors that determine mortality and morbidity.
Aims
We aimed to evaluate iron accumulation in the heart and liver by MRI in thalassemia major, thalassemia intermedia, and S-ß thalassemia patients and to examine its association with ferritin and hepcidin levels.
Methods
Serum ferritin and hepcidin levels were recorded. Iron overload (IOL) in the liver and heart parenchyma was determined based on the standardized R2 and T2* values calculated on MRI. The results were evaluated considering the tissue iron overload, serum ferritin and hepcidin levels.
Results
Comparing the 109 patients with the 30 healthy controls showed the mean age: 24.4±11 vs 31.2±5 years, and, median levels of serum ferritin and hepcidin: 1693 vs 40 ng/mL and 1.94 vs 0.355 ng/mL; (p=0.0001), respectively. In order of the disease diagnosis, the median cardiac T2* and hepatic R2 values were: 25.3 msec, 31.4 msec, 28.2 msec, and, 4.49 msec, 8.14 msec, and 10.35 msec on MRI, respectively. Comparing age, serum ferritin and hepcidin levels in the patients with or without iron overload, only ferritin was significantly higher (p=0.004) in the patients with IOL by means of cardiac tissue, and, age and ferritin were significantly higher (p=0.036 and p<0.001) in the patients with IOL by means of liver tissue. Positive correlations between serum ferritin levels and the severity of IOL were found (p=0.002 and p<0.001).
Conclusion
In the present study, enhanced intestinal iron absorption in the intervals between successive transfusions characterized by decreased serum hepcidin levels were considered to result in iron accumulation in our patients.
Session topic: E-poster
Keyword(s): Hepcidin, Magnetic resonance imaging, Thalassemia
Abstract: E1402
Type: Eposter Presentation
Background
Thalassemias are inherited disorders characterized by the presence of hypochromic microcytic anemia due to the reduced or absent production of one or more globin chains in hemoglobin. Individuals with thalassemia are classified according to genotype and the severity of anemia as thalassemia major, intermedia, or minor. Life expectancy is dependent on lifelong blood transfusions and iron-binding therapies. Iron overload (IOL) and associated tissue damage are the most important factors that determine mortality and morbidity.
Aims
We aimed to evaluate iron accumulation in the heart and liver by MRI in thalassemia major, thalassemia intermedia, and S-ß thalassemia patients and to examine its association with ferritin and hepcidin levels.
Methods
Serum ferritin and hepcidin levels were recorded. Iron overload (IOL) in the liver and heart parenchyma was determined based on the standardized R2 and T2* values calculated on MRI. The results were evaluated considering the tissue iron overload, serum ferritin and hepcidin levels.
Results
Comparing the 109 patients with the 30 healthy controls showed the mean age: 24.4±11 vs 31.2±5 years, and, median levels of serum ferritin and hepcidin: 1693 vs 40 ng/mL and 1.94 vs 0.355 ng/mL; (p=0.0001), respectively. In order of the disease diagnosis, the median cardiac T2* and hepatic R2 values were: 25.3 msec, 31.4 msec, 28.2 msec, and, 4.49 msec, 8.14 msec, and 10.35 msec on MRI, respectively. Comparing age, serum ferritin and hepcidin levels in the patients with or without iron overload, only ferritin was significantly higher (p=0.004) in the patients with IOL by means of cardiac tissue, and, age and ferritin were significantly higher (p=0.036 and p<0.001) in the patients with IOL by means of liver tissue. Positive correlations between serum ferritin levels and the severity of IOL were found (p=0.002 and p<0.001).
Conclusion
In the present study, enhanced intestinal iron absorption in the intervals between successive transfusions characterized by decreased serum hepcidin levels were considered to result in iron accumulation in our patients.
Session topic: E-poster
Keyword(s): Hepcidin, Magnetic resonance imaging, Thalassemia
Type: Eposter Presentation
Background
Thalassemias are inherited disorders characterized by the presence of hypochromic microcytic anemia due to the reduced or absent production of one or more globin chains in hemoglobin. Individuals with thalassemia are classified according to genotype and the severity of anemia as thalassemia major, intermedia, or minor. Life expectancy is dependent on lifelong blood transfusions and iron-binding therapies. Iron overload (IOL) and associated tissue damage are the most important factors that determine mortality and morbidity.
Aims
We aimed to evaluate iron accumulation in the heart and liver by MRI in thalassemia major, thalassemia intermedia, and S-ß thalassemia patients and to examine its association with ferritin and hepcidin levels.
Methods
Serum ferritin and hepcidin levels were recorded. Iron overload (IOL) in the liver and heart parenchyma was determined based on the standardized R2 and T2* values calculated on MRI. The results were evaluated considering the tissue iron overload, serum ferritin and hepcidin levels.
Results
Comparing the 109 patients with the 30 healthy controls showed the mean age: 24.4±11 vs 31.2±5 years, and, median levels of serum ferritin and hepcidin: 1693 vs 40 ng/mL and 1.94 vs 0.355 ng/mL; (p=0.0001), respectively. In order of the disease diagnosis, the median cardiac T2* and hepatic R2 values were: 25.3 msec, 31.4 msec, 28.2 msec, and, 4.49 msec, 8.14 msec, and 10.35 msec on MRI, respectively. Comparing age, serum ferritin and hepcidin levels in the patients with or without iron overload, only ferritin was significantly higher (p=0.004) in the patients with IOL by means of cardiac tissue, and, age and ferritin were significantly higher (p=0.036 and p<0.001) in the patients with IOL by means of liver tissue. Positive correlations between serum ferritin levels and the severity of IOL were found (p=0.002 and p<0.001).
Conclusion
In the present study, enhanced intestinal iron absorption in the intervals between successive transfusions characterized by decreased serum hepcidin levels were considered to result in iron accumulation in our patients.
Session topic: E-poster
Keyword(s): Hepcidin, Magnetic resonance imaging, Thalassemia
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