SEVERE DECREASE OF BONE MATERIAL STRENGTH IN MONOCLONAL GAMMOPATHY OF UNDETERMINED SIGNIFICANCE PATIENTS DETECTED BY OSTEOPROBE® MICROINDENTATION METHOD.
(Abstract release date: 05/19/16)
EHA Library. Gonzalez A. 06/09/16; 132860; E1311
Dr. Alba Gonzalez
Contributions
Contributions
Abstract
Abstract: E1311
Type: Eposter Presentation
Background
Monoclonal gammopathy of undetermined significance (MGUS) affects over 3% of adults over 50 years old. Previous studies show that MGUS patients experience a significant bone fracture risk increase and that MGUS prevalence is higher in osteoporotic patients (1). The microindentation for in vivo measurement of bone tissue method (2,3) has shown to detect decrease in Bone Material Strength (BMS) even at early stages. These findings correlate with bone fragility and risk of fracture independently of bone mineral density (BMD) (4) measured by bone densitometry (DXA).
Aims
To analyze the BMS by Osteoprobe® microindentation method and the BMD by densitometry in MGUS patients and compare with an age control matched group.
Methods
We have included 22 patients diagnosed with MGUS. An informed consent was obtained and a general laboratory workup was undertaken. BMD measurement at the lumbar spine and hip using DXA (Hologic QDR 4500 SR™, Hologic, Bedford, MA) was performed. BMS determination by inserting a probe assembly through the skin covering the anterior midtibia and applying 20 indentations with an Osteoprobe® (Active Life Scientific Sta Barbara CA) device (3) was done. The results were compared with controls adjusted by sex and age.
Results
MGUS patients present low values of BMS (68.3 ± 5) compared with control group values (83 ± 4, p<0.001). No significant difference was observed in BMD between controls and patients (0.977 vs 0.929 p :0,288 at lumbar spine; 0.783 vs 0.730 p: 0,179 at femoral neck; 0.902 vs 0.898 p: 0,157at total femur).
Conclusion
These results suggest that microindentation method directly measures bone mechanical properties at the tissue level and can detect significant decrease of BMS in MGUS patients, which correlates with a greater risk of fracture. This could be useful to identify MGUS patients that would benefit from early antiresorptive treatment despite a normal DXA.References:1- Drake MT Unveiling skeletal fragility in patients diagnosed with MGUS: no longer a condition of undetermined significance? J Bone Miner Res. 2014:2529-33. 2- Daniel Bridges, Connor Randall, and Paul K. Hansma. A new device for performing reference point indentation without a reference probe. Review of Scientific Instruments.2012;83,044301 3- Randall C, Bridges D, Guerri R, Nogues X, Puig L, Torres E, Mellibovsky L, Hoffseth K, Stalbaum T, Srikanth A, Weaver JC, Rosen S, Barnard H, Brimer D, Proctor A, Candy J, Saldana C, Chandrasekar S, Lescun T, Nielson CM, Orwoll E, Herthel D, Kopeikin H, Yang HT, Farr JN, McCready L, Khosla S, Diez-Perez A, Hansma PK. Applications of a New Handheld Reference Point Indentation Instrument Measuring Bone Material Strength. J Med Device. 2013:410051-56. 4- Mellibovsky L, Prieto-Alhambra D, Mellibovsky F, Güerri-Fernández R, Nogués X, Randall C, Hansma PK, Díez-Perez A. Bone Tissue Properties Measurement by Reference Point Indentation in Glucocorticoid-Induced Osteoporosis.J Bone Miner Res. 2015;30:1651-6
Session topic: E-poster
Keyword(s): Bone mineral density, MGUS
Type: Eposter Presentation
Background
Monoclonal gammopathy of undetermined significance (MGUS) affects over 3% of adults over 50 years old. Previous studies show that MGUS patients experience a significant bone fracture risk increase and that MGUS prevalence is higher in osteoporotic patients (1). The microindentation for in vivo measurement of bone tissue method (2,3) has shown to detect decrease in Bone Material Strength (BMS) even at early stages. These findings correlate with bone fragility and risk of fracture independently of bone mineral density (BMD) (4) measured by bone densitometry (DXA).
Aims
To analyze the BMS by Osteoprobe® microindentation method and the BMD by densitometry in MGUS patients and compare with an age control matched group.
Methods
We have included 22 patients diagnosed with MGUS. An informed consent was obtained and a general laboratory workup was undertaken. BMD measurement at the lumbar spine and hip using DXA (Hologic QDR 4500 SR™, Hologic, Bedford, MA) was performed. BMS determination by inserting a probe assembly through the skin covering the anterior midtibia and applying 20 indentations with an Osteoprobe® (Active Life Scientific Sta Barbara CA) device (3) was done. The results were compared with controls adjusted by sex and age.
Results
MGUS patients present low values of BMS (68.3 ± 5) compared with control group values (83 ± 4, p<0.001). No significant difference was observed in BMD between controls and patients (0.977 vs 0.929 p :0,288 at lumbar spine; 0.783 vs 0.730 p: 0,179 at femoral neck; 0.902 vs 0.898 p: 0,157at total femur).
Conclusion
These results suggest that microindentation method directly measures bone mechanical properties at the tissue level and can detect significant decrease of BMS in MGUS patients, which correlates with a greater risk of fracture. This could be useful to identify MGUS patients that would benefit from early antiresorptive treatment despite a normal DXA.References:1- Drake MT Unveiling skeletal fragility in patients diagnosed with MGUS: no longer a condition of undetermined significance? J Bone Miner Res. 2014:2529-33. 2- Daniel Bridges, Connor Randall, and Paul K. Hansma. A new device for performing reference point indentation without a reference probe. Review of Scientific Instruments.2012;83,044301 3- Randall C, Bridges D, Guerri R, Nogues X, Puig L, Torres E, Mellibovsky L, Hoffseth K, Stalbaum T, Srikanth A, Weaver JC, Rosen S, Barnard H, Brimer D, Proctor A, Candy J, Saldana C, Chandrasekar S, Lescun T, Nielson CM, Orwoll E, Herthel D, Kopeikin H, Yang HT, Farr JN, McCready L, Khosla S, Diez-Perez A, Hansma PK. Applications of a New Handheld Reference Point Indentation Instrument Measuring Bone Material Strength. J Med Device. 2013:410051-56. 4- Mellibovsky L, Prieto-Alhambra D, Mellibovsky F, Güerri-Fernández R, Nogués X, Randall C, Hansma PK, Díez-Perez A. Bone Tissue Properties Measurement by Reference Point Indentation in Glucocorticoid-Induced Osteoporosis.J Bone Miner Res. 2015;30:1651-6
Session topic: E-poster
Keyword(s): Bone mineral density, MGUS
Abstract: E1311
Type: Eposter Presentation
Background
Monoclonal gammopathy of undetermined significance (MGUS) affects over 3% of adults over 50 years old. Previous studies show that MGUS patients experience a significant bone fracture risk increase and that MGUS prevalence is higher in osteoporotic patients (1). The microindentation for in vivo measurement of bone tissue method (2,3) has shown to detect decrease in Bone Material Strength (BMS) even at early stages. These findings correlate with bone fragility and risk of fracture independently of bone mineral density (BMD) (4) measured by bone densitometry (DXA).
Aims
To analyze the BMS by Osteoprobe® microindentation method and the BMD by densitometry in MGUS patients and compare with an age control matched group.
Methods
We have included 22 patients diagnosed with MGUS. An informed consent was obtained and a general laboratory workup was undertaken. BMD measurement at the lumbar spine and hip using DXA (Hologic QDR 4500 SR™, Hologic, Bedford, MA) was performed. BMS determination by inserting a probe assembly through the skin covering the anterior midtibia and applying 20 indentations with an Osteoprobe® (Active Life Scientific Sta Barbara CA) device (3) was done. The results were compared with controls adjusted by sex and age.
Results
MGUS patients present low values of BMS (68.3 ± 5) compared with control group values (83 ± 4, p<0.001). No significant difference was observed in BMD between controls and patients (0.977 vs 0.929 p :0,288 at lumbar spine; 0.783 vs 0.730 p: 0,179 at femoral neck; 0.902 vs 0.898 p: 0,157at total femur).
Conclusion
These results suggest that microindentation method directly measures bone mechanical properties at the tissue level and can detect significant decrease of BMS in MGUS patients, which correlates with a greater risk of fracture. This could be useful to identify MGUS patients that would benefit from early antiresorptive treatment despite a normal DXA.References:1- Drake MT Unveiling skeletal fragility in patients diagnosed with MGUS: no longer a condition of undetermined significance? J Bone Miner Res. 2014:2529-33. 2- Daniel Bridges, Connor Randall, and Paul K. Hansma. A new device for performing reference point indentation without a reference probe. Review of Scientific Instruments.2012;83,044301 3- Randall C, Bridges D, Guerri R, Nogues X, Puig L, Torres E, Mellibovsky L, Hoffseth K, Stalbaum T, Srikanth A, Weaver JC, Rosen S, Barnard H, Brimer D, Proctor A, Candy J, Saldana C, Chandrasekar S, Lescun T, Nielson CM, Orwoll E, Herthel D, Kopeikin H, Yang HT, Farr JN, McCready L, Khosla S, Diez-Perez A, Hansma PK. Applications of a New Handheld Reference Point Indentation Instrument Measuring Bone Material Strength. J Med Device. 2013:410051-56. 4- Mellibovsky L, Prieto-Alhambra D, Mellibovsky F, Güerri-Fernández R, Nogués X, Randall C, Hansma PK, Díez-Perez A. Bone Tissue Properties Measurement by Reference Point Indentation in Glucocorticoid-Induced Osteoporosis.J Bone Miner Res. 2015;30:1651-6
Session topic: E-poster
Keyword(s): Bone mineral density, MGUS
Type: Eposter Presentation
Background
Monoclonal gammopathy of undetermined significance (MGUS) affects over 3% of adults over 50 years old. Previous studies show that MGUS patients experience a significant bone fracture risk increase and that MGUS prevalence is higher in osteoporotic patients (1). The microindentation for in vivo measurement of bone tissue method (2,3) has shown to detect decrease in Bone Material Strength (BMS) even at early stages. These findings correlate with bone fragility and risk of fracture independently of bone mineral density (BMD) (4) measured by bone densitometry (DXA).
Aims
To analyze the BMS by Osteoprobe® microindentation method and the BMD by densitometry in MGUS patients and compare with an age control matched group.
Methods
We have included 22 patients diagnosed with MGUS. An informed consent was obtained and a general laboratory workup was undertaken. BMD measurement at the lumbar spine and hip using DXA (Hologic QDR 4500 SR™, Hologic, Bedford, MA) was performed. BMS determination by inserting a probe assembly through the skin covering the anterior midtibia and applying 20 indentations with an Osteoprobe® (Active Life Scientific Sta Barbara CA) device (3) was done. The results were compared with controls adjusted by sex and age.
Results
MGUS patients present low values of BMS (68.3 ± 5) compared with control group values (83 ± 4, p<0.001). No significant difference was observed in BMD between controls and patients (0.977 vs 0.929 p :0,288 at lumbar spine; 0.783 vs 0.730 p: 0,179 at femoral neck; 0.902 vs 0.898 p: 0,157at total femur).
Conclusion
These results suggest that microindentation method directly measures bone mechanical properties at the tissue level and can detect significant decrease of BMS in MGUS patients, which correlates with a greater risk of fracture. This could be useful to identify MGUS patients that would benefit from early antiresorptive treatment despite a normal DXA.References:1- Drake MT Unveiling skeletal fragility in patients diagnosed with MGUS: no longer a condition of undetermined significance? J Bone Miner Res. 2014:2529-33. 2- Daniel Bridges, Connor Randall, and Paul K. Hansma. A new device for performing reference point indentation without a reference probe. Review of Scientific Instruments.2012;83,044301 3- Randall C, Bridges D, Guerri R, Nogues X, Puig L, Torres E, Mellibovsky L, Hoffseth K, Stalbaum T, Srikanth A, Weaver JC, Rosen S, Barnard H, Brimer D, Proctor A, Candy J, Saldana C, Chandrasekar S, Lescun T, Nielson CM, Orwoll E, Herthel D, Kopeikin H, Yang HT, Farr JN, McCready L, Khosla S, Diez-Perez A, Hansma PK. Applications of a New Handheld Reference Point Indentation Instrument Measuring Bone Material Strength. J Med Device. 2013:410051-56. 4- Mellibovsky L, Prieto-Alhambra D, Mellibovsky F, Güerri-Fernández R, Nogués X, Randall C, Hansma PK, Díez-Perez A. Bone Tissue Properties Measurement by Reference Point Indentation in Glucocorticoid-Induced Osteoporosis.J Bone Miner Res. 2015;30:1651-6
Session topic: E-poster
Keyword(s): Bone mineral density, MGUS
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