THE RULE OF QUALITY OF LIFE QUESTIONNAIRE IN OLDER ADULTS PATIENTS WITH ACUTE MYELOID LEUKEMIA IN A MONOCENTRIC EXPERIENCE
(Abstract release date: 05/21/15)
EHA Library. BUQUICCHIO C. 06/12/15; 102978; PB1978
Disclosure(s): ospedale dimiccoliematologia
Caterina BUQUICCHIO
Contributions
Contributions
Abstract
Abstract: PB1978
Type: Publication Only
Background
In older patients the concept of frailty is changing, infact actually it’s necessary to analize not only the age and the comorbidities but also how the tumoral pathology involve and modify the performance status of the patient s(generally calculated by karnosky, IADL and ADL scale)
Aims
We investigated the value and utility of a simple and fast questionnaire about physical and mental quality of life(SF12 Standard V1) administered to a group of elderly consecutive patients with acute myeloid leukemia in our single center.
Methods
During the years 2013-2015 twenty consecutive patients with acute myeloid leukemia (AML) and age >65 years treated with hypomethylating agents (azacitidine 75mg/m2 for seven consecutive days each twenty-eight days) compiled a simple questionnaire(SF12 Standard V1) with twelve questions to determine and quantify the degree of physical and mental fitness/frailty at the onset of AML and during the treatment(each six months with a monitoring an year
Results
We observed that the patients with higher score at the questionnaire (major impairments in physical activity and mental discomfort) had a poor outcome, while patients with lower score at AML onset or score improvement of 6th months questionnaire(during treatment) predicted longer overall survival (median 200 days versus 600 days;p0.03) and better response to therapy (overall response vs non response p0.04)
Summary
The quality of life questionnaire could help to have a more complete vision of the pathology in those vulnerable patients and to take therapeutic decision (non intensive care versus intensive care)considering the reversibility of frailty caused in part of the acute leukemia.Clinical trials are necessary to confirm the rule predictor of this quality of life questionnaire for overall survival and response to therapy in a large population of older AML patients.
Keyword(s): Acute myeloid leukemia, Old, Quality of life
Session topic: Publication Only
Type: Publication Only
Background
In older patients the concept of frailty is changing, infact actually it’s necessary to analize not only the age and the comorbidities but also how the tumoral pathology involve and modify the performance status of the patient s(generally calculated by karnosky, IADL and ADL scale)
Aims
We investigated the value and utility of a simple and fast questionnaire about physical and mental quality of life(SF12 Standard V1) administered to a group of elderly consecutive patients with acute myeloid leukemia in our single center.
Methods
During the years 2013-2015 twenty consecutive patients with acute myeloid leukemia (AML) and age >65 years treated with hypomethylating agents (azacitidine 75mg/m2 for seven consecutive days each twenty-eight days) compiled a simple questionnaire(SF12 Standard V1) with twelve questions to determine and quantify the degree of physical and mental fitness/frailty at the onset of AML and during the treatment(each six months with a monitoring an year
Results
We observed that the patients with higher score at the questionnaire (major impairments in physical activity and mental discomfort) had a poor outcome, while patients with lower score at AML onset or score improvement of 6th months questionnaire(during treatment) predicted longer overall survival (median 200 days versus 600 days;p0.03) and better response to therapy (overall response vs non response p0.04)
Summary
The quality of life questionnaire could help to have a more complete vision of the pathology in those vulnerable patients and to take therapeutic decision (non intensive care versus intensive care)considering the reversibility of frailty caused in part of the acute leukemia.Clinical trials are necessary to confirm the rule predictor of this quality of life questionnaire for overall survival and response to therapy in a large population of older AML patients.
Keyword(s): Acute myeloid leukemia, Old, Quality of life
Session topic: Publication Only
Abstract: PB1978
Type: Publication Only
Background
In older patients the concept of frailty is changing, infact actually it’s necessary to analize not only the age and the comorbidities but also how the tumoral pathology involve and modify the performance status of the patient s(generally calculated by karnosky, IADL and ADL scale)
Aims
We investigated the value and utility of a simple and fast questionnaire about physical and mental quality of life(SF12 Standard V1) administered to a group of elderly consecutive patients with acute myeloid leukemia in our single center.
Methods
During the years 2013-2015 twenty consecutive patients with acute myeloid leukemia (AML) and age >65 years treated with hypomethylating agents (azacitidine 75mg/m2 for seven consecutive days each twenty-eight days) compiled a simple questionnaire(SF12 Standard V1) with twelve questions to determine and quantify the degree of physical and mental fitness/frailty at the onset of AML and during the treatment(each six months with a monitoring an year
Results
We observed that the patients with higher score at the questionnaire (major impairments in physical activity and mental discomfort) had a poor outcome, while patients with lower score at AML onset or score improvement of 6th months questionnaire(during treatment) predicted longer overall survival (median 200 days versus 600 days;p0.03) and better response to therapy (overall response vs non response p0.04)
Summary
The quality of life questionnaire could help to have a more complete vision of the pathology in those vulnerable patients and to take therapeutic decision (non intensive care versus intensive care)considering the reversibility of frailty caused in part of the acute leukemia.Clinical trials are necessary to confirm the rule predictor of this quality of life questionnaire for overall survival and response to therapy in a large population of older AML patients.
Keyword(s): Acute myeloid leukemia, Old, Quality of life
Session topic: Publication Only
Type: Publication Only
Background
In older patients the concept of frailty is changing, infact actually it’s necessary to analize not only the age and the comorbidities but also how the tumoral pathology involve and modify the performance status of the patient s(generally calculated by karnosky, IADL and ADL scale)
Aims
We investigated the value and utility of a simple and fast questionnaire about physical and mental quality of life(SF12 Standard V1) administered to a group of elderly consecutive patients with acute myeloid leukemia in our single center.
Methods
During the years 2013-2015 twenty consecutive patients with acute myeloid leukemia (AML) and age >65 years treated with hypomethylating agents (azacitidine 75mg/m2 for seven consecutive days each twenty-eight days) compiled a simple questionnaire(SF12 Standard V1) with twelve questions to determine and quantify the degree of physical and mental fitness/frailty at the onset of AML and during the treatment(each six months with a monitoring an year
Results
We observed that the patients with higher score at the questionnaire (major impairments in physical activity and mental discomfort) had a poor outcome, while patients with lower score at AML onset or score improvement of 6th months questionnaire(during treatment) predicted longer overall survival (median 200 days versus 600 days;p0.03) and better response to therapy (overall response vs non response p0.04)
Summary
The quality of life questionnaire could help to have a more complete vision of the pathology in those vulnerable patients and to take therapeutic decision (non intensive care versus intensive care)considering the reversibility of frailty caused in part of the acute leukemia.Clinical trials are necessary to confirm the rule predictor of this quality of life questionnaire for overall survival and response to therapy in a large population of older AML patients.
Keyword(s): Acute myeloid leukemia, Old, Quality of life
Session topic: Publication Only
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