AGE-RELATED HEALTHCARE DISPARITIES IN MULTIPLE MYELOMA
(Abstract release date: 05/19/16)
EHA Library. Puyade M. 06/09/16; 132873; E1324
Disclosure(s): This work was supported by a grant from the Groupement Interrégional de Recherche Clinique du Grand Ouest, Fondation Université de Poitiers and from APEMSA (Association Pictave pour l’Etude des Maladies du Sang).
Travel: Actelion
Dr. Mathieu Puyade
Contributions
Contributions
Abstract
Abstract: E1324
Type: Eposter Presentation
Background
Age is a well-known factor in solid tumor linked to a lower adherence to guidelines. Scarce data exist for hematologic malignancies like Multiple Myeloma (MM), a disease that affects primarily elderly patients.
Aims
The aim of the study was to investigate the relationships between age, adherence to guidelines in MM and overall survival.
Methods
The Poitou-Charentes cancer registry has exhaustively registered the incident cases of MM from 2008 to 2010. Provided care (diagnosis, staging, prognosis and first-line treatment) was compared to international guidelines.
Results
Three hundred and sixty seven patients aged 36 to 93y were included. Compliance to diagnostic procedure was 98%, staging 62%, prognosis 30% and first-line treatment 89%. Cytogenetic analysis was compliant in 37% (74% < 66y, 31% between 66-74y and 13% for the oldest, P< 0.001). Age was the strongest factor associated to compliant provision of care (OR 14.4 [6.1-33.8] for < 66y, and 2.3 [0.9-6.1] for 66-74y; P <0.0001). The second independent factor was the diagnosis of multiple myeloma (OR 3.5 [1.6-7.3]; P =0.0009). Adherence to guidelines increased overall survival after adjustment on age HR: 1.8 [1.2-2.7], P = 0.008.
Conclusion
Age is linked with inadequate provision of care in MM, particularly prognosis and first-line treatment. Compliance to guidelines improves OS. Future guidelines should stress that age and frailty should be taken into account at Myeloma care, eventually with specific guidelines for this population.
Session topic: E-poster
Keyword(s): Age, Health care, Multiple myeloma
Type: Eposter Presentation
Background
Age is a well-known factor in solid tumor linked to a lower adherence to guidelines. Scarce data exist for hematologic malignancies like Multiple Myeloma (MM), a disease that affects primarily elderly patients.
Aims
The aim of the study was to investigate the relationships between age, adherence to guidelines in MM and overall survival.
Methods
The Poitou-Charentes cancer registry has exhaustively registered the incident cases of MM from 2008 to 2010. Provided care (diagnosis, staging, prognosis and first-line treatment) was compared to international guidelines.
Results
Three hundred and sixty seven patients aged 36 to 93y were included. Compliance to diagnostic procedure was 98%, staging 62%, prognosis 30% and first-line treatment 89%. Cytogenetic analysis was compliant in 37% (74% < 66y, 31% between 66-74y and 13% for the oldest, P< 0.001). Age was the strongest factor associated to compliant provision of care (OR 14.4 [6.1-33.8] for < 66y, and 2.3 [0.9-6.1] for 66-74y; P <0.0001). The second independent factor was the diagnosis of multiple myeloma (OR 3.5 [1.6-7.3]; P =0.0009). Adherence to guidelines increased overall survival after adjustment on age HR: 1.8 [1.2-2.7], P = 0.008.
Conclusion
Age is linked with inadequate provision of care in MM, particularly prognosis and first-line treatment. Compliance to guidelines improves OS. Future guidelines should stress that age and frailty should be taken into account at Myeloma care, eventually with specific guidelines for this population.
Session topic: E-poster
Keyword(s): Age, Health care, Multiple myeloma
Abstract: E1324
Type: Eposter Presentation
Background
Age is a well-known factor in solid tumor linked to a lower adherence to guidelines. Scarce data exist for hematologic malignancies like Multiple Myeloma (MM), a disease that affects primarily elderly patients.
Aims
The aim of the study was to investigate the relationships between age, adherence to guidelines in MM and overall survival.
Methods
The Poitou-Charentes cancer registry has exhaustively registered the incident cases of MM from 2008 to 2010. Provided care (diagnosis, staging, prognosis and first-line treatment) was compared to international guidelines.
Results
Three hundred and sixty seven patients aged 36 to 93y were included. Compliance to diagnostic procedure was 98%, staging 62%, prognosis 30% and first-line treatment 89%. Cytogenetic analysis was compliant in 37% (74% < 66y, 31% between 66-74y and 13% for the oldest, P< 0.001). Age was the strongest factor associated to compliant provision of care (OR 14.4 [6.1-33.8] for < 66y, and 2.3 [0.9-6.1] for 66-74y; P <0.0001). The second independent factor was the diagnosis of multiple myeloma (OR 3.5 [1.6-7.3]; P =0.0009). Adherence to guidelines increased overall survival after adjustment on age HR: 1.8 [1.2-2.7], P = 0.008.
Conclusion
Age is linked with inadequate provision of care in MM, particularly prognosis and first-line treatment. Compliance to guidelines improves OS. Future guidelines should stress that age and frailty should be taken into account at Myeloma care, eventually with specific guidelines for this population.
Session topic: E-poster
Keyword(s): Age, Health care, Multiple myeloma
Type: Eposter Presentation
Background
Age is a well-known factor in solid tumor linked to a lower adherence to guidelines. Scarce data exist for hematologic malignancies like Multiple Myeloma (MM), a disease that affects primarily elderly patients.
Aims
The aim of the study was to investigate the relationships between age, adherence to guidelines in MM and overall survival.
Methods
The Poitou-Charentes cancer registry has exhaustively registered the incident cases of MM from 2008 to 2010. Provided care (diagnosis, staging, prognosis and first-line treatment) was compared to international guidelines.
Results
Three hundred and sixty seven patients aged 36 to 93y were included. Compliance to diagnostic procedure was 98%, staging 62%, prognosis 30% and first-line treatment 89%. Cytogenetic analysis was compliant in 37% (74% < 66y, 31% between 66-74y and 13% for the oldest, P< 0.001). Age was the strongest factor associated to compliant provision of care (OR 14.4 [6.1-33.8] for < 66y, and 2.3 [0.9-6.1] for 66-74y; P <0.0001). The second independent factor was the diagnosis of multiple myeloma (OR 3.5 [1.6-7.3]; P =0.0009). Adherence to guidelines increased overall survival after adjustment on age HR: 1.8 [1.2-2.7], P = 0.008.
Conclusion
Age is linked with inadequate provision of care in MM, particularly prognosis and first-line treatment. Compliance to guidelines improves OS. Future guidelines should stress that age and frailty should be taken into account at Myeloma care, eventually with specific guidelines for this population.
Session topic: E-poster
Keyword(s): Age, Health care, Multiple myeloma
{{ help_message }}
{{filter}}