ARTERIAL ISCHEMIC DISEASE AND CONGENITAL THROMBOPHILIA TESTING IN YOUNG PATIENTS: DO OR NOT DO?
(Abstract release date: 05/21/15)
EHA Library. Moreno Vega M. 06/12/15; 102965; PB2054
Disclosure(s): Universitary Hospital of Gran Canaria Dr. NegrínHematology
Mrs. Melania Moreno Vega
Contributions
Contributions
Abstract
Abstract: PB2054
Type: Publication Only
Background
Cardiovascular disease (CVD) includes coronary, renal, cerebral and peripheral artery atherosclerosis and ischemia. It may be caused by several cardiovascular risk factors (CVRF), the most are acquired and modifiable like high blood pressure, smoking, diabetes, obesity or high blood cholesterol, and others unchangeable factors like age or family history of premature illness. Many researchs which have investigated association between congenital thrombophilia (CT) and CVD have obtained positive and negative results. In spite of the doubtful utility of CT analysis in these cases, it is not infrequent its request for young patients with CVD.
Aims
Our aim in this research is to assess CT prevalence in young patients (less or equal than 55 years old) with CVD and comparing to observed in patients with venous thrombotic disease with same age and that has been described in general population.
Methods
Sequential and retrospective analytical study of 149 patients (68 men and 81 women) ≤55 years old with arterial isqhemic event in different vascular areas whom were made CT analysis that included: Antithrombin (AT) and functional chromogenic Protein C (PrC), Functional coagulative Protein S (PrS) and immunological PrS; resistance to Activated Protein C and molecular analysis of factor V Leiden (FVL) and Prothrombin G20210A (FIIG20210A) by PCR. Data were taken from database of our Unit.
Results
Mean age at presentation was 42.9 years (18 - 55). Ischemic location was cerebral in 122 cases, 16 cardiac and 11 peripheral cases. Twelve patients (8%) presented postivie CT: six of them were heterozygous FIIG20210A mutation (4.02%), four heterozygous FVL mutation (2.6%) and one case was positive for type I PrS deficiency (0.67%); a patient presented double thrombophilia (FIIG20210a and PrS deficiency). Eight of twelve patients with TC (66,6%) presented some CVRF and the patient with double thrombophilia was taking oral contraceptives and she was obese, smoker, diabetic and hypertensive. Comparatively, CT prevalence in other previous research of ours about 253 young patients with venous thrombotic disease was 26.8%.
Summary
Congenital thrombophilia prevalence in young patients with CVD is not higher than in general population.
Keyword(s): Arterial thrombosis, Blood coagulation, Young adult
Session topic: Publication Only
Type: Publication Only
Background
Cardiovascular disease (CVD) includes coronary, renal, cerebral and peripheral artery atherosclerosis and ischemia. It may be caused by several cardiovascular risk factors (CVRF), the most are acquired and modifiable like high blood pressure, smoking, diabetes, obesity or high blood cholesterol, and others unchangeable factors like age or family history of premature illness. Many researchs which have investigated association between congenital thrombophilia (CT) and CVD have obtained positive and negative results. In spite of the doubtful utility of CT analysis in these cases, it is not infrequent its request for young patients with CVD.
Aims
Our aim in this research is to assess CT prevalence in young patients (less or equal than 55 years old) with CVD and comparing to observed in patients with venous thrombotic disease with same age and that has been described in general population.
Methods
Sequential and retrospective analytical study of 149 patients (68 men and 81 women) ≤55 years old with arterial isqhemic event in different vascular areas whom were made CT analysis that included: Antithrombin (AT) and functional chromogenic Protein C (PrC), Functional coagulative Protein S (PrS) and immunological PrS; resistance to Activated Protein C and molecular analysis of factor V Leiden (FVL) and Prothrombin G20210A (FIIG20210A) by PCR. Data were taken from database of our Unit.
Results
Mean age at presentation was 42.9 years (18 - 55). Ischemic location was cerebral in 122 cases, 16 cardiac and 11 peripheral cases. Twelve patients (8%) presented postivie CT: six of them were heterozygous FIIG20210A mutation (4.02%), four heterozygous FVL mutation (2.6%) and one case was positive for type I PrS deficiency (0.67%); a patient presented double thrombophilia (FIIG20210a and PrS deficiency). Eight of twelve patients with TC (66,6%) presented some CVRF and the patient with double thrombophilia was taking oral contraceptives and she was obese, smoker, diabetic and hypertensive. Comparatively, CT prevalence in other previous research of ours about 253 young patients with venous thrombotic disease was 26.8%.
Summary
Congenital thrombophilia prevalence in young patients with CVD is not higher than in general population.
Congenital thrombophilia positive result did not trigger any change in therapeutic attitude and it is the reason why its routing testing in arterial thrombosis cases presents little or no use.
Keyword(s): Arterial thrombosis, Blood coagulation, Young adult
Session topic: Publication Only
Abstract: PB2054
Type: Publication Only
Background
Cardiovascular disease (CVD) includes coronary, renal, cerebral and peripheral artery atherosclerosis and ischemia. It may be caused by several cardiovascular risk factors (CVRF), the most are acquired and modifiable like high blood pressure, smoking, diabetes, obesity or high blood cholesterol, and others unchangeable factors like age or family history of premature illness. Many researchs which have investigated association between congenital thrombophilia (CT) and CVD have obtained positive and negative results. In spite of the doubtful utility of CT analysis in these cases, it is not infrequent its request for young patients with CVD.
Aims
Our aim in this research is to assess CT prevalence in young patients (less or equal than 55 years old) with CVD and comparing to observed in patients with venous thrombotic disease with same age and that has been described in general population.
Methods
Sequential and retrospective analytical study of 149 patients (68 men and 81 women) ≤55 years old with arterial isqhemic event in different vascular areas whom were made CT analysis that included: Antithrombin (AT) and functional chromogenic Protein C (PrC), Functional coagulative Protein S (PrS) and immunological PrS; resistance to Activated Protein C and molecular analysis of factor V Leiden (FVL) and Prothrombin G20210A (FIIG20210A) by PCR. Data were taken from database of our Unit.
Results
Mean age at presentation was 42.9 years (18 - 55). Ischemic location was cerebral in 122 cases, 16 cardiac and 11 peripheral cases. Twelve patients (8%) presented postivie CT: six of them were heterozygous FIIG20210A mutation (4.02%), four heterozygous FVL mutation (2.6%) and one case was positive for type I PrS deficiency (0.67%); a patient presented double thrombophilia (FIIG20210a and PrS deficiency). Eight of twelve patients with TC (66,6%) presented some CVRF and the patient with double thrombophilia was taking oral contraceptives and she was obese, smoker, diabetic and hypertensive. Comparatively, CT prevalence in other previous research of ours about 253 young patients with venous thrombotic disease was 26.8%.
Summary
Congenital thrombophilia prevalence in young patients with CVD is not higher than in general population.
Keyword(s): Arterial thrombosis, Blood coagulation, Young adult
Session topic: Publication Only
Type: Publication Only
Background
Cardiovascular disease (CVD) includes coronary, renal, cerebral and peripheral artery atherosclerosis and ischemia. It may be caused by several cardiovascular risk factors (CVRF), the most are acquired and modifiable like high blood pressure, smoking, diabetes, obesity or high blood cholesterol, and others unchangeable factors like age or family history of premature illness. Many researchs which have investigated association between congenital thrombophilia (CT) and CVD have obtained positive and negative results. In spite of the doubtful utility of CT analysis in these cases, it is not infrequent its request for young patients with CVD.
Aims
Our aim in this research is to assess CT prevalence in young patients (less or equal than 55 years old) with CVD and comparing to observed in patients with venous thrombotic disease with same age and that has been described in general population.
Methods
Sequential and retrospective analytical study of 149 patients (68 men and 81 women) ≤55 years old with arterial isqhemic event in different vascular areas whom were made CT analysis that included: Antithrombin (AT) and functional chromogenic Protein C (PrC), Functional coagulative Protein S (PrS) and immunological PrS; resistance to Activated Protein C and molecular analysis of factor V Leiden (FVL) and Prothrombin G20210A (FIIG20210A) by PCR. Data were taken from database of our Unit.
Results
Mean age at presentation was 42.9 years (18 - 55). Ischemic location was cerebral in 122 cases, 16 cardiac and 11 peripheral cases. Twelve patients (8%) presented postivie CT: six of them were heterozygous FIIG20210A mutation (4.02%), four heterozygous FVL mutation (2.6%) and one case was positive for type I PrS deficiency (0.67%); a patient presented double thrombophilia (FIIG20210a and PrS deficiency). Eight of twelve patients with TC (66,6%) presented some CVRF and the patient with double thrombophilia was taking oral contraceptives and she was obese, smoker, diabetic and hypertensive. Comparatively, CT prevalence in other previous research of ours about 253 young patients with venous thrombotic disease was 26.8%.
Summary
Congenital thrombophilia prevalence in young patients with CVD is not higher than in general population.
Congenital thrombophilia positive result did not trigger any change in therapeutic attitude and it is the reason why its routing testing in arterial thrombosis cases presents little or no use.
Keyword(s): Arterial thrombosis, Blood coagulation, Young adult
Session topic: Publication Only
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