MRI BRAIN IN YOUNG EGYPTIAN SICKLE CELL DISEASE PATIENTS: RELATION TO CEREBRAL BLOOD FLOW AND NEUROPSYCHOMETRIC EVALUATION
(Abstract release date: 05/21/15)
EHA Library. tantawy a. 06/12/15; 102922; PB2004
Disclosure(s): Faculty of Medicine,Ain Shams University,Cairo,EgyptPediatric Department
Prof. azza tantawy
Contributions
Contributions
Abstract
Abstract: PB2004
Type: Publication Only
Background
Stroke is an important and common complication of sickle cell disease (SCD), affecting children as well as adults.
Aims
To evaluate the prevalence of abnormal MRI brain in sickle cell disease (SCD) patients and its relation to transcranial Doppler findings and the results of neurosychometric evaluation
Methods
A cohort of 30 SCD patients aged less than 18 years were recruited from the Children’s Hospital,Faculty of Medicine,Ain Shams University,Cairo,Egypt, examined in the steady state.Patients were subjected to full clinical and neurological examination and psychometric evaluation using Wechsler intelligence scale and Benton visual retention test, laboratory investigations including CBC,Hb electrophoresis,serum ferritin, MRI brain,transcranial Doppler ultrasonography for MCA,ACA,PCA,ICA,vertebral artery and basilar artery.
Results
The cohort included 12 males and 18 females, mean age 11+/-3.5 years., including 14 splenectomized patients. Abnormal MRI findings were present in 7/30 patients(23.3%), as tiny cortical infarctions in 5 patients (all were asymptomatic) and large infarctions in two patients (both had previous history of stroke). The presence of abnormal MRI was not related to age,sex,family history of SCD or stroke,neurological symptomatology,abnormal findings on neurological examination,or frequency of blood transfusion . Abnormal brain MRI was significantly related to frequency of sickling crises (p=0.002), surgical splenectomy (p=0.002),HDU therapy (p=0001),scholastic retardation (p=0.0001),impaired Penton visual perception (p=0.0001),impaired attention (p=0.001),impaired comprehension (p=0001), hematocrit value(p=0.001),HbS%(p=0.0001),HbF%(p=0.001),Total WBCs count(p=0.0001), absolute neutrophil count(p=0.0001), serum ferritin(p=0.0001).Abnormal MRI was related to cerebral blood flow in MCA (p=0001)and ICA (p=0001) but not related to cerebral blood flow in ACA,PCA, vertebral artery and basilar artery.
Summary
Conclusion: In patients with SCD,the neurologist should not only rely on standard neurological examination,but should add cerebral doppler and neuropsychometric assessment tools as soft signs to identify even minor MRI lesions and to identify the children at risk of stroke
Keyword(s): MRI, Sickle cell disease
Session topic: Publication Only
Type: Publication Only
Background
Stroke is an important and common complication of sickle cell disease (SCD), affecting children as well as adults.
Aims
To evaluate the prevalence of abnormal MRI brain in sickle cell disease (SCD) patients and its relation to transcranial Doppler findings and the results of neurosychometric evaluation
Methods
A cohort of 30 SCD patients aged less than 18 years were recruited from the Children’s Hospital,Faculty of Medicine,Ain Shams University,Cairo,Egypt, examined in the steady state.Patients were subjected to full clinical and neurological examination and psychometric evaluation using Wechsler intelligence scale and Benton visual retention test, laboratory investigations including CBC,Hb electrophoresis,serum ferritin, MRI brain,transcranial Doppler ultrasonography for MCA,ACA,PCA,ICA,vertebral artery and basilar artery.
Results
The cohort included 12 males and 18 females, mean age 11+/-3.5 years., including 14 splenectomized patients. Abnormal MRI findings were present in 7/30 patients(23.3%), as tiny cortical infarctions in 5 patients (all were asymptomatic) and large infarctions in two patients (both had previous history of stroke). The presence of abnormal MRI was not related to age,sex,family history of SCD or stroke,neurological symptomatology,abnormal findings on neurological examination,or frequency of blood transfusion . Abnormal brain MRI was significantly related to frequency of sickling crises (p=0.002), surgical splenectomy (p=0.002),HDU therapy (p=0001),scholastic retardation (p=0.0001),impaired Penton visual perception (p=0.0001),impaired attention (p=0.001),impaired comprehension (p=0001), hematocrit value(p=0.001),HbS%(p=0.0001),HbF%(p=0.001),Total WBCs count(p=0.0001), absolute neutrophil count(p=0.0001), serum ferritin(p=0.0001).Abnormal MRI was related to cerebral blood flow in MCA (p=0001)and ICA (p=0001) but not related to cerebral blood flow in ACA,PCA, vertebral artery and basilar artery.
Summary
Conclusion: In patients with SCD,the neurologist should not only rely on standard neurological examination,but should add cerebral doppler and neuropsychometric assessment tools as soft signs to identify even minor MRI lesions and to identify the children at risk of stroke
Keyword(s): MRI, Sickle cell disease
Session topic: Publication Only
Abstract: PB2004
Type: Publication Only
Background
Stroke is an important and common complication of sickle cell disease (SCD), affecting children as well as adults.
Aims
To evaluate the prevalence of abnormal MRI brain in sickle cell disease (SCD) patients and its relation to transcranial Doppler findings and the results of neurosychometric evaluation
Methods
A cohort of 30 SCD patients aged less than 18 years were recruited from the Children’s Hospital,Faculty of Medicine,Ain Shams University,Cairo,Egypt, examined in the steady state.Patients were subjected to full clinical and neurological examination and psychometric evaluation using Wechsler intelligence scale and Benton visual retention test, laboratory investigations including CBC,Hb electrophoresis,serum ferritin, MRI brain,transcranial Doppler ultrasonography for MCA,ACA,PCA,ICA,vertebral artery and basilar artery.
Results
The cohort included 12 males and 18 females, mean age 11+/-3.5 years., including 14 splenectomized patients. Abnormal MRI findings were present in 7/30 patients(23.3%), as tiny cortical infarctions in 5 patients (all were asymptomatic) and large infarctions in two patients (both had previous history of stroke). The presence of abnormal MRI was not related to age,sex,family history of SCD or stroke,neurological symptomatology,abnormal findings on neurological examination,or frequency of blood transfusion . Abnormal brain MRI was significantly related to frequency of sickling crises (p=0.002), surgical splenectomy (p=0.002),HDU therapy (p=0001),scholastic retardation (p=0.0001),impaired Penton visual perception (p=0.0001),impaired attention (p=0.001),impaired comprehension (p=0001), hematocrit value(p=0.001),HbS%(p=0.0001),HbF%(p=0.001),Total WBCs count(p=0.0001), absolute neutrophil count(p=0.0001), serum ferritin(p=0.0001).Abnormal MRI was related to cerebral blood flow in MCA (p=0001)and ICA (p=0001) but not related to cerebral blood flow in ACA,PCA, vertebral artery and basilar artery.
Summary
Conclusion: In patients with SCD,the neurologist should not only rely on standard neurological examination,but should add cerebral doppler and neuropsychometric assessment tools as soft signs to identify even minor MRI lesions and to identify the children at risk of stroke
Keyword(s): MRI, Sickle cell disease
Session topic: Publication Only
Type: Publication Only
Background
Stroke is an important and common complication of sickle cell disease (SCD), affecting children as well as adults.
Aims
To evaluate the prevalence of abnormal MRI brain in sickle cell disease (SCD) patients and its relation to transcranial Doppler findings and the results of neurosychometric evaluation
Methods
A cohort of 30 SCD patients aged less than 18 years were recruited from the Children’s Hospital,Faculty of Medicine,Ain Shams University,Cairo,Egypt, examined in the steady state.Patients were subjected to full clinical and neurological examination and psychometric evaluation using Wechsler intelligence scale and Benton visual retention test, laboratory investigations including CBC,Hb electrophoresis,serum ferritin, MRI brain,transcranial Doppler ultrasonography for MCA,ACA,PCA,ICA,vertebral artery and basilar artery.
Results
The cohort included 12 males and 18 females, mean age 11+/-3.5 years., including 14 splenectomized patients. Abnormal MRI findings were present in 7/30 patients(23.3%), as tiny cortical infarctions in 5 patients (all were asymptomatic) and large infarctions in two patients (both had previous history of stroke). The presence of abnormal MRI was not related to age,sex,family history of SCD or stroke,neurological symptomatology,abnormal findings on neurological examination,or frequency of blood transfusion . Abnormal brain MRI was significantly related to frequency of sickling crises (p=0.002), surgical splenectomy (p=0.002),HDU therapy (p=0001),scholastic retardation (p=0.0001),impaired Penton visual perception (p=0.0001),impaired attention (p=0.001),impaired comprehension (p=0001), hematocrit value(p=0.001),HbS%(p=0.0001),HbF%(p=0.001),Total WBCs count(p=0.0001), absolute neutrophil count(p=0.0001), serum ferritin(p=0.0001).Abnormal MRI was related to cerebral blood flow in MCA (p=0001)and ICA (p=0001) but not related to cerebral blood flow in ACA,PCA, vertebral artery and basilar artery.
Summary
Conclusion: In patients with SCD,the neurologist should not only rely on standard neurological examination,but should add cerebral doppler and neuropsychometric assessment tools as soft signs to identify even minor MRI lesions and to identify the children at risk of stroke
Keyword(s): MRI, Sickle cell disease
Session topic: Publication Only
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