ANALYSIS OF THE EFFICACY OF CCLG-ALL2008 PROTOCOL ON THE ADOLESCENTS AND YOUNG PATIENTS WITH ACUTE LYMPHOBLASTIC LEUKEMIA
(Abstract release date: 05/21/15)
EHA Library. Tan Y. 06/12/15; 102925; PB1616
Disclosure(s): First Hospital of Jilin UniversityTumor Center
Ye-Hui Tan
Contributions
Contributions
Abstract
Abstract: PB1616
Type: Publication Only
Background
Acute lymphocytic leukemia is a kind of heterogeneous disease, the prognosis of the pediatric patients was significantly better than that of adults. Adolescent and young adult (AYA) patients could adopt pediatric or adult chemotherapy regimens. In recent years, some studies showed pediatric like regimens could improve the prognosis of AYA ALL patients.
Aims
Analysis of efficacy and safety of the pediatric ALL chemotherapy regimen CCLG-ALL2008 on adolescents and young ALL.
Methods
15 to 30 years old ALL patients treated with CCLG-ALL 2008 regimen from January 2008 to December 2013 in our cancer center was retrospectively analyzed. CR rate on day 14 and day 28, relapse-free survival, overall survival and the relativity between the clinical characteristics and RFS were analyzed. The chemotherapy related toxicity was assessed with WHO criteria. The informed consents of each patient was obtained before the treatments.
Results
21 cases of adolescent ALL included 13 males and 8 females were analyzed, with a median age of 18 years old and 18 cases with median-risk and 3 cases with high-risk according to regimen CCLG-ALL2008. 14 days CR rate was 90.5% and 28 day CR rate was 100%, median CR time were 14 days (14 to 28d), median cytogenetic remission time was 2 months, 17 patients reached molecular biology remission with a median time of one month. Three cases relapsed and 1 patient was lost in follow-up, five cases underwent hematopoietic stem cell transplantation. 2-year OS rate was 100.0% and 2-year RFS rate was 66.6%; Univariate and multivariate analysis showed that the presence of extramedullary infiltration was unfavorable factors of 2-year RFS. Neutropenia was observed in 17 patients (81%), neutropenia fever occurred in 12 cases (57.1%) and were documented with infection, including 2 (9.5%) pneumonia and 5 sepsis (23.8%). 4 degree of thrombocytopenia occurred in 13 patients (61.9%) and coagulation abnormalities occurred in 16 patients (76.2%), Non-fatal bleeding occurred. 1-2 grade toxicity occurrence rates in heart, liver and kidney and gastrointestinal were 33.3%, 61.9%, 23.8% and 71.4% respectively.
Summary
The regimen of CCLG-ALL2008 has obtained good curative efficacy in AYA ALL patients, and the toxicity was easily tolerated.
Keyword(s): Acute lymphoblastic leukemia, Chemotherapy, Young adult
Session topic: Publication Only
Type: Publication Only
Background
Acute lymphocytic leukemia is a kind of heterogeneous disease, the prognosis of the pediatric patients was significantly better than that of adults. Adolescent and young adult (AYA) patients could adopt pediatric or adult chemotherapy regimens. In recent years, some studies showed pediatric like regimens could improve the prognosis of AYA ALL patients.
Aims
Analysis of efficacy and safety of the pediatric ALL chemotherapy regimen CCLG-ALL2008 on adolescents and young ALL.
Methods
15 to 30 years old ALL patients treated with CCLG-ALL 2008 regimen from January 2008 to December 2013 in our cancer center was retrospectively analyzed. CR rate on day 14 and day 28, relapse-free survival, overall survival and the relativity between the clinical characteristics and RFS were analyzed. The chemotherapy related toxicity was assessed with WHO criteria. The informed consents of each patient was obtained before the treatments.
Results
21 cases of adolescent ALL included 13 males and 8 females were analyzed, with a median age of 18 years old and 18 cases with median-risk and 3 cases with high-risk according to regimen CCLG-ALL2008. 14 days CR rate was 90.5% and 28 day CR rate was 100%, median CR time were 14 days (14 to 28d), median cytogenetic remission time was 2 months, 17 patients reached molecular biology remission with a median time of one month. Three cases relapsed and 1 patient was lost in follow-up, five cases underwent hematopoietic stem cell transplantation. 2-year OS rate was 100.0% and 2-year RFS rate was 66.6%; Univariate and multivariate analysis showed that the presence of extramedullary infiltration was unfavorable factors of 2-year RFS. Neutropenia was observed in 17 patients (81%), neutropenia fever occurred in 12 cases (57.1%) and were documented with infection, including 2 (9.5%) pneumonia and 5 sepsis (23.8%). 4 degree of thrombocytopenia occurred in 13 patients (61.9%) and coagulation abnormalities occurred in 16 patients (76.2%), Non-fatal bleeding occurred. 1-2 grade toxicity occurrence rates in heart, liver and kidney and gastrointestinal were 33.3%, 61.9%, 23.8% and 71.4% respectively.
Summary
The regimen of CCLG-ALL2008 has obtained good curative efficacy in AYA ALL patients, and the toxicity was easily tolerated.
Keyword(s): Acute lymphoblastic leukemia, Chemotherapy, Young adult
Session topic: Publication Only
Abstract: PB1616
Type: Publication Only
Background
Acute lymphocytic leukemia is a kind of heterogeneous disease, the prognosis of the pediatric patients was significantly better than that of adults. Adolescent and young adult (AYA) patients could adopt pediatric or adult chemotherapy regimens. In recent years, some studies showed pediatric like regimens could improve the prognosis of AYA ALL patients.
Aims
Analysis of efficacy and safety of the pediatric ALL chemotherapy regimen CCLG-ALL2008 on adolescents and young ALL.
Methods
15 to 30 years old ALL patients treated with CCLG-ALL 2008 regimen from January 2008 to December 2013 in our cancer center was retrospectively analyzed. CR rate on day 14 and day 28, relapse-free survival, overall survival and the relativity between the clinical characteristics and RFS were analyzed. The chemotherapy related toxicity was assessed with WHO criteria. The informed consents of each patient was obtained before the treatments.
Results
21 cases of adolescent ALL included 13 males and 8 females were analyzed, with a median age of 18 years old and 18 cases with median-risk and 3 cases with high-risk according to regimen CCLG-ALL2008. 14 days CR rate was 90.5% and 28 day CR rate was 100%, median CR time were 14 days (14 to 28d), median cytogenetic remission time was 2 months, 17 patients reached molecular biology remission with a median time of one month. Three cases relapsed and 1 patient was lost in follow-up, five cases underwent hematopoietic stem cell transplantation. 2-year OS rate was 100.0% and 2-year RFS rate was 66.6%; Univariate and multivariate analysis showed that the presence of extramedullary infiltration was unfavorable factors of 2-year RFS. Neutropenia was observed in 17 patients (81%), neutropenia fever occurred in 12 cases (57.1%) and were documented with infection, including 2 (9.5%) pneumonia and 5 sepsis (23.8%). 4 degree of thrombocytopenia occurred in 13 patients (61.9%) and coagulation abnormalities occurred in 16 patients (76.2%), Non-fatal bleeding occurred. 1-2 grade toxicity occurrence rates in heart, liver and kidney and gastrointestinal were 33.3%, 61.9%, 23.8% and 71.4% respectively.
Summary
The regimen of CCLG-ALL2008 has obtained good curative efficacy in AYA ALL patients, and the toxicity was easily tolerated.
Keyword(s): Acute lymphoblastic leukemia, Chemotherapy, Young adult
Session topic: Publication Only
Type: Publication Only
Background
Acute lymphocytic leukemia is a kind of heterogeneous disease, the prognosis of the pediatric patients was significantly better than that of adults. Adolescent and young adult (AYA) patients could adopt pediatric or adult chemotherapy regimens. In recent years, some studies showed pediatric like regimens could improve the prognosis of AYA ALL patients.
Aims
Analysis of efficacy and safety of the pediatric ALL chemotherapy regimen CCLG-ALL2008 on adolescents and young ALL.
Methods
15 to 30 years old ALL patients treated with CCLG-ALL 2008 regimen from January 2008 to December 2013 in our cancer center was retrospectively analyzed. CR rate on day 14 and day 28, relapse-free survival, overall survival and the relativity between the clinical characteristics and RFS were analyzed. The chemotherapy related toxicity was assessed with WHO criteria. The informed consents of each patient was obtained before the treatments.
Results
21 cases of adolescent ALL included 13 males and 8 females were analyzed, with a median age of 18 years old and 18 cases with median-risk and 3 cases with high-risk according to regimen CCLG-ALL2008. 14 days CR rate was 90.5% and 28 day CR rate was 100%, median CR time were 14 days (14 to 28d), median cytogenetic remission time was 2 months, 17 patients reached molecular biology remission with a median time of one month. Three cases relapsed and 1 patient was lost in follow-up, five cases underwent hematopoietic stem cell transplantation. 2-year OS rate was 100.0% and 2-year RFS rate was 66.6%; Univariate and multivariate analysis showed that the presence of extramedullary infiltration was unfavorable factors of 2-year RFS. Neutropenia was observed in 17 patients (81%), neutropenia fever occurred in 12 cases (57.1%) and were documented with infection, including 2 (9.5%) pneumonia and 5 sepsis (23.8%). 4 degree of thrombocytopenia occurred in 13 patients (61.9%) and coagulation abnormalities occurred in 16 patients (76.2%), Non-fatal bleeding occurred. 1-2 grade toxicity occurrence rates in heart, liver and kidney and gastrointestinal were 33.3%, 61.9%, 23.8% and 71.4% respectively.
Summary
The regimen of CCLG-ALL2008 has obtained good curative efficacy in AYA ALL patients, and the toxicity was easily tolerated.
Keyword(s): Acute lymphoblastic leukemia, Chemotherapy, Young adult
Session topic: Publication Only
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