EARLY AND RAPID INCREMENT OF CRP AND IL-8 LEVELS TOGETHER WITH FASTER AND DEEPER DECLINING OF LEUKOCYTES PREDICT FOR TYPHLITIS DEVELOPMENT IN TREATED AML PATIENTS.
(Abstract release date: 05/19/16)
EHA Library. Span L. 06/09/16; 132726; E1177
Dr. Lambert Span
Contributions
Contributions
Abstract
Abstract: E1177
Type: Eposter Presentation
Background
Neutropenic enterocolitis (NE) or typhlitis is an important and severe complication in patients with acute myeloid leukemia (AML) receiving intensive chemotherapy.
Aims
In this study we evaluated serum C-reactive protein (CRP), interleukin (IL)-8, fecal calprotectin, and oral mucositis score as possible time-dependent predictors of developing NE.
Methods
Adult patients with AML treated with intensive chemotherapy (with cytarabine) were included. Serum IL-8 and CRP levels were measured daily during 14 days after cessation of chemotherapy, as well as calprotectin in the stool. Oral mucositis was also scored daily. Furthermore, CT scan of the abdomen at day 21 was performed to objectively define patients with NE.
Results
In total, 34 patients were included and 11 episodes of NE were diagnosed. All patients with NE received conservative treatment and only one patient with NE died because of refractory Enterococcus faecium sepsis. From day 5 onward (after cessation of chemotherapy), median IL-8 and CRP levels increased more rapidly to significantly higher levels in patients with NE, whereas white blood cell (WBC) counts decreased faster to significantly lower levels as compared to the non-NE patients. Oral mucositis score and fecal calprotectin levels failed to be different in both groups. Cytarabine dose was of no influence. As was corrected for bacteraemia, no differences were seen between both groups.
Conclusion
Pattern recognition of early and rapidly increasing IL-8 and CRP levels with significantly lower WBC counts after cessation of chemotherapy can identify AML patients developing NE. Early recognition of developing NE can potentially decrease the high mortality rate (25-50%) of this complication.
Session topic: E-poster
Keyword(s): AML, IL-8, Neutropenia
Type: Eposter Presentation
Background
Neutropenic enterocolitis (NE) or typhlitis is an important and severe complication in patients with acute myeloid leukemia (AML) receiving intensive chemotherapy.
Aims
In this study we evaluated serum C-reactive protein (CRP), interleukin (IL)-8, fecal calprotectin, and oral mucositis score as possible time-dependent predictors of developing NE.
Methods
Adult patients with AML treated with intensive chemotherapy (with cytarabine) were included. Serum IL-8 and CRP levels were measured daily during 14 days after cessation of chemotherapy, as well as calprotectin in the stool. Oral mucositis was also scored daily. Furthermore, CT scan of the abdomen at day 21 was performed to objectively define patients with NE.
Results
In total, 34 patients were included and 11 episodes of NE were diagnosed. All patients with NE received conservative treatment and only one patient with NE died because of refractory Enterococcus faecium sepsis. From day 5 onward (after cessation of chemotherapy), median IL-8 and CRP levels increased more rapidly to significantly higher levels in patients with NE, whereas white blood cell (WBC) counts decreased faster to significantly lower levels as compared to the non-NE patients. Oral mucositis score and fecal calprotectin levels failed to be different in both groups. Cytarabine dose was of no influence. As was corrected for bacteraemia, no differences were seen between both groups.
Conclusion
Pattern recognition of early and rapidly increasing IL-8 and CRP levels with significantly lower WBC counts after cessation of chemotherapy can identify AML patients developing NE. Early recognition of developing NE can potentially decrease the high mortality rate (25-50%) of this complication.
Session topic: E-poster
Keyword(s): AML, IL-8, Neutropenia
Abstract: E1177
Type: Eposter Presentation
Background
Neutropenic enterocolitis (NE) or typhlitis is an important and severe complication in patients with acute myeloid leukemia (AML) receiving intensive chemotherapy.
Aims
In this study we evaluated serum C-reactive protein (CRP), interleukin (IL)-8, fecal calprotectin, and oral mucositis score as possible time-dependent predictors of developing NE.
Methods
Adult patients with AML treated with intensive chemotherapy (with cytarabine) were included. Serum IL-8 and CRP levels were measured daily during 14 days after cessation of chemotherapy, as well as calprotectin in the stool. Oral mucositis was also scored daily. Furthermore, CT scan of the abdomen at day 21 was performed to objectively define patients with NE.
Results
In total, 34 patients were included and 11 episodes of NE were diagnosed. All patients with NE received conservative treatment and only one patient with NE died because of refractory Enterococcus faecium sepsis. From day 5 onward (after cessation of chemotherapy), median IL-8 and CRP levels increased more rapidly to significantly higher levels in patients with NE, whereas white blood cell (WBC) counts decreased faster to significantly lower levels as compared to the non-NE patients. Oral mucositis score and fecal calprotectin levels failed to be different in both groups. Cytarabine dose was of no influence. As was corrected for bacteraemia, no differences were seen between both groups.
Conclusion
Pattern recognition of early and rapidly increasing IL-8 and CRP levels with significantly lower WBC counts after cessation of chemotherapy can identify AML patients developing NE. Early recognition of developing NE can potentially decrease the high mortality rate (25-50%) of this complication.
Session topic: E-poster
Keyword(s): AML, IL-8, Neutropenia
Type: Eposter Presentation
Background
Neutropenic enterocolitis (NE) or typhlitis is an important and severe complication in patients with acute myeloid leukemia (AML) receiving intensive chemotherapy.
Aims
In this study we evaluated serum C-reactive protein (CRP), interleukin (IL)-8, fecal calprotectin, and oral mucositis score as possible time-dependent predictors of developing NE.
Methods
Adult patients with AML treated with intensive chemotherapy (with cytarabine) were included. Serum IL-8 and CRP levels were measured daily during 14 days after cessation of chemotherapy, as well as calprotectin in the stool. Oral mucositis was also scored daily. Furthermore, CT scan of the abdomen at day 21 was performed to objectively define patients with NE.
Results
In total, 34 patients were included and 11 episodes of NE were diagnosed. All patients with NE received conservative treatment and only one patient with NE died because of refractory Enterococcus faecium sepsis. From day 5 onward (after cessation of chemotherapy), median IL-8 and CRP levels increased more rapidly to significantly higher levels in patients with NE, whereas white blood cell (WBC) counts decreased faster to significantly lower levels as compared to the non-NE patients. Oral mucositis score and fecal calprotectin levels failed to be different in both groups. Cytarabine dose was of no influence. As was corrected for bacteraemia, no differences were seen between both groups.
Conclusion
Pattern recognition of early and rapidly increasing IL-8 and CRP levels with significantly lower WBC counts after cessation of chemotherapy can identify AML patients developing NE. Early recognition of developing NE can potentially decrease the high mortality rate (25-50%) of this complication.
Session topic: E-poster
Keyword(s): AML, IL-8, Neutropenia
{{ help_message }}
{{filter}}