DOES TIMING OF CENTRAL VENOUS LINE REPLACEMENT MATTER DURING INDUCTION IN CHILDREN WITH ACUTE LYMPHOBLASTIC LEUKEMIA?
(Abstract release date: 05/19/16)
EHA Library. Ataseven E. 06/09/16; 132424; E875
Dr. Eda Ataseven
Contributions
Contributions
Abstract
Abstract: E875
Type: Eposter Presentation
Background
The use of central venous lines (CVL) in children with acute lymphoblastic leukemia (ALL) provides comfortable administration of intensive chemotherapy and blood sampling. The optimal time for insertion of CVL in patients with ALL is controversial.
Aims
The aim of this study is to define the frequency of CVL related complications and also to analyse the frequency of cases of catheter related infection and thrombosis in relation to timing of CVL replacement.
Methods
We reviewed the records of 52 pediatric ALL patients with CVL treated during a 10-year period. Demographics, preoperative blood counts, type of central line, time of CVL replacement, CVL related complications, and blood counts during complications were all noted. All the data were collected from those with the first catheter use.
Results
Fifty two pediatric ALL patients (29 male, 23 female) with a median age of 6,1 years were included in the study. Most of the patients (92.3%) had an internal line (port). CVL was replaced before treatment day 15 (early) in twenty six patients (50%) and after 15 days (late) in 26 patients (50%). Systemic infections occurred in 24 patients (46.2%). Regarding the infection rates, no difference was found between early and late CVL replacement (p=0.09). Most of the infections (68%) were due to coagulase negative Staphylococcus aureus. The median absolute neutrophil count during infections was 150/mm³ (0/mm³ to 17,700/mm³). There were three patients with thrombosis and no difference was found between early and late insertion of CVL replacement groups (p=0.35). Other catheter related complications was recorded in seven patients (leakage in one patient, accidental removal of line in one patient, line rupture in one patient, and line occlusion in four patients). CVLs had to be removed in seventeen patients (32.7%) before the end of chemotherapy protocol due to various reasons (catheter related infections in six patients, local skin infections in four patients, and other catheter related complications in seven patients).
Conclusion
The present study showed no relation between the timing of catheter replacement and occurrence of infection and thrombosis. Our results suggest CVLs can be replaced safely at the time of diagnosis or early period of treatment to provide a comfortable administration of chemotherapy and to decrease painful blood samplings.
Session topic: E-poster
Keyword(s): ALL, Catheter-related thrombosis, Central venous catheter
Type: Eposter Presentation
Background
The use of central venous lines (CVL) in children with acute lymphoblastic leukemia (ALL) provides comfortable administration of intensive chemotherapy and blood sampling. The optimal time for insertion of CVL in patients with ALL is controversial.
Aims
The aim of this study is to define the frequency of CVL related complications and also to analyse the frequency of cases of catheter related infection and thrombosis in relation to timing of CVL replacement.
Methods
We reviewed the records of 52 pediatric ALL patients with CVL treated during a 10-year period. Demographics, preoperative blood counts, type of central line, time of CVL replacement, CVL related complications, and blood counts during complications were all noted. All the data were collected from those with the first catheter use.
Results
Fifty two pediatric ALL patients (29 male, 23 female) with a median age of 6,1 years were included in the study. Most of the patients (92.3%) had an internal line (port). CVL was replaced before treatment day 15 (early) in twenty six patients (50%) and after 15 days (late) in 26 patients (50%). Systemic infections occurred in 24 patients (46.2%). Regarding the infection rates, no difference was found between early and late CVL replacement (p=0.09). Most of the infections (68%) were due to coagulase negative Staphylococcus aureus. The median absolute neutrophil count during infections was 150/mm³ (0/mm³ to 17,700/mm³). There were three patients with thrombosis and no difference was found between early and late insertion of CVL replacement groups (p=0.35). Other catheter related complications was recorded in seven patients (leakage in one patient, accidental removal of line in one patient, line rupture in one patient, and line occlusion in four patients). CVLs had to be removed in seventeen patients (32.7%) before the end of chemotherapy protocol due to various reasons (catheter related infections in six patients, local skin infections in four patients, and other catheter related complications in seven patients).
Conclusion
The present study showed no relation between the timing of catheter replacement and occurrence of infection and thrombosis. Our results suggest CVLs can be replaced safely at the time of diagnosis or early period of treatment to provide a comfortable administration of chemotherapy and to decrease painful blood samplings.
Session topic: E-poster
Keyword(s): ALL, Catheter-related thrombosis, Central venous catheter
Abstract: E875
Type: Eposter Presentation
Background
The use of central venous lines (CVL) in children with acute lymphoblastic leukemia (ALL) provides comfortable administration of intensive chemotherapy and blood sampling. The optimal time for insertion of CVL in patients with ALL is controversial.
Aims
The aim of this study is to define the frequency of CVL related complications and also to analyse the frequency of cases of catheter related infection and thrombosis in relation to timing of CVL replacement.
Methods
We reviewed the records of 52 pediatric ALL patients with CVL treated during a 10-year period. Demographics, preoperative blood counts, type of central line, time of CVL replacement, CVL related complications, and blood counts during complications were all noted. All the data were collected from those with the first catheter use.
Results
Fifty two pediatric ALL patients (29 male, 23 female) with a median age of 6,1 years were included in the study. Most of the patients (92.3%) had an internal line (port). CVL was replaced before treatment day 15 (early) in twenty six patients (50%) and after 15 days (late) in 26 patients (50%). Systemic infections occurred in 24 patients (46.2%). Regarding the infection rates, no difference was found between early and late CVL replacement (p=0.09). Most of the infections (68%) were due to coagulase negative Staphylococcus aureus. The median absolute neutrophil count during infections was 150/mm³ (0/mm³ to 17,700/mm³). There were three patients with thrombosis and no difference was found between early and late insertion of CVL replacement groups (p=0.35). Other catheter related complications was recorded in seven patients (leakage in one patient, accidental removal of line in one patient, line rupture in one patient, and line occlusion in four patients). CVLs had to be removed in seventeen patients (32.7%) before the end of chemotherapy protocol due to various reasons (catheter related infections in six patients, local skin infections in four patients, and other catheter related complications in seven patients).
Conclusion
The present study showed no relation between the timing of catheter replacement and occurrence of infection and thrombosis. Our results suggest CVLs can be replaced safely at the time of diagnosis or early period of treatment to provide a comfortable administration of chemotherapy and to decrease painful blood samplings.
Session topic: E-poster
Keyword(s): ALL, Catheter-related thrombosis, Central venous catheter
Type: Eposter Presentation
Background
The use of central venous lines (CVL) in children with acute lymphoblastic leukemia (ALL) provides comfortable administration of intensive chemotherapy and blood sampling. The optimal time for insertion of CVL in patients with ALL is controversial.
Aims
The aim of this study is to define the frequency of CVL related complications and also to analyse the frequency of cases of catheter related infection and thrombosis in relation to timing of CVL replacement.
Methods
We reviewed the records of 52 pediatric ALL patients with CVL treated during a 10-year period. Demographics, preoperative blood counts, type of central line, time of CVL replacement, CVL related complications, and blood counts during complications were all noted. All the data were collected from those with the first catheter use.
Results
Fifty two pediatric ALL patients (29 male, 23 female) with a median age of 6,1 years were included in the study. Most of the patients (92.3%) had an internal line (port). CVL was replaced before treatment day 15 (early) in twenty six patients (50%) and after 15 days (late) in 26 patients (50%). Systemic infections occurred in 24 patients (46.2%). Regarding the infection rates, no difference was found between early and late CVL replacement (p=0.09). Most of the infections (68%) were due to coagulase negative Staphylococcus aureus. The median absolute neutrophil count during infections was 150/mm³ (0/mm³ to 17,700/mm³). There were three patients with thrombosis and no difference was found between early and late insertion of CVL replacement groups (p=0.35). Other catheter related complications was recorded in seven patients (leakage in one patient, accidental removal of line in one patient, line rupture in one patient, and line occlusion in four patients). CVLs had to be removed in seventeen patients (32.7%) before the end of chemotherapy protocol due to various reasons (catheter related infections in six patients, local skin infections in four patients, and other catheter related complications in seven patients).
Conclusion
The present study showed no relation between the timing of catheter replacement and occurrence of infection and thrombosis. Our results suggest CVLs can be replaced safely at the time of diagnosis or early period of treatment to provide a comfortable administration of chemotherapy and to decrease painful blood samplings.
Session topic: E-poster
Keyword(s): ALL, Catheter-related thrombosis, Central venous catheter
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