THE EVALUATION OF FEBRILE NEUTROPENIA EPISODES IN CHILDHOOD MALIGNANCY; SINGLE CENTER EXPERIENCE
(Abstract release date: 05/21/15)
EHA Library. Toret E. 06/12/15; 102984; PB1799
Disclosure(s): Izmir Dr Behcet Uz hospitalpediatric hematology-oncology
Ersin Toret
Contributions
Contributions
Abstract
Abstract: PB1799
Type: Publication Only
Background
Febrile neutropenia (FN) is an oncologic emergency that may cause serious complications or death. Rapidly diagnosis and empirical antimicrobial therapy can decrease morbidity and mortality in FN. Agents for empirical therapy have choosen by clinicians must be bacterisidal, broad-spectrum and least toxic. Guidelines and current studies have anticipated about high risk factors and empirical therapy in FN.
Aims
To evaluation of febrile neutropenia episodes (FNEs) in our clinic is aimed in current study.
Methods
We retrospectively analyzed data of 131 FNEs of 48 patients who were admitted to the Pediatric Hematology and Oncology Department of Dr. Behçet Uz Children’s Hospital, Izmir, Turkey between January 2012 and March2014.
Results
The median age at diagnosis of FNEs was 7.4years (3 months - 17 years). Thirty-two of the 48 patients were male and 16 were female. The diagnosis were leukemia at 31, lymphoma at 2 and solid tumor at 15 of patients. Seventy-four per cent of 131 FNEs were determined in patients with leukemia. Focus of clinical infection were determined in 78% of episodes. The distribution of infection’s focus were shown at figure 1. Thirty of FNEs (23%) were documented microbiologically and 60% of them were gram negative bacteria, 30% of them were gram positive bacteria and 10% of them were fungus. Empirical antibiotherapy was applied with monotherapy in 28% of episodes as monotherapy with piperacillin-tazobactam. Piperacillin-tazobactam was also used in 47% of FNEs as duotherapy with aminoglycosides. Other empirical antibitherapy choose were 16% meropenem and 9% cefoperasone-sulbactam. Empirical antifungal was applied in 10% of episodes. Modification of therapy was made as adding antibiotics in 37% (adding aminoglycoside or glycopeptide) or changing antibiotics in 22% (changing to meropeneme) of FNEs. Fourty-eight per cent of FNEs had got response with monotherapy or duotherapy like controlled fever with clinical stabilization. Fever control was provided in 72% of episodes in first 72 hours and also in 83% of episodes in 5 days. Two of 48 patients (4%) were died during neutropenic fever due to pneumonia.
Summary
This study presents clinical findings of patients with FN in childhood malignancy at single center. FNEs were the most in leukemia than the other malignancy. In current study, we identified that we modificated to therapy in FNEs and this value is higher then expected. Even so, fever control rate of us was successfull in FNEs for initial 5 days. This study will contribute to rapidly and efficacious empirical therapy can decrease morbidity and mortality in FNEs.
Keyword(s): Febrile neutropenia
Session topic: Publication Only
Type: Publication Only
Background
Febrile neutropenia (FN) is an oncologic emergency that may cause serious complications or death. Rapidly diagnosis and empirical antimicrobial therapy can decrease morbidity and mortality in FN. Agents for empirical therapy have choosen by clinicians must be bacterisidal, broad-spectrum and least toxic. Guidelines and current studies have anticipated about high risk factors and empirical therapy in FN.
Aims
To evaluation of febrile neutropenia episodes (FNEs) in our clinic is aimed in current study.
Methods
We retrospectively analyzed data of 131 FNEs of 48 patients who were admitted to the Pediatric Hematology and Oncology Department of Dr. Behçet Uz Children’s Hospital, Izmir, Turkey between January 2012 and March2014.
Results
The median age at diagnosis of FNEs was 7.4years (3 months - 17 years). Thirty-two of the 48 patients were male and 16 were female. The diagnosis were leukemia at 31, lymphoma at 2 and solid tumor at 15 of patients. Seventy-four per cent of 131 FNEs were determined in patients with leukemia. Focus of clinical infection were determined in 78% of episodes. The distribution of infection’s focus were shown at figure 1. Thirty of FNEs (23%) were documented microbiologically and 60% of them were gram negative bacteria, 30% of them were gram positive bacteria and 10% of them were fungus. Empirical antibiotherapy was applied with monotherapy in 28% of episodes as monotherapy with piperacillin-tazobactam. Piperacillin-tazobactam was also used in 47% of FNEs as duotherapy with aminoglycosides. Other empirical antibitherapy choose were 16% meropenem and 9% cefoperasone-sulbactam. Empirical antifungal was applied in 10% of episodes. Modification of therapy was made as adding antibiotics in 37% (adding aminoglycoside or glycopeptide) or changing antibiotics in 22% (changing to meropeneme) of FNEs. Fourty-eight per cent of FNEs had got response with monotherapy or duotherapy like controlled fever with clinical stabilization. Fever control was provided in 72% of episodes in first 72 hours and also in 83% of episodes in 5 days. Two of 48 patients (4%) were died during neutropenic fever due to pneumonia.
Summary
This study presents clinical findings of patients with FN in childhood malignancy at single center. FNEs were the most in leukemia than the other malignancy. In current study, we identified that we modificated to therapy in FNEs and this value is higher then expected. Even so, fever control rate of us was successfull in FNEs for initial 5 days. This study will contribute to rapidly and efficacious empirical therapy can decrease morbidity and mortality in FNEs.
Keyword(s): Febrile neutropenia
Session topic: Publication Only
Abstract: PB1799
Type: Publication Only
Background
Febrile neutropenia (FN) is an oncologic emergency that may cause serious complications or death. Rapidly diagnosis and empirical antimicrobial therapy can decrease morbidity and mortality in FN. Agents for empirical therapy have choosen by clinicians must be bacterisidal, broad-spectrum and least toxic. Guidelines and current studies have anticipated about high risk factors and empirical therapy in FN.
Aims
To evaluation of febrile neutropenia episodes (FNEs) in our clinic is aimed in current study.
Methods
We retrospectively analyzed data of 131 FNEs of 48 patients who were admitted to the Pediatric Hematology and Oncology Department of Dr. Behçet Uz Children’s Hospital, Izmir, Turkey between January 2012 and March2014.
Results
The median age at diagnosis of FNEs was 7.4years (3 months - 17 years). Thirty-two of the 48 patients were male and 16 were female. The diagnosis were leukemia at 31, lymphoma at 2 and solid tumor at 15 of patients. Seventy-four per cent of 131 FNEs were determined in patients with leukemia. Focus of clinical infection were determined in 78% of episodes. The distribution of infection’s focus were shown at figure 1. Thirty of FNEs (23%) were documented microbiologically and 60% of them were gram negative bacteria, 30% of them were gram positive bacteria and 10% of them were fungus. Empirical antibiotherapy was applied with monotherapy in 28% of episodes as monotherapy with piperacillin-tazobactam. Piperacillin-tazobactam was also used in 47% of FNEs as duotherapy with aminoglycosides. Other empirical antibitherapy choose were 16% meropenem and 9% cefoperasone-sulbactam. Empirical antifungal was applied in 10% of episodes. Modification of therapy was made as adding antibiotics in 37% (adding aminoglycoside or glycopeptide) or changing antibiotics in 22% (changing to meropeneme) of FNEs. Fourty-eight per cent of FNEs had got response with monotherapy or duotherapy like controlled fever with clinical stabilization. Fever control was provided in 72% of episodes in first 72 hours and also in 83% of episodes in 5 days. Two of 48 patients (4%) were died during neutropenic fever due to pneumonia.
Summary
This study presents clinical findings of patients with FN in childhood malignancy at single center. FNEs were the most in leukemia than the other malignancy. In current study, we identified that we modificated to therapy in FNEs and this value is higher then expected. Even so, fever control rate of us was successfull in FNEs for initial 5 days. This study will contribute to rapidly and efficacious empirical therapy can decrease morbidity and mortality in FNEs.
Keyword(s): Febrile neutropenia
Session topic: Publication Only
Type: Publication Only
Background
Febrile neutropenia (FN) is an oncologic emergency that may cause serious complications or death. Rapidly diagnosis and empirical antimicrobial therapy can decrease morbidity and mortality in FN. Agents for empirical therapy have choosen by clinicians must be bacterisidal, broad-spectrum and least toxic. Guidelines and current studies have anticipated about high risk factors and empirical therapy in FN.
Aims
To evaluation of febrile neutropenia episodes (FNEs) in our clinic is aimed in current study.
Methods
We retrospectively analyzed data of 131 FNEs of 48 patients who were admitted to the Pediatric Hematology and Oncology Department of Dr. Behçet Uz Children’s Hospital, Izmir, Turkey between January 2012 and March2014.
Results
The median age at diagnosis of FNEs was 7.4years (3 months - 17 years). Thirty-two of the 48 patients were male and 16 were female. The diagnosis were leukemia at 31, lymphoma at 2 and solid tumor at 15 of patients. Seventy-four per cent of 131 FNEs were determined in patients with leukemia. Focus of clinical infection were determined in 78% of episodes. The distribution of infection’s focus were shown at figure 1. Thirty of FNEs (23%) were documented microbiologically and 60% of them were gram negative bacteria, 30% of them were gram positive bacteria and 10% of them were fungus. Empirical antibiotherapy was applied with monotherapy in 28% of episodes as monotherapy with piperacillin-tazobactam. Piperacillin-tazobactam was also used in 47% of FNEs as duotherapy with aminoglycosides. Other empirical antibitherapy choose were 16% meropenem and 9% cefoperasone-sulbactam. Empirical antifungal was applied in 10% of episodes. Modification of therapy was made as adding antibiotics in 37% (adding aminoglycoside or glycopeptide) or changing antibiotics in 22% (changing to meropeneme) of FNEs. Fourty-eight per cent of FNEs had got response with monotherapy or duotherapy like controlled fever with clinical stabilization. Fever control was provided in 72% of episodes in first 72 hours and also in 83% of episodes in 5 days. Two of 48 patients (4%) were died during neutropenic fever due to pneumonia.
Summary
This study presents clinical findings of patients with FN in childhood malignancy at single center. FNEs were the most in leukemia than the other malignancy. In current study, we identified that we modificated to therapy in FNEs and this value is higher then expected. Even so, fever control rate of us was successfull in FNEs for initial 5 days. This study will contribute to rapidly and efficacious empirical therapy can decrease morbidity and mortality in FNEs.
Keyword(s): Febrile neutropenia
Session topic: Publication Only
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