A RETROSPECTIVE ANALYSIS ABOUT STENOTROPHOMONAS MALTOPHILIA SEPSIS IN PATIENTS WITH HEMATOLOGICAL MALIGNANCY: A SINGLE CENTER STUDY FOR 12 YEARS
(Abstract release date: 05/19/16)
EHA Library. Asahi M. 06/09/16; 132738; E1189
Dr. Maki Asahi
Contributions
Contributions
Abstract
Abstract: E1189
Type: Eposter Presentation
Background
Febrile neutropenia (FN) is often observed in hematological malignancy. Most of FN cases are infections by various causative agents rarely including antibiotic-resistant bacteria or low virulent bacilli. Stenotrophomonas maltophiria (SM) is a low virulent bacillus widely existing in the environment, a causative agent of opportunistic infection and a rare pathogenic bacteria in FN. Recently, some cases of sepsis by SM were reported in FN with hematological malignancy, and most of them had often very poor prognosis.
Aims
To clarify the prognosis of SM sepsis in FN patients of hematological malignancy, we should perform the surveillance of SM infections sufficiently.
Methods
We reviewed all blood culture data from our single institute from 2004 to 2015, and evaluated retrospectively clinical data of sepsis cases by SM in FN of hematological malignancy.
Results
Total 3490 events of blood cultures (BC) were performed just before the first line antibiotic agent administration was started for FN patients in the Hematology-Oncology unit of our institute from 2004 to 2015. In the 16.4% of these BC events, some kinds of bacteria or fungus were detected. The frequency of BC positive cases for SM were rarely observed in 2.3% of all BC events, and total 15 cases of SM sepsis were diagnosed. The primary diagnosis of hematological disease in those SM sepsis cases were NHL(N=5), AML(N=4), ALL(N=5) and CML(N=1), and almost all of these disease were relapse or refractory cases with many treatments for long duration. SMs detected in 15 cases were widely resistant to many antibiotic agents. Fourteen cases died of MOF, and 9 cases died within 7 days after the finding of BC in spite of intensive care including administration of sensitive antibiotic therapies.
Conclusion
The prognosis of SM sepsis in patients with hematological disease was extremely poor. Surveillance for SM infection in high-risk patients is essential, and rapid administrations of appropriate antibiotics should be considered.
Session topic: E-poster
Keyword(s): Febrile neutropenia, Hematological malignancy
Type: Eposter Presentation
Background
Febrile neutropenia (FN) is often observed in hematological malignancy. Most of FN cases are infections by various causative agents rarely including antibiotic-resistant bacteria or low virulent bacilli. Stenotrophomonas maltophiria (SM) is a low virulent bacillus widely existing in the environment, a causative agent of opportunistic infection and a rare pathogenic bacteria in FN. Recently, some cases of sepsis by SM were reported in FN with hematological malignancy, and most of them had often very poor prognosis.
Aims
To clarify the prognosis of SM sepsis in FN patients of hematological malignancy, we should perform the surveillance of SM infections sufficiently.
Methods
We reviewed all blood culture data from our single institute from 2004 to 2015, and evaluated retrospectively clinical data of sepsis cases by SM in FN of hematological malignancy.
Results
Total 3490 events of blood cultures (BC) were performed just before the first line antibiotic agent administration was started for FN patients in the Hematology-Oncology unit of our institute from 2004 to 2015. In the 16.4% of these BC events, some kinds of bacteria or fungus were detected. The frequency of BC positive cases for SM were rarely observed in 2.3% of all BC events, and total 15 cases of SM sepsis were diagnosed. The primary diagnosis of hematological disease in those SM sepsis cases were NHL(N=5), AML(N=4), ALL(N=5) and CML(N=1), and almost all of these disease were relapse or refractory cases with many treatments for long duration. SMs detected in 15 cases were widely resistant to many antibiotic agents. Fourteen cases died of MOF, and 9 cases died within 7 days after the finding of BC in spite of intensive care including administration of sensitive antibiotic therapies.
Conclusion
The prognosis of SM sepsis in patients with hematological disease was extremely poor. Surveillance for SM infection in high-risk patients is essential, and rapid administrations of appropriate antibiotics should be considered.
Session topic: E-poster
Keyword(s): Febrile neutropenia, Hematological malignancy
Abstract: E1189
Type: Eposter Presentation
Background
Febrile neutropenia (FN) is often observed in hematological malignancy. Most of FN cases are infections by various causative agents rarely including antibiotic-resistant bacteria or low virulent bacilli. Stenotrophomonas maltophiria (SM) is a low virulent bacillus widely existing in the environment, a causative agent of opportunistic infection and a rare pathogenic bacteria in FN. Recently, some cases of sepsis by SM were reported in FN with hematological malignancy, and most of them had often very poor prognosis.
Aims
To clarify the prognosis of SM sepsis in FN patients of hematological malignancy, we should perform the surveillance of SM infections sufficiently.
Methods
We reviewed all blood culture data from our single institute from 2004 to 2015, and evaluated retrospectively clinical data of sepsis cases by SM in FN of hematological malignancy.
Results
Total 3490 events of blood cultures (BC) were performed just before the first line antibiotic agent administration was started for FN patients in the Hematology-Oncology unit of our institute from 2004 to 2015. In the 16.4% of these BC events, some kinds of bacteria or fungus were detected. The frequency of BC positive cases for SM were rarely observed in 2.3% of all BC events, and total 15 cases of SM sepsis were diagnosed. The primary diagnosis of hematological disease in those SM sepsis cases were NHL(N=5), AML(N=4), ALL(N=5) and CML(N=1), and almost all of these disease were relapse or refractory cases with many treatments for long duration. SMs detected in 15 cases were widely resistant to many antibiotic agents. Fourteen cases died of MOF, and 9 cases died within 7 days after the finding of BC in spite of intensive care including administration of sensitive antibiotic therapies.
Conclusion
The prognosis of SM sepsis in patients with hematological disease was extremely poor. Surveillance for SM infection in high-risk patients is essential, and rapid administrations of appropriate antibiotics should be considered.
Session topic: E-poster
Keyword(s): Febrile neutropenia, Hematological malignancy
Type: Eposter Presentation
Background
Febrile neutropenia (FN) is often observed in hematological malignancy. Most of FN cases are infections by various causative agents rarely including antibiotic-resistant bacteria or low virulent bacilli. Stenotrophomonas maltophiria (SM) is a low virulent bacillus widely existing in the environment, a causative agent of opportunistic infection and a rare pathogenic bacteria in FN. Recently, some cases of sepsis by SM were reported in FN with hematological malignancy, and most of them had often very poor prognosis.
Aims
To clarify the prognosis of SM sepsis in FN patients of hematological malignancy, we should perform the surveillance of SM infections sufficiently.
Methods
We reviewed all blood culture data from our single institute from 2004 to 2015, and evaluated retrospectively clinical data of sepsis cases by SM in FN of hematological malignancy.
Results
Total 3490 events of blood cultures (BC) were performed just before the first line antibiotic agent administration was started for FN patients in the Hematology-Oncology unit of our institute from 2004 to 2015. In the 16.4% of these BC events, some kinds of bacteria or fungus were detected. The frequency of BC positive cases for SM were rarely observed in 2.3% of all BC events, and total 15 cases of SM sepsis were diagnosed. The primary diagnosis of hematological disease in those SM sepsis cases were NHL(N=5), AML(N=4), ALL(N=5) and CML(N=1), and almost all of these disease were relapse or refractory cases with many treatments for long duration. SMs detected in 15 cases were widely resistant to many antibiotic agents. Fourteen cases died of MOF, and 9 cases died within 7 days after the finding of BC in spite of intensive care including administration of sensitive antibiotic therapies.
Conclusion
The prognosis of SM sepsis in patients with hematological disease was extremely poor. Surveillance for SM infection in high-risk patients is essential, and rapid administrations of appropriate antibiotics should be considered.
Session topic: E-poster
Keyword(s): Febrile neutropenia, Hematological malignancy
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