EHA Library - The official digital education library of European Hematology Association (EHA)

Unraveling the molecular biology of normal karyotype AML
EHA Library. Vassiliou G. 06/14/15; 103568 Topic: 2B Acute myeloid leukemia (AML) and leukemias of ambiguous lineage
Disclosure(s): Kymab (consultant & stockholder) Celgene (research grant)
Wellcome Trust Sanger Institute
Dr. George Vassiliou
Dr. George Vassiliou
Learning Objectives
After viewing this presentation the participant will be able to:
− Recognize the spectrum and molecular groups of mutations driving AML-NK and related myeloid neoplasms.
− Appreciate the pre-clinical clonal evolution and subclonal structure of AML-NK.
− Understand the known molecular effects of the most common mutations and how these promote leukemogenesis alone and in collaboration.
− Identify the prognostic impact and therapeutic implications of particular mutations.

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