Pediatric Hematology
Contributions
Type: Publication Only
Background
Sinus vein thrombosis is a type of stroke and a multifactorial disease that usually manifested by non-specific symptoms in children.In most cases there is an underlying prothrombotic risk factors or a combination of many clinical reasons. The prevalence of antithrombin III deficiency in patients with thrombosis incidence is 0.02%, as this rate in normal populations is 1% .In this article, we will discuss a case with antithrombin III deficiency that he do not receive the standard heparin treatment. A twenty years old male patient with sudden onset of headache, dizziness, nausea and vomiting was admitted to our clinic.His physical examination and vital findings were stable. His cranial MRI showed thrombosis of superior sagittal sinus and the left transverse and sigmoid sinuses.Clexane(enoxaparin) started 2x1 mg/kg/daily and contunied for 15 days.There was not any recanalization in the thrombosis veins on his repeated cranial MRI after the 15 days treatment.The patient's anti-thrombin III activity was 34.8% as other normal thrombophilia tests. Antithrombin III deficiency was diagnosed. Coumadin(warfarin) treatment was started due to ineffective low molecular weight heparins. The possibility of antithrombin III deficiency should be considered when a low molecular weight heparin therapy is not effective in the follow up patients with the diagnosis of thrombosis.
Sinus vein thrombosis is a type of stroke and a multifactorial disease that usually manifested by non-specific symptoms in children.In most cases there is an underlying prothrombotic risk factors or a combination of many clinical reasons.
Aims
The prevalence of antithrombin III deficiency in patients with thrombosis incidence is 0.02%, as this rate in normal populations is 1% .In this article, we will discuss a case with antithrombin III deficiency that he do not receive the standard heparin treatment.
Methods
A twelve years old male patient with sudden onset of headache, dizziness, nausea and vomiting was admitted to our clinic.His physical examination and vital findings were stable. His cranial MRI showed thrombosis of superior sagittal sinus and the left transverse and sigmoid sinuses.Clexane(enoxaparin) started 2x1 mg/kg/daily and contunied for 15 days.There was not any recanalization in the thrombosis veins on his repeated cranial MRI after the 15 days treatment.The patient's anti-thrombin III activity was 34.8% as other normal thrombophilia tests. Antithrombin III deficiency was diagnosed.
Results
Antithrombin III deficiency was diagnosed. Coumadin(warfarin) treatment was started due to ineffective low molecular weight heparins.
Summary
The possibility of antithrombin III deficiency should be considered when a low molecular weight heparin therapy is not effective in the follow up patients with the diagnosis of thrombosis.
Keyword(s): Children, Heparin, Thrombosis
Session topic: Publication Only
Type: Publication Only
Background
Sinus vein thrombosis is a type of stroke and a multifactorial disease that usually manifested by non-specific symptoms in children.In most cases there is an underlying prothrombotic risk factors or a combination of many clinical reasons. The prevalence of antithrombin III deficiency in patients with thrombosis incidence is 0.02%, as this rate in normal populations is 1% .In this article, we will discuss a case with antithrombin III deficiency that he do not receive the standard heparin treatment. A twenty years old male patient with sudden onset of headache, dizziness, nausea and vomiting was admitted to our clinic.His physical examination and vital findings were stable. His cranial MRI showed thrombosis of superior sagittal sinus and the left transverse and sigmoid sinuses.Clexane(enoxaparin) started 2x1 mg/kg/daily and contunied for 15 days.There was not any recanalization in the thrombosis veins on his repeated cranial MRI after the 15 days treatment.The patient's anti-thrombin III activity was 34.8% as other normal thrombophilia tests. Antithrombin III deficiency was diagnosed. Coumadin(warfarin) treatment was started due to ineffective low molecular weight heparins. The possibility of antithrombin III deficiency should be considered when a low molecular weight heparin therapy is not effective in the follow up patients with the diagnosis of thrombosis.
Sinus vein thrombosis is a type of stroke and a multifactorial disease that usually manifested by non-specific symptoms in children.In most cases there is an underlying prothrombotic risk factors or a combination of many clinical reasons.
Aims
The prevalence of antithrombin III deficiency in patients with thrombosis incidence is 0.02%, as this rate in normal populations is 1% .In this article, we will discuss a case with antithrombin III deficiency that he do not receive the standard heparin treatment.
Methods
A twelve years old male patient with sudden onset of headache, dizziness, nausea and vomiting was admitted to our clinic.His physical examination and vital findings were stable. His cranial MRI showed thrombosis of superior sagittal sinus and the left transverse and sigmoid sinuses.Clexane(enoxaparin) started 2x1 mg/kg/daily and contunied for 15 days.There was not any recanalization in the thrombosis veins on his repeated cranial MRI after the 15 days treatment.The patient's anti-thrombin III activity was 34.8% as other normal thrombophilia tests. Antithrombin III deficiency was diagnosed.
Results
Antithrombin III deficiency was diagnosed. Coumadin(warfarin) treatment was started due to ineffective low molecular weight heparins.
Summary
The possibility of antithrombin III deficiency should be considered when a low molecular weight heparin therapy is not effective in the follow up patients with the diagnosis of thrombosis.
Keyword(s): Children, Heparin, Thrombosis
Session topic: Publication Only