PERIPHERAL BLOOD LEUKOCYTE TELOMERE LENGTH AND RISK OF INFECTIOUS DISEASE: A PROSPECTIVE STUDY OF 75,919 INDIVIDUALS FROM THE GENERAL POPULATION
(Abstract release date: 05/19/16)
EHA Library. Petersen J. 06/09/16; 132678; E1129
Dr. Jens Helby Petersen
Contributions
Contributions
Abstract
Abstract: E1129
Type: Eposter Presentation
Background
In the general population, older age is associated with short leukocyte telomere length and with high risk of infections. In a recent study of allogeneic hematopoietic cell transplantation for severe aplastic anemia, long donor leukocyte telomere length was associated with improved long-term survival in the recipients. These findings suggest that leukocyte telomere length could possibly be a marker of overall immune competence. However, previous studies examining this hypothesis among individuals from the general population have produced conflicting results.
Aims
We tested the hypothesis that short telomere length in leukocytes is associated with high risk of infectious disease hospitalization.
Methods
Peripheral blood leukocyte telomere length was measured using quantitative polymerase chain reaction in 75,919 individuals from the general population. The participants were followed for up to 23 years.
Results
During follow-up, 9671 individuals were hospitalized due to infections. Short telomere length was associated with high risk of any infection (hazard ratio 1.05 per 1000 base pair shorter telomeres; 95% confidence interval 1.03-1.08), pneumonia (1.08;1.04-1.12) and endocarditis (1.32;1.06-1.66) after adjustment for other infectious disease risk factors. Telomere length was not associated with risk of skin infection, urinary tract infection, sepsis, diarrhoeal disease, meningitis or other infections.
Conclusion
Short leukocyte telomere length was associated with high risk of any infection, pneumonia and endocarditis. These findings indicate that leucocyte telomere length may be a marker of immune competence among individuals from the general population. Further studies are needed to determine whether risk of infections in allogeneic hematopoietic cell transplant recipients can be reduced by considering donor leukocyte telomere length when selecting donors.
Session topic: E-poster
Keyword(s): Donor, Infection, Stem cell transplant, Telomere length
Type: Eposter Presentation
Background
In the general population, older age is associated with short leukocyte telomere length and with high risk of infections. In a recent study of allogeneic hematopoietic cell transplantation for severe aplastic anemia, long donor leukocyte telomere length was associated with improved long-term survival in the recipients. These findings suggest that leukocyte telomere length could possibly be a marker of overall immune competence. However, previous studies examining this hypothesis among individuals from the general population have produced conflicting results.
Aims
We tested the hypothesis that short telomere length in leukocytes is associated with high risk of infectious disease hospitalization.
Methods
Peripheral blood leukocyte telomere length was measured using quantitative polymerase chain reaction in 75,919 individuals from the general population. The participants were followed for up to 23 years.
Results
During follow-up, 9671 individuals were hospitalized due to infections. Short telomere length was associated with high risk of any infection (hazard ratio 1.05 per 1000 base pair shorter telomeres; 95% confidence interval 1.03-1.08), pneumonia (1.08;1.04-1.12) and endocarditis (1.32;1.06-1.66) after adjustment for other infectious disease risk factors. Telomere length was not associated with risk of skin infection, urinary tract infection, sepsis, diarrhoeal disease, meningitis or other infections.
Conclusion
Short leukocyte telomere length was associated with high risk of any infection, pneumonia and endocarditis. These findings indicate that leucocyte telomere length may be a marker of immune competence among individuals from the general population. Further studies are needed to determine whether risk of infections in allogeneic hematopoietic cell transplant recipients can be reduced by considering donor leukocyte telomere length when selecting donors.
Session topic: E-poster
Keyword(s): Donor, Infection, Stem cell transplant, Telomere length
Abstract: E1129
Type: Eposter Presentation
Background
In the general population, older age is associated with short leukocyte telomere length and with high risk of infections. In a recent study of allogeneic hematopoietic cell transplantation for severe aplastic anemia, long donor leukocyte telomere length was associated with improved long-term survival in the recipients. These findings suggest that leukocyte telomere length could possibly be a marker of overall immune competence. However, previous studies examining this hypothesis among individuals from the general population have produced conflicting results.
Aims
We tested the hypothesis that short telomere length in leukocytes is associated with high risk of infectious disease hospitalization.
Methods
Peripheral blood leukocyte telomere length was measured using quantitative polymerase chain reaction in 75,919 individuals from the general population. The participants were followed for up to 23 years.
Results
During follow-up, 9671 individuals were hospitalized due to infections. Short telomere length was associated with high risk of any infection (hazard ratio 1.05 per 1000 base pair shorter telomeres; 95% confidence interval 1.03-1.08), pneumonia (1.08;1.04-1.12) and endocarditis (1.32;1.06-1.66) after adjustment for other infectious disease risk factors. Telomere length was not associated with risk of skin infection, urinary tract infection, sepsis, diarrhoeal disease, meningitis or other infections.
Conclusion
Short leukocyte telomere length was associated with high risk of any infection, pneumonia and endocarditis. These findings indicate that leucocyte telomere length may be a marker of immune competence among individuals from the general population. Further studies are needed to determine whether risk of infections in allogeneic hematopoietic cell transplant recipients can be reduced by considering donor leukocyte telomere length when selecting donors.
Session topic: E-poster
Keyword(s): Donor, Infection, Stem cell transplant, Telomere length
Type: Eposter Presentation
Background
In the general population, older age is associated with short leukocyte telomere length and with high risk of infections. In a recent study of allogeneic hematopoietic cell transplantation for severe aplastic anemia, long donor leukocyte telomere length was associated with improved long-term survival in the recipients. These findings suggest that leukocyte telomere length could possibly be a marker of overall immune competence. However, previous studies examining this hypothesis among individuals from the general population have produced conflicting results.
Aims
We tested the hypothesis that short telomere length in leukocytes is associated with high risk of infectious disease hospitalization.
Methods
Peripheral blood leukocyte telomere length was measured using quantitative polymerase chain reaction in 75,919 individuals from the general population. The participants were followed for up to 23 years.
Results
During follow-up, 9671 individuals were hospitalized due to infections. Short telomere length was associated with high risk of any infection (hazard ratio 1.05 per 1000 base pair shorter telomeres; 95% confidence interval 1.03-1.08), pneumonia (1.08;1.04-1.12) and endocarditis (1.32;1.06-1.66) after adjustment for other infectious disease risk factors. Telomere length was not associated with risk of skin infection, urinary tract infection, sepsis, diarrhoeal disease, meningitis or other infections.
Conclusion
Short leukocyte telomere length was associated with high risk of any infection, pneumonia and endocarditis. These findings indicate that leucocyte telomere length may be a marker of immune competence among individuals from the general population. Further studies are needed to determine whether risk of infections in allogeneic hematopoietic cell transplant recipients can be reduced by considering donor leukocyte telomere length when selecting donors.
Session topic: E-poster
Keyword(s): Donor, Infection, Stem cell transplant, Telomere length
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