THE INFLUENCE OF HAPLOTYPE HLA-BW4 IN EVOLUTION AFTER HSCT
(Abstract release date: 05/21/15)
EHA Library. Bratu D. 06/12/15; 103032; PB2041
Disclosure(s): Clinical Institute FundeniHaematology
Dr. Denisa Bratu
Contributions
Contributions
Abstract
Abstract: PB2041
Type: Publication Only
Background
Continuing to study haplotypes of patients like ligands for inhibitories and activatories donors KIR allele in HSCT,it is an evidence that haplotypes can be protective or not against postHSCT complication,like ligand or not.
Aims
Haplotype HLA-BW4 is described in literature like,,bad,, haplotype.We try to demonstrate the influence of this haplotype at patients with acute leukemia after HSCT.
Methods
Eighteen pairs patients-donors are evaluated :patients with acute leukemia,lymphoblastic and non-lymphoblastic and their genoidentics donors.Eleven patients have HLA-BW4 haplotype,seven HLA-BW6(absence of HLA-BW4) Following the impact of inhibitory KIR3DL1 and activatory KIR3DS1 on survival and complication development,we proved the protective effect of absence of HLA-BW4 haplotype,HLA-BW6,respectively.The source of HSCT was PBSC.The method used was PCR-SSP (Innotrain DIAGNOSTIK GMBH,Dynal BIOTECH PEL-FREEZE )The complications like graft versus host disease acute and chronic,relapse,TMA and the recovery with leucocytes and thrombocytes are followed
Results
Absence of HLA-BW4 haplotype(HLA-BW6,respectively) is protective for both types of leukemia,the patients survival is 100% in presence of KIR3DS1(activatory allele) and with statistical significance(sig<0,05) and 83% in presence of KIR3DL1(inhibitory allele)Is protective against relapse,TMA,aGVHD, leucocytes and thromboytes recovery,with statistical significance in presence of KIR3DS4,and also in presence of KIR3DL1 is protective against aGVHD,TMA and relapse,also thrombocytes recovery,without statistical significance.
Summary
Absence of HLA-BW4 improve survival and protect against most complication at patients with acute leukemia and related donors with 100% allele match,in presence of both types of KIR alleles and confirme the ”missing ” ligand theory.
Keyword(s): Haplotype, HLA, HSCT, Killer immunoglobulin receptors (KIR)
Session topic: Publication Only
Type: Publication Only
Background
Continuing to study haplotypes of patients like ligands for inhibitories and activatories donors KIR allele in HSCT,it is an evidence that haplotypes can be protective or not against postHSCT complication,like ligand or not.
Aims
Haplotype HLA-BW4 is described in literature like,,bad,, haplotype.We try to demonstrate the influence of this haplotype at patients with acute leukemia after HSCT.
Methods
Eighteen pairs patients-donors are evaluated :patients with acute leukemia,lymphoblastic and non-lymphoblastic and their genoidentics donors.Eleven patients have HLA-BW4 haplotype,seven HLA-BW6(absence of HLA-BW4) Following the impact of inhibitory KIR3DL1 and activatory KIR3DS1 on survival and complication development,we proved the protective effect of absence of HLA-BW4 haplotype,HLA-BW6,respectively.The source of HSCT was PBSC.The method used was PCR-SSP (Innotrain DIAGNOSTIK GMBH,Dynal BIOTECH PEL-FREEZE )The complications like graft versus host disease acute and chronic,relapse,TMA and the recovery with leucocytes and thrombocytes are followed
Results
Absence of HLA-BW4 haplotype(HLA-BW6,respectively) is protective for both types of leukemia,the patients survival is 100% in presence of KIR3DS1(activatory allele) and with statistical significance(sig<0,05) and 83% in presence of KIR3DL1(inhibitory allele)Is protective against relapse,TMA,aGVHD, leucocytes and thromboytes recovery,with statistical significance in presence of KIR3DS4,and also in presence of KIR3DL1 is protective against aGVHD,TMA and relapse,also thrombocytes recovery,without statistical significance.
Summary
Absence of HLA-BW4 improve survival and protect against most complication at patients with acute leukemia and related donors with 100% allele match,in presence of both types of KIR alleles and confirme the ”missing ” ligand theory.
Keyword(s): Haplotype, HLA, HSCT, Killer immunoglobulin receptors (KIR)
Session topic: Publication Only
Abstract: PB2041
Type: Publication Only
Background
Continuing to study haplotypes of patients like ligands for inhibitories and activatories donors KIR allele in HSCT,it is an evidence that haplotypes can be protective or not against postHSCT complication,like ligand or not.
Aims
Haplotype HLA-BW4 is described in literature like,,bad,, haplotype.We try to demonstrate the influence of this haplotype at patients with acute leukemia after HSCT.
Methods
Eighteen pairs patients-donors are evaluated :patients with acute leukemia,lymphoblastic and non-lymphoblastic and their genoidentics donors.Eleven patients have HLA-BW4 haplotype,seven HLA-BW6(absence of HLA-BW4) Following the impact of inhibitory KIR3DL1 and activatory KIR3DS1 on survival and complication development,we proved the protective effect of absence of HLA-BW4 haplotype,HLA-BW6,respectively.The source of HSCT was PBSC.The method used was PCR-SSP (Innotrain DIAGNOSTIK GMBH,Dynal BIOTECH PEL-FREEZE )The complications like graft versus host disease acute and chronic,relapse,TMA and the recovery with leucocytes and thrombocytes are followed
Results
Absence of HLA-BW4 haplotype(HLA-BW6,respectively) is protective for both types of leukemia,the patients survival is 100% in presence of KIR3DS1(activatory allele) and with statistical significance(sig<0,05) and 83% in presence of KIR3DL1(inhibitory allele)Is protective against relapse,TMA,aGVHD, leucocytes and thromboytes recovery,with statistical significance in presence of KIR3DS4,and also in presence of KIR3DL1 is protective against aGVHD,TMA and relapse,also thrombocytes recovery,without statistical significance.
Summary
Absence of HLA-BW4 improve survival and protect against most complication at patients with acute leukemia and related donors with 100% allele match,in presence of both types of KIR alleles and confirme the ”missing ” ligand theory.
Keyword(s): Haplotype, HLA, HSCT, Killer immunoglobulin receptors (KIR)
Session topic: Publication Only
Type: Publication Only
Background
Continuing to study haplotypes of patients like ligands for inhibitories and activatories donors KIR allele in HSCT,it is an evidence that haplotypes can be protective or not against postHSCT complication,like ligand or not.
Aims
Haplotype HLA-BW4 is described in literature like,,bad,, haplotype.We try to demonstrate the influence of this haplotype at patients with acute leukemia after HSCT.
Methods
Eighteen pairs patients-donors are evaluated :patients with acute leukemia,lymphoblastic and non-lymphoblastic and their genoidentics donors.Eleven patients have HLA-BW4 haplotype,seven HLA-BW6(absence of HLA-BW4) Following the impact of inhibitory KIR3DL1 and activatory KIR3DS1 on survival and complication development,we proved the protective effect of absence of HLA-BW4 haplotype,HLA-BW6,respectively.The source of HSCT was PBSC.The method used was PCR-SSP (Innotrain DIAGNOSTIK GMBH,Dynal BIOTECH PEL-FREEZE )The complications like graft versus host disease acute and chronic,relapse,TMA and the recovery with leucocytes and thrombocytes are followed
Results
Absence of HLA-BW4 haplotype(HLA-BW6,respectively) is protective for both types of leukemia,the patients survival is 100% in presence of KIR3DS1(activatory allele) and with statistical significance(sig<0,05) and 83% in presence of KIR3DL1(inhibitory allele)Is protective against relapse,TMA,aGVHD, leucocytes and thromboytes recovery,with statistical significance in presence of KIR3DS4,and also in presence of KIR3DL1 is protective against aGVHD,TMA and relapse,also thrombocytes recovery,without statistical significance.
Summary
Absence of HLA-BW4 improve survival and protect against most complication at patients with acute leukemia and related donors with 100% allele match,in presence of both types of KIR alleles and confirme the ”missing ” ligand theory.
Keyword(s): Haplotype, HLA, HSCT, Killer immunoglobulin receptors (KIR)
Session topic: Publication Only
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